Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 50 times since 2001 (2.2 per year) source: EuropePMC
Investigative radiology, Volume 36, Issue 11, 1 1 2001, Pages 648-651 Repeatability of lung density measurements with low-dose computed tomography in subjects with alpha-1-antitrypsin deficiency-associated emphysema. Stolk J, Dirksen A, van der Lugt AA, Hutsebaut J, Mathieu J, de Ree J, Reiber JH, Stoel BC
Rationale and objectives: Multislice computed tomography (MSCT) of the lungs provides a new opportunity for longitudinal assessment of lung densities because of shorter scan duration. The aim of the present study was to assess the intraindividual variation of lung densities measured by MSCT of patients with emphysema. Methods: Ten patients with emphysema participated in a study in which MSCT was obtained on two occasions, approximately 2 weeks apart. Scanning parameters were 140 kV, 20 mAs, 4 x... Abstract
Cited 47 times since 2001 (2.1 per year) source: EuropePMC
Human gene therapy, Volume 12, Issue 16, 1 1 2001, Pages 1989-2005 Highly efficient targeted transduction of undifferentiated human hematopoietic cells by adenoviral vectors displaying fiber knobs of subgroup B. Knaän-Shanzer S, Van Der Velde I, Havenga MJ, Lemckert AA, De Vries AA, Valerio D
Human hematopoietic stem cells (HSCs) are poorly transduced by vectors based on adenovirus serotype 5 (Ad5). This is primarily due to the paucity of the coxsackievirus-Ad receptor on these cells. In an attempt to change the tropism of Ad5, we constructed a series of chimeric E1-deleted Ad5 vectors in which the shaft and knob of the capsid fibers were exchanged with those of other Ad serotypes. In all these vectors, the Ad E1 region was replaced by an expression cassette containing the cytomegalo... Abstract
Cited 14 times since 2001 (0.6 per year) source: EuropePMC
Molecular biology of the cell, Volume 12, Issue 11, 1 1 2001, Pages 3680-3689 Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association. van Eenennaam H, van der Heijden A, Janssen RJ, van Venrooij WJ, Pruijn GJ
The RNase MRP and RNase P ribonucleoprotein particles both function as endoribonucleases, have a similar RNA component, and share several protein subunits. RNase MRP has been implicated in pre-rRNA processing and mitochondrial DNA replication, whereas RNase P functions in pre-tRNA processing. Both RNase MRP and RNase P accumulate in the nucleolus of eukaryotic cells. In this report we show that for three protein subunits of the RNase MRP complex (hPop1, hPop4, and Rpp38) basic domains are respon... Abstract
Cited 24 times since 2001 (1.1 per year) source: EuropePMC
European heart journal, Volume 22, Issue 22, 1 1 2001, Pages 2058-2074 Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy. Agema WR, Jukema JW, Pimstone SN, Kastelein JJ
Cited 6 times since 2001 (0.3 per year) source: EuropePMC
The Netherlands journal of medicine, Volume 59, Issue 4, 1 1 2001, Pages 161-169 The application of a Dutch consensus diagnostic strategy for pulmonary embolism in clinical practice. Hagen PJ, van Strijen MJ, Kieft GJ, Graafsma YP, Prins MH, Postmus PE
In The Netherlands, the 'Dutch consensus strategy' was formulated in 1993 as a diagnostic strategy for patients with suspected pulmonary embolism. Four years after its introduction, the application of this strategy was investigated. A questionnaire was sent to the hospital management and the departments of internal medicine and pulmonology of all Dutch hospitals. In total, 384 questionnaires were sent out. The response rates of the internists and pulmonologists were 63 and 65%, respect... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 9, Issue 7, 1 1 2001, Pages 267-268 Pulmonary valve insertion late after repair of Fallot's tetralogy. Vliegen HW, Hazekamp MG
Cited 61 times since 2001 (2.7 per year) source: EuropePMC
Circulation, Volume 104, Issue 17, 1 1 2001, Pages 2029-2033 Stent placement to prevent restenosis after angioplasty in small coronary arteries. Doucet S, Schalij MJ, Vrolix MC, Hilton D, Chenu P, de Bruyne B, Udayachalerm W, Seth A, Bilodeau L, Reiber JH, Harel F, Lespérance J, Stent In Small Arteries(SISA) Trial Investigators
Background: Lesions in small-diameter vessels ( Abstract
Cited 20 times since 2001 (0.9 per year) source: EuropePMC
The Journal of clinical endocrinology and metabolism, Volume 86, Issue 10, 1 1 2001, Pages 4638-4643 Six months of recombinant human GH therapy in patients with ischemic cardiac failure does not influence left ventricular function and mass. Smit JW, Janssen YJ, Lamb HJ, van der Wall EE, Stokkel MP, Viergever E, Biermasz NR, Bax JJ, Vliegen HW, de Roos A, Romijn JA, Roelfsema F
Beneficial effects of recombinant human GH on cardiac function have been reported in humans with GH deficiency and in patients with idiopathic dilated cardiomyopathy. No randomized controlled trial has been performed on the effects of recombinant human GH on cardiac function in patients with ischemic cardiac failure. We therefore randomly assigned 22 patients with ischemic cardiac failure (left ventricular ejection fraction, Abstract
Cited 54 times since 2001 (2.4 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 12, Issue 10, 1 1 2001, Pages 1359-1368 Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III study. Tjan-Heijnen VC, Postmus PE, Ardizzoni A, Manegold CH, Burghouts J, van Meerbeeck J, Gans S, Mollers M, Buchholz E, Biesma B, Legrand C, Debruyne C, Giaccone G, European Organisation for Research and Treatment of Cancer-Lung Cancer Group
Background: CDE (cyclophosphamide, doxorubicin, etoposide) is one of the standard chemotherapy regimens in the treatment of small-cell lung cancer (SCLC), with myelosuppression as dose-limiting toxicity. In this trial the impact of prophylactic antibiotics on incidence of febrile leucopenia (FL) during chemotherapy for SCLC was evaluated. Patients and methods: Patients with chemo-naïve SCLC were randomized to standard-dose CDE (C 1,000 mg/m2 day 1, D 45 mg/m2 day 1, E 100 mg/m2 days 1-3. i.v., q... Abstract
Cited 10 times since 2001 (0.4 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 122, Issue 4, 1 1 2001, Pages 767-774 Influence of clenbuterol treatment during six weeks of chronic right ventricular pressure overload as studied with pressure-volume analysis. Hon JK, Steendijk P, Petrou M, Wong K, Yacoub MH
Objectives: Chronic pressure overload cardiac hypertrophy produces ventricular dysfunction. There is evidence that clenbuterol, a beta(2)-adrenoceptor agonist, produces cardiac hypertrophy with preserved function in rodents. We sought to determine the cardiac hypertrophic effects of clenbuterol on the thin-walled ventricles of large animals undergoing chronic pressure overload by means of pulmonary artery banding. Methods: Right ventricular pressure-volume loops were obtained in open-chest sheep... Abstract
Cited 142 times since 2001 (6.3 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 19, Issue 20, 1 1 2001, Pages 4037-4047 Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients. Klein M, Taphoorn MJ, Heimans JJ, van der Ploeg HM, Vandertop WP, Smit EF, Leenstra S, Tulleken CA, Boogerd W, Belderbos JS, Cleijne W, Aaronson NK
Purpose: To evaluate the health-related quality of life (HRQOL) and cognitive functioning of high-grade glioma patients in the postneurosurgical period. Patients and methods: The HRQOL, as assessed by the Short-Form Health Survey-36, tumor-specific symptoms, and objective and subjective neuropsychologic functioning, of 68 newly diagnosed glioma patients were compared with that of 50 patients with non-small-cell lung cancer (NSCLC) and to age- and sex-matched healthy controls. The association bet... Abstract
Cited 42 times since 2001 (1.9 per year) source: EuropePMC
Chest, Volume 120, Issue 4, 1 1 2001, Pages 1327-1332 Autofluorescence bronchoscopy improves staging of radiographically occult lung cancer and has an impact on therapeutic strategy. Sutedja TG, Codrington H, Risse EK, Breuer RH, van Mourik JC, Golding RP, Postmus PE
Background: The ability of conventional CT scans and fiberoptic bronchoscopy to localize and properly stage radiographically occult lung cancer (ROLC) in the major airways is limited. High-resolution CT (HRCT) scanning and autofluorescence bronchoscopy (AFB) may improve the assessment of ROLC before the most appropriate therapy can be considered. Patients and methods: We prospectively studied 23 patients with ROLC, who were referred for intraluminal bronchoscopic treatment (IBT) with curative in... Abstract
Cited 11 times since 2001 (0.5 per year) source: EuropePMC
Respiratory medicine, Volume 95, Issue 10, 1 1 2001, Pages 802-805 Delays in the diagnosis and treatment of hospitalized patients with smear-positive pulmonary tuberculosis. Yilmaz A, Boğa S, Sulu E, Durucu M, Yilmaz D, Baran A, Poluman A
The aim of present study was to investigate whether there was any delay in the diagnosis and treatment of inpatients with smear-positive pulmonary tuberculosis followed-up in our centre. We reviewed clinical records in February 1999 and identified 134 hospitalized patients with smear-positive pulmonary tuberculosis. Clinical files of the patients were analysed and a questionnaire was completed. Several intervals and delays were calculated. Median application interval was 17.5 days [95% confidenc... Abstract
Cited 32 times since 2001 (1.4 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 21, Issue 10, 1 1 2001, Pages 1630-1635 Raman spectroscopic evaluation of the effects of diet and lipid-lowering therapy on atherosclerotic plaque development in mice. van De Poll SW, Römer TJ, Volger OL, Delsing DJ, Bakker Schut TC, Princen HM, Havekes LM, Jukema JW, van Der Laarse A, Puppels GJ
Quantitative characterization of atherosclerotic plaque composition with standard histopathological methods remains limited to sectioned plaques. Raman spectroscopy enables nondestructive quantification of atherosclerotic plaque composition. We used Raman spectroscopy to study the effects of diet and lipid-lowering therapy on plaque development in apolipoprotein (APO) E*3-Leiden transgenic mice. Raman spectra were obtained over the full width and entire length of the ascending aorta and aortic a... Abstract
Cited 5 times since 2001 (0.2 per year) source: EuropePMC
Cardiovascular research, Volume 51, Issue 4, 1 1 2001, Pages 729-735 The volume-dependency of parallel conductance throughout the cardiac cycle and its consequence for volume estimation of the left ventricle in patients. Kornet L, Schreuder JJ, van der Velde ET, Jansen JR
Objective: To study the hypothesis that the electrical conductance of tissues and fluids (parallel conductance (G(p))) around the ventricle depends on left ventricular volume throughout the cardiac cycle. Methods: We extended a recently developed method to determine G(p) throughout the cardiac cycle. First, we compared the estimates of parallel conductances obtained with the new method (G(a)(p)) with those of the conventional one (G(1)(p)), both averaged over the cardiac cycles. Secondly, G(a)(p... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 9, Issue 6, 1 1 2001, Pages 256-261 Scientific conference on therapeutic angiogenesis and myocardial laser revascularisation: Santa Fe, United States, 24-27 January 2001. Palmen M, Dekkers SC
Cited 2 times since 2001 (0.1 per year) source: EuropePMC
American journal of surgery, Volume 182, Issue 3, 1 1 2001, Pages 305-306 Prospective trial of computed tomography and ultrasonography for diagnosing appendicitis in the atypical patient. Poortman P, Hamming JF
Cited 7 times since 2001 (0.3 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 122, Issue 3, 1 1 2001, Pages 449-456 Prime solutions for cardiopulmonary bypass in neonates: antioxidant capacity of prime based on albumin or fresh frozen plasma. Molicki JS, Draaisma AM, Verbeet N, Munneke R, Huysmans HA, Hazekamp MG, Berger HM
Objective: Oxidative damage and inflammation are believed to play an important role in postoperative complications after cardiopulmonary bypass. During bypass, a prime solution with a high antioxidant capacity may reduce the oxidative damage and inflammation. We investigated total antioxidant capacity and individual scavengers during the preparation of 2 different prime solutions. Methods: The prime solutions were prepared with either pasteurized human albumin or fresh frozen plasma. The total a... Abstract
Cited 22 times since 2001 (1 per year) source: EuropePMC
Virology, Volume 288, Issue 2, 1 1 2001, Pages 236-246 Generation of a high-capacity hybrid vector: packaging of recombinant adenoassociated virus replicative intermediates in adenovirus capsids overcomes the limited cloning capacity of adenoassociated virus vectors. Gonçalves MA, Pau MG, de Vries AA, Valerio D
Gene therapy aims to complement or, ideally, correct defective genes. The broad clinical application of this emerging technology requires the development of safe high-capacity gene delivery vehicles that combine efficient transduction of dividing as well as quiescent cells with sustained transgene expression. Here we present a new hybrid vector system that unites favorable attributes of adenoassociated virus (AAV) and adenovirus (Ad) vectors in a single particle. This was achieved by inclusion o... Abstract
Cited 22 times since 2001 (1 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 24, Issue 9 Pt 1, 1 1 2001, Pages 1334-1342 Three-dimensional distribution of bipolar atrial electrogram voltages in patients with congenital heart disease. De Groot NM, Kuijper AF, Blom NA, Bootsma M, Schalij MJ
Voltage differences might be used to distinguish normal atrial tissue from abnormal atrial tissue. This study was aimed at identifying lowest voltage areas in patients with atrial tachycardia after surgical correction of congenital heart disease and to evaluate if identification of these areas in diseased hearts facilitates selection of critical conduction pathways in reentrant circuits as target sites for catheter ablation. Ten patients (four men, age 39 +/- 15 years) with normal sized atria an... Abstract