Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 21 times since 2001 (0.9 per year) source: EuropePMC
The Biochemical journal, Volume 356, Issue Pt 3, 1 1 2001, Pages 907-910 Cloning and characterization of human liver cytosolic beta-glycosidase. de Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ
Cytosolic beta-glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta-D-glycosides, including beta-D-glucoside and beta-D-galactoside. We therefore refer to this enzyme as cytosolic beta-glycosidase. We cloned the cDNA encoding the human cytosolic beta-glycosidase by performing PCR on cDNA prepared from total human liver RNA. Specific primers were based on human expressed sequence tags found in the... Abstract
Cited 28 times since 2001 (1.2 per year) source: EuropePMC
Radiology, Volume 219, Issue 3, 1 1 2001, Pages 637-643 Aortic valve replacement in patients with aortic valve stenosis improves myocardial metabolism and diastolic function. Beyerbacht HP, Lamb HJ, van Der Laarse A, Vliegen HW, Leujes F, Hazekamp MG, de Roos A, van Der Wall EE
Purpose: To evaluate whether functional and metabolic changes recover after aortic valve replacement (AVR). Materials and methods: Eighteen men with aortic valve stenosis (mean pressure gradient +/- SD, 79.9 mm Hg +/- 15.1) underwent magnetic resonance (MR) imaging and phosphorus 31 MR spectroscopy. In nine patients who underwent AVR, MR imaging and spectroscopy were repeated 40 weeks +/- 12 after AVR. Ten age-matched healthy men were control subjects. Results: Before AVR, the myocardial phospho... Abstract
Cited 19 times since 2001 (0.8 per year) source: EuropePMC
Virology, Volume 284, Issue 2, 1 1 2001, Pages 259-276 Recombinant equine arteritis virus as an expression vector. de Vries AA, Glaser AL, Raamsman MJ, Rottier PJ
Equine arteritis virus (EAV) is the prototypic member of the family Arteriviridae, which together with the Corona- and Toroviridae constitutes the order Nidovirales. A common trait of these positive-stranded RNA viruses is the 3'-coterminal nested set of six to eight leader-containing subgenomic mRNAs which are generated by a discontinuous transcription mechanism and from which the viral open reading frames downstream of the polymerase gene are expressed. In this study, we investigated whet... Abstract
Cited 7 times since 2001 (0.3 per year) source: EuropePMC
The British journal of surgery, Volume 88, Issue 6, 1 1 2001, Pages 884-886 Totally extraperitoneal endoscopic repair of recurrent inguinal hernia. van der Hem JA, Hamming JF, Meeuwis JD, Oostvogel HJ
Background: Conventional repair of recurrent inguinal hernia is associated with a re-recurrence rate as high as 35 per cent. Endoscopic mesh repair has promising results regarding both recurrence and complication rates. Methods: In a retrospective review, the results of endoscopic totally extraperitoneal repair were evaluated in 104 patients with 108 recurrent hernias. Follow-up was at least 1 year. Type of recurrence, time of occurrence after previous repair, duration of surgery, complications,... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 145, Issue 25, 1 1 2001, Pages 1214-1218 [Treatment of intra-atrial reentry tachycardia by catheter ablation, using three-dimensional electro-anatomical map of the atrial activation pattern]. de Groot NM, Schalij MJ
A 30-year-old man, who had been treated surgically for tricuspid valve atresia as a boy, suffered from recurrent supraventricular tachycardias. These atrial reentry tachycardias are frequent post-operative complications in patients with congenital heart disease. The reentry circuit in these patients often circulates around areas of scar tissue or surgically created barriers such as incision scars and implanted synthetic material. A possible curative treatment of these arrhythmias is radiofrequen... Abstract
Cited 486 times since 2001 (21.2 per year) source: EuropePMC
Blood, Volume 97, Issue 12, 1 1 2001, Pages 3951-3959 Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Sørensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N
Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. The known biologic functions reside in the C-terminus, which must be cleaved from the holoprotein to become active. Bovine and porcine cathelicidins are cleaved by elastase from the azurophil granules to yield the active antimicrobial peptides. The aim of this study was to identify the physiological setting for cleavage of the only human cathelicidin, hCAP-18, to liberate the antibacter... Abstract
Cited 27 times since 2001 (1.2 per year) source: EuropePMC
Cardiovascular research, Volume 50, Issue 3, 1 1 2001, Pages 516-524 Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice. Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA
Objective: To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. Methods: A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. Results: No significa... Abstract
Cited 13 times since 2001 (0.6 per year) source: EuropePMC
Early human development, Volume 63, Issue 1, 1 1 2001, Pages 9-21 Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study in newborn lambs. de Vroomen M, Lopes Cardozo RH, Steendijk P, Frölich M, Baan J, van Bel F
Objective: Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P(ap)) during RDS may give insight in the role of ET-1. Methods: ET-1 and P(ap) changes were studied in an experimental model of RDS, induced by lung lava... Abstract
Cited 27 times since 2001 (1.2 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 32, Issue 2, 1 1 2001, Pages 117-128 Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer. Dingemans AC, van Ark-Otte J, Span S, Scagliotti GV, van der Valk P, Postmus PE, Giaccone G
Resistance to chemotherapy is common in non-small cell lung cancer. The aim of this study was to investigate the prognostic impact of in vitro established drug resistance markers on the response to chemotherapy in patients with advanced non-small cell lung cancer. Samples of 38 patients were analyzed by immunohistochemical staining, for topoisomerase IIalpha and IIbeta, Ki-67, MRP and LRP. In addition, mutation analysis of the topoisomerase IIalpha gene, the B/DNBS and the Tyr804 region, was per... Abstract
Cited 46 times since 2001 (2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 19, Issue 5, 1 1 2001, Pages 667-670 Pulmonary valve insertion late after repair of Fallot's tetralogy. Hazekamp MG, Kurvers MM, Schoof PH, Vliegen HW, Mulder BM, Roest AA, Ottenkamp J, Dion RA
Objectives: To analyze the results of pulmonary valve insertion late after initial repair of Fallot's tetralogy. Pulmonary insufficiency (PI) after correction of Fallot's tetralogy is usually well tolerated in the short term, but is associated with symptomatic right ventricular dilatation and an increased risk of ventricular arrhythmias over longer periods of time. Methods: From 1993 to July 2000, 51 patients were reoperated for PI at a mean age of 25.7+/-11.9 years. The mean age at in... Abstract
Cited 16 times since 2001 (0.7 per year) source: EuropePMC
RNA (New York, N.Y.), Volume 7, Issue 5, 1 1 2001, Pages 741-752 Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs. Rutjes SA, Lund E, van der Heijden A, Grimm C, van Venrooij WJ, Pruijn GJ
Ro RNPs are small cytoplasmic RNA-protein complexes of unknown function that have been found in all metazoan cells studied so far. In human cells, Ro RNPs consist of one of four small RNA molecules, termed hY RNAs and at least two well-characterized proteins, Ro60 and La. In previous Xenopus laevis oocyte microinjection studies, we showed that an intact Ro60 binding site (Stem-loop 1) is a prerequisite for efficient nuclear export of hY1 RNA, whereas an intact La-binding site promotes nuclear re... Abstract
Cited 1 times since 2001 (0 per year) source: EuropePMC
Circulation, Volume 103, Issue 17, 1 1 2001, Pages E92-3 False aneurysms of an ascending-aorta-to-abdominal-aorta bypass for coarctation of the aorta. Roest AA, Wasser MN, Versteegh MI, de Roos A, van Der Wall EE, Helbing WA, Vliegen HW
Cited 34 times since 2001 (1.5 per year) source: EuropePMC
Journal of molecular biology, Volume 308, Issue 4, 1 1 2001, Pages 597-608 Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. Schepers A, Diffley JF
The Cdc6 protein is required to load a complex of Mcm2-7 family members (the MCM complex) into prereplicative complexes at budding yeast origins of DNA replication. Cdc6p is a member of the AAA(+) superfamily of proteins, which includes the prokaryotic and eukaryotic clamp loading proteins. These proteins share a number of conserved regions of homology and a common three-dimensional architecture. Two of the conserved sequence motifs are the Walker A and B motifs that are involved in nucleotide m... Abstract
Cited 9 times since 2001 (0.4 per year) source: EuropePMC
Clinical lung cancer, Volume 2, Issue 4, 1 1 2001, Pages 264-70; discussion 271-2 The curative potential of intraluminal bronchoscopic treatment for early-stage non-small-cell lung cancer. Sutedja TG, van Boxem AJ, Postmus PE
Bronchoscopic treatment modalities such as lasers, electrocautery, cryotherapy, photodynamic therapy, and brachytherapy are potentially curative for patients with very-early-stage non-small-cell lung cancer (NSCLC) in the central airways. Previously, studies had primarily focused on the effectiveness of surgery, surgical bronchoplasty, and photodynamic therapy. The cure rate of intraluminal bronchoscopic treatment is strongly related to the patient's functional status and tumor stage. Intra... Abstract
Cited 50 times since 2001 (2.2 per year) source: EuropePMC
Twin research : the official journal of the International Society for Twin Studies, Volume 4, Issue 2, 1 1 2001, Pages 81-93 Asthma genetics and intermediate phenotypes: a review from twin studies. Los H, Postmus PE, Boomsma DI
It has been long recognised that asthma and related phenotypes have an important hereditary nature, in which inheritance does not follow the classical Mendelian patterns and the exact mode of inheritance is not known. Linkage, association studies and genome-wide screening suggest that many genes are involved in the pathogenesis of asthma. Twin studies have contributed significantly to our understanding on the genetics of asthma, especially the large-scale twin studies in different parts of the w... Abstract
Cited 86 times since 2001 (3.7 per year) source: EuropePMC
Journal of virology, Volume 75, Issue 7, 1 1 2001, Pages 3335-3342 Improved adenovirus vectors for infection of cardiovascular tissues. Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, Valerio D, Bout A, Quax PH
To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed improv... Abstract
Cited 41 times since 2001 (1.8 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 12, Issue 4, 1 1 2001, Pages 557-561 Single-agent gemcitabine in patients with resistant small-cell lung cancer. van der Lee I, Smit EF, van Putten JW, Groen HJ, Schlösser NJ, Postmus PE, Schramel FM
Objective: This study was conducted to assess the activity and toxicity ofgemcitabine in patients with resistant small-cell lung cancer (SCLC). PATIENTS TAND METHODS: Forty-one patients with limited- or extensive-stage SCLC, who were previously treated with at least one chemotherapeutic regimen and progressed during or within three months of finishing the last regimen, were treated with 1000 mg/m2 gemcitabine on days 1, 8, and 15 of a four-week cycle. Results: Thirty-eight patients were evaluabl... Abstract
Cited 17 times since 2001 (0.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 85, Issue 4, 1 1 2001, Pages 458-462 Increased risk for ischaemic events is related to combined RAS polymorphism. van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH
Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS). Setting: University hospital. Patients: 885 male patients with stable coronary artery disease. Main outcome me... Abstract
Cited 5 times since 2001 (0.2 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 71, Issue 4, 1 1 2001, Pages 1382-1383 Implantation of cardioverter device in young children: the perirenal approach. Hazekamp MG, Blom NA, Schoof PH, Schalij MJ, Dion RA
Placement of Implantable cardioverter devices in young children is complicated because of the relatively large size and heavy weight of these devices. A technique is described where the device is implanted in the left perirenal space while an endovascular lead is used instead of an epicardial patch electrode. Abstract
Cited 4 times since 2001 (0.2 per year) source: EuropePMC
Thrombosis and haemostasis, Volume 85, Issue 4, 1 1 2001, Pages 746-747 Factor VII polymorphisms and myocardial infarction: what is special in Italians? REGRESS study group. Regression Growth Evaluation Statin Study. Nederhand RJ, de Maat MP, Jukema JW, Regression Growth Evaluation Statin Study group