Research

Publications

Below you can find a list of our published research.

5332 results

Advances in physiology education, Volume 43, Issue 1, 01 March 2019, Pages 7-14 Informing the uninformed: a multitier approach to uncover students' misconceptions on cardiovascular physiology. Versteeg M, Wijnen-Meijer M, Steendijk P

Misconceptions about physiology are a major threat to accurate scientific and clinical reasoning in medical education. Awareness is often mentioned as a prerequisite to achieve conceptual understanding; however, students are frequently unaware of their incorrect understanding. We explored the multitier approach as a tool to obtain insight into students' awareness and misconceptions regarding cardiovascular physiology. Biomedical sciences students ( N = 81) participated in a diagnostic multitier... Abstract

European heart journal cardiovascular Imaging, 11 December 2018 Referral of patients for fractional flow reserve using quantitative flow ratio. Smit JM, Koning G, van Rosendael AR, El Mahdiui M, Mertens BJ, Schalij MJ, Jukema JW, Delgado V, Reiber JHC, Bax JJ, Scholte AJ

Aims:Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select p... Abstract

Pediatric cardiology, 11 December 2018 Risk of Clinically Relevant Pericardial Effusion After Pediatric Cardiac Surgery. Adrichem R, Le Cessie S, Hazekamp MG, Van Dam NAM, Blom NA, Rammeloo LAJ, Filippini LHPM, Kuipers IM, Ten Harkel ADJ, Roest AAW

Pericardial effusion (PE) after pediatric cardiac surgery is common. Because of the lack of a uniform classification of the presence and severity of PE, we evaluated PE altering clinical management: clinically relevant PE. Risk factors for clinically relevant PE were studied. After cardiac surgery, children were followed until 1 month after surgery. Preoperative variables were studied in the complete cohort. Perioperative and postoperative variables were studied in a case-control manner. Patien... Abstract

Pacing and clinical electrophysiology : PACE, 10 December 2018 Remote monitoring of implantable cardioverter defibrillators: Patient experiences and preferences for follow-up. Timmermans I, Meine M, Szendey I, Aring J, Romero Roldán J, van Erven L, Kahlert P, Zitron E, Mabo P, Denollet J, Versteeg H

BACKGROUND:Patient satisfaction with remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) seems to be high, yet knowledge on long-term patient experiences is limited. The European REMOTE-CIED study explored patient experiences with RPM, examined patient preferences for ICD follow-up, and identified determinants of patient preferences in the first two years post-implantation. METHODS:European heart failure patients (N = 300; median age = 66 years (IQR = 59-73),... Abstract

Seminars in thoracic and cardiovascular surgery, 08 December 2018 Developing a quality standard for verbal communication during CABG procedures. van Wijngaarden RAFL, Siregar S, Legué J, Fraaije A, Abbas A, Dankelman J, Klautz RJM

OBJECTIVE:Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists. METHODS:Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures. Personal intervie... Abstract

Pacing and clinical electrophysiology : PACE, 05 December 2018 Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation. Keçe F, Scholte AJ, de Riva M, Naruse Y, Watanabe M, Alizadeh Dehnavi R, Schalij MJ, Zeppenfeld K, Trines SA

The posterior wall of the left atrium (LA) is a well-known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. This retrospective study evaluates the influence of box lesion surface area as a ratio of total LA surface area (box surface ratio) on arrhythmia recurrence. Seventy consecutive patients with persistent AF (63±11... Abstract

Biochimica et biophysica acta. Molecular and cell biology of lipids, 04 December 2018 Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls. van der Does AM, Heijink M, Mayboroda OA, Persson LJ, Aanerud M, Bakke P, Eagan TM, Hiemstra PS, Giera M

INTRODUCTION:Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators here collectively named oxylipins. These include classical eicosanoids, but also pro-resolving mediators. A balanced production of pro-inflammatory and pro-resolving oxylipins is of importance for adequate inflammatory responses and subsequent return to homeostasis. OBJECTIV... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 04 December 2018 Male-female differences in characteristics and early outcomes of patients undergoing tricuspid valve surgery: a national cohort study in the Netherlands. Veen KM, Mokhles MM, Braun J, Versteegh MIM, Bogers AJJC, Takkenberg JJM

This study aims to explore male-female differences in baseline and procedural characteristics, and outcomes of patients undergoing isolated or concomitant tricuspid valve (TV) surgery. All TV procedures registered between 2007 and 2016 in the database of the Netherlands Association for Cardio-Thoracic Surgery were analysed. Logistic regression analyses with interaction terms were used to determine whether sex was associated with hospital mortality. Five thousand five hundred and eighty-two patie... Abstract

Nature Communications, Volume 9, Issue 1, 03 December 2018, Pages 5141 GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Mela

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Coloc... Abstract

Nature genetics, Volume 50, Issue 12, 01 December 2018, Pages 1755 Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, El

In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper. Abstract

Cardiovascular research, Volume 114, Issue 14, 01 December 2018, Pages 1848-1859 Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity. Liu J, Volkers L, Jangsangthong W, Bart CI, Engels MC, Zhou G, Schalij MJ, Ypey DL, Pijnappels DA, de Vries AAF

Aims:The generation of homogeneous cardiomyocyte populations from fresh tissue or stem cells is laborious and costly. A potential solution to this problem would be to establish lines of immortalized cardiomyocytes. However, as proliferation and (terminal) differentiation of cardiomyocytes are mutually exclusive processes, their permanent immortalization causes loss of electrical and mechanical functions. We therefore aimed at developing conditionally immortalized atrial myocyte (iAM) lines allow... Abstract

The Pediatric infectious disease journal, Volume 37, Issue 12, 01 December 2018, Pages e283-e291 Nationwide Study on the Course of Influenza A (H1N1) Infections in Hospitalized Children in the Netherlands During the Pandemic 2009-2010. Ahout IML, Philipsen RLA, Las M, Baysan M, Brus F, Rahamat-Langendoen JC, Roeleveld N, Fraaij PL, Osterhaus ADME, Ferwerda G, de Groot R, Dutch H1N1 Research Group

BACKGROUND:The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (< 18 years). METHODS:Retrospective national chart study on hospitalized children with H1N1 infection during the 2009-2010 pH1N1 outbreak. RESULTS:Nine hundred forty patients (56% boys), median age 3.0 years, were enrolled; the majority were previously healthy. Treatment consisted of supplemental ox... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 6, 01 December 2018, Pages 1147-1148 Off-pump mitral valve repair: is less really more? Tomšic A, Klautz RJM, Palmen M

Abstract

Breathe (Sheffield, England), Volume 14, Issue 4, 01 December 2018, Pages 319-321 How to write a response to the reviewers of your manuscript. Hiemstra PS

Organising the process of writing a response to reviewers' comments and making best use of the expertise of your co-authors increases your chances of being successful in getting your paper published http://ow.ly/WAxV30lF1g3. Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 28 November 2018 Expectations and perceived barriers to widespread implementation of e‑Health in cardiology practice: Results from a national survey in the Netherlands. Treskes RW, Wildbergh TX, Schalij MJ, Scherptong RWC

INTRODUCTION:Expectations of physicians concerning e‑Health and perceived barriers to implementation in clinical practice are scarcely reported in the literature. The purpose of this study was to assess these aspects of cardiovascular e‑Health. METHODS:A survey was sent to members of the Netherlands Society of Cardiology. In total, the questionnaire contained 30 questions about five topics: personal use of smartphones, digital communication between respondents and patients, current e‑Hea... Abstract

European journal of preventive cardiology, 28 November 2018, Pages 2047487318816388 BENEFIT for all: An ecosystem to facilitate sustained healthy living and reduce the burden of cardiovascular disease. Keesman M, Janssen V, Kemps H, Hollander M, Reimer WSO, Gemert-Pijnen LV, Hoes A, Kraaij W, Chavannes N, Atsma D, Kraaijenhagen R, Evers A, BENEFIT consortium

Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 27 November 2018 Beyond the clinical impact of aortic and pulmonary valve implantation: health-related quality of life, informal care and productivity. Huygens SA, van der Kley F, Bekkers JA, Bogers AJJC, Takkenberg JJM, Rutten-van Mölken MPMH

OBJECTIVES:Our aim was to provide estimates of patient-reported health-related quality of life (HRQoL), use of informal care and productivity in patients after surgical aortic and pulmonary valve replacement and transcatheter aortic valve implantation. METHODS:Consecutive cohorts of 1239 adult patients who had surgical aortic valve replacement or surgical pulmonary valve replacement and 433 patients who had transcatheter aortic valve implantation at 2 Dutch heart centres were cross-sectionally s... Abstract

The Journal of clinical investigation, 26 November 2018 An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG

BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a heterogeneous smoking-related disease characterized by airway obstruction and inflammation. This inflammation may persist even after smoking cessation and responds variably to corticosteroids. Personalizing treatment to biologically similar "molecular phenotypes" may improve therapeutic efficacy in COPD. IL-17A is involved in neutrophilic inflammation and corticosteroid resistance, and thus may be particularly important in a COPD molec... Abstract

The European respiratory journal, 21 November 2018 Electronic Cigarettes - Task Force report from the European Respiratory Society. Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F

There is a marked increase in the development and use of electronic nicotine delivery systems (ENDS) or electronic cigarettes (ECIGs). This statement covers electronic cigarettes (ECIGs), defined as "electrical devices that generate an aerosol from a liquid" and thus excludes devices that contain tobacco. Database searches identified published articles that were used to summarise the current knowledge on: the epidemiology of ECIG use; their ingredients and accompanied health effects; secondhand... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 20 November 2018 Multimodality imaging: Bird's eye view from The European Society of Cardiology Congress 2018 Munich, August 25-29, 2018. Delgado V, Bucciarelli-Ducci C, Gaemperli O, Maurovich-Horvat P, Bax JJ

At the European Society of Cardiology (ESC) congress of this year 2018, held in Munich from August 25th to 29th, 4594 abstracts were presented. Of those, 423 (10.8%) belonged to an imaging category. Experts in echocardiography (VD), cardiovascular magnetic resonance (CMR) (CBD), nuclear imaging (OG), and cardiac computed tomography (CT) (PMH) have selected the abstracts in their areas of expertise that were of most interest to them and are summarized in this bird's eye view from this ESC meeting... Abstract