Research

Publications

Below you can find a list of our published research.

5823 results

European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Volume 27, Issue 4, 01 August 2020, Pages 243-244 The new era of chest pain evaluation in the Netherlands. Backus BE, Tolsma RT, Boogers MJ

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The European respiratory journal, Volume 56, Issue 1, 02 July 2020 Short-term and long-term effect of a high-intensity pulmonary rehabilitation programme in obese patients with asthma: a randomised controlled trial. Türk Y, Theel W, van Huisstede A, van de Geijn GM, Birnie E, Hiemstra PS, Sont JK, Taube C, Braunstahl GJ

OBJECTIVE:To determine the short-term and long-term effects of a high intensity pulmonary rehabilitation programme on asthma control, body composition, lung function and exercise capacity in obese asthma patients. METHODS:Patients with obesity (body mass index (BMI)≥30 kg·m-2) and suboptimal controlled asthma (Asthma Control Questionnaire (ACQ)≥0.75) were randomly assigned to a 3-month pulmonary rehabilitation programme (PR only), pulmonary rehabilitation programme with the use of an inte... Abstract

The European respiratory journal, Volume 56, Issue 1, 02 July 2020 The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19. Klok FA, Boon GJAM, Barco S, Endres M, Geelhoed JJM, Knauss S, Rezek SA, Spruit MA, Vehreschild J, Siegerink B

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Cited 2 times since 2020 (140.9 per year) source: Scopus

European heart journal cardiovascular Imaging, Volume 21, Issue 7, 01 July 2020, Pages 759-767 Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction. Kong WKF, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian Gay L, Fijałkowski M, Liang M, Chen RW, Ajmone Marsan N, Selvanayagam J, Pinto F, Zamorano JL, Pibarot P, Evangelista A, Delgado V, Bax JJ

AIMS:In patients with bicuspid aortic valve (BAV) and preserved left ventricular (LV) ejection fraction (EF), the frequency of impaired LV global longitudinal strain (GLS) and its prognostic implications are unknown. The present study evaluated the proportion and prognostic value of impaired LV GLS in patients with BAV and preserved LVEF. METHODS AND RESULTS:Five hundred and thirteen patients (68% men; mean age 44 ± 18 years) with BAV and preserved LVEF (>50%) were divided into five group... Abstract

Journal of vascular research, 01 July 2020, Pages 1-7 Three-Dimensional Imaging of Intraplaque Neovascularization in a Mouse Model of Advanced Atherosclerosis. Perrotta P, Pintelon I, de Vries MR, Quax PHA, Timmermans JP, De Meyer GRY, Martinet W

Multiple lines of evidence suggest that intraplaque (IP) neovascularization promotes atherosclerotic plaque growth, destabilization, and rupture. However, pharmacological inhibition of IP neovascularization remains largely unexplored due to the limited number of animal models that develop IP neovessels and the lack of reliable methods for visualizing IP angiogenesis. Here, we applied 3D confocal microscopy with an optimized tissue-clearing process, immunolabeling-enabled three-dimensional imagin... Abstract

Circulation. Genomic and precision medicine, 30 June 2020 Genome-wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in Hepatic Lipase (LIPC). Ibi D, Noordam R, van Klinken JB, Li-Gao R, de Mutsert R, Trompet S, Christen T, Blauw LL, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Dollé MET, Rensen PCN, Willems van Dijk K

Background - The increase in serum triglyceride (TG) concentrations in response to a meal is considered a risk factor for cardiovascular disease. We aimed to elucidate the genetics of the postprandial TG response through genome-wide association studies (GWAS). Methods - Participants of the Netherlands Epidemiology of Obesity (NEO) study (n=5,630) consumed a liquid mixed meal after an overnight fast. GWAS of fasting and postprandial serum TG at 150 minutes were performed. To identify genetic vari... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 29 June 2020 Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part 2: ventricular arrhythmias, channelopathies, and implantable defibrillators. Heidbuchel H, Arbelo E, D'Ascenzi F, Borjesson M, Boveda S, Castelletti S, Miljoen H, Mont L, Niebauer J, Papadakis M, Pelliccia A, Saenen J, Sanz de la Garza M, Schwartz PJ, Sharma S, Zeppenfeld K, Corrado D

This paper belongs to a series of recommendation documents for participation in leisure-time physical activity and competitive sports by the European Association of Preventive Cardiology (EAPC). Together with an accompanying paper on supraventricular arrhythmias, this second text deals specifically with those participants in whom some form of ventricular rhythm disorder is documented, who are diagnosed with an inherited arrhythmogenic condition, and/or who have an implanted pacemaker or cardiove... Abstract

European heart journal cardiovascular Imaging, 29 June 2020 Computer tomography-derived transoesophageal echocardiographic views in anomalous coronary artery origin. Fortuni F, Kuneman J, Delgado V

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Expert review of medical devices, 29 June 2020 How valvular calcification can affect the outcomes of transcatheter aortic valve implantation. Milhorini Pio S, Bax J, Delgado V

INTRODUCTION:In transcatheter aortic valve implantation (TAVI), assessment of aortic valve calcification is not as standardized as aortic annulus measurement. Aortic valve calcification is important for stable anchoring of the prosthesis to the aortic annulus. However, excessive aortic valve calcification is related to procedural complications. AREAS COVERED:This review covers the methods to assess aortic valve calcification and the implications of aortic valve calcium burden for TAVI outcomes.... Abstract

Progress in cardiovascular diseases, 26 June 2020 Speaking a common language: Introduction to a standard terminology for the bicuspid aortic valve and its aortopathy. Michelena HI, Corte AD, Evangelista A, Maleszewski JJ, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ

There is a growing need to develop a common language when referring to a frequent and heterogeneous condition such as the congenital bicuspid aortic valve and its aortopathy. The following short manuscript serves as an introduction to a standard terminology for the bicuspid aortic valve and its aortopathy. Abstract

European heart journal cardiovascular Imaging, 26 June 2020 Assessment of left atrial electro-mechanical delay to predict atrial fibrillation in hypertrophic cardiomyopathy. Tjahjadi C, Hiemstra YL, van der Bijl P, Pio SM, Bootsma M, Ajmone Marsan N, Delgado V, Bax JJ

AIMS:Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and is associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects the left atrial (LA) structural and electrical remodelling. The aim of this study was to evaluate the association between PA-TDI and new-onset AF in patients with HCM. METHODS AND RESULTS:From a large cohort of patients with HCM, 208 patients (64% mal... Abstract

Progress in cardiovascular diseases, 26 June 2020 Sex differences in bicuspid aortic valve disease. Kong WKF, Bax JJ, Michelena HI, Delgado V

Bicuspid aortic valve (BAV), the most frequent congenital heart disease, is characterized by an uneven distribution between sexes. BAV is three to four times more frequent in men than in women which could be associated with a reduced dosage of X chromosome genes. In addition, BAV has a multifactorial inheritance, low penetrance and variable phenotypes that may lead to different form of valve degeneration and dysfunction over time as well as different incidence of aortic valve and vascular compli... Abstract

European heart journal cardiovascular Imaging, 25 June 2020 Screening for cardiovascular disease risk using traditional risk factor assessment or coronary artery calcium scoring: the ROBINSCA trial. van der Aalst CM, Denissen SJAM, Vonder M, Gratama JWC, Adriaansen HJ, Kuijpers D, Vliegenthart R, van Lennep JER, van der Harst P, Braam RL, van Dijkman PRM, van Bruggen R, Oudkerk M, de Koning HJ

AIMS:Screening for a high cardiovascular disease (CVD) risk followed by preventive treatment can potentially reduce coronary heart disease-related morbidity and mortality. ROBINSCA (Risk Or Benefit IN Screening for CArdiovascular disease) is a population-based randomized controlled screening trial that investigates the effectiveness of CVD screening in asymptomatic participants using the Systematic COronary Risk Evaluation (SCORE) model or coronary artery calcium (CAC) scoring. This study descri... Abstract

European respiratory review : an official journal of the European Respiratory Society, Volume 29, Issue 156, 23 June 2020 COPD and acute myocardial infarction. Goedemans L, Bax JJ, Delgado V

COPD is strongly associated with cardiovascular disease, in particular acute myocardial infarction (AMI). Besides shared risk factors, COPD-related factors, such as systemic inflammation and hypoxia, underlie the pathophysiological interaction between COPD and AMI. The prevalence of COPD amongst AMI populations ranges from 7% to 30%, which is possibly even an underestimation due to underdiagnoses of COPD in general. Following the acute event, patients with COPD have an increased risk of mortalit... Abstract

International journal of cardiology, 23 June 2020 Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial. Deharo P, Ducrocq G, Bode C, Cohen M, Cuisset T, Mehta SR, Pollack CV, Wiviott SD, Rao SV, Jukema JW, Erglis A, Moccetti T, Elbez Y, Steg PG

BACKGROUND:The benefits and risks of blood transfusion in patients with acute myocardial infarction who are anemic or who experience bleeding are debated. We sought to study the association between blood transfusion and ischemic outcomes according to haemoglobin nadir and bleeding status in patients with NST-elevation myocardial infarction (NSTEMI). METHODS:The TAO trial randomized patients with NSTEMI and coronary angiogram scheduled within 72h to heparin plus eptifibatide versus otamixaban. Af... Abstract

JMIR human factors, Volume 7, Issue 2, 23 June 2020, Pages e17147 Perspectives of Patients and Professionals on Information and Education After Myocardial Infarction With Insight for Mixed Reality Implementation: Cross-Sectional Interview Study. Hilt AD, Mamaqi Kapllani K, Hierck BP, Kemp AC, Albayrak A, Melles M, Schalij MJ, Scherptong RWC

BACKGROUND:Patient education is crucial in the secondary prevention of cardiovascular disease. Novel technologies such as augmented reality or mixed reality expand the possibilities for providing visual support in this process. Mixed reality creates interactive digital three-dimensional (3D) projections overlaying virtual objects on the real-world environment. While augmented reality only overlays objects, mixed reality not just overlays but anchors virtual objects to the real world. However, re... Abstract

Cardiology and therapy, 20 June 2020 Optical Coherence Tomography: Current Applications for the Assessment of Coronary Artery Disease and Guidance of Percutaneous Coronary Interventions. Oosterveer TTM, van der Meer SM, Scherptong RWC, Jukema JW

INTRODUCTION:Coronary angiography (CAG) is the standard modality for assessment of coronary stenoses and intraprocedural guidance of percutaneous coronary interventions (PCI). However, the limitations of CAG are well recognized. Intracoronary imaging (ICI) can potentially overcome these limitations. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the main ICI techniques utilized in clinical practice. AIM:This narrative literature review addresses the current clinical a... Abstract

Macromolecular bioscience, 17 June 2020, Pages e2000024 Imaging the In Vivo Degradation of Tissue Engineering Implants by Use of Supramolecular Radiopaque Biomaterials. Talacua H, Söntjens SHM, Thakkar SH, Brizard AMA, van Herwerden LA, Vink A, van Almen GC, Dankers PYW, Bouten CVC, Budde RPJ, Janssen HM, Kluin J

For in situ tissue engineering (TE) applications it is important that implant degradation proceeds in concord with neo-tissue formation to avoid graft failure. It will therefore be valuable to have an imaging contrast agent (CA) available that can report on the degrading implant. For this purpose, a biodegradable radiopaque biomaterial is presented, modularly composed of a bisurea chain-extended polycaprolactone (PCL2000-U4U) elastomer and a novel iodinated bisurea-modified CA additive (I-U4U).... Abstract

European heart journal, 17 June 2020 EHRA 2020 during COVID-19 days. Burri H, Zeppenfeld K, Heidbuchel H

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Journal of cardiovascular translational research, 16 June 2020 The Role of Immunomodulation in Vein Graft Remodeling and Failure. Baganha F, de Jong A, Jukema JW, Quax PHA, de Vries MR

Obstructive arterial disease is a major cause of morbidity and mortality in the developed world. Venous bypass graft surgery is one of the most frequently used revascularization strategies despite its considerable short and long time failure rate. Due to vessel wall remodeling, inflammation, intimal hyperplasia, and accelerated atherosclerosis, vein grafts may (ultimately) fail to revascularize tissues downstream to occlusive atherosclerotic lesions. In the past decades, little has changed in th... Abstract