Research

Publications

Below you can find a list of our published research.

5945 results

Prenatal diagnosis, 22 January 2021 The prognosis of common arterial trunk from a fetal perspective: a prenatal cohort study and systematic literature review. van Nisselrooij AEL, Herling L, Clur SA, Linskens IH, Pajkrt E, Rammeloo LA, Ten Harkel ADJ, Hazekamp MG, Blom NA, Haak MC

ObjectiveThe limited number of large fetal cohort studies on common arterial trunk (CAT) impedes prenatal counselling at mid-gestation. This study evaluates the prognosis of CAT from a fetal perspective.MethodFetuses with a prenatally diagnosed CAT were extracted from the PRECOR registry (2002-2016). We evaluated fetal and postnatal survival and the presence of additional morbidity at last follow-up. Literature databases were searches systematically for additional cases.ResultsThirty-eight cases... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 20 January 2021 Diastolic dyssynchrony by SPECT: A novel parameter to predict post-infarct adverse remodeling. van der Bijl P, Delgado V, Bax JJ

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Circulation, Volume 143, Issue 3, 19 January 2021, Pages 209-211 Changing the Paradigm in the Management of Valvular Heart Disease: In Addition to Left Ventricular Ejection Fraction, Focus on the Myocardium. Fortuni F, Bax JJ, Delgado V

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Atherosclerosis, Volume 319, 18 January 2021, Pages 51-61 New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention? Atar D, Jukema JW, Molemans B, Taub PR, Goto S, Mach F, CerezoOlmos C, Underberg J, Keech A, Tokgözoğlu L, Bonaca MP

Elevated low-density lipoprotein cholesterol (LDL-C) is a principally modifiable cause of atherosclerotic cardiovascular disease; accordingly, recent European and US multisociety dyslipidaemia guidelines emphasise the importance of lowering LDL-C to reduce cardiovascular risk. This review provides perspectives on established and emerging agents that reduce LDL-C to help providers synthesize the abundance of new evidence related to prevention of cardiovascular disease. We provide hypothetical cas... Abstract

Heart (British Cardiac Society), 15 January 2021 Sacubitril/valsartan in the treatment of systemic right ventricular failure. Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD

ObjectivePharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients.MethodsData on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circulati... Abstract

Clinical toxicology (Philadelphia, Pa.), 15 January 2021, Pages 1-18 Is secondary chemical exposure of hospital personnel of clinical importance? De Groot R, Van Zoelen GA, Leenders MEC, Van Riel AJHP, De Vries I, De Lange DW

IntroductionThere is increasing concern among hospital personnel about potential secondary exposure when treating chemically contaminated patients.ObjectiveTo assess which circumstances and chemicals require the use of Level C Personal Protective Equipment (chemical splash suit and air-purifying respirator), to prevent secondary contamination of hospital personnel treating a chemically contaminated patient.MethodsThe US National Library of Medicine PubMed database was searched for the years 1985... Abstract

Journal of virology, Volume 95, Issue 3, 13 January 2021 Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species. Villabruna N, Schapendonk CME, Aron GI, Koopmans MPG, de Graaf M

Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investigated the potential of animals to serve as a reservoir of human noroviruses by testing norovirus attachment to formalin-fixed intestinal tissues of a range of potential reservoir ani... Abstract

International journal of molecular sciences, Volume 22, Issue 2, 13 January 2021 Cell-Based Tracers as Trojan Horses for Image-Guided Surgery. Sier VQ, de Vries MR, van der Vorst JR, Vahrmeijer AL, van Kooten C, Cruz LJ, de Geus-Oei LF, Ferreira V, Sier CFM, Alves F, Muthana M

Surgeons rely almost completely on their own vision and palpation to recognize affected tissues during surgery. Consequently, they are often unable to distinguish between different cells and tissue types. This makes accurate and complete resection cumbersome. Targeted image-guided surgery (IGS) provides a solution by enabling real-time tissue recognition. Most current targeting agents (tracers) consist of antibodies or peptides equipped with a radiolabel for Positron Emission Tomography (PET) an... Abstract

Scientific reports, Volume 11, Issue 1, 13 January 2021, Pages 949 Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide. Santamaria S, Cuffaro D, Nuti E, Ciccone L, Tuccinardi T, Liva F, D'Andrea F, de Groot R, Rossello A, Ahnström J

ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA. ADAMTS-5 shares high structural and functional similarities with ADAMTS-4, which makes the design of selective inhibitors particularly challenging. Here we exploited the ADAMTS-5 binding capacity of β-N-acety... Abstract

Circulation, 13 January 2021 Clinical Efficacy and Safety of Alirocumab after Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial. Schwartz GG, Steg PG, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Manvelian G, Pordy R, Sourdille T, White HD, Szarek M, ODYSSEY OUTCOMES Committees and Investigators

Background: Recent international guidelines have lowered recommended target levels of low-density lipoprotein-cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below conventional targets. Inferences from prior analyses are limited because patients who achieve lower versus higher LDL-C on lipid-lowering therapy differ in other characteristics prognostic for... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 11 January 2021 Paradigm shift in treatment of coarctation of the aorta? Sojak V, Hazekamp M

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Biomedicines, Volume 9, Issue 1, 09 January 2021 Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence? Kurakula K, Smolders VFED, Tura-Ceide O, Jukema JW, Quax PHA, Goumans MJ

Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is characterized by the abnormal remodeling of the pulmonary arteries that leads to right ventricular failure and death. Although our understanding of the causes for abnormal vascular remodeling in PAH is limited, accumulating evidence indicates that endothelial cell (EC) dysfunction is one of the first triggers initiating this process. EC dysfunction leads to the activation of several cellular signalling path... Abstract

PloS one, Volume 16, Issue 1, 07 January 2021, Pages e0244810 Variation in hospital admission in febrile children evaluated at the Emergency Department (ED) in Europe: PERFORM, a multicentre prospective observational study. Borensztajn DM, Hagedoorn NN, Rivero Calle I, Maconochie IK, von Both U, Carrol ED, Dewez JE, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Lim E, Martinon-Torres F, Nieboer D, Nijman RG, Pokorn M, Strle F, Tsolia M, Vermont C, Yeung S, Zavadska D, Zenz W, Levin M, Moll HA, PERFORM consortium: Personalised Risk assessment in febrile children to optimise Real-life Management across the European Union

ObjectivesHospitalisation is frequently used as a marker of disease severity in observational Emergency Department (ED) studies. The comparison of ED admission rates is complex in potentially being influenced by the characteristics of the region, ED, physician and patient. We aimed to study variation in ED admission rates of febrile children, to assess whether variation could be explained by disease severity and to identify patient groups with large variation, in order to use this to reduce unne... Abstract

JACC. Cardiovascular imaging, 07 January 2021 Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis. Hwang D, Kim HJ, Lee SP, Lim S, Koo BK, Kim YJ, Kook W, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ

ObjectivesThis study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA).BackgroundCoronary CTA can noninvasively assess coronary plaques quantitatively.MethodsPatients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by topological d... Abstract

European radiology, 06 January 2021 Associations between left ventricular function, vascular function and measures of cerebral small vessel disease: a cross-sectional magnetic resonance imaging study of the UK Biobank. van Hout MJP, Dekkers IA, Westenberg JJM, Schalij MJ, Scholte AJHA, Lamb HJ

ObjectivesImpaired cardiovascular function has been associated with cognitive deterioration; however, to what extent cardiovascular dysfunction plays a role in structural cerebral changes remains unclear. We studied whether vascular and left ventricular (LV) functions are associated with measures of cerebral small vessel disease (cSVD) in the middle-aged general population.MethodsIn this cross-sectional analysis of the UK Biobank, 4366 participants (54% female, mean age 61 years) underwent magne... Abstract

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 06 January 2021 Left ventricular myocardial work indices: a potential step forward for the assessment of myocardial performance in severe aortic stenosis. Fortuni F, Bax JJ, Delgado V, Marsan NA

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Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 06 January 2021 Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Pluymaekers NAHA, Dudink EAMP, Weijs B, Vernooy K, Hartgerink DEJ, Jacobs JS, Erküner Ö, Marcks NGHM, van Cauteren YJM, Dinh T, Ter Bekke RMA, Sels JEMW, Delnoij TSR, Geyik Z, Driessen RGH, Linz DK, den Uijl DW, Crijns HJGM, Luermans JGLM

BackgroundThe current standard of care for acute atrial fibrillation (AF) focuses primarily on immediate restoration of sinus rhythm by cardioversion, although AF often terminates spontaneously.ObjectiveTo identify determinants of early spontaneous conversion (SCV) in patients presenting at the emergency department (ED) because of AF.MethodsAn observational study was performed of patients who visited the ED with documented AF between July 2014 and December 2016. The clinical characteristics and... Abstract

Rheumatology (Oxford, England), 06 January 2021 Disease progression in Systemic Sclerosis. van Leeuwen NM, Liem SIE, Maurits MP, Ninaber M, Marsan NA, Allaart CF, Huizinga TWJ, Knevel R, de Vries-Bouwstra JK

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Health expectations : an international journal of public participation in health care and health policy, 06 January 2021 Patient and public involvement cultures and the perceived impact in the vulnerable context of palliative care: A qualitative study. Melchior I, van der Heijden A, Stoffers E, Suntjens F, Moser A

BackgroundCultural values are crucial to the practice and impact of patient and public involvement (PPI) in research.ObjectiveTo understand different PPI cultures among research teams and the impacts of PPI associated with each culture type.DesignA participatory action research design.Setting and participantsThe setting was 10 palliative care research projects. Seventeen patients and members of the public and 31 researchers participated.InterventionA programme consisting of four components: (1)... Abstract

Circulation. Cardiovascular imaging, Volume 14, Issue 1, 05 January 2021, Pages e011107 Computed Tomography-Derived Transesophageal Echocardiographic Views: Step Forward for Procedural Planning of Transcatheter Tricuspid Valve Annuloplasty. Fortuni F, Hirasawa K, Marques AI, Pio SM, Chimed S, Lustosa R, Tjahjadi C, Wang X, Bax JJ, Ajmone Marsan N, Delgado V

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