5222 results
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 26, Issue 10, 01 October 2018, Pages 473-483
Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology.
IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E
Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for appropriate use criteria.Twenty-one of all 184 members of the Dutch Working Group on Interventional Cardiology agreed to evaluate 49 pre-specified cases. During a meeting, factual indications were established whereupon members indiv...
Abstract
BMC endocrine disorders,
Volume 18, Issue 1, 19 September 2018, Pages 67
Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over.
Du Puy RS, Postmus I, Stott DJ, Blum MR, Poortvliet RKE, Den Elzen WPJ, Peeters RP, van Munster BC, Wolffenbuttel BHR, Westendorp RGJ, Kearney PM, Ford I, Kean S, Messow CM, Watt T, Jukema JW, Dekkers OM, Smit JWA, Rodondi N, Gussekloo J, Mooijaart SP
Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Bas...
Abstract
Nature genetics,
17 September 2018
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, Borst MH, Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify...
Abstract
European journal of heart failure,
17 September 2018
Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1-receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction.
Voors AA, Shah SJ, Bax JJ, Butler J, Gheorghiade M, Hernandez AF, Kitzman DW, McMurray JJV, Wirtz AB, Lanius V, van der Laan M, Solomon SD
Despite major advances in the treatment of chronic heart failure (HF) with reduced ejection fraction (HFrEF), morbidity and mortality associated with the condition remain high, suggesting the need for additional treatment options, particularly haemodynamically neutral treatments that do not alter blood pressure, heart rate, or renal function. HF with preserved ejection fraction (HFpEF) is also associated with high morbidity and mortality and adequate treatment options are limited; thus there is...
Abstract
EBioMedicine,
17 September 2018
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R
Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical trials using retinoids for emphysema patients have failed. Crucial information about the specific role of RA signaling in adult rodent and human lung epithelial progenitor cells is largely missing.Adult lung organoid cultures were generated from isolated primary mouse and human lung epithelial cells, and incubated with phar...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
12 September 2018
Reply to Böning.
Schneider AW, Klautz RJM, Hazekamp MG, Braun J
Abstract
Addiction (Abingdon, England),
12 September 2018
Association of alcohol consumption with allergic disease and asthma: a multicenter Mendelian Randomization analysis.
Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, Kårhus LL, Møllehave LT, Leth-Møller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hyppönen E, Kuh D, Hardy R, Meitinger T, Jukema JW, Völker U, Nauck M, Völzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munafò MR, Linneberg A
To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization, and serum total IgE.Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.Europe.We included a total of 466434 persons aged 15-82 years from 17 population-based studies co...
Abstract
Open heart,
Volume 5, Issue 2, 10 September 2018, Pages e000868
Male-female differences in aortic valve and combined aortic valve/coronary surgery: a national cohort study in the Netherlands.
Mokhles MM, Soloukey Tbalvandany S, Siregar S, Versteegh MIM, Noyez L, van Putte B, Vonk ABA, Roos-Hesselink JW, Bogers AJJC, Takkenberg JJM
The outcome of female patients after adult cardiac surgery has been reported to be less favourable compared with the outcome of male patients. This study compares men with women with respect to patient and procedural characteristics and early mortality in a contemporary national cohort of patients who underwent aortic valve (AV) and combined aortic valve/coronary (CABG/AV) surgery.All patients who underwent AV (n=8717, 56% male) or a combined CABG/AV surgery (n=5867, 67% male) in the Netherlands...
Abstract
JACC. Cardiovascular imaging,
06 September 2018
Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC trial.
Podlesnikar T, Pizarro G, Fernández-Jiménez R, Montero-Cabezas JM, Sánchez-González J, Bucciarelli-Ducci C, Ajmone Marsan N, Fras Z, Bax JJ, Fuster V, Ibáñez B, Delgado V
This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR).Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial.A total of 197 patients with acute anterior STEMI wh...
Abstract
The European respiratory journal,
Volume 52, Issue 3, 06 September 2018
microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.
Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA
Chronic mucus hypersecretion (CMH) is a common feature in chronic obstructive pulmonary disease (COPD) and is associated with worse prognosis and quality of life. This study aimed to identify microRNA (miRNA)-mRNA regulatory networks underlying CMH.The expression profiles of miRNA and mRNA in bronchial biopsies from 63 COPD patients were associated with CMH using linear regression. Potential mRNA targets of each CMH-associated miRNA were identified using Pearson correlations. Gene set enrichment...
Abstract
Nature,
Volume 561, Issue 7723, 01 September 2018, Pages 309
Biodiversity: sparring makes us strong.
de Groot R, Sukhdev P, Gough M
Abstract
European heart journal,
Volume 39, Issue 35, 01 September 2018, Pages 3322-3330
The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability.
Knuuti J, Ballo H, Juarez-Orozco LE, Saraste A, Kolh P, Rutjes AWS, Jüni P, Windecker S, Bax JJ, Wijns W
To determine the ranges of pre-test probability (PTP) of coronary artery disease (CAD) in which stress electrocardiogram (ECG), stress echocardiography, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance (CMR) can reclassify patients into a post-test probability that defines (>85%) or excludes (100 patients with stable CAD that utilized either ICA or ICA with FFR measurement as re...
Abstract
JAMA cardiology,
Volume 3, Issue 9, 01 September 2018, Pages 839-847
Association of Left Ventricular Global Longitudinal Strain With Asymptomatic Severe Aortic Stenosis: Natural Course and Prognostic Value.
Vollema EM, Sugimoto T, Shen M, Tastet L, Ng ACT, Abou R, Marsan NA, Mertens B, Dulgheru R, Lancellotti P, Clavel MA, Pibarot P, Genereux P, Leon MB, Delgado V, Bax JJ
The optimal timing to operate in patients with asymptomatic severe aortic stenosis (AS) remains controversial. Left ventricular global longitudinal strain (LV GLS) may help to identify patients who might benefit from undergoing earlier aortic valve replacement.To investigate the prevalence of impaired LV GLS, the natural course of LV GLS, and its prognostic implications in patients with asymptomatic severe AS with preserved left ventricular ejection fraction (LVEF).This registry-based study incl...
Abstract
Emerging Infectious Diseases,
Volume 24, Issue 9, 01 September 2018, Pages 1691-1695
Association of Batai Virus Infection and Encephalitis in Harbor Seals, Germany, 2016.
Jo WK, Pfankuche VM, Lehmbecker A, Martina B, Rubio-Garcia A, Becker S, Kruppa J, Jung K, Klotz D, Metzger J, Ludlow M, Baumgärtner W, van der Vries E, Osterhaus A
We isolated Batai virus from the brain of a euthanized, 26-year-old, captive harbor seal with meningoencephalomyelitis in Germany. We provide evidence that this orthobunyavirus can naturally infect the central nervous system of a mammal. The full-genome sequence showed differences from a previously reported virus isolate from a mosquito in Germany.
Abstract
Current opinion in cardiology,
Volume 33, Issue 5, 01 September 2018, Pages 470-478
Application of left ventricular strain in patients with aortic and mitral valve disease.
Ng ACT, Delgado V, Bax JJ
Left ventricular (LV) global longitudinal strain (GLS) is widely recognized as a more sensitive measure of LV systolic function compared with LV ejection fraction (LVEF). In addition, the measurement of LVGLS is more reproducible than two-dimensional LVEF. Current guidelines for diagnosis and treatment of valvular heart disease include LVEF as one of the parameters to take into consideration in the clinical decision-making. However, a large body of evidence is showing that LVGLS may be a better...
Abstract
International journal of cardiology,
01 September 2018
Borderline Q-waves in individuals without overt cardiovascular disease: Relations with adiposity, subclinical atherosclerosis and vascular stiffness.
Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW
Characteristics and risk factors associated with electrocardiographic borderline Q-waves are not fully elucidated, especially in individuals without overt cardiovascular disease (CVD). Also, the relation of isolated and non-isolated borderline Q-waves with subclinical atherosclerosis and vascular stiffness is unknown.We included 5746 Netherlands Epidemiology of Obesity study participants without overt CVD. Participants were divided in three groups: no Q-waves (93.7%), isolated (4.6%) and non-iso...
Abstract
JACC. Clinical electrophysiology,
Volume 4, Issue 9, 01 September 2018, Pages 1163-1165
Characterization of Septal Scars in Nonischemic Left Ventricular Cardiomyopathy by Cardiac Magnetic Resonance Imaging Versus Electroanatomical Mapping: Superior, Inferior, or Complementary?
Zeppenfeld K, Piers SRD
Abstract
JACC. Clinical electrophysiology,
Volume 4, Issue 9, 01 September 2018, Pages 1211-1213
Imaging to Evaluate the Substrate Underlying Sudden Cardiac Death.
Bax JJ, Delgado V
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 26, Issue 9, 01 September 2018, Pages 417-421
2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: comments from the Dutch ACS working group.
Arslan F, Bongartz L, Ten Berg JM, Jukema JW, Appelman Y, Liem AH, de Winter RJ, van 't Hof AWJ, Damman P
On behalf of the Dutch ACS working group, we discuss the most important changes in recommendations in the 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation relevant for both the general and interventional cardiologist.
Abstract
European heart journal cardiovascular Imaging,
Volume 19, Issue 9, 01 September 2018, Pages 975-976
The effect of blood pressure on left atrial size and function assessed by 3-dimensional echocardiography.
Abou R, Delgado V
Abstract
