7187 results
Nature,
26 4 2023
Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McD
Abstract
European heart journal. Cardiovascular Imaging,
26 4 2023, Pages jead110
Impact of statins based on high-risk plaque features on coronary plaque progression in mild stenosis lesions: results from the PARADIGM study.
Park HB, Arsanjani R, Sung JM, Heo R, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, Gonçalves PA, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Aims: To investigate the impact of statins on plaque progression according to high-risk coronary atherosclerotic plaque (HRP) features and to identify predictive factors for rapid plaque progression in mild coronary artery disease (CAD) using serial coronary computed tomography angiography (CCTA). Methods and results: We analyzed mild stenosis (25-49%) CAD, totaling 1432 lesions from 613 patients (mean age, 62.2 years, 63.9% male) and who underwent serial CCTA at a ≥2 year inter-scan interval us...
Abstract
Annals of vascular surgery,
25 4 2023, Pages S0890-5096(23)00278-9
Use of Omniflow® II biosynthetic graft for the treatment of vascular graft and endograft infections.
Liesker DJ, Gareb B, Speijers MJ, van der Vorst JR, Salemans PB, Tutein Nolthenius RP, Zeebregts CJ, Saleem BR
Objectives: Vascular graft/endograft infection is a rare but life-threatening complication of cardiovascular surgery and remains a surgical challenge. Several different graft materials are available for the treatment of vascular graft/endograft infection, each having its own advantages and disadvantages. Biosynthetic vascular grafts have shown low reinfection rates and could be a potential second best after autologous veins in the treatment of vascular graft/endograft infection. Therefore, the a...
Abstract
Molecular biology reports,
25 4 2023
Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children.
Yilmaz D, Soyoz M, Sahin A, Cerci-Alkac B, Karahan-Coven HI, Ekemen-Keles Y, Ustundag G, Kara-Aksay A, Yilmaz N, Pirim İ
Background: Mannose-binding lectin (MBL) is a member of innate immunity and acts with MASP (MBL-associated serine protease) to activate the lectin pathway of the complement system. MBL gene polymorphisms are associated with susceptibility to infectious diseases. This study investigated whether MBL2 genotype, serum MBL levels, and serum MASP-2 levels affect the course of SARS-CoV-2 infection. Methods and results: Pediatric patients diagnosed with COVID-19 by positive real-time polymerase chain re...
Abstract
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
24 4 2023, Pages S1053-2498(22)02248-3
The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update.
Saeed D, Feldman D, Banayosy AE, Birks E, Blume E, Cowger J, Hayward C, Jorde U, Kremer J, MacGowan G, Maltais S, Maybaum S, Mehra M, Mohacsi P, Schweiger M, Schroeder SE, Shah P, Slepian M, Tops LF, Alvarez P, Arabia F, Aslam S, Benson-Louis L, Birati E, Buchholz HW, Cedars A, Christensen D, Ciarka A, Coglianese E, Cogswell R, Cook J, Copeland J, Costello JG, Drakos SG, Eghtesady P, Elliot T, Estep JD, Eulert-Grehn JJ, Fabrizio R, Garbade J, Gelow J, Guglin M, Hernandez-Montfort J, Horstmanshof D, John R, Kanwar M, Khaliel F, Kim G, Kumar S, Lavee J, Leache M, Leprince P, Lim S, Loforte A, Maly J, Najjar S, Netuka I, Pamboukian SV, Patel SR, Pinney S, Pluym CV, Potapov E, Robson D, Rochlani Y, Russell S, Sandau K, Sandoval E, Sayer G, Schettle S, Schibilsky D, Schlöglhofer T, Schmitto J, Siddique A, Silvestry S, Slaughter MS, Sun B, Takayama H, Tedford R, Teuteberg JJ, Ton VK, Uriel N, Vierecke J, Zimpfer D, D'Alessandro D
Abstract
Journal of cardiac failure,
21 3 2023, Pages S1071-9164(23)00159-8
Fewer worsening heart failure events with HeartLogic<sup>TM</sup> on top of standard of care: a propensity-matched cohort analysis.
Feijen M, Beles M, Tan YZ, Cordon A, Dupont M, Treskes RW, Caputo ML, Van Bockstal K, Auricchio A, Egorova AD, Maes E, Beeres SLMA, Heggermont WA
Background: The implantable cardiac defibrillator (ICD) based HeartLogicTM algorithm aims to detect impending fluid retention in heart failure (HF) patients. Studies show that HeartLogicTM is safe to integrate in clinical practice. The current study investigates if HeartLogicTM provides clinical benefit on top of standard care and device telemonitoring in HF patients. Methods: A multicenter retrospective propensity-matched cohort analysis was performed in HF patients with and ICD and compared He...
Abstract
Interdisciplinary cardiovascular and thoracic surgery,
18 3 2023, Pages ivad072
Optimized Preoperative Planning of Double Outlet Right Ventricle Patients by 3D Printing and Virtual Reality: A Pilot Study.
Peek JJ, Bakhuis W, Sadeghi AH, Veen KM, Roest AAW, Bruining N, van Walsum T, Hazekamp MG, Bogers AJJC
Objectives: In complex double outlet right ventricle (DORV) patients, the optimal surgical approach may be difficult to assess based on conventional two-dimensional (2D) ultrasound (US) and computed tomography (CT) imaging. The aim of this study is to assess the added value of 3D printed and 3D Virtual Reality (VR) models of the heart used for surgical planning in DORV patients, supplementary to the gold standard 2D imaging modalities. Methods: Five patients with different DORV-subtypes and high...
Abstract
International journal of molecular sciences,
Volume 24, Issue 10, 18 3 2023, Pages 8948
Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism.
Knoop P, Yilmaz D, Paganoni R, Steele-Perkins P, Gruber A, Akdogan B, Zischka H, Leopold K, Vujić Spasić M
Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), a highly prevalent genetic disorder characterized by elevated iron deposition in multiple tissues. HFE acts in hepatocytes to control hepcidin expression, whereas HFE actions in myeloid cells are required for cell-autonomous and systemic iron regulation in aged mice. To address the role of HFE specifically in liver-resident macrophages, we generated mice with a selective Hfe deficiency in Kupffer cells (HfeClec4fCre). The analy...
Abstract
Circulation. Cardiovascular imaging,
Volume 16, Issue 5, 16 3 2023, Pages e014850
Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry.
Lowenstern A, Ng N, Takagi H, Rymer JA, Koweek LM, Douglas PS, Duran JM, Rabbat M, Pontone G, Fairbairn T, Chinnaiyan K, Berman DS, De Bruyne B, Bax JJ, Akasaka T, Amano T, Nieman K, Rogers C, Kitabata H, Sand NPR, Kawasaki T, Mullen S, Matsuo H, Norgaard BL, Patel MR, Leipsic J, Daubert MA
Background: The relationship between body size and cardiovascular events is complex. This study utilized the ADVANCE (Assessing Diagnostic Value of Noninvasive FFRCT in Coronary Care) Registry to investigate the association between body mass index (BMI), coronary artery disease (CAD), and clinical outcomes. Methods: The ADVANCE registry enrolled patients undergoing evaluation for clinically suspected CAD who had >30% stenosis on cardiac computed tomography angiography. Patients were stratifie...
Abstract
The American journal of cardiology,
16 3 2023, Pages S0002-9149(23)00278-3
Corrigendum to 'Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction'.
Chimed S, Stassen J, Galloo X, Meucci MC, van der Bijl P, Knuuti J, Delgado V, Marsan NA, Bax JJ
Abstract
The British journal of surgery,
16 3 2023, Pages znad111
Surgical team dynamics in a reflective team meeting to improve quality of care: a qualitative analysis of a shared mental model.
Verhagen MJ, de Vos MS, van Schaik J, van der Vorst JR, Schepers A, Marang-van de Mheen PJ, Hamming JF
Abstract
The American journal of cardiology,
15 3 2023, Pages S0002-9149(23)00241-2
Coronary Volume to Left Ventricular Mass Ratio in Patients With Hypertension.
van Rosendael SE, van Rosendael AR, Kuneman JH, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, Koweek LMH, Pontone G, Kawasaki T, Sand NPR, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, Rogers C, Matsuo H, Leipsic JA, Marsan NA, Jukema JW, Bax JJ, Saraste A, Knuuti J
The coronary vascular volume to left ventricular mass (V/M) ratio assessed by coronary computed tomography angiography (CCTA) is a promising new parameter to investigate the relation of coronary vasculature to the myocardium supplied. It is hypothesized that hypertension decreases the ratio between coronary volume and myocardial mass by way of myocardial hypertrophy, which could explain the detected abnormal myocardial perfusion reserve reported in patients with hypertension. Individuals enrolle...
Abstract
The American journal of cardiology,
15 3 2023, Pages S0002-9149(23)00234-5
Changes in Computed-Tomography-Derived Segmental Left Ventricular Longitudinal Strain After Transcatheter Aortic Valve Implantation.
Singh GK, Fortuni F, Kuneman JH, Vollema EM, van der Kley F, Marsan NA, Delgado V, Bax JJ
Patients with severe aortic stenosis (AS) may show left ventricular (LV) apical longitudinal strain sparing. Transcatheter aortic valve implantation (TAVI) improves LV systolic function in patients with severe AS. However, the changes in regional longitudinal strain after TAVI have not been extensively evaluated. This study aimed to characterize the effect of the pressure overload relief after TAVI on LV apical longitudinal strain sparing. A total of 156 patients (mean age 80 ± 7 years, 53% men)...
Abstract
The British journal of surgery,
13 2 2023, Pages znad118
Future surgeon: bridging the intergenerational gap.
Huizing F, Sier VQ, Tresfon JAS, van der Vorst JR, Liem RSL, Schmitz RF, Schepers A, Houwert RM, Vriens MR, Snijders HS, Blok JJ
Abstract
The British journal of dermatology,
13 2 2023, Pages ljad159
Successful tapering of dupilumab in atopic dermatitis patients with low disease activity: a large pragmatic daily practice study from the BioDay registry.
Spekhorst LS, Boesjes CM, Loman L, Zuithoff NPA, Bakker DS, Kamphuis E, Kamsteeg M, Haeck I, Oosting AJ, van Lumig PPM, van Lynden-van Nes AMT, Tupker RA, Flinterman A, Garritsen FM, Touwslager WRH, de Bruin-Weller MS, Schuttelaar ML, de Graaf M
Background: Limited data is available regarding patient-centered dosing of dupilumab for atopic dermatitis (AD) in daily practice. Objectives: To evaluate our patient-centered dupilumab dosing regimen in daily practice, to assess prognostic factors for successful tapering and to estimate medication-related cost savings. Methods: This prospective multicenter study included adult AD patients, participating in the BioDay registry, treated with dupilumab for ≥1.3 years. Interval prolongation was con...
Abstract
GeroScience,
13 2 2023
Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study.
Zonneveld MH, Trompet S, Jukema JW, Noordam R
Prospective cohort studies have implied associations between blood levels of troponin T, troponin I, NT-proBNP, GDF15, dementia, and cognitive function, without providing evidence favoring possible causality. We aimed to assess the causal associations of these cardiac blood biomarkers with dementia and cognition using two-sample Mendelian randomization (MR). Independent genetic instruments (p
Abstract
Heart (British Cardiac Society),
11 2 2023, Pages heartjnl-2022-322332
Tolerability and beneficial effects of sacubitril/valsartan on systemic right ventricular failure.
Nederend M, Kiès P, Regeer MV, Vliegen HW, Mertens BJ, Robbers-Visser D, Bouma BJ, Tops LF, Schalij MJ, Jongbloed MRM, Egorova AD
Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV. Methods: In this two-centre, prospective cohort study, all consecutive adult patients with symptomatic h...
Abstract
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
11 2 2023, Pages 15266028231172400
Elastic Deformation Measurement Using Duplex Ultrasound for the Detection of High Aneurysm Sac Pressure Following EVAR.
van Genderen OS, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR
Purpose: To describe the concept of aortic elastic deformation (ED) measurement using duplex ultrasonography (DUS) as a tool for detection of high aneurysm sac pressure following endovascular aortic repair (EVAR). Technique: High aneurysm sac pressure, with or without proven endoleak, will result in a less compressible aneurysm. Using the dual image function in B-mode of the DUS device and a standardized amount of applied probe pressure, ED can be measured. It is defined as the percentage of def...
Abstract
Respiratory research,
Volume 24, Issue 1, 11 2 2023, Pages 130
Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium.
Pouwels SD, van den Berge M, Vasse GF, Timens W, Brandsma CA, Aliee H, Hiemstra PS, Guryev V, Faiz A
After more than two years the COVID-19 pandemic, that is caused by infection with the respiratory SARS-CoV-2 virus, is still ongoing. The risk to develop severe COVID-19 upon SARS-CoV-2 infection is increased in individuals with a high age, high body mass index, and who are smoking. The SARS-CoV-2 virus infects cells of the upper respiratory tract by entering these cells upon binding to the Angiotensin-converting enzyme 2 (ACE2) receptor. ACE2 is expressed in various cell types in the lung but t...
Abstract
European heart journal. Cardiovascular Imaging,
11 2 2023, Pages jead094
Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography.
van Rosendael SE, Bax AM, Lin FY, Achenbach S, Andreini D, Budoff MJ, Cademartiri F, Callister TQ, Chinnaiyan K, Chow BJW, Cury RC, DeLago AJ, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Chang HJ, Berman DS, Min JK, Bax JJ, Shaw LJ, van Rosendael AR
Aims: The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. Methods and results: From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and...
Abstract
