Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 5 times since 2002 (0.2 per year) source: EuropePMC
Journal of cardiovascular pharmacology, Volume 39, Issue 1, 1 1 2002, Pages 61-72 Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium. Trines SA, Smits CA, van der Moer J, Slager CJ, Verdouw PD, Krams R
External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVO2) are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (E(es)), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty... Abstract
Cited 54 times since 2002 (2.4 per year) source: EuropePMC
Inflammation research : official journal of the European Histamine Research Society ... [et al.], Volume 51, Issue 1, 1 1 2002, Pages 8-15 Neutrophil defensins stimulate the release of cytokines by airway epithelial cells: modulation by dexamethasone. van Wetering S, Mannesse-Lazeroms SP, van Sterkenburg MA, Hiemstra PS
Objective and design: Neutrophils may contribute to recruiting other cells to sites of inflammation by generating chemotactic signals themselves, or by stimulating other cell types to release chemoattractants such as interleukin-8 (IL-8). Recently, we demonstrated that neutrophil-derived alpha-defensins are able to increase IL-8 expression in airway epithelial cells. In addition, it has previously been reported that neutrophil elastase-induced IL-8 synthesis was insensitive to inhibition by the... Abstract
Cancer chemotherapy and biological response modifiers, Volume 20, 1 1 2002, Pages 697-716 Update on the systemic treatment of lung cancer. Giaccone G, Smit EF
Cited 10 times since 2002 (0.4 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 4, Issue 3, 1 1 2002, Pages 353-357 Noninvasive and invasive evaluation of noncompaction cardiomyopathy. Bax JJ, Atsma DE, Lamb HJ, Rebergen SA, Bootsma M, Voogd PJ, Somer S, Schalij MJ, de Roos A, van der Wall EE
Noncompaction cardiomyopathy is a recently described rare congenital cardiomyopathy; patients can be asymptomatic or develop diastolic and/or systolic left ventricular dysfunction with heart failure, systemic emboli or ventricular arrhythmias. Long-term prognosis is poor. Currently, diagnosis is based on findings on 2D echocardiography; in the current case report we demonstrate the use of MRI to diagnose noncompaction cardiomyopathy. Abstract
Cited 11 times since 2002 (0.5 per year) source: EuropePMC
Journal of pediatric surgery, Volume 37, Issue 1, 1 1 2002, Pages 80-82 Evaluation of the location of the anus by a modified technique in the neonate. Genç A, Taneli C, Tansuğ N, Kasirga E, Yilmaz D, Küçükoğlu T, Onağ A
Purpose: The aim of the current study was to bring to notice the anterior displacement of the anus and to recommend the measurement of anal position index in the neonate by a modified method. Methods: Sixty newborns (34 girls and 26 boys) were taken into study, and the anal position index (API), which is the ratio of anus-fourchette (scrotum) distance to coccyx fourchette (scrotum) distance, was measured. To obtain the measurement, a transparent adhesive tape was placed along the midline on the... Abstract
Cited 1 times since 2002 (0 per year) source: EuropePMC
Journal of experimental therapeutics & oncology, Volume 2, Issue 1, 1 1 2002, Pages 47-52 Recombinant human interleukin-3 administered concomitantly with chemotherapy in patients with relapsed small cell lung cancer. Biesma B, van Kralingen KW, van Leen RW, Koster MC, Postmus PE
Although recombinant human interleukin-3 (rhIL-3) shortens both the duration of chemotherapy-induced neutropenia and thrombocytopenia, its effect on nadir counts is limited. Concurrent administration of rhIL-3 and chemotherapy may enhance this effect. However, simultaneous administration of other hematopoietic growth factors and chemotherapy has resulted in enhanced myelosuppression. We investigated whether concomitant administration of rhIL-3 and chemotherapy would result in enhanced myelosuppr... Abstract
Cited 36 times since 2001 (1.6 per year) source: EuropePMC
Chest, Volume 120, Issue 6, 1 1 2001, Pages 1811-1814 Tracheobronchial stenting in the terminal care of cancer patients with central airways obstruction. Vonk-Noordegraaf A, Postmus PE, Sutedja TG
Study objectives: To evaluate the palliative benefit of stent insertion in a group of patients with central airways obstruction due to terminal cancer. Design: Retrospective analysis of the symptomatic score of patients immediately after stent insertion, and questionnaires completed by the general practitioner (GP) after the patients died at home. Setting: Academic hospital, tertiary referral center for interventional bronchoscopy. Patients and methods: Fourteen patients with imminent suffocatio... Abstract
Cited 48 times since 2001 (2.1 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 281, Issue 6, 1 1 2001, Pages H2697-704 Biventricular systolic function in young lambs subject to chronic systemic right ventricular pressure overload. Leeuwenburgh BP, Helbing WA, Steendijk P, Schoof PH, Baan J
In various clinical situations of congenital heart disease, the right ventricle (RV) is subject to a chronic systemic pressure overload which affects biventricular function and may progress to the development of RV failure. Young lambs (2-3 wk old) underwent adjustable pulmonary artery banding (PAB) at systemic (aortic) level for 8 wk. Biventricular function was determined by using load-independent indexes of global ventricular contractile performance by the end-systolic pressure-volume relation... Abstract
Cited 25 times since 2001 (1.1 per year) source: EuropePMC
Paediatric respiratory reviews, Volume 2, Issue 4, 1 1 2001, Pages 306-310 Epithelial antimicrobial peptides and proteins: their role in host defence and inflammation. Hiemstra PS
Various antimicrobial mechanisms act in concert to protect the lung from infection by forming an efficient host defence system. Most microbial challenges are counteracted by elements of the innate immune system and antimicrobial peptides and proteins have been identified as key components of innate immunity. Although phagocytes are an important cellular source of these so-called endogenous antibiotics, it is now recognized that the airway epithelium is also a major site of synthesis. Antimicrobi... Abstract
Cited 2 times since 2001 (0.1 per year) source: EuropePMC
The Netherlands journal of medicine, Volume 59, Issue 6, 1 1 2001, Pages 292-294 Exercise-induced spontaneous hemothorax insinuates trauma; yet unmasks a lament disorder. Hadithi M, van Boxem TJ, Giaccone G, Postmus PE
The investigation for a plausible explanation of the development of massive spontaneous hemothorax during exercise in two patients led to the disclosure of two different malignancies. The first patient (pleural fibrosarcoma) passed away shortly after diagnosis. The second patient is alive without signs of disease (peripheral neuro-ectodermal tumor, PNET) since the diagnosis was made 3 years before. Spontaneous hemothorax (SH) arising during exercise does not exclusively designate trauma and full... Abstract
Cited 53 times since 2001 (2.4 per year) source: EuropePMC
Free radical biology & medicine, Volume 31, Issue 11, 1 1 2001, Pages 1442-1447 Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. Peters EA, Hiltermann JT, Stolk J
Apocynin is an inhibitor of NADPH oxidase present in inflammatory cells such as eosinophils and neutrophils. We investigated the effect of inhaled apocynin on ozone-induced bronchial hyperresponsiveness in vivo. Seven mild atopic asthmatics participated in a placebo-controlled, cross-over study with two exposures to O(3) at 2-week intervals. Apocynin (3 ml of 0.5 mg/ml) was inhaled 2 times before and 6 times after O(3) exposure at hourly intervals. At 36 h before and 16 h after O(3) exposure, me... Abstract
Cited 4 times since 2001 (0.2 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 34 Suppl 3, 1 1 2001, Pages S35-8 The role of photodynamic therapy in the management of stage I/II NSCLC. Sutedja G, Postmus PE
There is a resurgence of interest in lung cancer screening, motivated by the fact that many lung cancer patients cannot be cured due to advanced disease at presentation. Lung cancer screening may detect more early stage disease. Very early stage squamous cell type lung cancer in the central tracheobronchial tree can be detected and local bronchoscopic treatments such as photodynamic therapy can be applied if the tumor is strictly intraluminal and nodal disease is absent. So, accurate staging reg... Abstract
Cited 3 times since 2001 (0.1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 86, Issue 5, 1 1 2001, Pages 533-539 Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial. Mulder HJ, Schalij MJ, Kauer B, Visser RF, van Dijkman PR, Jukema JW, Zwinderman AH, Bruschke AV
Objective: To test the hypothesis that the 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor pravastatin ameliorates endothelium mediated responses of dilated coronary segments: the PREFACE (pravastatin related effects following angioplasty on coronary endothelium) trial. Design: A double blind, randomised, placebo controlled, multicentre study. Setting: Four hospitals in the Netherlands. Patients: 63 non-smoking, non-hypercholesterolaemic patients scheduled for elective balloon angiopla... Abstract
Cited 6 times since 2001 (0.3 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 12, Issue 11, 1 1 2001, Pages 1567-1573 A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients. Huisman C, Postmus PE, Giaccone G, Smit EF
Purpose: The topoisomerase I inhibitor topotecan (T) and the topoisomerase II inhibitor etoposide (E) are active drugs in lung cancer. The complementary functions of their targets may suggest benefit from the combined use of these agents but drug scheduling has been shown to play a critical role in preclinical models. To establish the optimal schedule and assess the impact of sequential administration of the combination of T and E, we conducted a dose finding study of sequential intravenous T an... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 9, Issue 8, 1 1 2001, Pages 343-345 Safety of statins in the new millennium. Jukema JW, Lansberg PJ
Looking at the world today and six months ago in retrospect, it becomes clear that things have changed dramatically. Not only are global economic forecasts in turmoil, other certainties have also been proven to be not as steadfast as we had hoped and expected. Safety in the world has gained a different perspective since the assault on the twin towers of the World Trade Centre in New York and the Pentagon. The safety of medicine and especially statins has also become an issue since the withdrawal... Abstract
Cited 9 times since 2001 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 88, Issue 9, 1 1 2001, Pages 1011-1017 Prolonged cardiac recovery from exercise in asymptomatic adults late after atrial correction of transposition of the great arteries: evaluation with magnetic resonance flow mapping. Roest AA, Kunz P, Helbing WA, Lamb HJ, Vliegen HW, van den Aardweg JG, Ruitenberg Q, de Roos A, van der Wall EE
After atrial correction of transposition of the great arteries (TGA), dysfunction of the systemic right ventricle at rest and during exercise has been reported. Information on changes in systemic right ventricular function during recovery from exercise is lacking. This study evaluates cardiac recovery from supine exercise using magnetic resonance (MR) imaging in patients with asymptomatic TGA after atrial correction. Flow in the ascending aorta, representing stroke volume of the systemic ventric... Abstract
Cited 9 times since 2001 (0.4 per year) source: EuropePMC
British journal of cancer, Volume 85, Issue 10, 1 1 2001, Pages 1456-1461 Accelerated cisplatin and high-dose epirubicin with G-CSF support in patients with relapsed non-small-cell lung cancer: feasibility and efficacy. Huisman C, Biesma B, Postmus PE, Giaccone G, Schramel FM, Smit EF
The purpose of this study is to determine whether it is feasible to administer high-dose epirubicin (135 mg m(-2)) combined with a fixed dose of cisplatin every 2 weeks with G-CSF support in patients with metastatic non-small-cell lung cancer (NSCLC). Subsequently, the efficacy of the recommended dose of this regimen was tested in a phase II study in patients with relapsed NSCLC. In the initial feasibility study at least 6 patients were entered at each of the 4 dose levels tested. A fixed dose o... Abstract
Cited 27 times since 2001 (1.2 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 34, Issue 2, 1 1 2001, Pages 157-168 Fluorescence bronchoscopy for early detection of lung cancer: a clinical perspective. Sutedja TG, Venmans BJ, Smit EF, Postmus PE
The conventional method of bronchoscopy has only a 30% sensitivity to detect early stage cancer in the central airways. For patients with positive sputum cytology who clearly harbor early cancers, repeat and lengthy sessions of bronchoscopies are required for accurate localization of these lesions. This leads to a significant delay in obtaining the diagnosis, postponing an appropriate treatment and reduces the chance for cure. There are valid reasons for improving the detection rate of early sta... Abstract
Cited 3 times since 2001 (0.1 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 19, Issue 22, 1 1 2001, Pages 4271-4272 Positron emission tomography scans can detect radiographically occult lung cancer in the central airways. Herder GJ, Breuer RH, Comans EF, Risse EK, van Mourik JC, Postmus PE, Sutedja TG
Cited 9 times since 2001 (0.4 per year) source: Scopus
The International journal of artificial organs, Volume 24, Issue 11, 1 1 2001, Pages 821-831 Enhancing filtration rates by the use of blood flow around the capillaries of plasmafilters: an in vitro study. Unger JK, Janssen VR, Kashefi A, Haltern C, Klosterhalfen B, Fischer Y, Gressner AM, Rossaint R
As the low clearance rate of plasmaseparation limits its use in the treatment of patients suffering from liver failure, sepsis or MOF, we intend to develop strategies for a plasmaseparation unit which increases plasmafiltration rates. Our first question focused on whether commercially available plasmaseparation filters, and in particular their membranes, are suitable for the inversion of blood and plasma compartments. This experimental study was performed using in vitro systems. Commercially ava... Abstract