Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 6 times since 2002 (0.3 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 29, Issue 4, 19 3 2002, Pages 452-457 Feasibility, safety and image quality of cardiac FDG studies during hyperinsulinaemic-euglycaemic clamping. Bax JJ, Visser FC, Poldermans D, van Lingen A, Elhendy A, Boersma E, Visser CA
Fluorine-18 fluorodeoxyglucose (FDG) imaging for the assessment of myocardial viability has become an integral part of the diagnostic and prognostic work-up of patients with ischaemic cardiomyopathy. To ensure good image quality, in particular in patients with diabetes mellitus, hyperinsulinaemic-euglycaemic clamping has been proposed. In this study we evaluated the safety and the image quality of cardiac FDG imaging during clamping in a large group of patients, including a subgroup with diabete... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 2, 1 1 2002, Pages 101-103 Einthoven meeting 2002: 9-11 June, Leiden. Schalij MJ, Van der Wall EE
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 2, 1 1 2002, Pages 43-47 Rhythmic sensory stimulation improves fitness by conditioning the autonomic nervous system. Frederiks J, Swenne CA, Ghafoerkhan A, Lalmahomed H, Maan AC, Schalij MJ, Bruschke AV, van der Wall EE
Background: Endurance training is known to alter the functioning of the autonomic nervous system, a major goal when pursuing fitness. Here, we test the hypothesis that the training-associated rhythmic sensations alone, hence without the usual accompanying physical exercise, accomplish this effect. Method: We studied sixteen resting healthy male volunteers, age (mean±SD) 25.9±3.7 years. During one hour we applied, at marching pace (2 bursts per second), bipolar transcutaneous electrical sensory n... Abstract
Cited 15 times since 2002 (0.7 per year) source: EuropePMC
British journal of cancer, Volume 86, Issue 3, 1 1 2002, Pages 436-442 Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras. van Etten B, ten Hagen TL, de Vries MR, Ambagtsheer G, Huet T, Eggermont AM
Ras mutations are present in 40-50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressing an intracellular, neutralizing single chain antibody to p21-ras (Y28). In in vitro studies transfection levels of the K-ras mutated rat colon carcinoma cell line CC531 were studied using the LacZ marker gene. In our in vivo liver metastases model di... Abstract
Cited 11 times since 2002 (0.5 per year) source: EuropePMC
Cardiovascular surgery (London, England), Volume 10, Issue 1, 1 1 2002, Pages 62-64 Organized thrombus in the ascending aorta originating from the ostium of the right coronary artery. Shahin GM, Bosker HA, Knaepen PJ, Morshuis WJ, Lindeboom JE
This case report describes the rare finding of a pedunculate thrombus in the ascending aorta originating from the ostium of the right coronary artery (RCA) detected after an inferior wall myocardial infarction in a young female. The thrombus was removed surgically during an emergency cardiopulmonary bypass procedure Abstract
Cited 1 times since 2002 (0 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 73, Issue 2, 1 1 2002, Pages 699 Double-inlet left ventricle: successfully staged ventricular septation with 12.5 years follow-up. Ottenkamp J, Hazekamp MG
Cited 291 times since 2002 (13 per year) source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950), Volume 168, Issue 3, 1 1 2002, Pages 1286-1293 In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. Wolfs TG, Buurman WA, van Schadewijk A, de Vries B, Daemen MA, Hiemstra PS, van 't Veer C
The reported requirement of functional Toll-like receptor (TLR)4 for resistance to Gram-negative pyelonephritis prompted us to localize the expression of TLR2 and TLR4 mRNA in the kidney at the cellular level by in situ hybridization. The majority of the constitutive TLR2 and TLR4 mRNA expression was found to be strategically located in the renal epithelial cells. Assuming that the TLR mRNA expression is representative of apical protein expression, this suggests that these cells are able to dete... Abstract
Cited 15 times since 2002 (0.7 per year) source: EuropePMC
Physiological measurement, Volume 23, Issue 1, 1 1 2002, Pages 237-243 Epoprostenol-induced pulmonary vasodilatation in patients with pulmonary hypertension measured by electrical impedance tomography. Smit HJ, Vonk Noordegraaf A, Roeleveld RJ, Bronzwaer JG, Postmus PE, de Vries PM, Boonstra A
Electrical impedance tomography (EIT) has been proposed as a method to monitor dynamic changes in the pulmonary vascular bed. In this study we examined the validity of EIT in the measurement of pulmonary vasodilatation in eight patients with primary and secondary pulmonary hypertension when given the vasodilating agent epoprostenol (Flolan). Therefore, catheterization of the pulmonary artery was performed in the ICU and the cardiac output was measured by means of the Fick method. The pulmonary v... Abstract
Cited 4 times since 2002 (0.2 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 123, Issue 2, 1 1 2002, Pages 348-349 Quadricuspid aortic valve in transposition of the great arteries. Portela FA, Hazekamp MG, Bartelings MM, Gittenberger-De Groot AC
Cited 84 times since 2002 (3.8 per year) source: EuropePMC
Circulation, Volume 105, Issue 6, 1 1 2002, Pages 702-706 Cardiac autonomic dysfunction in Brugada syndrome. Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M
Background: Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and... Abstract
Cited 67 times since 2002 (3 per year) source: EuropePMC
Clinical genetics, Volume 61, Issue 2, 1 1 2002, Pages 115-125 ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraja R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJ, Hayden MR
The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the... Abstract
Cited 65 times since 2002 (2.9 per year) source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 8, Issue 2, 1 1 2002, Pages 596-606 Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460. Huisman C, Ferreira CG, Bröker LE, Rodriguez JA, Smit EF, Postmus PE, Kruyt FA, Giaccone G
Purpose: Here we report on the role of mitochondria, death receptors (DRs), and caspases in exerting the cytotoxic effect of clinically relevant concentrations of paclitaxel in the non-small cell lung cancer cell line NCI-H460. Experimental design: We have characterized paclitaxel-induced cell death with annexin V, propidium iodide staining, and poly(ADP-ribose) polymerase cleavage assays. The involvement of the mitochondria pathway was studied by monitoring cytochrome c release and using H460 c... Abstract
Cited 5 times since 2002 (0.2 per year) source: EuropePMC
Cardiovascular and interventional radiology, Volume 25, Issue 1, 17 3 2002, Pages 72-73 Successful emergency stenting of acute ruptured false iliac aneurysm. Bierdrager E, Lohle PN, Schoemaker CM, Lampmann LE, van Berge Henegouwen DP, Hamming JF
A 75-year-old man complaining of acute abdominal pain, 1 month after elective surgical repair of an abdominal aortic aneurysm by an aortabi-iliac bypass graft, was referred and admitted to the emergency room. Imaging by sonography and computed tomography scan revealed a ruptured iliac pseudoaneurysm at the right iliac anastomotic site with associated large retroperitoneal hematoma. We inserted a self-expanding covered Z-stent graft by a transfemoral approach and the iliac anastomotic pseudoaneur... Abstract
Cited 30 times since 2002 (1.3 per year) source: EuropePMC
Thorax, Volume 57, Issue 1, 1 1 2002, Pages 11-14 Practice, efficacy and cost of staging suspected non-small cell lung cancer: a retrospective study in two Dutch hospitals. Herder GJ, Verboom P, Smit EF, van Velthoven PC, van den Bergh JH, Colder CD, van Mansom I, van Mourik JC, Postmus PE, Teule GJ, Hoekstra OS
Background: A study was undertaken to investigate the clinical practice, yield, and costs of preoperative staging in patients with suspected NSCLC and to obtain baseline data for prospective studies on the cost effectiveness of (18)F-fluorodeoxyglucose positron emission tomography in the management of these patients. Methods: A retrospective study of the medical records of all patients with suspected NSCLC was performed during a 2 year interval (1993-4) in an academic and a large community hospi... Abstract
Cited 25 times since 2002 (1.1 per year) source: EuropePMC
Radiology, Volume 222, Issue 1, 1 1 2002, Pages 127-135 MR flow mapping in coronary artery bypass grafts: a validation study with Doppler flow measurements. Langerak SE, Kunz P, Vliegen HW, Jukema JW, Zwinderman AH, Steendijk P, Lamb HJ, van der Wall EE, de Roos A
Purpose: To validate fast magnetic resonance (MR) flow mapping with intravascular Doppler flow measurements in vitro and in patients with nonstenotic and stenotic coronary artery bypass grafts. Materials and methods: MR and Doppler flow measurements were performed in a small-diameter flow phantom with physiologic flow conditions and at baseline and during adenosine stress in 27 grafts in 23 patients, who were scheduled for cardiac catheterization. At invasive analysis, the grafts were divided in... Abstract
Cited 75 times since 2002 (3.4 per year) source: EuropePMC
Circulation, Volume 105, Issue 3, 1 1 2002, Pages 328-333 Detection of vein graft disease using high-resolution magnetic resonance angiography. Langerak SE, Vliegen HW, de Roos A, Zwinderman AH, Jukema JW, Kunz P, Lamb HJ, van Der Wall EE
Background: The application of previous magnetic resonance (MR) angiography techniques has enabled noninvasive differentiation between patent and occluded coronary artery bypass grafts. However, the detection of graft stenosis remains difficult. The purpose of our study was to determine the accuracy of high-resolution navigator-gated 3-dimensional (3-D) MR angiography in detecting vein graft disease. Methods and Results- MR angiography was performed in addition to coronary angiography with quant... Abstract
Cited 2 times since 2002 (0.1 per year) source: EuropePMC
International journal of technology assessment in health care, Volume 18, Issue 3, 1 1 2002, Pages 576-585 Staging of non-small-cell lung cancer and application of FDG-PET. A cost modeling approach. Verboom P, Herder GJ, Hoekstra OS, Smit EF, van den Bergh JH, van Velthoven PC, Grijseels EW
Background: The presence of (distant) metastases affects the therapy (operation) and prognosis of patients with non-small-cell lung cancer (NSCLC). Fifty percent of the operations are futile due to the presence of a locally advanced tumor or distant metastases. Therefore, more accurate preoperative staging is required with respect to the outcomes (reduction of futile operations) and costs. This study examines current staging procedures and assesses possible situations for incorporating positron... Abstract
Cited 5 times since 2002 (0.2 per year) source: EuropePMC
Methods in molecular biology (Clifton, N.J.), Volume 178, 1 1 2002, Pages 379-387 Expression of scFvs and scFv fusion proteins in eukaryotic cells. de Graaf M, van der Meulen-Muileman IH, Pinedo HM, Haisma HJ
Cited 38 times since 2002 (1.7 per year) source: EuropePMC
Annals of medicine, Volume 34, Issue 2, 1 1 2002, Pages 96-101 Role of defensins in inflammatory lung disease. Aarbiou J, Rabe KF, Hiemstra PS
The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins--small non-enzymatic and cationic peptides. Besides their extensively studied role in antimicrobial defense, recent studies have demonstrated that defensins are also able to modula... Abstract
Cited 56 times since 2002 (2.5 per year) source: EuropePMC
Current pharmaceutical design, Volume 8, Issue 15, 1 1 2002, Pages 1391-1403 Beta-glucuronidase-mediated drug release. de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM
The selective activation of a relatively non-toxic prodrug by an enzyme present only in the tumour should enhance the drug concentration at the tumour site and result in a better anti-tumour effect and a reduction in systemic toxicity as compared to conventional chemotherapy. beta-Glucuronidase is such an enzyme. It is normally expressed in the lysosomes of cells. In larger tumours, however, high levels of the enzyme are present in necrotic areas. Several glucuronide prodrugs have been synthesis... Abstract