Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 92 times since 2002 (4.2 per year) source: EuropePMC
Journal of clinical pathology, Volume 55, Issue 5, 1 1 2002, Pages 332-339 Multidrug resistance related molecules in human and murine lung. Scheffer GL, Pijnenborg AC, Smit EF, Müller M, Postma DS, Timens W, van der Valk P, de Vries EG, Scheper RJ
Aims: Transporter proteins known to mediate multidrug resistance (MDR) in tumour cells--MDR1 P-glycoprotein (P-gp) and multidrug resistance related protein 1 (MRP1)--are thought to be involved in protecting the lungs against inhaled toxic pollutants. Recently, several new transporter family members have been identified--for example, MRP2, MRP3, and breast cancer resistance protein (BCRP). To study the possible contribution of these proteins and the earlier defined MDR1 and MDR3 P-gp molecules, M... Abstract
Cited 13 times since 2002 (0.6 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 23, Issue 5, 1 1 2002, Pages 393-397 The additional value of angiography after colour-coded duplex on decision making in patients with critical limb ischaemia. A prospective study. Avenarius JK, Breek JC, Lampmann LE, van Berge Henegouwen DP, Hamming JF
Objective: to investigate prospectively the additional value of intra arterial digital subtraction arteriography (IADSA) for decision making in patients with critical limb ischemia (CLI). Treatment plans based on colour-duplex imaging (CDI) were compared with treatment plans based on IADSA. Methods: ninety-eight consecutive patients with 112 legs with CLI were investigated by CDI and IADSA. Treatment plans based on CDI and IADSA were made separately during a multidisciplinary meeting. Both plans... Abstract
Cited 113 times since 2002 (5.1 per year) source: EuropePMC
Journal of virology, Volume 76, Issue 9, 1 1 2002, Pages 4612-4620 Exploiting the natural diversity in adenovirus tropism for therapy and prevention of disease. Havenga MJ, Lemckert AA, Ophorst OJ, van Meijer M, Germeraad WT, Grimbergen J, van Den Doel MA, Vogels R, van Deutekom J, Janson AA, de Bruijn JD, Uytdehaag F, Quax PH, Logtenberg T, Mehtali M, Bout A
Since targeting of recombinant adenovirus vectors to defined cell types in vivo is a major challenge in gene therapy and vaccinology, we explored the natural diversity in human adenovirus tissue tropism. Hereto, we constructed a library of Ad5 vectors carrying fibers from other human serotypes. From this library, we identified vectors that efficiently infect human cells that are important for diverse gene therapy approaches and for induction of immunity. For several medical applications (prenata... Abstract
Cited 52 times since 2002 (2.4 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 13, Issue 5, 1 1 2002, Pages 417-423 Long-term follow-up after radiofrequency catheter ablation of ventricular tachycardia: a successful approach? Borger van der Burg AE, de Groot NM, van Erven L, Bootsma M, van der Wall EE, Schalij MJ
Introduction: Radiofrequency ablation (RFCA) of ventricular tachycardia (VT) is a potential curative treatment modality. We evaluated the results of RFCA in patients with VT. Methods and results: One hundred fifty-one consecutive patients (122 men and 29 women; age 57 +/- 16 years) with drug-refractory VT were treated. Underlying heart disease was ischemic heart disease in 89 (59%), arrhythmogenic right ventricular cardiomyopathy (ARVC) in 32 (21%), and idiopathic VT in 30 (20%; left ventricle i... Abstract
Cited 20 times since 2002 (0.9 per year) source: EuropePMC
Atherosclerosis, Volume 162, Issue 1, 1 1 2002, Pages 103-110 VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area. Tacken PJ, Delsing DJ, Gijbels MJ, Quax PH, Havekes LM, Hofker MH, van Dijk KW
The very low density lipoprotein receptor (VLDLR) has been shown to modulate cell migration and foam cell formation in vitro. This suggests a role for the VLDLR in vascular pathology associated with intimal thickening and atherogenesis. In the present paper both intimal thickening and atherosclerosis were studied using VLDLR knockout and transgenic mouse models. The role of the VLDLR in intimal thickening was established in an in vivo model for vascular injury. A non-restrictive cuff was placed... Abstract
Cited 20 times since 2002 (0.9 per year) source: EuropePMC
Circulation research, Volume 90, Issue 10, 1 1 2002, Pages 1128-1134 Adenoviral activin a expression prevents intimal hyperplasia in human and murine blood vessels by maintaining the contractile smooth muscle cell phenotype. Engelse MA, Lardenoye JH, Neele JM, Grimbergen JM, De Vries MR, Lamfers ML, Pannekoek H, Quax PH, De Vries CJ
Activin A alters the characteristics of human arterial smooth muscle cells (SMCs) toward a contractile, quiescent phenotype. We hypothesize that activin A may prevent SMC-rich neointimal hyperplasia. Here, we study the effect of adenovirus-mediated expression of activin A on neointima formation in vitro and in vivo. Human saphenous vein organ cultures, in which a neointima is formed spontaneously, were infected either with activin A- or lacZ-adenovirus. Activin A-overexpression reduces neointima... Abstract
Cited 14 times since 2002 (0.6 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 29, Issue 6, 10 2 2002, Pages 721-727 Accuracy of PET in predicting functional recovery after revascularisation in patients with chronic ischaemic dysfunction: head-to-head comparison between blood flow, glucose utilisation and water-perfusable tissue fraction. Bax JJ, Fath-Ordoubadi F, Boersma E, Wijns W, Camici PG
Accurate prediction of improvement in left ventricular ejection fraction (LVEF) after revascularisation is critical in the therapeutic decision-making process in patients with chronic ischaemic dysfunction. Positron emission tomography (PET) allows non-invasive evaluation of myocardial blood flow (MBF), metabolic rate of glucose (MRG, absolute and relative) and the water-perfusable tissue fraction (PTF). Each of these indices has been proposed for the prediction of functional recovery. Their rel... Abstract
Cited 26 times since 2002 (1.2 per year) source: EuropePMC
The American journal of cardiology, Volume 89, Issue 8, 1 1 2002, Pages 964-968 Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imaging. Elhendy A, van Domburg RT, Vantrimpont P, Poldermans D, Bax JJ, van Gelder T, Baan CC, Schinkel A, Roelandt JR, Balk AH
Cardiac allograft vasculopathy is a major cause of mortality in heart transplant recipients. The aim of this study was to assess the prognostic value of stress myocardial perfusion imaging in heart transplant recipients. We studied 166 patients (age 54 +/- 10 years, 140 men) by symptom-limited bicycle exercise or dobutamine (up to 40 microg/kg/min) stress myocardial perfusion imaging 7.4 +/- 2.5 years after heart transplantation. An intravenous dose of 370 MBq of technetium-99m tetrofosmin was i... Abstract
Cited 11 times since 2002 (0.5 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 123, Issue 4, 1 1 2002, Pages 826-828 Carotid artery patch plasty as a last resort repair for long-segment congenital tracheal stenosis. Dodge-Khatami A, Nijdam NC, Broekhuis E, Von Rosenstiel IA, Dahlem PG, Hazekamp MG
Cited 94 times since 2002 (4.3 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 87, Issue 4, 1 1 2002, Pages 356-362 Health related quality of life and health status in adult survivors with previously operated complex congenital heart disease. Kamphuis M, Ottenkamp J, Vliegen HW, Vogels T, Zwinderman KH, Kamphuis RP, Verloove-Vanhorick SP
Objective: To examine the impact of previously operated complex congenital heart disease on health related quality of life and subjective health status and to determine the relation between these parameters and physical status. Design: Cross sectional; information on medical follow up was sought retrospectively. Setting: Patients were randomly selected from the archives of the paediatric cardiology department, Leiden University Medical Centre, Leiden, The Netherlands, and approached irrespective... Abstract
Cited 58 times since 2002 (2.6 per year) source: EuropePMC
Journal of biomechanics, Volume 35, Issue 4, 1 1 2002, Pages 499-510 Finite element and experimental models of cemented hip joint reconstructions can produce similar bone and cement strains in pre-clinical tests. Stolk J, Verdonschot N, Cristofolini L, Toni A, Huiskes R
Finite element (FE) models could be used for pre-clinical testing of cemented hip replacement implants against the damage accumulation failure scenario. To accurately predict mechanical failure, the models should accurately predict stresses and strains. This should be the case for various implants. In the current study, two FE models of composite hip reconstructions with two different implants were validated relative to experimental bone and cement strains. The objective was an overall agreement... Abstract
Cited 15 times since 2002 (0.7 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 38, Issue 6, 1 1 2002, Pages 779-783 A phase II EORTC study of temozolomide in patients with malignant pleural mesothelioma. van Meerbeeck JP, Baas P, Debruyne C, Smit EF, van Klaveren RJ, Galdermans D, Lentz MA, Manegold C, Giaccone G, EORTC Lung Cancer Group
The aim of this study was to investigate the anti-tumour activity of temozolomide in patients with malignant pleural mesothelioma. 27 chemotherapy-naïve patients with histologically-proven malignant mesothelioma were treated with temozolomide 200 mg/m2/day, given orally on days 1-5 of each 28-day cycle. Therapy continued up to 10 cycles unless disease progression or excessive toxicity mandated discontinuation. Toxicity, symptom improvement and pain intensity were regularly assessed. With a media... Abstract
Cited 90 times since 2002 (4.1 per year) source: EuropePMC
Biochemical Society transactions, Volume 30, Issue 2, 1 1 2002, Pages 116-120 Novel roles of protease inhibitors in infection and inflammation. Hiemstra PS
The local balance between proteinase inhibitors and proteinases determines local proteolytic activity. Various studies have demonstrated the importance of serine proteinase inhibitors in regulating the activity of serine proteinases that are released by leucocytes during inflammation. Recently it has been shown that these inhibitors may also display functions that are distinct from those associated with the inhibition of leucocyte-derived proteinases. In this review the results of selected studi... Abstract
Cited 1 times since 2002 (0 per year) source: EuropePMC
Seminars in oncology, Volume 29, Issue 2 Suppl 5, 1 1 2002, Pages 17-22 Pemetrexed as a single agent in the therapy of advanced lung cancer. Postmus PE, Bunn PA
Pemetrexed is a multitargeted antifolate with activity as a single agent against non-small cell lung cancer at a recommended dose of 500 mg/m(2) as a 10-minute infusion every 21 days. The response rate in untreated patients with stage IIIB/IV disease is from 18% to 23%. It is also active in the second-line setting in patients progressing after pretreatment with a number of drugs or after a very short treatment-free interval. The response rate in these difficult-to-treat patients is approximately... Abstract
Cited 395 times since 2002 (17.9 per year) source: EuropePMC
Lancet (London, England), Volume 359, Issue 9315, 1 1 2002, Pages 1388-1393 Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial. van Tinteren H, Hoekstra OS, Smit EF, van den Bergh JH, Schreurs AJ, Stallaert RA, van Velthoven PC, Comans EF, Diepenhorst FW, Verboom P, van Mourik JC, Postmus PE, Boers M, Teule GJ
Background: Up to 50% of curative surgery for suspected non-small-cell lung cancer is unsuccessful. Accuracy of positron emission tomography (PET) with 18-fluorodeoxyglucose (18FDG) is thought to be better than conventional staging for diagnosis of this malignancy. Up to now however, there has been no evidence that PET leads to improved management of patients in routine clinical practice. We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were schedul... Abstract
Cited 68 times since 2002 (3.1 per year) source: EuropePMC
Radiology, Volume 223, Issue 1, 1 1 2002, Pages 204-211 Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of fallot repair. Roest AA, Helbing WA, Kunz P, van den Aardweg JG, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A
Purpose: To assess the responses of pulmonary regurgitation (PR) and biventricular function to submaximal exercise by using a magnetic resonance (MR) imaging exercise protocol with young adult patients who underwent tetralogy of Fallot repair at a young age. Materials and methods: Fifteen patients with corrected tetralogy of Fallot (mean age, 17.5 years +/- 2.5 [SD]) underwent MR imaging at rest and during exercise for the evaluation of PR and biventricular function. Results were compared with f... Abstract
Cited 70 times since 2002 (3.2 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 282, Issue 4, 1 1 2002, Pages H1350-8 Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs. Leeuwenburgh BP, Steendijk P, Helbing WA, Baan J
Diastolic function is a major determinant of ventricular performance, especially when loading conditions are altered. We evaluated biventricular diastolic function in lambs and studied possible load dependence of diastolic parameters [minimum first derivative of pressure vs. time (dP/dt(min)) and time constant of isovolumic relaxation (tau)] in normal (n = 5) and chronic right ventricular (RV) pressure-overloaded (n = 5) hearts by using an adjustable band on the pulmonary artery (PAB). Pressure-... Abstract
The Netherlands journal of medicine, Volume 60, Issue 1, 1 1 2002, Pages 17-21 Failure patterns of combined modality treatment in lung cancer: the impact of staging. Hoekstra CJ, Rijna H, Smit EF, Van Mourik JC, Postmus PE, Lammertsma AA, Hoekstra OS
Background: Patients with locally advanced non-small cell lung cancer (NSCLC) may be treated with induction chemotherapy (IC) followed by surgery with curative intent. The impact of staging inaccuracies on the failure rate of this intensive combined modality treatment approach, i.e. non-curative chemotherapy and thoracotomy, requires further investigation. Methods: The records of a cohort of 38 consecutive NSCLC IIIA-N2 patients treated with IC followed by surgery were reviewed. Results: The cli... Abstract
Cited 149 times since 2002 (6.7 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 20, Issue 6, 1 1 2002, Pages 1657-1667 Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. Kuenen BC, Rosen L, Smit EF, Parson MR, Levi M, Ruijter R, Huisman H, Kedde MA, Noordhuis P, van der Vijgh WJ, Peters GJ, Cropp GF, Scigalla P, Hoekman K, Pinedo HM, Giaccone G
Purpose: To investigate the feasibility and pharmacokinetics of the combination cisplatin, gemcitabine, and SU5416. Patients and methods: Patients received cisplatin 80 mg/m(2) on day 1, gemcitabine 1,250 mg/m(2) on days 1 and 8, repeated every 3 weeks, and SU5416 (85 and 145 mg/m(2)) intravenously twice weekly. Pharmacokinetics of all three agents, side effects, and antitumor response were investigated in patients with solid tumors amenable to therapy with cisplatin/gemcitabine. Results: In the... Abstract
Cited 2 times since 2002 (0.1 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 146, Issue 10, 1 1 2002, Pages 473-477 [Surgery and referral for subsequent 131I therapy for patients with differentiated thyroid carcinoma in the south-east of the Netherlands, 1983-1996, compared to the consensus guidelines from 1987]. Kuijpens JL, Hoekstra OS, Hamming JF, Haak HR, Ribot JG, Coebergh JW
Objective: To evaluate the treatment of patients with differentiated (papillary or follicular) thyroid cancer in general hospitals in the south-east of the Netherlands during the period 1983-1996, in relation to the 1987 national consensus recommendations. Design: Population-based, retrospective, descriptive. Method: For the period 1 January 1983-31 December 1996, data on the histology, TNM-stage and treatment (hospital, specialist, type of operation, referral for 131I therapy) of all 236 patien... Abstract