Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 70 times since 2001 (3 per year) source: EuropePMC
Circulation, Volume 103, Issue 13, 1 1 2001, Pages 1778-1786 Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Delsing DJ, Offerman EH, van Duyvenvoorde W, van Der Boom H, de Wit EC, Gijbels MJ, van Der Laarse A, Jukema JW, Havekes LM, Princen HM
Background: The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and results: Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet. The HC diet resulted in a plasma cholesterol concentration of 18.7+/-2.6 mmol/L. Addition of avasimibe lowered plasma cholesterol by 56% to 8.1+/-1.2 mmol/... Abstract
Cited 22 times since 2001 (1 per year) source: EuropePMC
Gene therapy, Volume 8, Issue 7, 1 1 2001, Pages 534-541 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI. Lamfers ML, Lardenoye JH, de Vries MR, Aalders MC, Engelse MA, Grimbergen JM, van Hinsbergh VW, Quax PH
Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding... Abstract
Cited 9 times since 2001 (0.4 per year) source: EuropePMC
Seminars in oncology, Volume 28, Issue 2 Suppl 4, 1 1 2001, Pages 48-52 Treatment of relapsed small cell lung cancer. Postmus PE, Smit EF
Small cell lung cancer is a frequently relapsing tumor despite a high rate of response after first-line chemotherapy. For these patients, treatment at relapse depends on the response to first-line treatment, time off therapy, and the site of progression. For patients with a good performance status and a relapse more than 3 months after first-line treatment, the choice of chemotherapy at relapse is the same as initial therapy. In case of earlier progression, so-called non-cross-resistant chemothe... Abstract
Cited 1 times since 2001 (0 per year) source: EuropePMC
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, Volume 56, Issue 2, 1 1 2001, Pages 128-131 Photodynamic therapy for treating early stage lung cancer. Sutedja G, Postmus PE
The importance of treating lung cancer at the earliest stage possible has been increasingly recognised. With the resurgence of interest in lung cancer screening, the use of less invasive staging and treatment procedures has gained momentum. Technical advances have propelled the use of bronchoscopic procedures into clinical practice, providing alternatives for conventional diagnostic and treatment modalities. Many lung cancer patients are limited in their pulmonary reserve capacity due to their s... Abstract
Cited 6 times since 2001 (0.3 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 19, Issue 3, 1 1 2001, Pages 377-378 Mediastinoscopy as a standardised procedure for mediastinal lymph node staging in non-small cell lung carcinoma. Daniels JM, Rijna H, Postmus PE, van Mourik JC
Cited 169 times since 2001 (7.3 per year) source: EuropePMC
Circulation, Volume 103, Issue 9, 1 1 2001, Pages 1198-1205 Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J, Kastelein JJ, Hayden MR
Background: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within the ABCA1 gene are associated with decreased HDL-C, increased triglycerides, and an increased risk of CAD. However, the extent to which common variation within this gene influences plasma lipid levels an... Abstract
Cited 17 times since 2001 (0.7 per year) source: EuropePMC
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), Volume 45, Issue 1, 1 1 2001, Pages 108-114 Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT. Bavelaar-Croon CD, Wahba FF, Van Hecke MV, Atsma DE, Stokkel MP, Pauwels EK, Van der Wall EE
Background: The presence of a left bundle branch block (LBBB) pattern on the electrocardiogram may frequently lead to perfusion defects in the septum not necessarily due to ischemic heart disease, but probably due to abnormal septal wall motion. The introduction of gated single photon emission computed tomography (SPECT) allows the evaluation of myocardial perfusion and function in one study. Accordingly, we analysed perfusion and function and the relation between perfusion and regional function... Abstract
Cited 74 times since 2001 (3.2 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 24, Issue 3, 1 1 2001, Pages 282-294 Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. White SR, Williams P, Wojcik KR, Sun S, Hiemstra PS, Rabe KF, Dorscheid DR
Changes in epithelial cell shape can lead to cell death and detachment. Actin filaments are cleaved during apoptosis, but whether disruption in the actin cytoskeletal network, as one manifestation of cell shape change, can itself induce apoptosis is not known. We tested this hypothesis in the airway epithelial cell line 1HAEo(-) and in primary airway epithelial cells by preventing actin filament elongation with cytochalasin D or by aggregating actin filaments with jasplakinolide. Disruption of a... Abstract
Cited 13 times since 2001 (0.6 per year) source: EuropePMC
Analytical biochemistry, Volume 290, Issue 2, 1 1 2001, Pages 283-291 Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer. Havenga MJ, van Dam B, Groot BS, Grimbergen JM, Valerio D, Bout A, Quax PH
Nitric oxide (NO) is involved in the regulation of SMC proliferation during intimal hyperplasia as has been shown by the inhibitory effect on intimal hyperplasia of adenovirus-mediated ceNOS overexpression in injured arteries in pig. Good assays to quantify the NO-producing enzymes, i.e., NO synthases (NOS), are essential to analyze the mechanism of action of NO in this process. We have developed novel flow cytometric assays for the simultaneous detection of NOS-3 protein, using NOS-3 specific a... Abstract
Cited 10 times since 2001 (0.4 per year) source: EuropePMC
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 31, Issue 3, 1 1 2001, Pages 504-508 Image analysis and quantification in lung tissue. De Boer WI, Hiemstra PS, Sont JK, De Heer E, Rabe KF, Van Krieken JH, Sterk PJ
On 9-10 September 1999, an international workshop on image analysis and quantification in lung tissue was held at the Leiden University Medical Center, Leiden, The Netherlands. Participants with expertise in pulmonary and/or pathology research discussed the validity and applicability of techniques used for quantitative examination of inflammatory cell patterns and gene expression in bronchial or parenchymal tissue in studies focusing on asthma and chronic obstructive pulmonary disease (COPD). Di... Abstract
Cited 13 times since 2001 (0.6 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 71, Issue 2, 1 1 2001, Pages 601-7; discussion 607-8 Outcome and follow-up of aortic valve replacement with the freestyle stentless bioprosthesis. Kappetein AP, Braun J, Baur LH, Prat A, Peels K, Hazekamp MG, Schoof PH, Huysmans HA
Background: The aim of this study was to determine the morbidity, mortality, and hemodynamics after implantation of the Freestyle stentless bioprosthesis in the aortic position. Methods: A total of 280 patients were operated on from June 1993 to July 1999 as part of a multicenter investigation. Factors influencing hospital mortality and long-term survival were assessed by logistic regression and Cox proportional hazards analysis. Patients were evaluated postoperatively at discharge, at 3 to 6 mo... Abstract
Cited 17 times since 2001 (0.7 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 90, Issue 2, 1 1 2001, Pages 586-592 Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. De Gouw HW, Marshall-Partridge SJ, Van Der Veen H, Van Den Aardweg JG, Hiemstra PS, Sterk PJ
A role of nitric oxide (NO) has been suggested in the airway response to exercise. However, it is unclear whether NO may act as a protective or a stimulatory factor. Therefore, we examined the role of NO in the airway response to exercise by using N-monomethyl-L-arginine (L-NMMA, an NO synthase inhibitor), L-arginine (the NO synthase substrate), or placebo as pretreatment to exercise challenge in 12 healthy nonsmoking, nonatopic subjects and 12 nonsmoking, atopic asthmatic patients in a double-b... Abstract
Cited 9 times since 2001 (0.4 per year) source: EuropePMC
Controlled clinical trials, Volume 22, Issue 1, 1 1 2001, Pages 89-98 Toward less futile surgery in non-small cell lung cancer? A randomized clinical trial to evaluate the cost-effectiveness of positron emission tomography. van Tinteren H, Hoekstra OS, Smit EF, Verboom P, Boers M, PLUS Study Group
Non-small cell lung cancer can be cured if the patient is medically operable and the tumor resectable. Current diagnostic strategies are aimed to detect tumor deposits that preclude resection with curative intent. However, these strategies are rather inefficient, resulting in a large number of futile invasive procedures. In the early 1990s positron emission tomography (PET) showed promising results at its introduction in the clinic, especially in oncology. A large number of accuracy studies have... Abstract
Cited 40 times since 2001 (1.7 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 21, Issue 2, 1 1 2001, Pages 118-122 Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaire. Breek JC, Hamming JF, De Vries J, Aquarius AE, van Berge Henegouwen DP
Objective: to assess quality of life (QOL) in patients with intermittent claudication. Design: a prospective, open study. Material and method: one hundred and fifty-one consecutive claudicants (100 men, 51 women), and 161 healthy controls (70 men and 91 women) completed an adapted version of the World Health Organisation Quality of Life Assessment Instrument-100. Results: patients scored significantly worse on the domains Physical health and Level of independence, as well as on the facets Pain a... Abstract
Cited 20 times since 2001 (0.9 per year) source: EuropePMC
Pflugers Archiv : European journal of physiology, Volume 441, Issue 5, 1 1 2001, Pages 717-724 Within-subject electrocardiographic differences at equal heart rates: role of the autonomic nervous system. Frederiks J, Swenne CA, Kors JA, van Herpen G, Maan AC, Levert JV, Schalij MJ, Bruschke AV
Various combinations of sympathetic and vagal tone can yield the same heart rate, while ventricular electrophysiology differs. To demonstrate this in humans, we studied healthy volunteers in the sitting position with horizontal legs. First, heart rate was increased by lowering the legs to 60 degrees and back. Thereafter, heart rate was increased by handgrip. In each subject, a leg-lowering angle was selected at which heart rate matched best with heart rate in the third handgrip minute. Thirteen... Abstract
Cited 26 times since 2001 (1.1 per year) source: EuropePMC
Radiology, Volume 218, Issue 2, 1 1 2001, Pages 540-547 Improved MR flow mapping in coronary artery bypass grafts during adenosine-induced stress. Langerak SE, Kunz P, Vliegen HW, Lamb HJ, Jukema JW, van Der Wall EE, de Roos A
Purpose: To validate a recently developed fast high-temporal-resolution magnetic resonance (MR) flow sequence and use it to assess coronary artery bypass graft function during pharmacologic stress. Materials and methods: Aortic and internal mammary artery flow was measured in 11 healthy volunteers by using conventional cine gradient-echo imaging as a reference standard method and turbo-field echo-planar imaging (TFEPI). By using TFEPI, breath-hold flow mapping with a spatial and temporal resolut... Abstract
Cited 34 times since 2001 (1.5 per year) source: EuropePMC
European journal of immunology, Volume 31, Issue 1, 1 1 2001, Pages 146-155 Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. van der Burg SH, de Cock K, Menon AG, Franken KL, Palmen M, Redeker A, Drijfhout J, Kuppen PJ, van de Velde C, Erdile L, Tollenaar RA, Melief CJ, Offringa R
Colorectal carcinoma is commonly associated with mutation and overexpression of p53, making this antigen a potential target for immune intervention. We analyzed humoral and proliferative immunity against p53 in the blood of patients with resected primary colorectal cancer. The majority of these patients displayed anti-p53 T helper (Th) immunity in the absence of measurable p53 specific antibody levels. The Th responses were long-lasting since they could be detected up to several years after rese... Abstract
Cited 34 times since 2001 (1.5 per year) source: EuropePMC
Circulation, Volume 103, Issue 4, 1 1 2001, Pages 562-569 Adenoviral expression of a urokinase receptor-targeted protease inhibitor inhibits neointima formation in murine and human blood vessels. Quax PH, Lamfers ML, Lardenoye JH, Grimbergen JM, de Vries MR, Slomp J, de Ruiter MC, Kockx MM, Verheijen JH, van Hinsbergh VW
Background: Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid protein designed to inhibit the activity of cell surface-bound plasmin, which cannot be inhibited by its natural inhibitors, such as alpha(2)-antiplasmin.... Abstract
Cancer chemotherapy and biological response modifiers, Volume 19, 1 1 2001, Pages 485-534 Lung cancer. Giaccone G, Smit EF
Cited 35 times since 2001 (1.5 per year) source: EuropePMC
Biochemical and biophysical research communications, Volume 280, Issue 2, 1 1 2001, Pages 522-525 Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids. Duits LA, Rademaker M, Ravensbergen B, van Sterkenburg MA, van Strijen E, Hiemstra PS, Nibbering PH
Intensive use of corticosteroids may be accompanied by increased susceptibility to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta-defensins (hBD), by cultured bronchial epithelial cells and mononuclear phagocytes. The results revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamethasone did not affect the (stimulated) mRNA express... Abstract