Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 14 times since 1995 (0.5 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 36, Issue 12, 1 1 1995, Pages 2356-2362 Pharmacokinetics and scintigraphy of indium-111-DTPA-MOC-31 in small-cell lung carcinoma. Kosterink JG, de Jonge MW, Smit EF, Piers DA, Kengen RA, Postmus PE, Shochat D, Groen HJ, The HT, de Leij L
Unlabelled: Radiolabeled MOC-31 retains its immunoreactivity and shows good in vivo immunolocalization to human SCLC xenografted in nude rats. Methods: We evaluated the immunotargeting properties and safety of 111In-labeled monoclonal antibody (MAb) MOC-31 (125 MBq, 5 mg) in six patients with histologically proven small-cell lung cancer (SCLC). Scintigraphy and pharmacokinetics were performed up to 3 days after injection. Results: No adverse reactions were found after injection of MAb MOC-31. Ph... Abstract
Cited 6 times since 1995 (0.2 per year) source: EuropePMC
British journal of cancer, Volume 72, Issue 6, 1 1 1995, Pages 1547-1550 Phase I study of high-dose epirubicin and vinorelbine in previously untreated non-small-cell lung cancer stage IIIB-IV. Bakker M, Groen HJ, Smit EF, Smeets J, Riggi M, Postmus PE
The aim of the study was to determine the maximum tolerated dose (MTD) for the combination of high-dose epirubicin and vinorelbine in chemotherapy-naive patients with inoperable non-small-cell lung cancer (NSCLC). Twenty-one patients with stage IIIB and IV NSCLC were treated in a single-centre study with escalating doses of epirubicin and vinorelbine given on an outpatient basis. The first dose level comprised epirubicin 100 mg m-2 on day 1 and vinorelbine 20 mg m-2 (days 1 and 8) given intraven... Abstract
Cited 4 times since 1995 (0.1 per year) source: EuropePMC
Cell calcium, Volume 18, Issue 6, 1 1 1995, Pages 515-525 Alpha-adrenergic agonist and endothelin-1 induced intracellular Ca2+ response in the presence of a Ca2+ entry blocker in cultured rat ventricular myocytes. De Jonge HW, Atsma DE, van der Valk-Kokshoorn EJ, van Heugten HA, van der Laarse A, Lamers JM
Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly. The aim of this study was to examine whether stimulation by alpha 1-adrenergic agonist and endothelin-1 could still elicit phosphatidylinositol cycle mediated intracellular Ca2+ m... Abstract
Cited 24 times since 1995 (0.8 per year) source: EuropePMC
Clinical science (London, England : 1979), Volume 89, Issue 6, 1 1 1995, Pages 619-624 Effect of ozone exposure on maximal airway narrowing in non-asthmatic and asthmatic subjects. Hiltermann TJ, Stolk J, Hiemstra PS, Fokkens PH, Rombout PJ, Sont JK, Sterk PJ, Dijkman JH
1. Ozone is a major constituent of air pollution in the summer. Epidemiological studies have demonstrated that there is an increase in hospital admissions for respiratory diseases 1 day after peak levels of ambient ozone. This may be due to an increase in the responsiveness of the airways to bronchoconstrictor stimuli. 2. In the present study we therefore studied the effect of a controlled exposure to ozone on the maximal degree of airway narrowing to a non-specific bronchoconstrictor, methachol... Abstract
Cited 5 times since 1995 (0.2 per year) source: EuropePMC
American heart journal, Volume 130, Issue 5, 1 1 1995, Pages 1020-1025 Heart rate variability profiles in symptomatic coronary artery disease and preserved left ventricular function: relation to ventricular tachycardia and transient myocardial ischemia. Regression Growth Evaluation Statin Study (REGRESS). van Boven AJ, Jukema JW, Crijns HJ, Lie KI
We studied heart rate variability in ambulatory electrocardiographic recordings from 312 patients with significant coronary artery disease and a left ventricular ejection fraction of > or = 30%. Only those patients who had both episodes of ischemia and nonsustained ventricular arrhythmias showed diminished values for parasympathetic nonspectral and spectral heart rate (HR) variability parameters. The root mean square of difference of successive R-R intervals (RMSSD) and high-frequency (HF) po... Abstract
Cited 147 times since 1995 (5.2 per year) source: EuropePMC
Circulation, Volume 92, Issue 9, 1 1 1995, Pages 2419-2425 Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program. Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV, Hoen H, Furberg CD, Mancini GB
Background: It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary patients with less than severely elevated lipid levels and in subgroups of this population. Methods and results: Clinical data from four atherosclerosis regression trials that ev... Abstract
Cited 81 times since 1995 (2.8 per year) source: EuropePMC
Circulation, Volume 92, Issue 9, 1 1 1995, Pages 2723-2739 Magnetic resonance imaging in coronary artery disease. van der Wall EE, Vliegen HW, de Roos A, Bruschke AV
The cardiovascular applications of nuclear magnetic resonance (MR) techniques in coronary artery disease have increased considerably in recent years. Technical advantages of MR imaging in comparison with other techniques are the excellent spatial resolution, the characterization of myocardial tissue, and the potential for three-dimensional imaging. This allows the accurate assessment of left ventricular mass and volume, the differentiation of infarcted tissue from normal myocardial tissue, and t... Abstract
Cited 2 times since 1995 (0.1 per year) source: EuropePMC
The American journal of cardiology, Volume 76, Issue 12, 1 1 1995, Pages 922-927 Similar orthostatic defense in active, healthy young adult and late middle-aged men. Bootsma M, Swenne CA, Bruschke AV
Orthostatic defense is commonly validated with a 60 degrees to 80 degrees head-up tilt test, addressing the step response rather than the response to permanent orthostatis. During the initial phase of tilt, neural factors predominate, while later, the slower humoral factors fade in. It has been demonstrated that, during adaptation of the circulatory system to the standing conditions, overshoot and undershoot occur. These oscillations hamper straight-forward interpretation of a tilt test, and may... Abstract
Cited 6 times since 1995 (0.2 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 6, Issue 9, 1 1 1995, Pages 951-952 Bronchoscopic treatment modalities in lung cancer, indications and limitations. Sutedja G, Schramel F, Postmus PE
Cited 10 times since 1995 (0.4 per year) source: EuropePMC
Magnetic resonance in medicine, Volume 34, Issue 5, 1 1 1995, Pages 728-737 Magnetic resonance imaging analysis of left ventricular pressure-volume relations: validation with the conductance method at rest and during dobutamine stress. Pattynama PM, de Roos A, Van der Velde ET, Lamb HJ, Steendijk P, Hermans J, Baan J
The accuracy of magnetic resonance (MR) imaging was assessed for in vivo measurement of the ventricular end-systolic pressure-volume relation (ESPVR) and preload recruitable stroke work (PRSW). The conductance catheter was used as reference. In 10 pigs, ventricular volumes were measured with both methods under different loading conditions at two levels of contractility. Increased contractility resulted in a significant leftward shift of the ESPVR and PRSW for both methods. The magnitude of these... Abstract
Cited 3 times since 1995 (0.1 per year) source: EuropePMC
Laboratory animals, Volume 29, Issue 4, 1 1 1995, Pages 459-463 Spleen pigmentation in young C57BL mice is caused by accumulation of melanin. van der Heijden A, van Dijk JE, Lemmens AG, Beynen AC
It has been previously reported that in 2 C57BL mouse sublines a dark pigmentation of the cranial part of the spleen occurs in up to 30% of the animals within the populations. It was not clear whether this discoloration is caused by melanosis, lipofuscinosis or haemosiderosis. With the use of light and electron microscopy of stained spleen sections, we identified the pigment in 14 out of 60 C57BL mice aged 8-10 wks. In the mice with pigmented spleens there was accumulation of melanin, predominan... Abstract
Cited 49 times since 1995 (1.7 per year) source: EuropePMC
The American journal of cardiology, Volume 76, Issue 9, 1 1 1995, Pages 40C-46C Effect of pravastatin on progression and regression of coronary atherosclerosis and vessel wall changes in carotid and femoral arteries: a report from the Regression Growth Evaluation Statin Study. de Groot E, Jukema JW, van Boven AJ, Reiber JH, Zwinderman AH, Lie KI, Ackerstaff RA, Bruschke AV
Few data are available about the potential benefit of serum cholesterol reduction in the broad range of patients with coronary atherosclerosis and normal to moderately elevated serum cholesterol levels. REGRESS is a double-blind, placebo-controlled, multicenter study to assess the effect of a 2-year treatment with the 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin on progression and regression of coronary atherosclerosis using quantitative coronary arteriography in 885 ma... Abstract
Cited 16 times since 1995 (0.6 per year) source: EuropePMC
Investigative radiology, Volume 30, Issue 9, 1 1 1995, Pages 552-562 Quantitative analysis of computed tomography scans of the lungs for the diagnosis of pulmonary emphysema. A validation study of a semiautomated contour detection technique. Zagers R, Vrooman HA, Aarts NJ, Stolk J, Schultze Kool LJ, van Voorthuisen E, Reiber JH
Rationale and objectives: To develop an analytic software package based on automated contour detection for the objective and reproducible assessment of emphysema from computed tomography (CT) scans. Methods: A semiautomated technique was developed for the definition of lung contours in CT cross-sections followed by the assessment of pulmonary CT parameters describing the disease state. For 78 images, the semiautomated contour detection was performed and compared with contours drawn by an experie... Abstract
Cited 48 times since 1995 (1.7 per year) source: EuropePMC
The Journal of general virology, Volume 76 ( Pt 9), 1 1 1995, Pages 2223-2233 Comparison of equine arteritis virus isolates using neutralizing monoclonal antibodies and identification of sequence changes in GL associated with neutralization resistance. Glaser AL, de Vries AA, Dubovi EJ
Three murine monoclonal antibodies (MAbs) that neutralize equine arteritis virus (EAV) infectivity were identified and characterized. The antibodies, 93B, 74D(B) and 38F, recognized the major envelope glycoprotein (GL) encoded by open reading frame (ORF) 5 in immunoblots and by immunoprecipitation. All three MAbs were used to compare the Bucyrus isolate of EAV and MAb neutralization-resistant (NR) escape mutants with the vaccine virus and 19 independent field isolates of EAV by virus neutralizat... Abstract
Cited 13 times since 1995 (0.5 per year) source: EuropePMC
German journal of ophthalmology, Volume 4, Issue 5, 1 1 1995, Pages 311-314 Microperimetry in patients with central serous retinopathy. Toonen F, Remky A, Janssen V, Wolf S, Reim M
In patients with acute central serous retinopathy (CSR), evaluation of visual acuity alone may not represent visual function. In patients with acute CSR, visual function may be disturbed by localized scotomas, distortion, and waviness. For the assessment of localized light sensitivity and stability of fixation, patients with CSR were evaluated by fundus perimetry with a scanning laser ophthalmoscope (SLO 101, Rodenstock Instruments). In all, 21 patients with acute CSR and 19 healthy volunteers w... Abstract
Cited 13 times since 1995 (0.5 per year) source: EuropePMC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Volume 10, Issue 9, 1 1 1995, Pages 1374-1384 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. de Bart AC, Quax PH, Löwik CW, Verheijen JH
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of whether the enhanced bone turnover in osteosarcomas is mediated by t-PA or by u-PAA and to study the effect of the cytokine interleukin-1 alpha (IL-1 alpha), k... Abstract
Cited 4 times since 1995 (0.1 per year) source: EuropePMC
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume 76, Issue 4, 1 1 1995, Pages 344-348 Management of hemoptysis in a Third World city hospital: a retrospective study. van Kralingen KW, van Kralingen-Heijboer AC, Zimmerman M, Postmus PE
Background: Massive hemoptysis (defined as blood loss greater than 600 ml/24h) is said to have a fatal outcome in up to 85% of patients when managed only medically. Methods: A retrospective patient chart study was undertaken to analyse underlying pathology, management and outcome of hemoptysis patients in a hospital with no thoracic surgical, bronchoscopic or embolisation facilities. Results: 63 patients were admitted for hemoptysis during a 2.5 year study period. Tuberculosis and sequelae of pr... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 139, Issue 31, 1 1 1995, Pages 1583-1587 [High-resolution computerized tomography of the lungs: current diagnostic possibilities]. Gratama JW, Stolk J, van Persijn van Meerten EL, Bloem JL
Cited 46 times since 1995 (1.6 per year) source: EuropePMC
Journal of virology, Volume 69, Issue 8, 1 1 1995, Pages 4668-4674 The two major envelope proteins of equine arteritis virus associate into disulfide-linked heterodimers. de Vries AA, Post SM, Raamsman MJ, Horzinek MC, Rottier PJ
In a coimmunoprecipitation assay with monospecific antisera, the two major envelope proteins GL and M of equine arteritis virus were found to occur in heteromeric complexes in virions and infected cells. While the GL protein associated with M rapidly and efficiently, newly synthesized M protein was incorporated into complexes at a slower rate, which implies that it interacts with GL molecules synthesized earlier. Analysis under nonreducing conditions revealed that the GL/M complexes consist of d... Abstract
Cited 33 times since 1995 (1.1 per year) source: EuropePMC
Magnetic resonance in medicine, Volume 34, Issue 2, 1 1 1995, Pages 161-169 Quantitative analysis of regional left ventricular function after myocardial infarction in the pig assessed with cine magnetic resonance imaging. Holman ER, Vliegen HW, van der Geest RJ, Reiber JH, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE
To assess the accuracy of quantitative analysis of global and regional wall motion and wall thickening of the left ventricle with cine magnetic resonance (MR), images obtained in eight pigs before and after myocardial infarction were compared with those obtained using gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced multislice spin-echo MR imaging and determination of pathology. The region with abnormal wall motion and wall thickening, as determined with cine MR imaging, identifi... Abstract