Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7476 results
Cited 71 times since 1995 (2.4 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 12, Issue 3, 1 1 1995, Pages 351-357 Human neutrophil defensin and serpins form complexes and inactivate each other. Panyutich AV, Hiemstra PS, van Wetering S, Ganz T
Defensins, antimicrobial and cytotoxic peptides of neutrophils, bind to and are inactivated by blood proteins. We identified defensin interactions with alpha 1-proteinase inhibitor (alpha 1-PI), alpha 1-antichymotrypsin (alpha 1-ACT), alpha 2-antiplasmin (alpha 2-AP), and antithrombin III (AT III) and examined defensin binding to alpha 1-PI and alpha 1-ACT in more detail. Defensin interactions with either alpha 1-PI or alpha 1-ACT were not affected by iodoacetamide or high salt concentration. Pr... Abstract
Cited 4 times since 1995 (0.1 per year) source: EuropePMC
The Journal of investigative dermatology, Volume 104, Issue 3, 1 1 1995, Pages 374-378 Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts. Boxman IL, Quax PH, Löwik CW, Papapoulos SE, Verheijen J, Ponec M
The plasminogen activator (PA)/plasmin system is thought to be involved in processes such as tumor invasion and wound healing, during which epithelial and mesenchymal cells come close together. However, information on regulation of the PA/plasmin system during epithelial-mesenchymal interactions is scarce. Therefore, we examined the in vitro modulation of the production and activity of the components of the PA/plasmin system in squamous carcinoma cells (SCC-4) and normal human keratinocytes in r... Abstract
Cited 28 times since 1995 (1 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 13, Issue 3, 1 1 1995, Pages 660-665 Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. Postmus PE, Smit EF, Haaxma-Reiche H, van Zandwijk N, Ardizzoni A, Quoix E, Kirkpatrick A, Sahmoud T, Giaccone G
Purpose: Here we report the results of a phase II study of teniposide, one of the most active drugs against small-cell lung cancer (SCLC), in patients with brain metastases. Patients and methods: Patients with SCLC who presented with brain metastases at diagnosis (n = 11) or during follow-up evaluation after treatment (n = 69) were treated with teniposide at a dose of 150 mg/m2 intravenously on days 1, 3, and 5 at 3-week intervals in an outpatient setting. Response in the brain was evaluated by... Abstract
Cited 60 times since 1995 (2.1 per year) source: EuropePMC
Virology, Volume 207, Issue 2, 1 1 1995, Pages 518-527 Identification of a neutralization site in the major envelope glycoprotein (GL) of equine arteritis virus. Balasuriya UB, Maclachlan NJ, De Vries AA, Rossitto PV, Rottier PJ
A panel of six neutralizing monoclonal antibodies (MAbs), neutralization-resistant variant (escape mutant [EM]) viruses, and individual viral proteins derived from a vaccinia virus expression system were used to identify the neutralizing determinants of equine arteritis virus (EAV). The neutralizing MAbs recognize a single neutralization site on the 29-kDa envelope glycoprotein of EAV (U. B. R. Balasuriya et al., 1993, J. Gen. Virol., 74, 2525-2529). Vaccinia virus recombinants which express eit... Abstract
Cited 120 times since 1995 (4.1 per year) source: EuropePMC
Circulation research, Volume 76, Issue 2, 1 1 1995, Pages 199-208 cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells. Draijer R, Atsma DE, van der Laarse A, van Hinsbergh VW
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an endogenous modulator of endothelial barrier function. Thrombin increased the passage of macromolecules through human umbilical vein and human aortic endothelia... Abstract
Cited 4 times since 1995 (0.1 per year) source: EuropePMC
Respiratory medicine, Volume 89, Issue 2, 1 1 1995, Pages 139-141 Acute necrotizing pneumonia 16 years after aspiration of a conifer branch. Henselmans JM, Schramel FM, Sutedja G, Postmus PE
Cited 45 times since 1995 (1.5 per year) source: EuropePMC
Chest, Volume 107, Issue 2, 1 1 1995, Pages 556-558 Bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid. Sutedja TG, Schreurs AJ, Vanderschueren RG, Kwa B, vd Werf TS, Postmus PE
Objective: To study the efficacy of bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid. Design: Retrospective analysis of the data of patients with bronchial carcinoid, treated primarily with bronchoscopic techniques such as Nd-YAG laser in various hospitals in the Netherlands. Subjects: Eleven patients with pulmonary complaints, ages 22 to 60 years, who were found to have intraluminal typical bronchial carcinoid. BRONCHOSCOPIC INTERVENTIONS: Six of the 11 patients r... Abstract
Diagnostic and therapeutic endoscopy, Volume 1, Issue 4, 1 1 1995, Pages 195-200 Diagnostic thoracoscopy. Janssen JP, Postmus PE, Van Mourik JC, Cuesta MA
Since the introduction of video-imaging and endoscopic surgical interventions, there is a worldwide renewed interest in thoracoscopy. However, thoracoscopy for diagnosis of pleural and pulmonary disease has been performed for more than 30 years. An overview is presented here of the results and experiences in the past 3 decades of thoracoscopy for diagnosis of pulmonary and pleural disease. Thoracoscopy is a simple and safe method to obtain a diagnosis in case of pleural effusion, pleural mass, o... Abstract
Cited 12 times since 1995 (0.4 per year) source: EuropePMC
Diagnostic and therapeutic endoscopy, Volume 2, Issue 1, 1 1 1995, Pages 1-5 Prognostic factors in patients with spontaneous pneumothorax treated with video-assisted thoracoscopy. Schramel FM, Sutedja TG, Janssen JP, Cuesta MA, van Mourik JC, Postmus PE
To analyse the efficacy of video-assisted thoracoscopy (VAT) in patients with spontaneous pneumothorax (SP) and to identify clinical factors associated with outcome after VAT, one hundred and one VATs were performed in 97 patients in this prospective study. Based on thoracoscopic appearance of the visceral pleura three groups were identified, group 1 (n = 23) showing no abnormalities treated with talcage, group 2 (n = 23) showing bullae less than 2 cm treated with talcage and coagulation, and gr... Abstract
Cited 5 times since 1995 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 139, Issue 3, 1 1 1995, Pages 131-133 [Diagnosis of pneumothorax not improved by additional roentgen pictures of the thorax in the expiration phase]. Schramel FM, Wagenaar M, Sutedja TG, Golding RP, Postmus PE
Objective: To evaluate whether an expiratory chest roentgenogram adds anything to the results obtained by a standard inspiratory chest roentgenogram in patients with a pneumothorax. Design: Retrospective analysis and blinded re-evaluation of the radiographs. Setting: Free University Hospital, Amsterdam. Method: Of 59 patients with a proven pneumothorax the chest roentgenograms at the time of the pneumothorax (54 inspiratory and 46 expiratory roentgenograms) were evaluated independently by 4 inve... Abstract
Cited 8 times since 1995 (0.3 per year) source: EuropePMC
Seminars in radiation oncology, Volume 5, Issue 1, 1 1 1995, Pages 69-73 Brain Metastases From Small Cell Lung Cancer: Chemotherapy, Radiotherapy, or Both? Postmus PE
Brain metastasis is one of the most troublesome forms of metastatic disease in small cell lung cancer and is seen in more than half of the patients during the course of their disease. Treatment is very often indicated to improve the usually dramatic symptoms. Whole brain radiotherapy is effective with regard to improvement of clinical symptoms in the majority of the patients. Evaluation with currently used standard response criteria if it is used as a single treatment modality has unfortunately... Abstract
Cited 9 times since 1995 (0.3 per year) source: EuropePMC
Respiration; international review of thoracic diseases, Volume 62, Issue 3, 1 1 1995, Pages 148-150 Stent placement is justifiable in end-stage patients with malignant airway tumours. Sutedja G, Schramel F, van Kralingen K, Postmus PE
Extraluminal tumour compression can be treated with the use of stenting. In 8 patients with end-stage malignant tumours of the tracheobronchial tree, tumor compression of the major airways became apparent after Nd-YAG laser debulking. Dumon-type stents (Endoxane), were inserted under general anaesthesia. There were no complications during and after stent insertion. All stents were well tolerated, with significant symptomatic relief in all patients. This symptomatic relief was considered worthwhi... Abstract
Cited 6 times since 1995 (0.2 per year) source: EuropePMC
The Journal of asthma : official journal of the Association for the Care of Asthma, Volume 32, Issue 1, 1 1 1995, Pages 69-74 Subjective sleep quality and mental fitness in asthmatic patients. van Keimpema AR, Ariaansz M, Nauta JJ, Postmus PE
Asthmatic patients from our outpatient pulmonary clinic were asked to fill out a questionnaire about their sleep and daytime fitness. Seventy-eight responded. Sixty-five healthy persons served as a control group. Patients reported decreased sleep quality, decreased daytime mental fitness, and increased daytime somnolence. There was no relation between these features and lung function, bronchial hyperreactivity, or nocturnal asthma. We conclude that these asthmatic patients reported more sleep di... Abstract
Cited 3 times since 1995 (0.1 per year) source: EuropePMC
Diagnostic and therapeutic endoscopy, Volume 2, Issue 2, 1 1 1995, Pages 89-92 Video-Assisted Thoracoscopy is Superior to Standard Computer Tomography of the Thorax for Selection of Patients With Spontaneous Pneumothorax for Bullectomy. Janssen JP, Golding RP, Cuesta MA, Sutedja T, Postmus PE
Background: Spontaneous pneumothorax (SP) is a common disease of unknown cause often attributed to rupture of a subpleural bulla or bleb [in this study described as emphysema-like changes (ELC)]. Treatment of SP varies from conservative (rest) to aggressive (surgery). Patients with bullae >2 cm diameter, found either by chest roentgenogram or during thoracoscopy, are often treated surgically (bullectomy and pleurectomy, or abrasion). Thoracoscopy is frequently used as the method of choice to... Abstract
Cited 1 times since 1995 (0 per year) source: EuropePMC
Diagnostic and therapeutic endoscopy, Volume 1, Issue 4, 1 1 1995, Pages 227-228 Severe bronchomalacia in a 65-year-old man treated with stent insertion instead of surgical bronchoplasty. Sutedja TG, de Graaf JC, Schramel FM, Van Kralingen KW, Postmus PE
Bronchomalacia in adults is rare. A case is reported here of a 65-year-old man with severe cough and mucostasis, caused by a benign bronchomalacia of the ventral wall of the left main bronchus. This was treated successfully with the insertion of a silicone Dumon stent as an alternative to surgical bronchoplasty. Abstract
Cited 11 times since 1995 (0.4 per year) source: EuropePMC
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Volume 139, 1 1 1995, Pages 105-122 Properties of metastasizing and nonmetastasizing human melanoma cells. van Muijen GN, Danen EH, de Vries TJ, Quax PH, Verheijen JH, Ruiter DJ
Dissemination of tumor cells includes several steps, such as: (a) detachment of tumor cells from the primary tumor, (b) traversement of the basement membrane, and (c) migration into the extracellular matrix. In these processes, at least two important categories of proteins are involved: proteases and adhesion molecules. In this contribution we describe the expression and function of components of the plasminogen activator (PA) system (proteases) and of integrins (cell-matrix adhesion molecules)... Abstract
Cited 19 times since 1995 (0.6 per year) source: EuropePMC
The American journal of cardiovascular pathology, Volume 5, Issue 1, 1 1 1995, Pages 27-31 Polyploidy of myocyte nuclei in pressure overloaded human hearts: a flow cytometric study in left and right ventricular myocardium. Vliegen HW, Eulderink F, Bruschke AV, van der Laarse A, Cornelisse CJ
Increased heart weight is known to be associated with polyploidy of myocardial nuclei. However, the relation between polyploidy and myocardial hypertrophy at a cellular level, i.e. myocyte hypertrophy, has not yet been investigated. The present study was conducted to reveal this relation in different regions in the heart using two recently developed techniques, i.e. flow cytometry to measure polyploidy and microscopic morphometry to measure myocyte dimensions in fixed tissue sections. We investi... Abstract
Cited 21 times since 1995 (0.7 per year) source: EuropePMC
The Journal of pathology, Volume 175, Issue 1, 1 1 1995, Pages 59-67 Components of the plasminogen activation system in uveal melanoma--a clinico-pathological study. De Vries TJ, Mooy CM, Van Balken MR, Luyten GP, Quax PH, Verspaget HW, Weidle UH, Ruiter DJ, Van Muijen GN
In tumour development, proteases such as plasminogen activators (PAs) play a role in degradation of the extracellular matrix and other tissue barriers. Recently, we demonstrated that plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of cutaneous melanocytic tumour progression. In this study we investigated the expression and distribution of the various components of the PA system and the presence of PA enzyme activity in 45 freshly frozen primary uveal melano... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 138, Issue 50, 1 1 1994, Pages 2502-2506 [Nitric oxide to combat pulmonary hypertension in an infant following heart surgery for septum defect]. Gesink-van der Veer BJ, Hazekamp MG, de Beaufort AJ, Stolk B, Helbing WA
A 5-month-old female infant with Down syndrome underwent surgical repair of a complete atrioventricular septal defect and a patent ductus arteriosus. The postoperative course was complicated by life-threatening pulmonary hypertensive crises which did not respond to conventional vasodilating therapy. Nitric oxide inhalation resulted in rapid decrease in pulmonary artery pressure and improvement of haemodynamics and oxygenation without causing any untoward side effects. Inhalation of NO was contin... Abstract
Cited 2 times since 1994 (0.1 per year) source: EuropePMC
Chest, Volume 106, Issue 6, 1 1 1994, Pages 1927-1928 Thoracoscopic ultrasonography of the aortopulmonary window. Janssen JP, Staal R, Cuesta MA, Tan TP, Postmus PE