Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 40 times since 2009 (2.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 8, 27 4 2010, Pages 992-999 Long-term prognosis of patients with peripheral arterial disease with or without polyvascular atherosclerotic disease. van Kuijk JP, Flu WJ, Welten GM, Hoeks SE, Chonchol M, Vidakovic R, Verhagen HJ, Bax JJ, Poldermans D
Aims: Patients with peripheral atherosclerotic disease often have multiple affected vascular beds (AVB), however, data on long-term follow-up and medical therapy are scarce. We assessed the prevalence and prognostic implications of polyvascular disease on long-term outcome in symptomatic peripheral arterial disease (PAD) patients. Methods and results: Two thousand nine hundred and thirty-three consecutive patients were screened prior to surgery for concomitant documented cerebrovascular disease... Abstract
Cited 1 times since 2009 (0.1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 26, Issue 3, 24 4 2009, Pages 355-358 CT perfusion angiography; beware of artifacts! van der Wall EE, Schuijf JD, Bax JJ, Jukema JW, Schalij MJ
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
Journal of vascular surgery, Volume 51, Issue 2, 24 4 2009, Pages 429-437 In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor. Eefting D, de Vries MR, Grimbergen JM, Karper JC, van Bockel JH, Quax PH
Background: Smooth muscle cell (SMC) migration and proliferation are important in the development of intimal hyperplasia, the major cause of vein graft failure. Proteases of the plasminogen activator (PA) system and of the matrix metalloproteinase (MMP) system are pivotal in extracellular matrix degradation and, by that, SMC migration. Previously, we demonstrated that inhibition of both protease systems simultaneously with viral gene delivery of the hybrid protein TIMP-1.ATF, consisting of the t... Abstract
Cited 21 times since 2009 (1.5 per year) source: EuropePMC
Journal of virology, Volume 84, Issue 5, 23 4 2009, Pages 2533-2546 The latent origin of replication of Epstein-Barr virus directs viral genomes to active regions of the nucleus. Deutsch MJ, Ott E, Papior P, Schepers A
The Epstein-Barr virus efficiently infects human B cells. The EBV genome is maintained extrachromosomally and replicates synchronously with the host's chromosomes. The latent origin of replication (oriP) guarantees plasmid stability by mediating two basic functions: replication and segregation of the viral genome. While the segregation process of EBV genomes is well understood, little is known about its chromatin association and nuclear distribution during interphase. Here, we analyzed the... Abstract
Cited 27 times since 2009 (1.9 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 30, Issue 3, 23 4 2009, Pages 605-611 Activation of hemostasis and decline in cognitive function in older people. Stott DJ, Robertson M, Rumley A, Welsh P, Sattar N, Packard CJ, Shepherd J, Trompet S, Westendorp RG, de Craen AJ, Jukema JW, Buckley B, Ford I, Lowe GD
Objective: To determine whether activation of hemostatic function (thrombosis and fibrinolysis) is associated with cognitive decline in older people. Methods and results: We studied 5804 people (age, 70-82 years) in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Mean follow-up was 3.2 years, including annual measurement of speed of information processing (letter, digit coding, and Stroop), verbal memory (picture-word naming), and basic and instrumental activities of daily... Abstract
Cited 6 times since 2009 (0.4 per year) source: EuropePMC
Brain & development, Volume 32, Issue 6, 23 4 2009, Pages 467-471 Tau proteins in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis. Yuksel D, Yilmaz D, Uyar NY, Senbil N, Gurer Y, Anlar B
Neurodegenerative diseases characterized by cytoskeletal deformation and neurofibrillary tangles are associated with altered levels of tau and related proteins in cerebrospinal fluid (CSF). Neuronal or glial fibrillary tangles have been shown in 20% of subacute sclerosing panencephalitis (SSPE) patients. We therefore investigated CSF samples from 60 newly diagnosed SSPE and 31 neurological control patients for total tau (t-tau), phosphorylated tau (p-tau), and S100-B levels by ELISA. There was n... Abstract
Cited 18 times since 2009 (1.2 per year) source: EuropePMC
Atherosclerosis, Volume 210, Issue 2, 22 4 2009, Pages 596-601 Metabolic syndrome is an independent predictor of cardiovascular events in high-risk patients with occlusive and aneurysmatic peripheral arterial disease. van Kuijk JP, Flu WJ, Chonchol M, Bax JJ, Verhagen HJ, Poldermans D
Objective: Metabolic syndrome (MetSyn) is a well-known risk factor for cardiovascular (CV) disease in the general population; however, the additional predictive value for CV events in high-risk patients with peripheral arterial disease (PAD) is unknown. The aims of the current study were to assess and compare: (1) prevalence of MetSyn, and (2) predictive value of MetSyn for CV events, in patients with either occlusive or aneurysmatic PAD. Methods: We screened 2069 patients scheduled for lower oc... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 3, 21 3 2009, Pages 302-305 Diagnostic accuracy of 64-slice multislice computed tomographic coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease. van Werkhoven JM, Heijenbrok MW, Schuijf JD, Jukema JW, Boogers MM, van der Wall EE, Schreur JH, Bax JJ
Data on the diagnostic accuracy of multislice computed tomographic coronary angiography (CTA) have been mostly derived from patients with a high pretest likelihood of coronary artery disease. Systematic comparisons with invasive angiography in patients with an intermediate pretest likelihood are scarce. The purpose of the present study was to determine the diagnostic accuracy of CTA in patients without known coronary artery disease with an intermediate pretest likelihood. A total of 61 patients... Abstract
Cited 219 times since 2009 (15.2 per year) source: EuropePMC
Circulation, Volume 121, Issue 1, 21 3 2009, Pages 80-90 Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP
Background: Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR signaling may optimize reperfusion therapy and enhance cell survival and heart function after myocardial infarction. Here, we evaluated the role of TLR2 as a therapeutic target using a novel monoclonal anti-TLR2 antibody. Method and results: Mice underwent 30 minutes of ischemia followed by reperfusion. Compounds were administer... Abstract
Cited 22 times since 2009 (1.5 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 3, 21 3 2009, Pages 306-311 Impact of left ventricular dyssynchrony early on left ventricular function after first acute myocardial infarction. Nucifora G, Bertini M, Marsan NA, Delgado V, Scholte AJ, Ng AC, van Werkhoven JM, Siebelink HM, Holman ER, Schalij MJ, van der Wall EE, Bax JJ
The impact of left ventricular (LV) dyssynchrony after acute myocardial infarction (AMI) on LV ejection fraction (EF) is unknown. One hundred twenty-nine patients with a first ST-elevation AMI (58 + or - 11 years, 78% men) and QRS duration Abstract
Cited 42 times since 2009 (2.9 per year) source: EuropePMC
European heart journal, Volume 31, Issue 7, 16 3 2009, Pages 842-848 The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening. Christiaans I, Birnie E, van Langen IM, van Spaendonck-Zwarts KY, van Tintelen JP, van den Berg MP, Atsma DE, Helderman-van den Enden AT, Pinto YM, Hermans-van Ast JF, Bonsel GJ, Wilde AA
Aims: We investigated the presence of a clinical diagnosis of hypertrophic cardiomyopathy (HCM) and of risk factors for sudden cardiac death (SCD) at the first cardiological evaluation after predictive genetic testing in asymptomatic carriers of an MYBPC3 gene mutation. Methods and results: Two hundred and thirty-five mutation carriers were cardiologically evaluated on the presence of HCM and risk factors. A clinical diagnosis of HCM was made in 53 carriers (22.6%). Disease penetrance at 65 year... Abstract
Cited 23 times since 2009 (1.6 per year) source: EuropePMC
British journal of cancer, Volume 102, Issue 2, 15 3 2009, Pages 268-275 CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients. Vroling L, Lind JS, de Haas RR, Verheul HM, van Hinsbergh VW, Broxterman HJ, Smit EF
Background: Blood-based biomarkers may be particularly useful for patient selection and prediction of treatment response for angiogenesis inhibitors. Circulating endothelial cells (CECs) and haematopoietic progenitor cells (HPCs) might have a role in tumour angiogenesis and in tumour growth. Measurement of CECs and HPCs in the blood of patients could be a simple, non-invasive way to monitor or predict responses to treatment. Methods: (VEGFR2(+)) CECs(,) (CD133(+)) HPCs, plasma vascular endotheli... Abstract
Cited 11 times since 2009 (0.8 per year) source: EuropePMC
Respiratory medicine, Volume 104, Issue 5, 14 2 2009, Pages 690-696 Co-existence of COPD and left ventricular dysfunction in vascular surgery patients. Flu WJ, van Gestel YR, van Kuijk JP, Hoeks SE, Kuiper R, Verhagen HJ, Bax JJ, Sin DD, Poldermans D
Background: The co-existence between chronic obstructive pulmonary disease (COPD) and heart failure has been previously described. However, the co-existence between COPD and subclinical left ventricular (LV) dysfunction, without the presence of heart failure symptoms, is less well understood. This study determined the relationship and clinical relevance of COPD and subclinical LV dysfunction in vascular surgery patients. Methods: 1005 consecutive vascular surgery patients were included in which... Abstract
Cited 4 times since 2009 (0.3 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 26, Issue 2, 12 2 2009, Pages 249-252 Fingertip digital thermal monitoring: a fingerprint for cardiovascular disease? van der Wall EE, Schuijf JD, Bax JJ, Jukema JW, Schalij MJ
Cited 76 times since 2009 (5.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 181, Issue 5, 3 1 2009, Pages 501-506 Patient outcomes after acute pulmonary embolism. A pooled survival analysis of different adverse events. Klok FA, Zondag W, van Kralingen KW, van Dijk AP, Tamsma JT, Heyning FH, Vliegen HW, Huisman MV
Rationale: There is a lack of information on the long-term prognosis of patients with acute pulmonary embolism (PE). Objectives: To assess the long-term risk for adverse events after PE. Methods: Consecutive patients diagnosed with PE between January 2001 and July 2007, and patients in whom PE was ruled out from a previous study were followed until July 2008 for the occurrence of adverse clinical events: mortality, symptomatic recurrent venous thromboembolism, cancer, arterial cardiovascular eve... Abstract
Cited 11 times since 2009 (0.8 per year) source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 4, Issue 12, 1 1 2009, Pages 1585-1586 Dramatic response to low-dose erlotinib of epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer after severe cutaneous toxicity. Lind JS, Postmus PE, Heideman DA, Thunnissen EB, Bekers O, Smit EF
Erlotinib is increasingly being used for the treatment of non-small cell lung cancer. The recommended dose is 150 mg/day and no efficacy data is available for lower doses. We describe a case of dramatic tumor response to 50 mg erlotinib in a patient with EGFR mutation positive NSCLC who developed a severe rash on full dose erlotinib. Rash is known to correlate with response and survival in patients treated with erlotinib. Our case suggests that in the presence of rash, dose reductions to "s... Abstract
Cited 25 times since 2009 (1.7 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 17, Issue 2, 1 1 2009, Pages 225-231 Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: A comparison with 2D-echocardiography. de Graaf FR, Schuijf JD, van Velzen JE, Nucifora G, Kroft LJ, de Roos A, Schalij MJ, Jukema JW, van der Wall EE, Bax JJ
Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocar... Abstract
Cited 2 times since 2009 (0.1 per year) source: EuropePMC
Endocrine reviews, Volume 30, Issue 7, 1 1 2009, Pages 927-928 Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 33, Issue 4, 1 1 2009, Pages 431-436 Implementation of lead safety recommendations. VAN Rees JB, Borleffs CJ, Bax JJ, Nagtegaal EM, VAN DER Velde ET, VAN Erven L, Schalij MJ
Background: The Medtronic Sprint Fidelis (SF) implantable cardioverter defibrillator (ICD; Medtronic Inc., Minneapolis, MN, USA) lead has a higher than expected failure rate. Because of patient safety, Medtronic announced two advisories consisting of (1) adjustments in device settings (October 2007) and (2) installation of a lead integrity algorithm (May 2008). The objective of this study was to evaluate the effect of Medtronic's announcements on patient safety. Methods: To comply with the... Abstract
Cited 29 times since 2009 (2 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 12, 1 1 2009, Pages 1425-1435 Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. Bertini M, Sengupta PP, Nucifora G, Delgado V, Ng AC, Marsan NA, Shanks M, van Bommel RJ, Schalij MJ, Narula J, Bax JJ
The authors discuss an incremental value of assessing left ventricular (LV) twist mechanics in patients with heart failure (HF) and its potential usefulness in characterizing response to cardiac resynchronization therapy (CRT) and reversal of LV remodeling at 6 months follow-up. They also underscore a critical relationship between LV lead position and changes in LV twist after CRT, and suggest that the reversal of LV remodeling in HF patients following CRT primarily results from restoration of t... Abstract