Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 1 times since 2012 (0.1 per year) source: EuropePMC
The pharmacogenomics journal, Volume 13, Issue 4, 1 1 2012, Pages 318-324 Added value of pharmacogenetic testing in predicting statin response: results from the REGRESS trial. van der Baan FH, Knol MJ, Maitland-van der Zee AH, Regieli JJ, van Iperen EP, Egberts AC, Klungel OH, Grobbee DE, Jukema JW
It was investigated whether pharmacogenetic factors, both as single polymorphism and as gene-gene interactions, have an added value over non-genetic factors in predicting statin response. Five common polymorphisms were selected in apolipoprotein E, angiotensin-converting enzyme, hepatic lipase and toll-like receptor 4. Linear regression models were built and compared on R(2) to estimate the added value of single polymorphisms and gene-gene interactions. The selected polymorphisms and the gene-ge... Abstract
Cited 5 times since 2012 (0.4 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 5, 1 1 2012, Pages 197-201 Potential cardiovascular consequences of switching from atorvastatin to generic simvastatin in the Netherlands. Liew D, Webb K, Meerding WJ, Buskens E, Jukema JW
Background: The statin authorisation form implemented in the Netherlands in January 2009 has led to significant switching of patients from atorvastatin to generic simvastatin, but often to less than equipotent doses. We sought to assess the potential consequences of this. Methods: A modelling analysis was undertaken using data from a pharmacy database covering the majority of drug prescriptions in the Netherlands. Recent meta-analyses provided data on the dose-specific, lipid-modifying potencies... Abstract
Cited 20 times since 2012 (1.7 per year) source: EuropePMC
Clinical science (London, England : 1979), Volume 122, Issue 9, 1 1 2012, Pages 421-428 Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study. Meijer CA, Le Haen PA, van Dijk RA, Hira M, Hamming JF, van Bockel JH, Lindeman JH
Animal studies implicate the AP-1 (activator protein-1) pro-inflammatory pathway as a promising target in the treatment of atherosclerotic disease. It is, however, unclear whether these observations apply to human atherosclerosis. Therefore we evaluated the profile of AP-1 activation through histological analysis and tested the potential benefit of AP-1 inhibition in a clinical trial. AP-1 activation was quantified by phospho-c-Jun nuclear translocation (immunohistochemistry) on a biobank of aor... Abstract
Cited 26 times since 2012 (2.2 per year) source: EuropePMC
Pharmacogenomics, Volume 13, Issue 7, 1 1 2012, Pages 831-840 Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives. Postmus I, Verschuren JJ, de Craen AJ, Slagboom PE, Westendorp RG, Jukema JW, Trompet S
Statins are the most commonly prescribed class of drug worldwide and therapy is highly effective in reducing low-density lipoprotein cholesterol levels and cardiovascular events. However, there is large variability in clinical response to statin treatment. Recent research provides evidence that genetic variation contributes to this variable response to statin treatment. Until recently, pharmacogenetic studies have used mainly candidate gene approaches to investigate these effects. Since candidat... Abstract
Cited 26 times since 2012 (2.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 98, Issue 9, 1 1 2012, Pages 743-754 Transcatheter aortic valve implantation: implications of multimodality imaging in patient selection, procedural guidance, and outcomes. Delgado V, Kapadia S, Schalij MJ, Schuijf JD, Tuzcu EM, Bax JJ
Cited 1 times since 2012 (0.1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 5, 1 1 2012, Pages 240-244 Einthoven dissertation prizes 2011. van der Wall EE, Schalij MJ, Umans V, van Gilst WH
Journal of the American College of Cardiology, Volume 59, Issue 21, 1 1 2012, Pages e41 Quadruple valve replacement: visualization with 256-slice computed tomography. Symersky P, Budde RP, Koolbergen DR, de Mol BA
Cited 10 times since 2012 (0.8 per year) source: Scopus
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 5, 1 1 2012, Pages 202-207 Preexisting heart failure is an underestimated risk factor in cardiac surgery. Kortekaas KA, Lindeman JH, Versteegh MI, Stijnen T, Dion RA, Klautz RJ
Background: Heart failure is characterised as a strong risk factor for systemic failure after cardiac surgery. However, the impact has never been substantiated. Methods: Patients with heart failure (n = 48) - scheduled for elective ventricular reconstruction or external constraint device-were compared with a one-to-one matched control group of patients without heart failure undergoing cardiac surgery between 2006 and 2009. Results: As expected, patients with heart failure more frequently experie... Abstract
Cited 31 times since 2012 (2.6 per year) source: EuropePMC
Archives of orthopaedic and trauma surgery, Volume 132, Issue 8, 24 4 2012, Pages 1191-1197 Contralateral hip fractures and other osteoporosis-related fractures in hip fracture patients: incidence and risk factors. An observational cohort study of 1,229 patients. Vochteloo AJ, Borger van der Burg BL, Röling MA, van Leeuwen DH, van den Berg P, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P
Purpose: To report risk factors, 1-year and overall risk for a contralateral hip and other osteoporosis-related fractures in a hip fracture population. Methods: An observational study on 1,229 consecutive patients of 50 years and older, who sustained a hip fracture between January 2005 and June 2009. Fractures were scored retrospectively for 2005-2008 and prospectively for 2008-2009. Rates of a contralateral hip and other osteoporosis-related fractures were compared between patients with and wit... Abstract
Cited 13 times since 2012 (1.1 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 4, 23 4 2012, Pages 1305-1310 Does left ventricular size impact on intrinsic right ventricular function in hypoplastic left heart syndrome? Schlangen J, Fischer G, Steendijk P, Petko C, Scheewe J, Hart C, Hansen JH, Ahrend F, Rickers C, Kramer HH, Uebing A
Background: The size of the remnant left ventricle (LV) may influence right ventricular function and thus long-term outcome in palliated hypoplastic left heart syndrome (HLHS). We therefore sought to assess the impact of the size of the hypoplastic LV on intrinsic RV function in HLHS patients after Fontan surgery. Methods: Fifty-seven HLHS patients were studied 2.5 (range: 0.8-12.6) years after Fontan-type palliation with the pressure-volume conductance system. The patient cohort was divided int... Abstract
Cited 18 times since 2012 (1.5 per year) source: EuropePMC
Heart rhythm, Volume 9, Issue 10, 20 3 2012, Pages 1605-1612 The mode of death in implantable cardioverter-defibrillator and cardiac resynchronization therapy with defibrillator patients: results from routine clinical practice. Thijssen J, van Rees JB, Venlet J, Borleffs CJ, Höke U, Putter H, van der Velde ET, van Erven L, Schalij MJ
Background: Although data on the mode of death of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy with defibrillator (CRT-D) patients have been examined in randomized clinical trials, in routine clinical practice data are scarce. To provide reasonable expectations and prognosis for patients and physicians, this study assessed the mode of death in routine clinical practice. Objective: To assess the mode of death in ICD/CRT-D recipients in routine clinical practi... Abstract
Cited 35 times since 2012 (2.9 per year) source: EuropePMC
The European respiratory journal, Volume 40, Issue 5, 20 3 2012, Pages 1098-1105 Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. van den Berge M, Vonk JM, Gosman M, Lapperre TS, Snoeck-Stroband JB, Sterk PJ, Kunz LI, Hiemstra PS, Timens W, Ten Hacken NH, Kerstjens HA, Postma DS
Bronchial hyperresponsiveness (BHR) is regarded as a hallmark of asthma, yet it is also present in a considerable number of chronic obstructive pulmonary disease (COPD) patients. Epidemiological studies have shown that BHR provides complementary information to forced expiratory volume in 1 s (FEV(1)) for development and progression of COPD. We hypothesised that the severity of BHR and its longitudinal changes associate with both clinical and airway inflammation measures in COPD. Our hypothesis w... Abstract
Interactive cardiovascular and thoracic surgery, Volume 15, Issue 1, 19 3 2012, Pages 10-13 Surgical left ventricular radius enlargement by patch insertion on the beating heart: a new experimental aneurysm model. Gründeman PF, van der Spoel TI, Steendijk P, van Slochteren F, Cramer MJ, Doevendans PA, Pasterkamp G
We presented a novel experimental aneurysm model for studies in left ventricular (LV) reconstruction techniques and assessed LV function. In eight pigs, the LV radius and geometry were enlarged surgically on the beating heart by inserting an aortic allograft construct. Haemodynamics and LV dimensions were assessed by echocardiography at baseline and under dobutamine stress. Surgery was successfully performed without lethal blood loss or arrhythmias. LV end-diastolic and end-systolic short-axis a... Abstract
Cited 1 times since 2012 (0.1 per year) source: EuropePMC
Congestive heart failure (Greenwich, Conn.), Volume 18, Issue 4, 18 3 2012, Pages 198-204 Prognostic implications of left ventricular dilation in patients with nonischemic heart failure: interactions with restrictive filling pattern and mitral regurgitation. Ghio S, Temporelli PL, Marsan NA, Poppe K, Giannuzzi P, Dini FL, Rossi A, Doughty RN, Whalley G, MeRGE HF collaborators
The aim of this study was to evaluate whether small left ventricular (LV) volumes increase the negative prognostic impact of a restrictive filling pattern (RFP) and that of mitral regurgitation (MR) in patients with nonischemic heart failure (HF). The Meta-analysis Research Group in Echocardiography (MeRGE) is a meta-analysis that collated individual patient data from several prospective echocardiography outcome studies. This analysis was restricted to 10 studies and 601 patients with nonischemi... Abstract
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 25, Issue 6, 17 3 2012, Pages 674-681 Right ventricular longitudinal peak systolic strain measurements from the subcostal view in patients with suspected pulmonary hypertension: a feasibility study. Haeck ML, Scherptong RW, Antoni ML, Marsan NA, Vliegen HW, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: The assessment of right ventricular (RV) function with two-dimensional echocardiography can be challenging in patients with pulmonary hypertension, especially in those with chronic pulmonary disease. The aim of the present study was to evaluate the feasibility of measuring RV longitudinal peak systolic strain (LPSS) in the echocardiographic subcostal view in patients with suspected pulmonary hypertension. Methods: A total of 179 patients evaluated for pulmonary hypertension were incl... Abstract
Cited 761 times since 2012 (62.9 per year) source: EuropePMC
Nature genetics, Volume 44, Issue 5, 15 3 2012, Pages 491-501 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, M
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identifi... Abstract
Cited 96 times since 2012 (7.9 per year) source: EuropePMC
PloS one, Volume 7, Issue 4, 13 2 2012, Pages e34076 Changes to airborne pollen counts across Europe. Ziello C, Sparks TH, Estrella N, Belmonte J, Bergmann KC, Bucher E, Brighetti MA, Damialis A, Damialis A, Detandt M, Galán C, Gehrig R, Grewling L, Gutiérrez Bustillo AM, Hallsdóttir M, Kockhans-Bieda MC, De Linares C, Myszkowska D, Pàldy A, Sánchez A, Smith M, Thibaudon M, Travaglini A, Uruska A, Valencia-Barrera RM, Vokou D, Wachter R, de Weger LA, Menzel A
A progressive global increase in the burden of allergic diseases has affected the industrialized world over the last half century and has been reported in the literature. The clinical evidence reveals a general increase in both incidence and prevalence of respiratory diseases, such as allergic rhinitis (common hay fever) and asthma. Such phenomena may be related not only to air pollution and changes in lifestyle, but also to an actual increase in airborne quantities of allergenic pollen. Experim... Abstract
Cited 107 times since 2012 (8.8 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 53, Issue 5, 10 2 2012, Pages 701-708 Repeatability of 18F-FDG uptake measurements in tumors: a metaanalysis. de Langen AJ, Vincent A, Velasquez LM, van Tinteren H, Boellaard R, Shankar LK, Boers M, Smit EF, Stroobants S, Weber WA, Hoekstra OS
Unlabelled: PET with the glucose analog (18)F-FDG is increasingly used to monitor tumor response to therapy. To use quantitative measurements of tumor (18)F-FDG uptake for assessment of tumor response, the repeatability of this quantitative metabolic imaging method needs to be established. Therefore, we determined the repeatability of different standardized uptake value (SUV) measurements using the available data. Methods: A systematic literature search was performed to identify studies addressi... Abstract
Cited 6 times since 2012 (0.5 per year) source: EuropePMC
Antonie van Leeuwenhoek, Volume 102, Issue 2, 10 2 2012, Pages 401-406 In vivo analysis of Saccharomyces cerevisiae plasma membrane ATPase Pma1p isoforms with increased in vitro H+/ATP stoichiometry. de Kok S, Yilmaz D, Daran JM, Pronk JT, van Maris AJ
Plasma membrane H(+)-ATPase isoforms with increased H(+)/ATP ratios represent a desirable asset in yeast metabolic engineering. In vivo proton coupling of two previously reported Pma1p isoforms (Ser800Ala, Glu803Gln) with increased in vitro H(+)/ATP stoichiometries was analysed by measuring biomass yields of anaerobic maltose-limited chemostat cultures expressing only the different PMA1 alleles. In vivo H(+)/ATP stoichiometries of wildtype Pma1p and the two isoforms did not differ significantly. Abstract
Cited 66 times since 2012 (5.5 per year) source: EuropePMC
The European respiratory journal, Volume 40, Issue 6, 10 2 2012, Pages 1362-1373 Extracellular matrix composition in COPD. Annoni R, Lanças T, Yukimatsu Tanigawa R, de Medeiros Matsushita M, de Morais Fernezlian S, Bruno A, Fernando Ferraz da Silva L, Roughley PJ, Battaglia S, Dolhnikoff M, Hiemstra PS, Sterk PJ, Rabe KF, Mauad T
Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung pare... Abstract