Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7496 results
Cited 265 times since 1999 (10.8 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 5 Pt 1, 1 1 1999, Pages 1468-1472 A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy. Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DC, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JH, Hansen NC, Heckscher T, Viskum K, Stolk J
We have investigated whether restoration of the balance between neutrophil elastase and its inhibitor, alpha(1)-antitrypsin, can prevent the progression of pulmonary emphysema in patients with alpha(1)-antitrypsin deficiency. Twenty-six Danish and 30 Dutch ex-smokers with alpha(1)-antitrypsin deficiency of PI*ZZ phenotype and moderate emphysema (FEV(1) between 30% and 80% of predicted) participated in a double-blind trial of alpha(1)-antitrypsin augmentation therapy. The patients were randomized... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 143, Issue 40, 1 1 1999, Pages 1992-1996 [Role of chemo(radio)theray prior to surgery for stage IIIa non-small cell lung carcinoma (localized non-resectable tumor)]. Smit EF, van Mourik JC, Slotman BJ, Postmus PE
Neoadjuvant chemotherapy with or without combined radiotherapy followed by surgery may yield a survival profit for selected patients with non-small cell lung carcinoma in stage IIIA. It has not yet been established which is the most efficacious neoadjuvant chemotherapy nor what is the best postneoadjuvant chemotherapy, especially resection or radiotherapy. Comparative clinical studies to find the answer to these two questions are in progress. New forms of treatment are required in order to achie... Abstract
Cited 4 times since 1999 (0.2 per year) source: EuropePMC
Seminars in thoracic and cardiovascular surgery, Volume 11, Issue 4 Suppl 1, 1 1 1999, Pages 133-138 Dehiscence of the Freestyle stentless bioprosthesis. Schoof PH, Baur LH, Kappetein AP, Hazekamp MG, van Rijk-Zwikker GL, Huysmans HA
This study aimed to identify and characterize patients who developed prosthetic dehiscence after aortic valve replacement with the Freestyle Stentless bioprosthesis. Review of patients' records and preoperative echocardiogram was performed. Prosthetic dehiscence developed in 10 patients after 2.5 to 49 months (mean 19). Most patients were symptomatic at presentation. Nine patients were reoperated. Dehiscence was typically located at the inflow suture line beneath the noncoronary cusp. Four... Abstract
Cited 73 times since 1999 (3 per year) source: EuropePMC
Cell death and differentiation, Volume 6, Issue 10, 1 1 1999, Pages 976-986 The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Pruijn GJ
In the past few years, a role for apoptotic processes in the development of autoimmune diseases has been suggested. An increasing number of cellular proteins, which are modified during apoptosis, has been described, and many of these proteins have been identified as autoantigens. We have studied the effects of apoptosis on the La protein in more detail and for the first time demonstrate that this autoantigen is rapidly dephosphorylated after the induction of apoptosis. Dephosphorylation of the L... Abstract
Cited 39 times since 1999 (1.6 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 4, 1 1 1999, Pages 1110-1118 Compliance, hysteresis, and collapsibility of human small airways. Tiddens HA, Hofhuis W, Bogaard JM, Hop WC, de Bruin H, Willems LN, de Jongste JC
We tested the hypothesis that airway wall dimensions are important determinants for the mechanical properties of airways. Lung tissue was obtained from 31 smokers with different degrees of chronic obstructive pulmonary disease (COPD) who were operated on for a solitary lung lesion. Segments of small airways (n = 35) were mounted on cannulas in an organ bath and inflated and deflated cyclically between +15 and -15 cm H(2)O. For each airway this was done at baseline, after methacholine, and after... Abstract
Cited 12 times since 1999 (0.5 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 10, Issue 3, 1 1 1999, Pages 434-441 Evaluation of coronary artery bypass grafts by magnetic resonance imaging. Langerak SE, Kunz P, de Roos A, Vliegen HW, van Der Wall EE
Magnetic resonance (MR) angiography and flow mapping have the potential to become a major noninvasive diagnostic tool for the assessment of coronary artery bypass graft morphology and function. Several MR sequences, such as conventional non-respiratory compensated methods, and phase contrast cine flow sequences have been reported for the evaluation of bypass graft patency. However the visualization of different graft segments and the detection of graft stenosis remains difficult. Recent advances... Abstract
Cited 5 times since 1999 (0.2 per year) source: EuropePMC
Indian journal of pediatrics, Volume 66, Issue 5, 1 1 1999, Pages 651-655 Antioxidant defense systems in newborns undergoing phototherapy. Akisü M, Yilmaz D, Tüzün S, Kültürsay N
This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell anti-oxidation enzymes (superoxide dismutase, catalase and glutathione peroxidase) before and after 72 h of phototherapy. Serum vitamin E levels were not different before and after 72 h of phototherapy i... Abstract
Cited 36 times since 1999 (1.5 per year) source: EuropePMC
Chest, Volume 116, Issue 3, 1 1 1999, Pages 676-681 Atmospheric pressure changes and outdoor temperature changes in relation to spontaneous pneumothorax. Smit HJ, Devillé WL, Schramel FM, Schreurs JM, Sutedja TG, Postmus PE
Study aims: To examine the influence of atmospheric pressure (AP) and temperature changes on the incidence of idiopathic spontaneous pneumothorax (SP). Methods: From December 1991 through November 1993, 115 consecutive SP cases were selected. Patients were included after being in Amsterdam at least 1 full day before contracting the SP. Differences in air temperature and AP (provided hourly by the national weather bureau) for the days of the SP occurrence and the days previous to it were recorded... Abstract
Cited 6 times since 1999 (0.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 12, Issue 9, 1 1 1999, Pages 729-735 Echocardiographic parameters of the freestyle stentless bioprosthesis in aortic position: the European experience. Baur LH, Jin XY, Houdas Y, Peels CH, Braun J, Kappetein AP, Prat A, Hazekamp MG, Van Straten BH, Ploeg A, Sieders A, Voogd PJ, Bruschke AV, van der Wall EE, Westaby S, Huysmans HA
The objective of this study was to determine normal Doppler and 2-dimensional characteristics of the Freestyle stentless aortic bioprosthesis. The Freestyle aortic bioprosthesis is a new type of aortic xenograft, and experience is limited. We therefore determined the normal range of echocardiographic and Doppler examinations of this valve. Three hundred thirty-nine consecutive patients with a Freestyle aortic bioprosthesis underwent an echocardiographic and Doppler examination according to a com... Abstract
Cited 11 times since 1999 (0.4 per year) source: EuropePMC
Anti-cancer drugs, Volume 10, Issue 8, 1 1 1999, Pages 693-698 Results of an independent oncology review board of pivotal clinical trials of gemcitabine in non-small cell lung cancer. Gwyther SJ, Aapro MS, Hatty SR, Postmus PE, Smith IE
Response rates reported in early phase II clinical trials are often not reproduced in subsequent larger or phase III studies. Independent review of claimed partial or complete responders to gemcitabine was undertaken in four pivotal, open-label phase II studies of advanced, non-small cell lung cancer (NSCLC) to provide accurate, consistent, reproducible response rates. Patients were chemonaive and had stage III or IV NSCLC. In three trials, gemcitabine (800 and 1250 mg/m2) was administered once-... Abstract
Cited 4 times since 1999 (0.2 per year) source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 48, Issue 1, 1 1 1999, Pages 105-112 Stenting of long coronary artery lesions: initial angiographic results and 6-month clinical outcome of the micro stent II-XL. Schalij MJ, Udayachalerm W, Oemrawsingh P, Jukema JW, Reiber JH, Bruschke AV
To evaluate the results of long Micro Stent II (MS-XL) implantations, 119 MS-XLs were implanted in 102 patients (age, 62.83 years). Nineteen stents (16%) were implanted in saphenous vein grafts; 100 stents (84%) were implanted in native coronary arteries. Twenty-five patients (25%) were treated because of acute myocardial infarction (AMI); 30 patients (29%) because of unstable angina or angina class IV, and 47 patients (46%) because of stable angina. Eighty-six de novo lesions (84%) and 16 reste... Abstract
Cited 66 times since 1999 (2.7 per year) source: EuropePMC
Journal of leukocyte biology, Volume 66, Issue 3, 1 1 1999, Pages 423-428 Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. Hiemstra PS, van den Barselaar MT, Roest M, Nibbering PH, van Furth R
Previously we have identified and characterized three murine microbicidal proteins purified from the granule fraction of cells from the murine macrophage cell line RAW264.7. During these studies evidence was obtained for the presence of an additional antimicrobial protein in the cytosolic fraction of RAW264.7 cells that had been activated with interferon-gamma (IFN-gamma). In this study we have purified this protein, designated ubiquicidin, to apparent homogeneity and demonstrated that it is a c... Abstract
Cited 32 times since 1999 (1.3 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 118, Issue 2, 1 1 1999, Pages 252-258 Brom's three-patch technique for repair of supravalvular aortic stenosis. Hazekamp MG, Kappetein AP, Schoof PH, Ottenkamp J, Witsenburg M, Huysmans HA, Bogers AJ
Objective: Case histories of all patients (n = 29) operated on for supravalvular aortic stenosis from 1962 to the present were reviewed to study different techniques and outcomes. The technique of symmetric aortoplasty with 3 patches (1 in each sinus) is described and compared with other methods. Methods: Case reports were reviewed and follow-up was completed by contacting the patient's (pediatric) cardiologist. We aimed for a last follow-up visit, including Doppler echocardiographic studie... Abstract
Cited 4 times since 1999 (0.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 82, Issue 2, 1 1 1999, Pages 126-127 Matching treatment to the genetic basis of (lipid) disorder in patients with coronary artery disease. Jukema JW
Cited 116 times since 1999 (4.7 per year) source: EuropePMC
Journal of virology, Volume 73, Issue 8, 1 1 1999, Pages 6335-6345 Identification of a novel structural protein of arteriviruses. Snijder EJ, van Tol H, Pedersen KW, Raamsman MJ, de Vries AA
Arteriviruses are positive-stranded RNA viruses with an efficiently organized, polycistronic genome. A short region between the replicase gene and open reading frame (ORF) 2 of the equine arteritis virus (EAV) genome was previously assumed to be untranslated. However, here we report that this segment of the EAV genome contains the 5' part of a novel gene (ORF 2a) which is conserved in all arteriviruses. The 3' part of EAV ORF 2a overlaps with the 5' part of the former ORF 2 (now r... Abstract
Cited 5 times since 1999 (0.2 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 18, Issue 2, 1 1 1999, Pages 174-175 Spontaneous perforation of an aortic endoprosthesis. Breek JC, Hamming JF, Lohle PN, Lampmann LE, van Berge Henegouwen DP
Cited 33 times since 1999 (1.3 per year) source: EuropePMC
Cancer treatment reviews, Volume 25, Issue 4, 1 1 1999, Pages 199-206 Second-line chemotherapy and its evaluation in small cell lung cancer. Huisman C, Postmus PE, Giaccone G, Smit EF
The literature on second-line chemotherapy for small cell lung cancer between 1989-1999 is reviewed. The reports consisted mainly of phase II studies and included a total of 1749 patients. The information was frequently incomplete with respect to duration of response on first-line chemotherapy and the length of treatment free interval. The overall second-line response rate was 20%. Obviously, new chemotherapy regimens are needed for relapsed small cell lung cancer. We propose a methodology for f... Abstract
Cited 60 times since 1999 (2.4 per year) source: EuropePMC
The Journal of biological chemistry, Volume 274, Issue 35, 1 1 1999, Pages 24799-24807 Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Rutjes SA, van der Heijden A, Utz PJ, van Venrooij WJ, Pruijn GJ
We have investigated the fate of the RNA components of small ribonucleoprotein particles in apoptotic cells. We show that the cytoplasmic Ro ribonucleoprotein-associated Y RNAs are specifically and rapidly degraded during apoptosis via a caspase-dependent mechanism. This is the first study describing the selective degradation of a specific class of small structural RNA molecules in apoptotic cells. Cleavage and subsequent truncation of Y RNAs was observed upon exposure of cells to a variety of a... Abstract
Cited 61 times since 1999 (2.5 per year) source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 5, Issue 8, 1 1 1999, Pages 2048-2058 Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer. Dingemans AM, Witlox MA, Stallaert RA, van der Valk P, Postmus PE, Giaccone G
Drug resistance is a major problem in patients with small cell lung cancer; in fact, most die of resistant disease, despite an initial response. Several markers of drug resistance have been described in preclinical models, but the mechanism of drug resistance in lung cancer patients remains unknown. The objective of this study was to evaluate the role of the expression of a number of markers of drug resistance, proliferation, and apoptosis in relation to response to chemotherapy and survival in... Abstract
Cited 61 times since 1999 (2.5 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 1, 1 1 1999, Pages 93-99 Lung function and sputum characteristics of patients with severe asthma during an induced exacerbation by double-blind steroid withdrawal. in't Veen JC, Smits HH, Hiemstra PS, Zwinderman AE, Sterk PJ, Bel EH
Some patients with severe asthma are difficult to control and suffer from frequent exacerbations, whereas others remain stable with anti-inflammatory therapy. To investigate mechanisms of exacerbations, we compared 13 patients 20 to 51 yr of age (11 female, two male) with difficult-to-control asthma (two or more exacerbations during the previous year) and 15 patients 20 to 47 yr of age (13 female, two male) with severe but stable asthma (no exacerbations) after matching for sex, age, atopy, lung... Abstract