Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7487 results
Cited 43 times since 2000 (1.8 per year) source: EuropePMC
The oncologist, Volume 5 Suppl 1, 1 1 2000, Pages 45-50 Targeting vascular endothelial growth factor blockade: ascites and pleural effusion formation. Verheul HM, Hoekman K, Jorna AS, Smit EF, Pinedo HM
Primary purpose: Formation of ascites and pleural effusion (PE) is a common problem for patients with advanced-stage cancer. These fluid accumulations cause severe symptoms such as abdominal distention, shortness of breath, cachexia, anorexia, and fatigue. Preclinical models have demonstrated that vascular endothelial growth factor (VEGF) plays a pivotal role in the accumulation of malignant PE or ascites. This study investigated whether blockade of VEGF activity would reduce biological activity... Abstract
Cited 33 times since 1999 (1.4 per year) source: EuropePMC
Free radical biology & medicine, Volume 27, Issue 11-12, 1 1 1999, Pages 1448-1454 Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma. Hiltermann JT, Lapperre TS, van Bree L, Steerenberg PA, Brahim JJ, Sont JK, Sterk PJ, Hiemstra PS, Stolk J
We investigated correlations between ozone-induced increases in inflammatory markers in induced sputum and in bronchial lavage fluid. Sixteen volunteers with intermittent asthma participated in a placebo-controlled parallel study with two exposures. Six days before and 16 h after the first exposure to ozone (0.4 ppm during 2 h) sputum was induced with hypertonic saline. This resulted in a significant increase in the sputum levels of eosinophil cationic protein (ECP; 1.8-fold; p = .03), neutrophi... Abstract
Cited 7 times since 1999 (0.3 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 82, Issue 6, 1 1 1999, Pages 697-703 Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair. Niezen RA, Helbing WA, van Der Wall EE, van Der Geest RJ, Vliegen HW, de Roos A
Objective: To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation. Setting: The radiology department of a tertiary referral centre. Patients: 14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging. Main outcome measures: Biventricular volumes, global biventricular function, and regional left ventricular function were... Abstract
Cited 31 times since 1999 (1.3 per year) source: EuropePMC
Chest, Volume 116, Issue 6, 1 1 1999, Pages 1695-1702 Electrical impedance tomography in the assessment of extravascular lung water in noncardiogenic acute respiratory failure. Kunst PW, Vonk Noordegraaf A, Raaijmakers E, Bakker J, Groeneveld AB, Postmus PE, de Vries PM
Study objectives: To establish the value of electrical impedance tomography (EIT) in assessing pulmonary edema in noncardiogenic acute respiratory failure (ARF), as compared to the thermal dye double indicator dilution technique (TDD). Design: Prospective clinical study. Setting: ICU of a general hospital. Patients: Fourteen ARF patients. Interventions: In order to use the TDD to determine the amount of extravascular lung water (EVLW), a fiberoptic catheter was placed in the femoral artery. Meas... Abstract
Cited 31 times since 1999 (1.3 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 40, Issue 12, 1 1 1999, Pages 2073-2080 Imaging of bacterial infections with 99mTc-labeled human neutrophil peptide-1. Welling MM, Nibbering PH, Paulusma-Annema A, Hiemstra PS, Pauwels EK, Calame W
Unlabelled: This study was undertaken to evaluate whether 99mTc-labeled human neutrophil peptide (HNP)-1 can be used as a tracer for rapid visualization of bacterial infections. Methods: Mice were injected intramuscularly with 1 million Staphylococcus aureus or Klebsiella pneumoniae organisms and 5 min later were injected intravenously with 0.4 microg (0.8 MBq) 99mTc-HNP-1. At various intervals, detailed information about clearance and accumulation of this tracer at sites of infection and in var... Abstract
Cited 101 times since 1999 (4.1 per year) source: EuropePMC
The Journal of allergy and clinical immunology, Volume 104, Issue 6, 1 1 1999, Pages 1131-1138 Defensins: key players or bystanders in infection, injury, and repair in the lung? van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS
Antimicrobial peptides have been identified as key elements in the innate host defense against infection. Recent studies have indicated that the activity of antimicrobial peptides may be decreased in cystic fibrosis, suggesting a major role for these peptides in host defense against infection. One of the most intensively studied classes of antimicrobial peptides are defensins. Defensins comprise a family of cationic peptides that in human subjects can be divided into the alpha- and beta-defensin... Abstract
Nederlands tijdschrift voor tandheelkunde, Volume 106, Issue 11, 1 1 1999, Pages 408-414 [Smoking and lung cancer]. Postmus PE
Since fifty years it is clear now that smoking of tobacco products is responsible for the lung cancer epidemic that is currently in progress worldwide. Although in the Western world a small decrease of lung cancer in males is found, the number of female patients is steadily increasing. Changes in tobacco production have resulted in exposition of smokers to other carcinogens. This is probably the cause of the change in the histological pattern with an increase of adenocarcinoma and stabilisation... Abstract
Cited 13 times since 1999 (0.5 per year) source: EuropePMC
Annals of human genetics, Volume 63, Issue Pt 6, 1 1 1999, Pages 499-510 Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E, Kastelein JJ
Simultaneously analysing genotype effects at several closely-linked loci may be preferable to analysing them separately, but can be difficult, due to multiple genotype classes, small class sizes, and non-independence induced by associations among loci. Analysis of haplotype effects offers an alternative approach. We studied effects of haplotypes comprising 3 loci (5' to 3': PvuII, HindIII, and Ser 447 -Stop) in the lipoprotein lipase (LPL) gene on plasma lipid levels and LPL activity,... Abstract
Cited 192 times since 1999 (7.8 per year) source: EuropePMC
The American journal of cardiology, Volume 84, Issue 10, 1 1 1999, Pages 1192-1197 The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Jukema JW, Hyland M, Gaw A, Lagaay AM, Perry IJ, Macfarlane PW, Meinders AE, Sweeney BJ, Packard CJ, Westendorp RG, Twomey C, Stott DJ
The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized, double-blind, placebo-controlled trial designed to test the hypothesis that treatment with pravastatin will diminish risk of subsequent major vascular events in a cohort of men and women (70 to 82 years old) with preexisting vascular disease or significant risk of developing this condition. Five thousand eight hundred four men and women in addition to receiving advice on diet and smoking, have been randomized... Abstract
Cited 13 times since 1999 (0.5 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 6, Issue 6, 1 1 1999, Pages 577-582 Automated ejection fraction determination from gated myocardial FDG-PET data. Willemsen AT, Siebelink HJ, Blanksma PK, Paans AM
Background: The aim of this study was to determine the potential of the automated calculation of the left ventricular ejection fraction from gated myocardial positron emission tomography (PET) scans. Methods: We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose (FDG)-PET and equilibrium radionuclide angiography (ERNA). Gated PET data were analyzed by 2 independent programs (ie, quantitative gated single photon emission computed tomography [QGS]) o... Abstract
Cited 265 times since 1999 (10.8 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 5 Pt 1, 1 1 1999, Pages 1468-1472 A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy. Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DC, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JH, Hansen NC, Heckscher T, Viskum K, Stolk J
We have investigated whether restoration of the balance between neutrophil elastase and its inhibitor, alpha(1)-antitrypsin, can prevent the progression of pulmonary emphysema in patients with alpha(1)-antitrypsin deficiency. Twenty-six Danish and 30 Dutch ex-smokers with alpha(1)-antitrypsin deficiency of PI*ZZ phenotype and moderate emphysema (FEV(1) between 30% and 80% of predicted) participated in a double-blind trial of alpha(1)-antitrypsin augmentation therapy. The patients were randomized... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 143, Issue 40, 1 1 1999, Pages 1992-1996 [Role of chemo(radio)theray prior to surgery for stage IIIa non-small cell lung carcinoma (localized non-resectable tumor)]. Smit EF, van Mourik JC, Slotman BJ, Postmus PE
Neoadjuvant chemotherapy with or without combined radiotherapy followed by surgery may yield a survival profit for selected patients with non-small cell lung carcinoma in stage IIIA. It has not yet been established which is the most efficacious neoadjuvant chemotherapy nor what is the best postneoadjuvant chemotherapy, especially resection or radiotherapy. Comparative clinical studies to find the answer to these two questions are in progress. New forms of treatment are required in order to achie... Abstract
Cited 4 times since 1999 (0.2 per year) source: EuropePMC
Seminars in thoracic and cardiovascular surgery, Volume 11, Issue 4 Suppl 1, 1 1 1999, Pages 133-138 Dehiscence of the Freestyle stentless bioprosthesis. Schoof PH, Baur LH, Kappetein AP, Hazekamp MG, van Rijk-Zwikker GL, Huysmans HA
This study aimed to identify and characterize patients who developed prosthetic dehiscence after aortic valve replacement with the Freestyle Stentless bioprosthesis. Review of patients' records and preoperative echocardiogram was performed. Prosthetic dehiscence developed in 10 patients after 2.5 to 49 months (mean 19). Most patients were symptomatic at presentation. Nine patients were reoperated. Dehiscence was typically located at the inflow suture line beneath the noncoronary cusp. Four... Abstract
Cited 73 times since 1999 (3 per year) source: EuropePMC
Cell death and differentiation, Volume 6, Issue 10, 1 1 1999, Pages 976-986 The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Pruijn GJ
In the past few years, a role for apoptotic processes in the development of autoimmune diseases has been suggested. An increasing number of cellular proteins, which are modified during apoptosis, has been described, and many of these proteins have been identified as autoantigens. We have studied the effects of apoptosis on the La protein in more detail and for the first time demonstrate that this autoantigen is rapidly dephosphorylated after the induction of apoptosis. Dephosphorylation of the L... Abstract
Cited 39 times since 1999 (1.6 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 4, 1 1 1999, Pages 1110-1118 Compliance, hysteresis, and collapsibility of human small airways. Tiddens HA, Hofhuis W, Bogaard JM, Hop WC, de Bruin H, Willems LN, de Jongste JC
We tested the hypothesis that airway wall dimensions are important determinants for the mechanical properties of airways. Lung tissue was obtained from 31 smokers with different degrees of chronic obstructive pulmonary disease (COPD) who were operated on for a solitary lung lesion. Segments of small airways (n = 35) were mounted on cannulas in an organ bath and inflated and deflated cyclically between +15 and -15 cm H(2)O. For each airway this was done at baseline, after methacholine, and after... Abstract
Cited 12 times since 1999 (0.5 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 10, Issue 3, 1 1 1999, Pages 434-441 Evaluation of coronary artery bypass grafts by magnetic resonance imaging. Langerak SE, Kunz P, de Roos A, Vliegen HW, van Der Wall EE
Magnetic resonance (MR) angiography and flow mapping have the potential to become a major noninvasive diagnostic tool for the assessment of coronary artery bypass graft morphology and function. Several MR sequences, such as conventional non-respiratory compensated methods, and phase contrast cine flow sequences have been reported for the evaluation of bypass graft patency. However the visualization of different graft segments and the detection of graft stenosis remains difficult. Recent advances... Abstract
Cited 5 times since 1999 (0.2 per year) source: EuropePMC
Indian journal of pediatrics, Volume 66, Issue 5, 1 1 1999, Pages 651-655 Antioxidant defense systems in newborns undergoing phototherapy. Akisü M, Yilmaz D, Tüzün S, Kültürsay N
This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell anti-oxidation enzymes (superoxide dismutase, catalase and glutathione peroxidase) before and after 72 h of phototherapy. Serum vitamin E levels were not different before and after 72 h of phototherapy i... Abstract
Cited 36 times since 1999 (1.5 per year) source: EuropePMC
Chest, Volume 116, Issue 3, 1 1 1999, Pages 676-681 Atmospheric pressure changes and outdoor temperature changes in relation to spontaneous pneumothorax. Smit HJ, Devillé WL, Schramel FM, Schreurs JM, Sutedja TG, Postmus PE
Study aims: To examine the influence of atmospheric pressure (AP) and temperature changes on the incidence of idiopathic spontaneous pneumothorax (SP). Methods: From December 1991 through November 1993, 115 consecutive SP cases were selected. Patients were included after being in Amsterdam at least 1 full day before contracting the SP. Differences in air temperature and AP (provided hourly by the national weather bureau) for the days of the SP occurrence and the days previous to it were recorded... Abstract
Cited 6 times since 1999 (0.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 12, Issue 9, 1 1 1999, Pages 729-735 Echocardiographic parameters of the freestyle stentless bioprosthesis in aortic position: the European experience. Baur LH, Jin XY, Houdas Y, Peels CH, Braun J, Kappetein AP, Prat A, Hazekamp MG, Van Straten BH, Ploeg A, Sieders A, Voogd PJ, Bruschke AV, van der Wall EE, Westaby S, Huysmans HA
The objective of this study was to determine normal Doppler and 2-dimensional characteristics of the Freestyle stentless aortic bioprosthesis. The Freestyle aortic bioprosthesis is a new type of aortic xenograft, and experience is limited. We therefore determined the normal range of echocardiographic and Doppler examinations of this valve. Three hundred thirty-nine consecutive patients with a Freestyle aortic bioprosthesis underwent an echocardiographic and Doppler examination according to a com... Abstract
Cited 11 times since 1999 (0.4 per year) source: EuropePMC
Anti-cancer drugs, Volume 10, Issue 8, 1 1 1999, Pages 693-698 Results of an independent oncology review board of pivotal clinical trials of gemcitabine in non-small cell lung cancer. Gwyther SJ, Aapro MS, Hatty SR, Postmus PE, Smith IE
Response rates reported in early phase II clinical trials are often not reproduced in subsequent larger or phase III studies. Independent review of claimed partial or complete responders to gemcitabine was undertaken in four pivotal, open-label phase II studies of advanced, non-small cell lung cancer (NSCLC) to provide accurate, consistent, reproducible response rates. Patients were chemonaive and had stage III or IV NSCLC. In three trials, gemcitabine (800 and 1250 mg/m2) was administered once-... Abstract