Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7496 results
Cited 6 times since 1999 (0.2 per year) source: EuropePMC
Early human development, Volume 55, Issue 3, 1 1 1999, Pages 237-245 Electrocortical brain activity during hypoxia and hypotension in anesthetized newborn lambs. van de Bor M, Meinesz J, Benders MJ, Steendijk P, Lopes Cardozo RH, van Bel F
Blood gas and blood pressure disturbances do influence cerebral blood flow in newborns. To what extent cerebral blood flow changes affect electrocortical brain activity remains uncertain. We studied the effect of severe hypoxia and hemorrhagic hypotension on carotid artery blood flow and electrocortical brain activity in newborn anesthetized lambs. During hypoxia carotid artery blood flow increased significantly, whereas electrocortical brain activity remained unchanged. The hemorrhagic hypotens... Abstract
Cited 12 times since 1999 (0.5 per year) source: EuropePMC
Cardiovascular research, Volume 43, Issue 1, 1 1 1999, Pages 86-95 Right ventricular systolic function and ventricular interaction during acute embolisation of the left anterior descending coronary artery in sheep. Jerzewski A, Steendijk P, Pattynama PM, Leeuwenburgh BP, de Roos A, Baan J
Objective: Regional LV ischemia involving the septum affects LV systolic function and geometry. We investigated the effects of these changes on RV function and geometry. Methods: In six closed-chest sheep end-systolic pressure-volume relationships (ESPVRs) were constructed from ventricular volumes, measured with magnetic resonance imaging (MRI) and matching intraventricular pressures, before and after selective embolisation of the left anterior descending coronary artery (LAD). The extent of myo... Abstract
Cited 56 times since 1999 (2.3 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 10, Issue 7, 1 1 1999, Pages 753-759 Chemotherapy for brain metastases of lung cancer: a review. Postmus PE, Smit EF
In lung cancer patients brain metastases develop with a high frequency. For years radiotherapy has been the standard treatment for these patients. Here we review the experience with chemotherapy for brain metastases in lung cancer patients. The concept of the brain as pharmacological sanctuary site when brain metastases are present is challenged and it is argued that chemotherapy does play a role in this situation. Recent clinical trials indicate that the combination of chemotherapy and radiothe... Abstract
Cited 9 times since 1999 (0.4 per year) source: EuropePMC
Clinical nuclear medicine, Volume 24, Issue 7, 1 1 1999, Pages 529-530 Thoracic actinomycosis imaging with fluorine-18 fluorodeoxyglucose positron emission tomography. Hoekstra CJ, Hoekstra OS, Teengs JP, Postmus PE, Smit EF
Cited 91 times since 1999 (3.7 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 17, Issue 7, 1 1 1999, Pages 2190-2197 Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer. Kroep JR, Giaccone G, Voorn DA, Smit EF, Beijnen JH, Rosing H, van Moorsel CJ, van Groeningen CJ, Postmus PE, Pinedo HM, Peters GJ
Purpose: To assess possible pharmacokinetic and pharmacodynamic interactions between gemcitabine and paclitaxel in a phase I/II study in non-small-cell lung cancer (NSCLC) patients. Patients and methods: Eighteen patients with advanced NSCLC received the following in a 3-week schedule: gemcitabine 1,000 mg/m(2) (30 minutes, days 1 and 8) and paclitaxel 150 (n = 9) or 200 mg/m(2) (n = 9) before gemcitabine (3 hours, day 1). Plasma pharmacokinetics and pharmacodynamics in mononuclear cells were st... Abstract
Cited 10 times since 1999 (0.4 per year) source: EuropePMC
European journal of clinical investigation, Volume 29, Issue 6, 1 1 1999, Pages 553-560 Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases. De Vries MR, Borel Rinkes IH, Swaak AJ, Hack CE, Van De Velde CJ, Wiggers T, Tollenaar RA, Kuppen PJ, Eggermont AM
Background: In this study, we have evaluated hepatotoxicity, secondary cytokine production and hepatic acute-phase response (APR) in patients who underwent isolated hepatic perfusion (IHP) with tumour necrosis factor (TNF) alpha and melphalan for irresectable colorectal liver metastases. Design: An extracorporeal veno-venous bypass was used to shunt blood from the lower body and intestines to the heart. Inflow catheters were placed in the hepatic artery and portal vein, and an outflow catheter i... Abstract
Cited 17 times since 1999 (0.7 per year) source: EuropePMC
Journal of chromatography. A, Volume 844, Issue 1-2, 1 1 1999, Pages 295-305 Trace-level determination of polar flavour compounds in butter by solid-phase extraction and gas chromatography-mass spectrometry. Adahchour M, Vreuls RJ, van der Heijden A, Brinkman UA
Volatile compounds are responsible for the aromas of butter. A simple technique for the determination of these components is described which is based on solid-phase extraction (SPE) after melting of the butter and separation of the aqueous phase from the fat. Volatile flavours present in the water fraction are collected by off-line SPE on cartidges packed with a copolymer sorbent. After desorption with 500 microliters of methyl acetate, 1-microliter aliquots are quantified and/or identified by g... Abstract
Cited 12 times since 1999 (0.5 per year) source: EuropePMC
Acta cardiologica, Volume 54, Issue 3, 1 1 1999, Pages 163-168 Treatment and prevention of coronary heart disease by lowering serum cholesterol levels; from the pioneer work of C.D. de Langen to the third "Dutch Consensus on Cholesterol". Jukema JW, Simoons ML
In the beginning of this century a possible relation was observed between cholesterol-rich foods, blood cholesterol levels and atherosclerosis by "pioneers" in this field as Anitschkow and De Langen. In the second half of this century a definite link was established between serum cholesterol levels and development of coronary heart disease (CHD). In angiographic studies it has recently been shown that a decrease in total cholesterol as well as in low-density lipoprotein cholesterol lev... Abstract
International journal of cardiac imaging, Volume 15, Issue 3, 1 1 1999, Pages 209-214 Dynamic obstruction, an unusual complication after aortic valve replacement with a stentless porcine valve. van Roosmalen RP, Baur LH, Braun J, Atsma DE, Hazekamp MG, van der Wall EE, Huysmans HA
In the early nineties, the stentless porcine aortic bioprosthesis has been reintroduced successfully. Because of the limited experience, knowledge of clinical complications is limited. Therefore, we describe an unusual complication of dynamic obstruction after aortic valve replacement with a stentless porcine valve in a 70 year old man 18 months after implantation. We discuss the complications of stentless aortic prostheses known so far, describe operative techniques used and their characteristi... Abstract
Cited 17 times since 1999 (0.7 per year) source: EuropePMC
International journal of cardiac imaging, Volume 15, Issue 3, 1 1 1999, Pages 253-8; discussion 259 Diagnosis and management of anomalous origin of the right coronary artery from the left coronary sinus. Bekedam MA, Vliegen HW, Doornbos J, Jukema JW, de Roos A, van der Wall EE
The anomalous origin of the right coronary artery (RCA) from the left sinus of Valsalva coursing between the aorta and the pulmonary artery or right ventricular outflow tract, is considered a potentially fatal abnormality which may require surgery. However, diagnosing the correct course with coronary arteriography may be difficult. Fast gradient echo magnetic resonance (MR) imaging can be helpful to identify and confirm the course of aberrant coronary arteries and their relationship to the surro... Abstract
Cited 9 times since 1999 (0.4 per year) source: EuropePMC
Anticancer research, Volume 19, Issue 3B, 1 1 1999, Pages 2349-2353 99mTc-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours. Bakker M, van der Graaf WT, Piers DA, Franssen EJ, Groen HJ, Smit EF, Kool W, Hollema H, Müller EA, De Vries EG
Background: Our aim was to determine the value of 99mTc-Sestamibi scanning as functional detection method of P-glycoprotein (Pgp) blockade by PSC 833 in solid tumour patients. Patients and methods: Day 1 and day 4 after 2,200 mg orally administered PSC 833 the tumour area was scanned after intravenous (i.v.) administration of 400 MBq 99mTc-Sestamibi. In tumours with net 99mTc-Sestamibi uptake and in the hepatic region K-efflux was determined. Whole blood was analyzed for 99mTc-Sestamibi, and PSC... Abstract
Cited 44 times since 1999 (1.8 per year) source: EuropePMC
Journal of hepatology, Volume 30, Issue 5, 1 1 1999, Pages 876-881 Hepatic arterial pulsatility index in cirrhosis: correlation with portal pressure. Schneider AW, Kalk JF, Klein CP
Background/aims: Determination of the pulsatility index by means of duplex sonography provides the opportunity to evaluate the vascular resistance of the hepatic artery noninvasively. The aim of this study was to investigate the relationship between the hepatic arterial pulsatility index and the hepatic venous pressure gradient in cirrhosis. Methods: In 50 patients with cirrhosis, hepatic venous pressure gradient was determined in the fasting state. Immediately thereafter, hepatic arterial pulsa... Abstract
Cited 43 times since 1999 (1.7 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 35, Issue 5, 1 1 1999, Pages 808-814 Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice. van Moorsel CJ, Pinedo HM, Veerman G, Vermorken JB, Postmus PE, Peters GJ
We used the gemcitabine (dFdC) and cisplatin (cis-diamine dichloroplatinum CDDP) resistant murine NSCLC tumour Lewis Lung (LL) in C57/B16 mice to optimise scheduling of both drugs, since in previous in vivo studies no effective combination schedule of both compounds was found to overcome resistance to either drug. dFdC could not be combined at the previously determined maximum tolerated dose (MTD) (120 mg/kg, q3dx4) with CDDP at its MTD (9 mg/kg, q6dx2) (mean weight loss < 15% and < 15% to... Abstract
Cited 16 times since 1999 (0.6 per year) source: EuropePMC
The Netherlands journal of medicine, Volume 54, Issue 5, 1 1 1999, Pages 207-212 Sleep complaints and sleep disordered breathing in hemodialysis patients. Venmans BJ, van Kralingen KW, Chandi DD, de Vries PM, ter Wee PM, Postmus PE
Background: The objective of the study was to determine the prevalence of sleep complaints and of sleep disordered breathing (SDB) in hemodialysis patients not selected for sleep complaints and to determine the effect of hemodialysis on SDB. The feasibility of home recording of sleep related respiration in these patients was also studied. Methods: The patients completed a questionnaire and parameters of SDB were examined in the home setting on nights following dialysis and nights following no di... Abstract
Cited 11 times since 1999 (0.4 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 24, Issue 2, 1 1 1999, Pages 115-121 A dose and schedule finding study of gemcitabine and etoposide in patients with progressive non-small cell lung cancer after platinum containing chemotherapy. Biesma B, Smit EF, Postmus PE
Background: Combination chemotherapy improves survival in patients with disseminated non-small cell lung cancer (NSCLC). Gemcitabine is active against NSCLC and etoposide has an additive effect in vitro. We describe a dose finding study for the combination of these drugs. Patients and methods: NSCLC patients progressive after chemotherapy received gemcitabine (1000 mg/m2 days 1, 8, 15) and one of five etoposide schedules in doses ranging from 60 to 100 mg/m2 per day administered on days 1-3 (sch... Abstract
Cited 61 times since 1999 (2.4 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 10, Issue 4, 1 1 1999, Pages 441-448 Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors. van Moorsel CJ, Kroep JR, Pinedo HM, Veerman G, Voorn DA, Postmus PE, Vermorken JB, van Groeningen CJ, van der Vijgh WJ, Peters GJ
Purpose: To determine possible schedule dependent pharmacokinetic and pharmacodynamic interactions between gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and cisplatin (cis-diammine-dichloroplatinum, CDDP) in patients with advanced stage solid tumors in a phase I trial. Patients and methods: A total of 33 patients with advanced stage solid tumors were treated with gemcitabine (30-min infusion, 800 mg/m2) and cisplatin (one-hour infusion, 50 mg/m2). Sixteen patients had a four-hour int... Abstract
Cited 25 times since 1999 (1 per year) source: EuropePMC
Chest, Volume 115, Issue 4, 1 1 1999, Pages 1102-1106 Evaluation of electrical impedance tomography in the measurement of PEEP-induced changes in lung volume. Kunst PW, de Vries PM, Postmus PE, Bakker J
Study objectives: A new noninvasive practical technique called electrical impedance tomography (EIT) was examined for the measurement of alveolar recruitment. Design: Prospective clinical study. Setting: ICU of a general hospital. Patients: Acute respiratory failure (ARF) patients. Measurements: The ventilation-induced impedance changes (VICs) of the nondependent and the dependent part of the lung were determined by EIT as a measure of tidal volume distribution. By the use of an impedance ratio... Abstract
Cited 52 times since 1999 (2.1 per year) source: EuropePMC
Cancer research, Volume 59, Issue 7, 1 1 1999, Pages 1505-1513 Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy. Vrouenraets MB, Visser GW, Stewart FA, Stigter M, Oppelaar H, Postmus PE, Snow GB, van Dongen GA
A limitation of photodynamic therapy is the lack of tumor selectivity of the photosensitizer. To overcome this problem, a protocol was developed for coupling of meta-tetrahydroxyphenylchlorin (mTHPC), one of the most promising photosensitizers, to tumor-selective monoclonal antibodies (MAbs). mTHPC was radiolabeled with 131I to facilitate the assessment of the in vitro and in vivo behavior. After the modification to 131I-mTHPC-(CH2COOH)4, thus increasing the water solubility and creating a funct... Abstract
Cited 59 times since 1999 (2.3 per year) source: EuropePMC
Journal of lipid research, Volume 40, Issue 4, 1 1 1999, Pages 735-743 Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. Henderson HE, Kastelein JJ, Zwinderman AH, Gagné E, Jukema JW, Reymer PW, Groenemeyer BE, Lie KI, Bruschke AV, Hayden MR, Jansen H
Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in nu... Abstract
Cited 40 times since 1999 (1.6 per year) source: EuropePMC
Investigative radiology, Volume 34, Issue 4, 1 1 1999, Pages 303-309 Sources of error in lung densitometry with CT. Stoel BC, Vrooman HA, Stolk J, Reiber JH
Rationale and objectives: To determine and analyze the most important error sources in lung CT densitometry in vivo. Methods: The authors examined the influences of CT acquisition errors, physiologic changes, and image segmentation errors on lung densitometry. Among others, spatial dependency and long-term reproducibility of the density measurements of blood and air were examined over a period of 4 years in a group of 28 patients with pulmonary emphysema. These results were related to the measur... Abstract