Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 85 times since 2010 (6 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 23, Issue 2, 1 1 2010, Pages 109-115 Reference values for right ventricular volumes and ejection fraction with real-time three-dimensional echocardiography: evaluation in a large series of normal subjects. Tamborini G, Marsan NA, Gripari P, Maffessanti F, Brusoni D, Muratori M, Caiani EG, Fiorentini C, Pepi M
Background: The quantification of right ventricular (RV) size and function is of diagnostic and prognostic importance. Recently, new software for the analysis of RV geometry using three-dimensional (3D) echocardiographic images has been validated. The aim of this study was to provide normal reference values for RV volumes and function using this technique. Methods: A total of 245 subjects, including 15 to 20 subjects for each gender and age decile, were studied. Dedicated 3D acquisitions of the... Abstract
Cited 8 times since 2010 (0.6 per year) source: EuropePMC
COPD, Volume 7, Issue 1, 1 1 2010, Pages 70-75 Predictive value of NT-proBNP in vascular surgery patients with COPD and normal left ventricular systolic function. van Gestel YR, Goei D, Hoeks SE, Sin DD, Flu WJ, Stam H, Mertens FW, Bax JJ, van Domburg RT, Poldermans D
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is commonly used to identify a cardiac cause of dyspnoea. However, patients with chronic obstructive pulmonary disease (COPD) may also have increased plasma NT-proBNP levels because of right-sided myocardial stress caused by pulmonary hypertension. We investigated the relationship between COPD and elevated NT-proBNP levels as well as the impact of elevated NT-proBNP levels on mortality in vascular surgery patients with normal left ventricular... Abstract
Cited 9 times since 2010 (0.6 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 140, Issue 4, 1 1 2010, Pages 807-815 Noninvasive estimation of left ventricular filling pressures in patients with heart failure after surgical ventricular restoration and restrictive mitral annuloplasty. ten Brinke EA, Bertini M, Klautz RJ, Antoni ML, Holman ER, van de Veire NR, Bax JJ, Steendijk P
Objective: Doppler echocardiography, including tissue Doppler imaging, is widely applied to assess diastolic left ventricular function using early transmitral flow velocity combined with mitral annular velocity as a noninvasive estimate of left ventricular filling pressures. However, the accuracy of early transmitral flow velocity/mitral annular velocity in patients with heart failure, particularly after extensive cardiac surgery, is debated. Global diastolic strain rate during isovolumic relaxa... Abstract
Critical care medicine, Volume 38, Issue 2, 1 1 2010, Pages 725-727 Toward therapeutic use of hydrogen sulfide in critical care? Steendijk P
Cited 1 times since 2010 (0.1 per year) source: EuropePMC
Journal of molecular histology, Volume 41, Issue 1, 1 1 2010, Pages 27-37 Expression patterns of protein C inhibitor in mouse development. Wagenaar GT, Uhrin P, Weipoltshammer K, Almeder M, Hiemstra PS, Geiger M, Meijers JC, Schöfer C
Proteolysis of extracellular matrix is an important requirement for embryonic development and is instrumental in processes such as morphogenesis, angiogenesis, and cell migration. Efficient remodeling requires controlled spatio-temporal expression of both the proteases and their inhibitors. Protein C inhibitor (PCI) effectively blocks a range of serine proteases, and recently has been suggested to play a role in cell differentiation and angiogenesis. In this study, we mapped the expression patte... Abstract
Cited 18 times since 2010 (1.3 per year) source: EuropePMC
Journal of vascular surgery, Volume 51, Issue 2, 1 1 2010, Pages 360-71.e1 Functional status as a prognostic factor for primary revascularization for critical limb ischemia. Flu HC, Lardenoye JH, Veen EJ, Van Berge Henegouwen DP, Hamming JF
Background: Lower extremity arterial revascularization (LEAR) is the gold-standard for critical lower limb ischemia (CLI). The goal of this study was twofold. First, we evaluated the long-term functional status of patients undergoing primary LEAR for CLI. Second, prognostic factors of long-term functional status and survival after primary LEAR for CLI were assessed. Methods: All primary LEAR procedures were analyzed. Patients were stratified by preoperative functional status: ambulatory (group I... Abstract
Cited 17 times since 2010 (1.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 2, 1 1 2010, Pages 275-276 Attitude towards redundant leads and the practice of lead extractions: a European survey. van Erven L, Morgan JM, Scientific Initiatives Committee (SIC)
This survey has compared attitudes towards (endocardial) lead extraction, among European electrophysiology centres, with special attention paid to 'redundant leads'. The main findings of this survey are: (i) most of the centres performing lead extractions do so in low volume even though the number of implants may be high. (ii) Approaches to the practice of lead extraction are based largely on clinical experience and individual sentiment but not on a rigorous evidence based. (iii) Tract... Abstract
Cited 26 times since 2010 (1.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 5, 1 1 2010, Pages 542-551 Imaging and atrial fibrillation: the role of multimodality imaging in patient evaluation and management of atrial fibrillation. Tops LF, Schalij MJ, Bax JJ
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is associated with an increased risk of cardiac morbidity and mortality. In this review, the role of multimodality imaging in the evaluation and treatment of AF is discussed in two main parts. First, an overview of the initial assessment of an AF patient is provided, including the role of different imaging techniques. Conditions that are associated with AF (coronary artery disease, heart failure, valvular heart disease, and left... Abstract
Cited 93 times since 2010 (6.5 per year) source: EuropePMC
Journal of cellular and molecular medicine, Volume 14, Issue 6A, 30 5 2010, Pages 1225-1240 Epigenetics in atherosclerosis and inflammation. Wierda RJ, Geutskens SB, Jukema JW, Quax PH, van den Elsen PJ
Atherosclerosis is a multifactorial disease with a severe burden on western society. Recent insights into the pathogenesis of atherosclerosis underscore the importance of chronic inflammation in both the initiation and progression of vascular remodelling. Expression of immunoregulatory molecules by vascular wall components within the atherosclerotic lesions is accordingly thought to contribute to the ongoing inflammatory process. Besides gene regulatory proteins (transcription factors), epigenet... Abstract
Cited 106 times since 2010 (7.4 per year) source: EuropePMC
Circulation, Volume 121, Issue 5, 25 4 2010, Pages 626-634 Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapy. Sweeney MO, van Bommel RJ, Schalij MJ, Borleffs CJ, Hellkamp AS, Bax JJ
Background: Cardiac resynchronization therapy for heart failure with left bundle branch block reduces left ventricular (LV) conduction delay, contraction asynchrony, and LV end-systolic volume ("reverse remodeling"). Up to one third of patients do not improve, and the electric requirements for reverse remodeling are unclear. We hypothesized that reverse remodeling is predicted by the left bundle branch block ventricular activation sequence, the paced activation sequence, and interactio... Abstract
Cited 7 times since 2010 (0.5 per year) source: EuropePMC
European journal of heart failure, Volume 12, Issue 3, 22 4 2010, Pages 288-293 Prevalence and pharmacological treatment of left-ventricular dysfunction in patients undergoing vascular surgery. Flu WJ, van Kuijk JP, Galal W, Kuiper R, van de Ven LL, Verhagen HJ, Bax JJ, Poldermans D
Aims: This study evaluated the prevalence of left-ventricular (LV) dysfunction in vascular surgery patients and pharmacological treatment, according ESC guidelines. Methods and results: Echocardiography was performed pre-operatively in 1,005 consecutive patients. Left ventricular ejection fraction (LVEF) Abstract
Cited 38 times since 2010 (2.7 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 199, Issue 1, 22 4 2010, Pages 43-52 Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction. Post H, Schmitto JD, Steendijk P, Christoph J, Holland R, Wachter R, Schöndube FW, Pieske B
Aim: The induction of mild hypothermia (MH; 33 degrees C) has become the guideline therapy to attenuate hypoxic brain injury after out-of-hospital cardiopulmonary resuscitation. While MH exerts a positive inotropic effect in vitro, MH reduces cardiac output in vivo and is thus discussed critically when severe cardiac dysfunction is present in patients. We thus assessed the effect of MH on the function of the normal heart in an in vivo model closely mimicking the clinical setting. Methods: Ten an... Abstract
Cited 10 times since 2010 (0.7 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 69, Issue 3, 22 4 2010, Pages 302-306 Pemetrexed and cisplatin with concurrent radiotherapy for locally advanced non-small cell and limited disease small cell lung cancer: results from 2 phase I studies. Surmont V, Smit EF, de Jonge M, Aerts JG, Nackaerts K, Vernhout R, Gras J, Van Wijk A, Phernambucq EC, van Meerbeeck JP, Senan S, Kraaij CJ, Chouaki N, Praag J, van Klaveren RJ
Background: The objectives were to determine the maximum tolerated dose (MTD) of pemetrexed and cisplatin with concurrent radiotherapy. Secondary objectives include incidence and nature of acute and late toxicities, tumor response and overall survival. Patients and methods: Treatment naïve patients received 1 cycle of cisplatin 80 mg/m(2) in study I (stage III NSCLC), 75 mg/m(2) in study II (LD-SCLC) and pemetrexed 500 mg/m(2) before the phase I part. In study I, patients were treated in cohorts... Abstract
Cited 32 times since 2010 (2.2 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 5, 22 4 2010, Pages 592-597 Incremental prognostic value of novel left ventricular diastolic indexes for prediction of clinical outcome in patients with ST-elevation myocardial infarction. Shanks M, Ng AC, van de Veire NR, Antoni ML, Bertini M, Delgado V, Nucifora G, Holman ER, Choy JB, Leung DY, Schalij MJ, Bax JJ
This study examined the prognostic value of novel diastolic indexes in ST-elevation acute myocardial infarction (AMI), derived from strain and strain rate analysis using 2-dimensional speckle tracking imaging. Echocardiograms were obtained within 48 hours of admission in 371 consecutive patients with first ST-elevation AMI (59.7 +/- 11.6 years old). Indexes of diastolic function including mean strain rate during isovolumic relaxation (SR(IVR)), mean early diastolic strain rate (SR(E)) and mean d... Abstract
Cited 2 times since 2010 (0.1 per year) source: EuropePMC
Neurobiology of aging, Volume 32, Issue 3, 22 4 2010, Pages 549.e1-8 Variation in the CBP gene involved in epigenetic control associates with cognitive function. Trompet S, de Craen AJ, Jukema JW, Pons D, Slagboom PE, Kremer D, Bollen EL, Westendorp RG
Research into the pathologic mechanisms of neurodegenerative diseases has revealed that CREB binding protein (CBP) plays an important role in cognitive dysfunction. Loss of one copy of this gene leads to a syndrome with severe cognitive dysfunction. We investigated the association between four common variants in the CBP gene and cognitive function in 5804 participants of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Baseline associations between genetic variation and cog... Abstract
Cited 19 times since 2010 (1.3 per year) source: EuropePMC
Haemophilia : the official journal of the World Federation of Hemophilia, Volume 16, Issue 3, 18 3 2010, Pages 487-494 The value of early treatment in patients with haemophilia and inhibitors. Kavakli K, Yesilipek A, Antmen B, Aksu S, Balkan C, Yilmaz D, Kupesiz A, Sasmaz I, Lindgren P, Mesterton J
Development of inhibitors to infused factor concentrates represents a major clinical and economic challenge in the treatment of haemophilic patients. It has been shown that a delay in initiation of treatment leads to requirement of a larger number of injections to stop the bleeding but this has never been formally linked to costs associated with the bleeding. The objectives of this study were to assess the relationship between time to initiation of NovoSeven and total costs, number of doses admi... Abstract
Cited 42 times since 2010 (2.9 per year) source: EuropePMC
BMC medical genetics, Volume 11, 15 3 2010, Pages 7 Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
Background: Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis of COPD. These include the matrix metalloproteinase (MMP) genes which play a role in tissue remodelling and fit in with the protease--antiprotease imbalance theory for the cause of COPD. Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting asso... Abstract
Cited 12 times since 2010 (0.8 per year) source: EuropePMC
The European respiratory journal, Volume 36, Issue 2, 14 2 2010, Pages 261-268 Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins. Wu T, Boezen HM, Postma DS, Los H, Postmus PE, Snieder H, Boomsma DI
It is unclear to what extent the same set of environmental or genetic factors regulate objective intermediate asthma phenotypes. We examined heritabilities of these phenotypes and estimated their environmental and genetic overlap. We studied baseline lung function (forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC), bronchial hyperresponsiveness, number of positive skin prick tests (SPT) to 11 allergens, serum total immunoglobulin (Ig)E, number of positive spec... Abstract
Cited 29 times since 2010 (2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 26, Issue 4, 14 2 2010, Pages 473-482 Assessment of coronary artery calcium by using volumetric 320-row multi-detector computed tomography: comparison of 0.5 mm with 3.0 mm slice reconstructions. van der Bijl N, de Bruin PW, Geleijns J, Bax JJ, Schuijf JD, de Roos A, Kroft LJ
The purpose of this study was to assess the performance of 0.5 versus 3.0 mm slice reconstructions in depicting coronary calcium with special attention to patients having zero calcium scores at 3.0 mm reconstructions by using computed tomography (CT). Imaging was performed by volumetric 320-detector row CT. Scans of 100 patients with a negative and 100 patients with a positive Agatston score at 3.0 mm reconstructions were consecutively selected. Non-overlapping volume sets with 3.0 and 0.5 mm sl... Abstract
Cited 81 times since 2010 (5.7 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 48, Issue 6, 11 2 2010, Pages 1215-1224 Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles. Lai RC, Arslan F, Tan SS, Tan B, Choo A, Lee MM, Chen TS, Teh BJ, Eng JK, Sidik H, Tanavde V, Hwang WS, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Tan KH, Lim SK
The therapeutic effects of mesenchymal stem cells (MSCs) transplantation are increasingly thought to be mediated by MSC secretion. We have previously demonstrated that human ESC-derived MSCs (hESC-MSCs) produce cardioprotective microparticles in pig model of myocardial ischemia/reperfusion (MI/R) injury. As the safety and availability of clinical grade human ESCs remain a concern, MSCs from fetal tissue sources were evaluated as alternatives. Here we derived five MSC cultures from limb, kidney a... Abstract