Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7518 results
Cited 12 times since 2004 (0.6 per year) source: EuropePMC
European journal of pharmacology, Volume 491, Issue 2-3, 1 1 2004, Pages 173-179 Hemodynamic characterization of left ventricular function in experimental coxsackieviral myocarditis: effects of carvedilol and metoprolol. Tschöpe C, Westermann D, Steendijk P, Noutsias M, Rutschow S, Weitz A, Schwimmbeck PL, Schultheiss HP, Pauschinger M
Background: Carvedilol, a vasodilating nonselective beta-adrenoceptor antagonist, but not metoprolol, a selective beta1-adrenoceptor antagonist, has been shown to increase the production of cardiac antiinflammatory cytokines in experimental myocarditis. However, the hemodynamic consequences of these differences had not been investigated until today. Therefore, we determined the effects of carvedilol and metoprolol on left ventricular function in a murine model of coxsackievirus B3 (CVB3)-induced... Abstract
Cited 1 times since 2004 (0 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue 5, 1 1 2004, Pages 214-222 Recommendations and cardiological evaluation of athletes with arrhythmias: Part 2. Hoogsteen J, Bennekers JH, van der Wall EE, van Hemel NM, Wilde AA, Crijns HJ, Gorgels AP, Smeets JL, Hauer RN, Jordaens JL, Schalij MJ
Confronted with a competitive or recreational athlete, the physician has to discriminate between benign, paraphysiological and pathological arrhythmias. Benign arrhythmias do not represent a risk for SCD, nor do they induce haemodynamic consequences during athletic activities. These arrhythmias are not markers for heart disease. Paraphysiological arrhythmias are related to athletic performance. Long periods of endurance training induce changes in rhythm, conduction and repolarisation. These chan... Abstract
Cited 42 times since 2004 (2.1 per year) source: EuropePMC
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Volume 13, Issue 4, 1 1 2004, Pages 735-745 A cardiac-specific health-related quality of life module for young adults with congenital heart disease: development and validation. Kamphuis M, Zwinderman KH, Vogels T, Vliegen HW, Kamphuis RP, Ottenkamp J, Verloove-Vanhorick SP, Bruil J
This study represents the development and validation of a cardiac-specific module of the generic health-related quality of life (HRQoL) instrument, the TAAQOL (TNO/AZL Adult Quality Of Life), for young adults with congenital heart disease (CHD). Items were selected based on literature, an explorative previous study in CHD patients, interviews with patients, and the advice of experts. The newly developed Congenital Heart Disease-TNO/AZL Adult Quality of Life (CHD-TAAQOL) was tested in 156 patient... Abstract
Cited 36 times since 2004 (1.8 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 15, Issue 5, 1 1 2004, Pages 831-838 Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors. Giaccone G, González-Larriba JL, van Oosterom AT, Alfonso R, Smit EF, Martens M, Peters GJ, van der Vijgh WJ, Smith R, Averbuch S, Fandi A
Background: The aim of this study was to investigate the tolerability, pharmacokinetic interaction and antitumor activity of gefitinib ("Iressa", ZD1839), an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor, combined with gemcitabine and cisplatin in chemotherapy-naïve patients with advanced solid tumors. Patients and methods: This was an open-label feasibility trial evaluating two doses of gefitinib (250 and 500 mg/day) in combination with gemcitabin... Abstract
Cited 239 times since 2004 (11.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 15, Issue 5, 1 1 2004, Pages 544-549 Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. Bleeker GB, Schalij MJ, Molhoek SG, Verwey HF, Holman ER, Boersma E, Steendijk P, Van Der Wall EE, Bax JJ
Introduction: Patients with end-stage heart failure and a wide QRS complex are considered candidates for cardiac resynchronization therapy (CRT). However, 20% to 30% of patients do not respond to CRT. Lack of left ventricular dyssynchrony may explain the nonresponse. Accordingly, we evaluated the presence of left ventricular dyssynchrony using tissue Doppler imaging (TDI) in 90 consecutive patients with heart failure. Methods and results: Ninety patients with severe heart failure (left ventricul... Abstract
Cited 14 times since 2004 (0.7 per year) source: EuropePMC
Heart rhythm, Volume 1, Issue 1, 1 1 2004, Pages 51-57 Standardized screening and treatment of patients with life-threatening arrhythmias: the Leiden out-of-hospital cardiac arrest evaluation study. van der Burg AE, Bax JJ, Boersma E, van Erven L, Bootsma M, van der Wall EE, Schalij MJ
Objectives: The aim of this study was to evaluate the effect of a systematic screening/treatment protocol on outcome in patients after aborted sudden death. Background: Patients after aborted sudden death are at high risk for recurrent events. In this regard, systematic screening is mandatory to reveal the underlying etiology, to detect and subsequently treat reversible causes, and to establish patient-tailored antiarrhythmic treatment. Methods: A total of 417 consecutive patients after aborted... Abstract
Cited 9 times since 2004 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 93, Issue 10, 1 1 2004, Pages 1298-1302 Anatomical observations of the pulmonary veins with intracardiac echocardiography and hemodynamic consequences of narrowing of pulmonary vein ostial diameters after radiofrequency catheter ablation of atrial fibrillation. Jongbloed MR, Bax JJ, Zeppenfeld K, van der Wall EE, Schalij MJ
Intracardiac echocardiography was used to explore pulmonary venous (PV) anatomy and to monitor PV stenosis in 31 patients referred for radiofrequency catheter ablation at PV ostia. Interindividual variations in PV anatomy and insertion in the left atrium were observed. Narrowing of PV ostia after radiofrequency catheter ablation did not produce significant hemodynamic changes. Abstract
Cited 96 times since 2004 (4.8 per year) source: EuropePMC
The Journal of experimental medicine, Volume 199, Issue 10, 1 1 2004, Pages 1409-1420 CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1. Lee SP, Brooks JM, Al-Jarrah H, Thomas WA, Haigh TA, Taylor GS, Humme S, Schepers A, Hammerschmidt W, Yates JL, Rickinson AB, Blake NW
The Epstein-Barr virus (EBV) nuclear antigen (EBNA)1 contains a glycine-alanine repeat (GAr) domain that appears to protect the antigen from proteasomal breakdown and, as measured in cytotoxicity assays, from major histocompatibility complex (MHC) class I-restricted presentation to CD8+ T cells. This led to the concept of EBNA1 as an immunologically silent protein that although unique in being expressed in all EBV malignancies, could not be exploited as a CD8 target. Here, using CD8+ T cell clon... Abstract
Cited 102 times since 2004 (5.1 per year) source: EuropePMC
European heart journal, Volume 25, Issue 10, 1 1 2004, Pages 815-836 Imaging techniques for the assessment of myocardial hibernation. Report of a Study Group of the European Society of Cardiology. Underwood SR, Bax JJ, vom Dahl J, Henein MY, Knuuti J, van Rossum AC, Schwarz ER, Vanoverschelde JL, van der Wall EE, Wijns W, Study Group of the European Society of Cardiology
This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernation, it reviews the morphological findings in hibernation and it describes relevant clinical settings. The imaging and other techniques that are reviewed are electrocardiography, po... Abstract
Cited 17 times since 2004 (0.8 per year) source: EuropePMC
Chest, Volume 125, Issue 5, 1 1 2004, Pages 1735-1741 Actual and predicted postoperative changes in lung function after pneumonectomy: a retrospective analysis. Smulders SA, Smeenk FW, Janssen-Heijnen ML, Postmus PE
Study objectives: Little is known about long-term effects of pneumonectomy on lung function and exercise tolerance. We evaluated the long-term validity of two formulas frequently used to predict postoperative lung function, as well as trends in postoperative lung function and late postoperative exercise capacity. Setting: Nonuniversity teaching hospital of Eindhoven, the Netherlands. Patients: Patients who underwent pneumonectomy between 1993 and 1998 and survived for > 1 year after the opera... Abstract
Cited 39 times since 2004 (1.9 per year) source: EuropePMC
Basic research in cardiology, Volume 99, Issue 5, 16 3 2004, Pages 351-359 Left ventricular pressure-volume measurements in mice: comparison of closed-chest versus open-chest approach. Lips DJ, van der Nagel T, Steendijk P, Palmen M, Janssen BJ, van Dantzig JM, de Windt LJ, Doevendans PA
Objective: We investigated whether in vivo closed-chest left ventricular pressure-volume measurements would yield similar values for LV hemodynamics compared with open-chest PV measurements under several anesthetics. Methods: The right common carotid of C57Bl/6 mice was cannulated with a combined pressure-conductance catheter and inserted retrogradely into the left ventricle in the closed-chest model. The open-chest model consisted of an abdominal approach involving the opening of the thoracic c... Abstract
Cited 275 times since 2004 (13.6 per year) source: EuropePMC
Annals of the rheumatic diseases, Volume 63, Issue 4, 1 1 2004, Pages 373-381 Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Vossenaar ER, Radstake TR, van der Heijden A, van Mansum MA, Dieteren C, de Rooij DJ, Barrera P, Zendman AJ, van Venrooij WJ
Background: Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptidylarginine deiminase (PAD) enzymes. Objective: To investigate the expression and activity of four isotypes of PAD in peripheral blood and synovial fluid cells of patients with RA.... Abstract
Cited 67 times since 2004 (3.3 per year) source: EuropePMC
The American journal of cardiology, Volume 93, Issue 7, 1 1 2004, Pages 860-863 Comparison of benefits from cardiac resynchronization therapy in patients with ischemic cardiomyopathy versus idiopathic dilated cardiomyopathy. Molhoek SG, Bax JJ, van Erven L, Bootsma M, Boersma E, Steendijk P, van der Wall EE, Schalij MJ
Cardiac resynchronization therapy (CRT) is a recently introduced therapeutic option for patients with severe heart failure and intraventricular conduction disturbances. However, it is estimated that 20% to 30% of patients may not respond to CRT. Patients with ischemic cardiomyopathy (IC) may respond less favorably to CRT compared with patients with idiopathic dilated cardiomyopathy (IDC). Accordingly, the beneficial effects of CRT were evaluated in 2 subsets of patients (IC and IDC). Seventy-fou... Abstract
Cited 5 times since 2004 (0.2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 20, Issue 2, 1 1 2004, Pages 113-116 Thrombus in the left atrial appendage detected by intracardiac echocardiography. Jongbloed MR, Bax JJ, van der Wall EE, Schalij MJ
Radiofrequency catheter ablation (RFCA) at the ostium of the pulmonary veins can potentially cure atrial fibrillation. Left-sided ablation procedures may carry a risk of thrombo-embolic events. Emboli from intracardiac thrombus originate from the left atrial appendage (LAA) in a substantial number of patients. The presence of spontaneous echo contrast in the left atrium (LA) and LAA peak emptying flow < or = 20 cm/s are also significantly related to thrombo-embolic events. Evaluation of the a... Abstract
Cited 16 times since 2004 (0.8 per year) source: EuropePMC
Critical care medicine, Volume 32, Issue 4, 1 1 2004, Pages 1087-1089 Right ventricular function and failure: methods, models, and mechanisms. Steendijk P
Cited 4 times since 2004 (0.2 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue 4, 1 1 2004, Pages 157-164 Recommendations and cardiological evaluation of athletes with arrhythmias: Part 1. Hoogsteen J, Bennekers JH, van der Wall EE, van Hemel NM, Wilde AA, Crijns HJ, Gorgels AP, Smeets JL, Hauer RN, Jordaens JL, Schalij MJ
Besides the consensus meeting in Amersfoort in 1988 and the Bethesda conference in 1994 recommendations are not available in the Netherlands for screening and evaluation of athletes with cardiac arrhythmias. Guidelines for competitive athletes with cardiac arrhythmias in the United States and Italy were published in 2000. In 1998 Estes et al. published the most important opinions on sudden cardiac death, screening and evaluation of athletes and arrhythmias. This study addresses the physiological... Abstract
Cited 1 times since 2004 (0 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 44, Issue 1, 1 1 2004, Pages 129-130 Bronchial typical carcinoid tumors: histological study of intra- versus extraluminal growth pattern. Brokx HA, Kunst PW, van Diest PJ, Postmus PE, Sutedja TG
Cited 10 times since 2004 (0.5 per year) source: EuropePMC
International journal of cancer, Volume 109, Issue 3, 1 1 2004, Pages 412-417 Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ). Snijders PJ, Breuer RH, Sutedja TG, Egging M, Voorhorst FJ, Steenbergen RD, van der Linden HC, Risse EK, Berkhof J, de Vries EG, van der Zee AG, Postmus PE, Meijer CJ, Smit EF
Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with increasing hTERT mRNA levels (OR = 6.04, 95% CI = 1.02-37). Group B was comprised of 21 patients who underwent autofluorescence bronchoscopy. After analysis of 66 bronchial biopsie... Abstract
Cited 46 times since 2004 (2.3 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 44, Issue 1, 1 1 2004, Pages 53-60 Towards a minimally invasive staging strategy in NSCLC: analysis of PET positive mediastinal lesions by EUS-FNA. Annema JT, Hoekstra OS, Smit EF, Veseliç M, Versteegh MI, Rabe KF
Study objective: To asses the value of endoscopic ultrasound guided fine needle aspiration (EUS-FNA) in the nodal staging of patients with (suspected) non-small cell lung cancer (NSCLC) and a (18)FDG positron emission tomography (PET) scan suspect for N2/N3 mediastinal lymph node (MLN) metastases. Background: Due to the imperfect specificity of positron emission tomography, PET positive MLN should be biopsied in order to confirm or rule out metastasis. Currently, invasive surgical diagnostic tec... Abstract
Cited 2 times since 2004 (0.1 per year) source: EuropePMC
Physiological measurement, Volume 25, Issue 2, 1 1 2004, Pages 565-576 Assessment of parallel conductance for the trans-cardiac conductance method: can we use the hypertonic saline method with pulmonary artery injections? Staal EM, Baan J, Jukema JW, van der Wall EE, Steendijk P
The trans-cardiac conductance (TCC) method provides on-line left ventricular (LV) volume signals by determining the electrical conductance of blood in the LV using central venous and epithoracic electrodes. Conductive structures outside the LV cause a 'parallel conductance' offset term (Vp) that is determined by bolus injections of hypertonic saline in the pulmonary artery (Vp(saline)). Analysis of the increased conductance signal during passage of the bolus through the LV yields Vp(sa... Abstract