Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 7 times since 2006 (0.4 per year) source: EuropePMC
BMC genomics, Volume 7, 18 3 2006, Pages 9 A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes. Vos JB, Datson NA, van Kampen AH, Luyf AC, Verhoosel RM, Zeeuwen PL, Olthuis D, Rabe KF, Schalkwijk J, Hiemstra PS
Background: Epithelia are barrier-forming tissues that protect the organism against external noxious stimuli. Despite the similarity in function of epithelia, only few common protective mechanisms that are employed by these tissues have been systematically studied. Comparative analysis of genome-wide expression profiles generated by means of Serial Analysis of Gene Expression (SAGE) is a powerful approach to yield further insight into epithelial host defense mechanisms. We performed an extensive... Abstract
Cited 53 times since 2006 (2.9 per year) source: EuropePMC
The American journal of cardiology, Volume 97, Issue 5, 10 2 2006, Pages 662-670 Histology of vascular myocardial wall of left atrial body after pulmonary venous incorporation. Douglas YL, Jongbloed MR, Gittenberger-de Groot AC, Evers D, Dion RA, Voigt P, Bartelings MM, Schalij MJ, Ebels T, DeRuiter MC
During embryonic development, the common pulmonary vein (PV) becomes incorporated into the left atrium, giving rise to separate PV ostia. We describe the consequences of this incorporation process for the histology of the left atrium and the possible clinical implications. The histology of the left atrial (LA) wall in relation to PV incorporation was studied immunohistochemically in 16 human embryos and fetuses, 1 neonate, and 5 adults. The PV wall, surrounded by extrapericardially differentiate... Abstract
Cited 4 times since 2006 (0.2 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 47, Issue 1, 1 1 2006, Pages 68-73 Impact of diabetes mellitus on prediction of clinical outcome after coronary revascularization by 18F-FDG SPECT in patients with ischemic left ventricular dysfunction. Schinkel AF, Poldermans D, Rizzello V, van Domburg RT, Valkema R, Elhendy A, Biagini E, Krenning EP, Simoons ML, Bax JJ
Unlabelled: Nuclear imaging using (18)F-FDG is an established method for the noninvasive assessment of myocardial viability. Data on the value of (18)F-FDG imaging in patients with diabetes mellitus are scarce. The aim of this study was to assess whether, in patients with diabetes mellitus and ischemic left ventricular (LV) dysfunction, (18)F-FDG imaging can predict improvement of LV function and heart failure symptoms after coronary revascularization. Methods: A total of 130 consecutive patient... Abstract
Cited 28 times since 2006 (1.5 per year) source: EuropePMC
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, Volume 19, Issue 3, 1 1 2006, Pages 385-391 Assessing a system to capture stray aerosol during inhalation of nebulized liposomal cisplatin. Wittgen BP, Kunst PW, Perkins WR, Lee JK, Postmus PE
The aim of this study was to determine the efficacy of using a high-efficiency particulate air (HEPA) filter air cleaning system, a demistifier, to reduce the potential risk of fugitive aerosol contact in health care personnel working with patients inhaling nebulized liposomal encapsulated SLIT (Sustained-release Lipid Inhalation Targeting) Cisplatin. Filters were used to sample platinum in the air outside the tent and from the tent's exhaust stream. Air collection was performed under three... Abstract
Cited 1 times since 2006 (0.1 per year) source: EuropePMC
Annals of nuclear medicine, Volume 20, Issue 1, 1 1 2006, Pages 51-56 Effect of left ventricular function on diagnostic accuracy of FDG SPECT. Matsunari I, Bax JJ, Blanksma PK, Visser FC, Kanayama S, Yoneyama T, Nekolla SG, Tonami N, Hisada K
Objectives: Fluorine-18 fluorodeoxyglucose (FDG) SPECT has emerged as an alternative to dedicated PET imaging. However, it remains uncertain whether FDG SPECT is an as accurate for viability assessment as FDG PET in patients with severely reduced left ventricular function. The aim of the study was to assess the diagnostic accuracy of FDG SPECT in a head-to-head comparison with FDG PET, and divide the patients according to the severity of left ventricular dysfunction. Methods: A total of 47 patie... Abstract
Cited 41 times since 2006 (2.2 per year) source: EuropePMC
Human mutation, Volume 27, Issue 1, 1 1 2006, Pages 103-109 Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Chappell S, Daly L, Morgan K, Guetta Baranes T, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra P, Miniati M, Monti S, O'Connor CM, Kalsheker N
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. While cigarette smoking is a major cause of COPD, only 15% of smokers develop the disease, indicating major genetic influences. The most widely recognized candidate gene in COPD is SERPINA1, although it has been suggested that SERPINA3 may also play a role. To detect cryptic genetic variants that might contribute to disease, we identified 15 SNP haplotype tags from high-density SNP maps of the two... Abstract
Cited 2 times since 2006 (0.1 per year) source: EuropePMC
Radiology, Volume 238, Issue 1, 1 1 2006, Pages 374-5; author reply 375 Prediction of pulmonary function in COPD on the basis of CT measurements of bronchial wall thickness. Nieber M, Putter H, Stolk J, Reiber JH, Stoel BC
Cited 23 times since 2006 (1.3 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 1, 1 1 2006, Pages 123-126 Multimodality imaging to diagnose takotsubo cardiomyopathy. Scholte AJ, Bax JJ, Stokkel MP, Plokker T, Kaandorp TA, Lamb HJ, de Roos A, van der Wall EE
Cited 25 times since 2006 (1.4 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 1, 1 1 2006, Pages 11-18 Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: combined use of stress myocardial perfusion imaging and coronary calcium scoring. Scholte AJ, Bax JJ, Wackers FJ
Diabetes mellitus and coronary artery disease constitute an ominous clinical combination. Rates of morbidity and mortality as a result of cardiovascular complications are high in patients with type 2 diabetes mellitus. Screening for silent coronary artery disease, to detect the disease in an early stage and to be able to initiate early appropriate treatment, has recently become an important focus of clinical investigation. Recent prospective studies have shown that the overall prevalence of sile... Abstract
Cited 4 times since 2006 (0.2 per year) source: EuropePMC
Substance use & misuse, Volume 41, Issue 1, 1 1 2006, Pages 45-60 Effects on smoking cessation: naltrexone combined with a cognitive behavioral treatment based on the community reinforcement approach. Roozen HG, Van Beers SE, Weevers HJ, Breteler MH, Willemsen MC, Postmus PE, Kerkhof AJ
A promising option in substance abuse treatment is the Community Reinforcement Approach (CRA). The opioid antagonist naltrexone (NTX) may work in combination with nicotine replacement therapy (NRT) to block the effects of smoking stimuli in abstinent smokers. Effects of lower doses than 50 mg/dd. have not been reported. A study was conducted in Amsterdam in 2000/2001 with the objective to explore the effects of the combination NTX (25/50-mg dd.), NRT, and CRA in terms of craving and abstinence.... Abstract
Cited 24 times since 2006 (1.3 per year) source: Scopus
Animal reproduction science, Volume 91, Issue 1-2, 1 1 2006, Pages 55-76 Pregnancy effects on distribution of progesterone receptors, oestrogen receptor alpha, glucocorticoid receptors, Ki-67 antigen and apoptosis in the bovine interplacentomal uterine wall and foetal membranes. Boos A, Kohtes J, Janssen V, Mülling C, Stelljes A, Zerbe H, Hässig M, Thole HH
Until recently, studies dealing with the uterus of the pregnant cow focus primarily on the placentome or on early and late pregnancy. Thus, there is a paucity of information about many aspects of the interplacentomal uterine wall including adherent foetal membranes. Corresponding tissue specimens were collected at the slaughterhouse and in animals undergoing premature caesarean section. Two specimens per month of pregnancy were assessed immunohistochemically for progesterone receptors, oestrogen... Abstract
Cited 4 times since 2006 (0.2 per year) source: EuropePMC
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Volume 17, Issue 1, 1 1 2006, Pages 57-58 Massive pulmonary embolism with cardiac arrest after an intracardiac electrophysiological study: a strong case for venous thromboprophylaxis. Bauer MP, Vliegen HW, Huisman MV
A 47-year-old woman was referred to our hospital for an intracardiac electrophysiological study. The procedure was complicated by cardiac arrest due to massive pulmonary embolism, which only successfully resolved after the administration of a thrombolytic agent. This case suggests that there is a real risk of venous thromboembolism in certain patients during electrophysiological studies. Therefore, a consensus should be reached concerning the prevention of venous thromboembolism during these pro... Abstract
Cited 16 times since 2006 (0.9 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 150, Issue 1, 1 1 2006, Pages 18-23 [The practice guideline 'Diagnosis and treatment of familial hypercholesterolaemia' of the Dutch Health Care Insurance Board]. Walma EP, Visseren FL, Jukema JW, Kastelein JJ, Hoes AW, Stalenhoef AF
Until 2010, the Dutch ministry of Health, Welfare and Sport will fund a nationwide project to identify the approximately 40,000 patients with familial hypercholesterolaemia (FH) in the Netherlands. The Health Care Insurance Board will coordinate the project and safeguard its quality, while the 'Stichting Opsporing Erfelijke Hypercholesterolemie' [Foundation for the Detection of Hereditary Hypercholesterolaemia], with its national network of genetic fieldworkers, will search systematica... Abstract
Cited 13 times since 2006 (0.7 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 17, Issue 1, 1 1 2006, Pages 101-103 Acceleration-dependent left bundle branch block with severe left ventricular dyssynchrony results in acute heart failure: are there more patients who benefit from cardiac resynchronization therapy? Zeppenfeld K, Schalij MJ, Bleeker GB, Holman ER, Bax JJ
Cardiac resynchronization therapy (CRT) has been proposed to improve hemodynamics in patients with heart failure and left bundle branch block (LBBB) by resynchronization of left ventricular (LV) dyssynchrony. The current report concerns a patient with narrow QRS complex without LV dyssynchrony who experienced an acute exacerbation of heart failure following exercise. Careful analysis revealed that an increase of heart rate induced acceleration-dependent LBBB with severe LV dyssynchrony and mitra... Abstract
Cited 25 times since 2006 (1.4 per year) source: EuropePMC
ASAIO journal (American Society for Artificial Internal Organs : 1992), Volume 52, Issue 1, 1 1 2006, Pages 4-8 Modeling ventricular function during cardiac assist: does time-varying elastance work? Vandenberghe S, Segers P, Steendijk P, Meyns B, Dion RA, Antaki JF, Verdonck P
The time-varying elastance theory of Suga et al. is widely used to simulate left ventricular function in mathematical models and in contemporary in vitro models. We investigated the validity of this theory in the presence of a left ventricular assist device. Left ventricular pressure and volume data are presented that demonstrate the heart-device interaction for a positive-displacement pump (Novacor) and a rotary blood pump (Medos). The Novacor was implanted in a calf and used in fixed-rate mode... Abstract
Cited 58 times since 2006 (3.2 per year) source: EuropePMC
The European respiratory journal, Volume 27, Issue 1, 1 1 2006, Pages 60-64 Increased number of B-cells in bronchial biopsies in COPD. Gosman MM, Willemse BW, Jansen DF, Lapperre TS, van Schadewijk A, Hiemstra PS, Postma DS, Timens W, Kerstjens HA, Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group
Recently, it has been shown that the accumulated volume of B-cells in small airways is increased in chronic obstructive pulmonary disease (COPD) Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 3 and 4. Little is known about the number of B-cells in central airways in COPD. The present authors hypothesised that the number of B-cells in bronchial biopsies of large airways is higher in patients with COPD than in controls without airflow limitation and higher in more severe COPD... Abstract
Critical care medicine, Volume 34, Issue 1, 1 1 2006, Pages 255-257 The role of nitric oxide signaling in sepsis-induced myocardial dysfunction. Steendijk P
Cited 31 times since 2006 (1.7 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 33, Issue 1, 1 1 2006, Pages 93-104 Diagnostic and prognostic value of non-invasive imaging in known or suspected coronary artery disease. Schuijf JD, Poldermans D, Shaw LJ, Jukema JW, Lamb HJ, de Roos A, Wijns W, van der Wall EE, Bax JJ
The role of non-invasive imaging techniques in the evaluation of patients with suspected or known coronary artery disease (CAD) has increased exponentially over the past decade. The traditionally available imaging modalities, including nuclear imaging, stress echocardiography and magnetic resonance imaging (MRI), have relied on detection of CAD by visualisation of its functional consequences (i.e. ischaemia). However, extensive research is being invested in the development of non-invasive anatom... Abstract
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 1, Issue 1, 1 1 2006, Pages 69-70 Where is the heart after left-sided pneumonectomy? Smulders SA, van den Bosch HC, Post JC, Vonk Noordegraaf A, Postmus PE
Cited 17 times since 2006 (0.9 per year) source: EuropePMC
Crisis, Volume 27, Issue 2, 1 1 2006, Pages 77-81 High rates of suicide and attempted suicide using pesticides in Nickerie, Suriname, South America. Graafsma T, Kerkhof A, Gibson D, Badloe R, van de Beek LM
Suicide and attempted suicide are identified as a serious mental health problem in Suriname, especially in the district of Nickerie. An epidemiological study in the Nickerie catchment area revealed high rates of suicide (48 per 100,000) and attempted suicide (207 per 100,000) on average in the years 2000-2004. Particularly remarkable is the high number of attempted suicides among males (49%), and the use of pesticides in both fatal (55%) and nonfatal suicidal behavior (44%). Probably this high i... Abstract