Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7496 results
Cited 31 times since 1997 (1.2 per year) source: EuropePMC
European heart journal, Volume 18, Issue 9, 1 1 1997, Pages 1505-1513 Comparison of echocardiography with magnetic resonance imaging in the assessment of the athlete's heart. Pluim BM, Beyerbacht HP, Chin JC, Zwinderman A, Van der Laarse A, De Roos A, Vliegen HW, Van der Wall EE
Aim: The purpose of the study was to compare the accuracy of M-mode echocardiography and two different two-dimensional echocardiographic approaches in the assessment of left ventricular mass and volumes in endurance-trained and strength-trained athletes, using magnetic resonance imaging as reference standard. Methods and results: We studied 19 athletes and 10 untrained control subjects, M-mode and two-dimensional echocardiography were compared to magnetic resonance imaging. M-mode echocardiograp... Abstract
Cited 5 times since 1997 (0.2 per year) source: EuropePMC
Circulation, Volume 96, Issue 3, 1 1 1997, Pages 1025-1030 Hemodynamic effects of chronic prenatal ventricular pacing for the treatment of complete atrioventricular block. Liddicoat JR, Klein JR, Reddy VM, Klautz RJ, Teitel DF, Hanley FL
Background: Increasing the heart rate of the fetus with cardiac failure caused by complete AV block (CAVB) may allow delivery of a full-term, stable neonate with preserved ventricular function. Direct fetal pacing may be a feasible method to achieve this, but the effect of pacing on the structure and function of the rapidly developing fetal heart is unknown. Methods and results: CAVB was created in fetal lambs at 80% gestation by cryoablating the AV node. Epicardial ventricular pacing at 130 bpm... Abstract
Cited 94 times since 1997 (3.5 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 156, Issue 2 Pt 1, 1 1 1997, Pages 609-616 Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Grünberg K, Smits HH, Timmers MC, de Klerk EP, Dolhain RJ, Dick EC, Hiemstra PS, Sterk PJ
Asthma exacerbations are often associated with respiratory virus infections, particularly with rhinovirus. In the present study we investigated the effect of experimental rhinovirus 16 (RV16) infection on airway inflammation as assessed by analysis of hypertonic saline-induced sputum. Twenty-seven nonsmoking atopic, mildly asthmatic subjects participated in a placebo-controlled parallel study. RV16 (n = 19) or its diluent (n = 8) was nasally administered. Sputum inductions were performed at entr... Abstract
Cited 37 times since 1997 (1.4 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 64, Issue 2, 1 1 1997, Pages 521-525 Modified ultrafiltration after cardiopulmonary bypass in pediatric cardiac surgery. Draaisma AM, Hazekamp MG, Frank M, Anes N, Schoof PH, Huysmans HA
Background: Cardiopulmonary bypass in children results in considerable water retention, especially in neonates and small infants. Dilution of plasma proteins increases water loss into the extravascular compartments. Excessive total body water may prolong ventilatory support and may contribute to a prolongation of intensive care convalescence. After discontinuation of cardiopulmonary bypass, modified ultrafiltration can be used to withdraw plasma water from the total circulating volume. Methods:... Abstract
Cited 56 times since 1997 (2.1 per year) source: EuropePMC
Journal of leukocyte biology, Volume 62, Issue 2, 1 1 1997, Pages 217-226 Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production. Van Wetering S, Mannesse-Lazeroms SP, Dijkman JH, Hiemstra PS
Neutrophil accumulation in the lung may contribute to tissue injury as observed in inflammatory diseases. Both oxidative and non-oxidative mechanisms are involved in neutrophil-mediated tissue injury. Non-oxidative mechanisms include the release of neutrophil granule proteins such as the serine proteinases elastase and cathepsin G, and the non-enzymatic defensins. Because stimulated neutrophils are thought to release their products simultaneously, we investigated possible interactions between pu... Abstract
Cited 34 times since 1997 (1.3 per year) source: EuropePMC
Journal of clinical epidemiology, Volume 50, Issue 8, 1 1 1997, Pages 881-890 Antimicrobial treatment in acute maxillary sinusitis: a meta-analysis. de Bock GH, Dekker FW, Stolk J, Springer MP, Kievit J, van Houwelingen JC
Objective: The aims of this study were to assess which antibiotic is most effective in the treatment of acute maxillary sinusitis in otherwise healthy adults and adolescents, and which has the fewest side effects. Design: To assess the short-term effects of antimicrobial treatments, a meta-analysis was performed using Mantel-Haenszel procedures on 16 comparative, randomized studies with a total number of 3358 patients. No placebo-controlled studies were available. Antimicrobial treatments were c... Abstract
Cited 60 times since 1997 (2.2 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 15, Issue 8, 1 1 1997, Pages 2840-2849 Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited-disease patients with small-cell lung cancer: a European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group Study. Gregor A, Drings P, Burghouts J, Postmus PE, Morgan D, Sahmoud T, Kirkpatrick A, Dalesio O, Giaccone G
Purpose: To evaluate the effectiveness of alternating or sequential schedules of cyclophosphamide, doxorubicin, and etoposide (CDE) chemotherapy and irradiation in patients with previously untreated small-cell lung cancer (SCLC). Materials and methods: A total of 335 eligible patients were randomized between five courses of CDE chemotherapy followed by thoracic irradiation 50 Gy in 20 daily fractions (S) and the same total dose of chemotherapy and irradiation split into four courses of five dail... Abstract
Cited 27 times since 1997 (1 per year) source: EuropePMC
The Prostate, Volume 32, Issue 3, 1 1 1997, Pages 196-204 Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: correlation with metastatic behavior in vivo. Quax PH, de Bart AC, Schalken JA, Verheijen JH
Background: The plasminogen activation (PA) and metalloproteinase (MMP) system are involved in tumor cell migration and invasion. Methods: The proteolytic activity of cell lines originating from the rat Dunning R-3327 prostate tumor was analyzed by measuring in vitro extracellular matrix degradation, enzyme activity, and mRNA levels of enzymes, inhibitors, and receptors, and compared with their known metastatic behavior in vivo. Results: Only the highly metastatic sublines AT-3, MATLu, and MATLy... Abstract
Cited 31 times since 1997 (1.2 per year) source: EuropePMC
Thrombosis and haemostasis, Volume 78, Issue 2, 1 1 1997, Pages 880-886 The migration of human smooth muscle cells in vitro is mediated by plasminogen activation and can be inhibited by alpha2-macroglobulin receptor associated protein. Wijnberg MJ, Quax PH, Nieuwenbroek NM, Verheijen JH
The plasminogen activation system is thought to be important in cell migration processes. A role for this system during smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about its involvement in human vascular remodelling. We studied the involvement of the plasminogen activation system in human smooth muscle cell migration in more detail using an in vitro wound assay and a matrix invasion assay. Inhibition of plasmin act... Abstract
Cited 5 times since 1997 (0.2 per year) source: EuropePMC
European heart journal, Volume 18, Issue 8, 1 1 1997, Pages 1313-1321 Beneficial effect of enalapril on left ventricular remodelling in patients with a severe residual stenosis after acute anterior wall infarction. Baur LH, Schipperheyn JJ, van der Wall EE, van der Velde EA, Schalij MJ, van Eck-Smit BL, van der Laarse A, Voogd PJ, Sedney MI, Reiber JH, Bruschke AV
Objective: The present study was designed to evaluate the effects of early angiotensin converting enzyme (ACE) inhibition on left ventricular enlargement in patients with anterior wall infarction following reperfusion therapy. Methods: Seventy-one consecutive patients with an anterior wall myocardial infarction were randomly allocated to enalapril (n = 36) or placebo (n = 35). All patients received either thrombolytic therapy (n = 46) or underwent primary coronary angioplasty (n = 25). Medicatio... Abstract
Cited 9 times since 1997 (0.3 per year) source: EuropePMC
European journal of pediatrics, Volume 156, Issue 7, 1 1 1997, Pages 516-520 The value of MRI in diagnosing vascular abnormalities causing stridor. Beekman RP, Beek FJ, Hazekamp MG, Meijboom EJ
Unlabelled: In a 2 year period seven patients who presented with stridor, without respiratory compromise, and three patients without obstructive symptoms were prospectively selected, and underwent MRI. In eight patients with a vascular ring and a pulmonary sling, MRI delineated the vascular abnormality and normal great vessels were found in two patients. Conclusion: MRI successfully delineates the great vessels and demonstrates the presence of a vascular ring and pulmonary sling. Abstract
Nederlands tijdschrift voor geneeskunde, Volume 141, Issue 28, 1 1 1997, Pages 1400 [Reading children's temperatures with the tympanic infrared thermometer and the rectal mercury thermometer: equally good results in the emergency room]. Groeneveld Y, Stolk J
Nederlands tijdschrift voor geneeskunde, Volume 141, Issue 27, 1 1 1997, Pages 1327-1330 [A new surgical treatment with reduction of lung volume for severe pulmonary emphysema]. Stolk J, Versteegh MI, van der Peijl ID, Jaddoe VW
Current drug treatment of pulmonary emphysema has little effect on quality of life and duration of survival. Surgical treatment for patients with severe pulmonary emphysema was recently introduced; it consists of resection of lung tissue with poor ventilation and perfusion. Surgical reduction of lung volume improves the forced expiratory pressure per second by 80-100% from 0.8 to 1.51. This increases the exercise tolerance and improves the patient's functioning in everyday life. The postope... Abstract
Cited 3 times since 1997 (0.1 per year) source: EuropePMC
Anti-cancer drugs, Volume 8, Issue 6, 1 1 1997, Pages 549-564 Dose intensification of chemotherapy and the role of granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor in small cell lung cancer. Tjan-Heijnen VC, Postmus PE, Wagener DJ
The natural history of small cell lung cancer (SCLC) is characterized by early dissemination. Despite the high responsiveness to chemotherapy, the disease remains ultimately fatal in the majority of patients. One of the strategies to improve final outcome is the administration of intensified chemotherapy, either by dose escalation or by chemotherapy given at shortened intervals. By now, in only one randomized study, in which cyclophosphamide and cisplatin dosage was escalated by 30% in the first... Abstract
Cited 14 times since 1997 (0.5 per year) source: EuropePMC
Biochemical and biophysical research communications, Volume 236, Issue 3, 1 1 1997, Pages 544-548 Autosomal recessive liver phosphorylase kinase deficiency caused by a novel splice-site mutation in the gene encoding the liver gamma subunit (PHKG2). van Beurden EA, de Graaf M, Wendel U, Gitzelmann R, Berger R, van den Berg IE
To facilitate mutation analysis of patients with an autosomal recessive form of liver phosphorylase kinase deficiency, the genomic structure of the gene encoding the testis/liver gamma subunit (PHKG2) was established. The gene consist of 10 exons. The translation start site is located in exon 2. Analysis of DNA from two female siblings, affected with liver phosphorylase kinase deficiency, by exon specific amplification followed by direct sequencing, revealed a single donor splice site mutation i... Abstract
Cited 110 times since 1997 (4.1 per year) source: EuropePMC
The Journal of infectious diseases, Volume 176, Issue 1, 1 1 1997, Pages 300-303 Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. Tomee JF, Wierenga AT, Hiemstra PS, Kauffman HK
Aspergillus fumigatus is a pathogen causing diverse respiratory disorders. Several studies have suggested that fungal proteases may play a role in the pathogenicity of fungi. Since the airways are the most common route for entry of A. fumigatus, this study focused on the ability of fungal proteases to induce the release of proinflammatory cytokines and to cause cell detachment in human pulmonary epithelial cell lines. It was shown that fungal serine protease activity induced the production of in... Abstract
Cited 76 times since 1997 (2.8 per year) source: EuropePMC
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 27, Issue 7, 1 1 1997, Pages 769-779 Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies. Grootendorst DC, Sont JK, Willems LN, Kluin-Nelemans JC, Van Krieken JH, Veselic-Charvat M, Sterk PJ
Background: Induced sputum potentially allows monitoring of airway inflammation in patients with asthma in a non-invasive way. However, the relationship between the cellular content in sputum and airway tissue has not been fully clarified. Objective: We compared the cellular compositions of hypertonic saline-induced sputum, bronchoalveolar lavage fluid (BAL) and bronchial biopsies in 18 clinically stable patients with mild to moderate atopic asthma (baseline FEV1: range 61-114%pred, PC20 methach... Abstract
Cited 24 times since 1997 (0.9 per year) source: EuropePMC
Circulation, Volume 96, Issue 2, 1 1 1997, Pages 429-435 Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS) Aengevaeren WR, Uijen GJ, Jukema JW, Bruschke AV, van der Werf T
Background: Lipid-lowering therapy during 2 years in the Regression Growth Evaluation Statin Study (REGRESS) was associated with less progression of coronary atherosclerosis in the pravastatin group compared with the placebo group. The effect of lipid-lowering therapy on the functional state of the coronary circulation is less well known. The purpose of this study was to evaluate this effect. Methods and results: In a substudy of REGRESS, 69 patients were randomized to pravastatin or placebo. Th... Abstract
Cited 131 times since 1997 (4.9 per year) source: EuropePMC
The European respiratory journal, Volume 10, Issue 6, 1 1 1997, Pages 1372-1379 Current aspects of spontaneous pneumothorax. Schramel FM, Postmus PE, Vanderschueren RG
Although spontaneous pneumothoraces have been recognized and treated for almost 180 yrs, new aspects have emerged concerning pathogenesis, diagnostic procedures and treatment modalities. In spite of the fact that blebs and bullae are frequently found in patients with primary spontaneous pneumothorax, they seldom seem to be the actual cause of the pneumothorax. Inflammatory changes in the distal airways play an important role in the occurrence of the pneumothorax during transpulmonary pressure ch... Abstract
Cited 87 times since 1997 (3.2 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 15, Issue 6, 1 1 1997, Pages 2456-2466 Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer. Apolinario RM, van der Valk P, de Jong JS, Deville W, van Ark-Otte J, Dingemans AM, van Mourik JC, Postmus PE, Pinedo HM, Giaccone G
Purpose: To assess the prognostic value of p53, bcl-2, bax, and neovascularization in radically resected non-small-cell lung cancer (NSCLC) patients. Patients and methods: Tumors from 116 patients were assessed by immunohistochemistry for expression of p53 (DO7 and PAb1081), bcl-2, and the quantification of microvessel density (CD-31). In addition, the expression of bax was assessed in 61 stage I tumors. The median levels of expression of each marker were used as cutoff points. Results: p53 was... Abstract