Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 8 times since 1997 (0.3 per year) source: EuropePMC
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Volume 13, 1 1 1997, Pages 72-76 Restriction coefficients of low molecular weight solutes and macromolecules during peritoneal dialysis. Ho-dac-Pannekeet MM, Koopmans JG, Struijk DG, Krediet RT
The intrinsic permeability of the peritoneal membrane can be functionally represented by the restriction coefficient (RC). The RC can be calculated as the exponent of the power relation between the mass transfer area coefficients (MTACs) of various solutes and their free diffusion coefficients in water. When the RC = 1.0, transport is determined by free diffusion only, as is expected for low molecular weight (LMW) solutes. A RC > 1.0 suggests that transport is restricted by the peritoneal mem... Abstract
Cited 12 times since 1997 (0.4 per year) source: EuropePMC
British journal of cancer, Volume 76, Issue 1, 1 1 1997, Pages 29-35 A quantitative reverse transcriptase polymerase chain reaction-based assay to detect carcinoma cells in peripheral blood. Helfrich W, ten Poele R, Meersma GJ, Mulder NH, de Vries EG, de Leij L, Smit EF
The presence of tumour cells in the circulation may predict disease recurrence and metastasis. To improve on existing methods of cytological or immunocytological detection, we have developed a sensitive and quantitative technique for the detection of carcinoma cells in blood, using the reverse transcriptase polymerase chain reaction (RT-PCR) identifying transcripts of the pancarcinoma-associated tumour marker EGP-2 (KSA or 17-1A antigen). The amount of EGP2 mRNA was quantified using an internal... Abstract
Cited 18 times since 1997 (0.7 per year) source: EuropePMC
The Journal of infectious diseases, Volume 175, Issue 1, 1 1 1997, Pages 108-117 Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. Dentener MA, Francot GJ, Hiemstra PS, Tool AT, Verhoeven AJ, Vandenabeele P, Buurman WA
In this study, the release of bactericidal/permeability-increasing protein (BPI), which is stored in polymorphonuclear leukocytes (PMNL), was analyzed in a whole blood ex vivo system. Of the microbial products tested, lipopolysaccharide (LPS) most potently induced BPI release; FMLP, serum-treated zymosan (STZ), and lipoteichoic acid (LTA) also induced BPI release. In addition, the inflammatory mediator tumor necrosis factor (TNF)-alpha potently activated PMNL in whole blood, via TNF receptor p55... Abstract
Cited 13 times since 1997 (0.5 per year) source: EuropePMC
British journal of cancer, Volume 75, Issue 10, 1 1 1997, Pages 1447-1453 Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan. Borel Rinkes IH, de Vries MR, Jonker AM, Swaak TJ, Hack CE, Nooyen PT, Wiggers T, Eggermont AM
Isolated limb perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan is well tolerated and highly effective in irresectable sarcoma and melanoma. No data are available on isolated hepatic perfusion (IHP) with these drugs for irresectable hepatic malignancies. This study was undertaken to assess the feasibility of such an approach by analysing hepatic and systemic toxicity of IHP with TNF-alpha with and without melphalan in pigs. Ten healthy pigs underwent IHP. After vascular isola... Abstract
Cited 7 times since 1997 (0.3 per year) source: EuropePMC
Respiration; international review of thoracic diseases, Volume 64, Issue 1, 1 1 1997, Pages 29-34 Nocturnal waking and morning dip of peak expiratory flow in clinically stable asthma patients during treatment. Occurrence and patient characteristics. Van Keimpema AR, Ariaansz M, Tamminga JJ, Nauta JJ, Postmus PE
The occurrence of nocturnal waking due to asthma and morning dip of the peak expiratory flow (PEF), and the associated patient characteristics were investigated in 103 clinically stable asthmatic patients from a pulmonary outpatient clinic. Analysis of a 1 week diary showed a mean week morning PEF dip (i.e. morning/daytime highest PEF) of 12%. A mean dip of > or = 20% was found in 20% of the patients. Three groups were distinguished: 10% were 'nocturnal-waking patients' (waking up &... Abstract
Cited 93 times since 1997 (3.4 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 15, Issue 1, 1 1 1997, Pages 317-329 Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre. Huizing MT, Giaccone G, van Warmerdam LJ, Rosing H, Bakker PJ, Vermorken JB, Postmus PE, van Zandwijk N, Koolen MG, ten Bokkel Huinink WW, van der Vijgh WJ, Bierhorst FJ, Lai A, Dalesio O, Pinedo HM, Veenhof CH, Beijnen JH
Purpose: To investigate the pharmacokinetics and pharmacodynamics of paclitaxel (P) and carboplatin (C) in a sequence-finding and dose-escalating study in untreated non-small-cell lung cancer (NSCLC) patients. Patients and methods: Fifty-five chemotherapy-naive patients with NSCLC were entered onto the pharmacokinetic part of a large phase I trial in which P was administered as a 3-hour infusion at dosages of 100 to 250 mg/m2, and C over 30 minutes at dosages of 300 to 400 mg/m2. Patients were r... Abstract
Cited 112 times since 1997 (4.1 per year) source: EuropePMC
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 27, Issue 1, 1 1 1997, Pages 36-45 Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Grünberg K, Timmers MC, Smits HH, de Klerk EP, Dick EC, Spaan WJ, Hiemstra PS, Sterk PJ
Background: Asthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear. Objective: To examine the effect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine, and on interleukin-8 (IL-8) in nasal lavage. Methods: Twenty-seven non-smoking atopic, mildly asthmatic subjects participated in a placebo-controlled, parallel study. A dose of 0.5-2.9 x 10(4) TCID50 RV16 o... Abstract
Cited 14 times since 1997 (0.5 per year) source: EuropePMC
Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 216-226 Effect of post-hypoxic-ischemic inhibition of nitric oxide synthesis on cerebral blood flow, metabolism and electrocortical brain activity in newborn lambs. Dorrepaal CA, Shadid M, Steendijk P, Van der Velde ET, Van de Bor M, Baan J, Van Bel F
Since an excessive production of nitric oxide upon reperfusion/reoxygenation may play an important role in post-hypoxic-ischemic (HI) brain injury, we investigated whether immediate post-HI blockade of nitric oxide synthesis by N-omega-nitro-L-arginine (NLA) may reduce this injury. In 18 newborn lambs, subjected to severe HI, changes from pre-HI values were measured for carotid blood flow (Qcar [ml/min]) as a measure of changes in brain blood flow, (relative) cerebral metabolic rate of oxygen (C... Abstract
Cited 105 times since 1996 (3.8 per year) source: EuropePMC
The European respiratory journal, Volume 9, Issue 12, 1 1 1996, Pages 2441-2447 Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. in 't Veen JC, de Gouw HW, Smits HH, Sont JK, Hiemstra PS, Sterk PJ, Bel EH
Sputum induced by inhalation of nebulized hypertonic saline is increasingly used to monitor airways inflammation in asthma. The aim of this study was to assess the repeatability of measuring cellular and soluble markers of inflammation in whole sputum samples as obtained by sputum induction in patients both with mild and moderate-to-severe asthma. Twelve patients with mild, atopic asthma without inhaled steroid treatment and nine patients with moderate-to-severe, atopic asthma treated with inhal... Abstract
Cited 1 times since 1996 (0 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 140, Issue 52, 1 1 1996, Pages 2632-2635 [Hypertension caused by licorice consumption]. Seelen MA, de Meijer PH, Braun J, Swinkels LM, Waanders H, Meinders AE
In a 38-year-old woman who was hospitalized because of hypertension and hypokalaemic alkalosis, the intake of liquorice (200 g per day) was proven to be the cause. A liquorice provocation test produced all the expected clinical and biochemical abnormalities. Some kinds of liquorice contain glycyrrhetic acid which inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase (e.g. in the kidney) leading to decreased transformation of cortisol into cortisone. The mineralocorticoid action of cortisol ca... Abstract
Cited 18 times since 1996 (0.7 per year) source: EuropePMC
Investigative radiology, Volume 31, Issue 12, 1 1 1996, Pages 761-767 Assessment of the progression of emphysema by quantitative analysis of spirometrically gated computed tomography images. Zagers H, Vrooman HA, Aarts NJ, Stolk J, Schultze Kool LJ, Dijkman JH, Van Voorthuisen AE, Reiber JH
Rationale and objectives: The authors assessed the progression of pulmonary emphysema by means of quantitative analysis of computed tomography images. Methods: Twenty-three patients suffering from emphysema due to an alpha 1-antitrypsin deficiency, aged 45 +/- 7 years and exsmokers, were scanned twice with a 1-year time interval. At 90% of the vital lung capacity, slices with a thickness of 1.5 mm were acquired at the level of the carina and 5 cm above the carina; slices with a thickness of 1 cm... Abstract
Cited 4 times since 1996 (0.1 per year) source: EuropePMC
Basic research in cardiology, Volume 91, Issue 6, 1 1 1996, Pages 468-478 Systolic coronary flow reduction in the canine heart in situ: effects of left ventricular pressure and elastance. Baan J, Steendijk P, Mikuniya A, Baan J
In the externally perfused coronary bed of the isolated heart, LV elastance (Elv) rather than LV pressure (Plv) appears to be the major factor responsible for systolic coronary flow reduction, although effects of both have been demonstrated. However, normal perfusion in the presence of intact autoregulation in the heart in situ may modify these effects. To investigate the systolic coronary flow (Qsyst) responses to changes in end-systolic Elv and in systolic Plv in the intact coronary bed, we st... Abstract
Cited 6 times since 1996 (0.2 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 6, Issue 6, 1 1 1996, Pages 948-949 Development of an MRI-compatible catheter for pacing the heart: initial in vitro and in vivo results. Jerzewski A, Pattynama PM, Steendijk P, Doornbos J, de Roos A, Baan J
An MRI-compatible catheter was developed for pacing the heart during MRI imaging. The device was tested in vitro and in vivo in 10 animal experiments, using spin-echo, gradient-echo, and echo-planar MRI sequences. Images were of good quality in all sequences. Pacing was effective without induced arrhythmias. Therefore, pacing the heart during MRI is feasible and seems to be safe when using dedicated hardware. Abstract
Nederlands tijdschrift voor geneeskunde, Volume 140, Issue 46, 1 1 1996, Pages 2261-2262 [All lung tumors are not the same]. Stolk J, van Klink HC, Willems LN
Cited 27 times since 1996 (1 per year) source: EuropePMC
Journal of photochemistry and photobiology. B, Biology, Volume 36, Issue 2, 1 1 1996, Pages 199-204 Photodynamic therapy in lung cancer. A review. Sutedja TG, Postmus PE
Photodynamic therapy (PDT) in lung cancer was introduced in 1980 to treat tumours located in the major airways. After systemic injection of photosensitizers, tumour illumination is performed using a laser fibre to transmit light of a specific wavelength. PDT can be performed under local anaesthesia using the flexible fibreoptic bronchoscope. Skin photosensitivity is the most important treatment morbidity caused by the prolonged cutaneous retention of photosensitizer molecules. Ample data have sh... Abstract
Cited 209 times since 1996 (7.6 per year) source: EuropePMC
Infection and immunity, Volume 64, Issue 11, 1 1 1996, Pages 4520-4524 Antibacterial activity of antileukoprotease. Hiemstra PS, Maassen RJ, Stolk J, Heinzel-Wieland R, Steffens GJ, Dijkman JH
Antileukoprotease (ALP), or secretory leukocyte proteinase inhibitor, is an endogenous inhibitor of serine proteinases that is present in various external secretions. ALP, one of the major inhibitors of serine proteinases present in the human lung, is a potent reversible inhibitor of elastase and, to a lesser extent, of cathepsin G. In equine neutrophils, an antimicrobial polypeptide that has some of the characteristics of ALP has been identified (M. A. Couto, S. S. L. Harwig, J. S. Cullor, J. P... Abstract
Cited 11 times since 1996 (0.4 per year) source: EuropePMC
Annals of hematology, Volume 73, Issue 4, 1 1 1996, Pages 183-188 Hb Malmö [beta-97(FG-4)His-->Gln] leading to polycythemia in a Dutch family. Giordano PC, Harteveld CL, Brand A, Willems LN, Kluin-Nelemans HC, Plug RJ, Batelaan DN, Bernini LF
We have examined six individuals from a two-generation Dutch family for a suspected hemoglobin (Hb) abnormality. The propositus presented with polycythemia and complained of persistent weakness, headache, and epistaxis. All family members initially showed a normal Hb-electrophoretic pattern, but on isoelectric focusing, three of them displayed a fast-moving band associated with high packed red cell volumes (PCV) and increased red blood cell count. The Hb mutant was analyzed at the DNA level by s... Abstract
Cited 87 times since 1996 (3.2 per year) source: EuropePMC
Circulation, Volume 94, Issue 7, 1 1 1996, Pages 1503-1505 Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. REGRESS Study Group. van Boven AJ, Jukema JW, Zwinderman AH, Crijns HJ, Lie KI, Bruschke AV
Background: Lipid-lowering therapy reduces cardiac morbidity and mortality. Less is known about its potential anti-ischemic effect. Methods and results: In a 2-year prospective randomized placebo-controlled study, the effect of pravastatin 40 mg on transient myocardial ischemia was assessed. Forty-eight-hour ambulatory ECGs with continuous ST-segment analysis were performed in 768 male patients with stable angina pectoris, documented coronary artery disease, and serum cholesterol between 4 and 8... Abstract
Cited 9 times since 1996 (0.3 per year) source: EuropePMC
Seminars in oncology, Volume 23, Issue 5 Suppl 12, 1 1 1996, Pages 10-13 Results of the phase II EORTC study comparing paclitaxel/cisplatin with teniposide/cisplatin in patients with non-small cell lung cancer. EORTC Lung Cancer Cooperative Group. Postmus PE, Giaccone G, Debruyne C, Sahmoud T, Splinter TA, van Zandwijk N
Toxicity and response rates are evaluated in a randomized phase II study comparing paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ)/cisplatin with teniposide/cisplatin in the treatment of non-small cell lung cancer to decide whether this study should continue as a phase III trial. A response was seen in 26% (10 of 38) of the patients receiving teniposide/cisplatin and in 40% (14 of 35) of those receiving paclitaxel/cisplatin. Overall, evidence of toxicity was more severe in the ci... Abstract
Cited 57 times since 1996 (2.1 per year) source: EuropePMC
Circulation, Volume 94, Issue 8, 1 1 1996, Pages 1913-1918 The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. Jukema JW, van Boven AJ, Groenemeijer B, Zwinderman AH, Reiber JH, Bruschke AV, Henneman JA, Molhoek GP, Bruin T, Jansen H, Gagné E, Hayden MR, Kastelein JJ
Background: Many patients suffering from premature coronary artery disease report a family history for such events. A mutation in a particular gene, which confers susceptibility for atherosclerosis, will be found more frequently in individuals suffering from coronary atherosclerosis than in the general population. We have recently reported the identification of an Asp9 Asn substitution in the lipoprotein lipase (LPL) enzyme. We analyzed the impact of this mutation on the progression of coronary... Abstract