Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7496 results
Cited 37 times since 1998 (1.4 per year) source: EuropePMC
American heart journal, Volume 135, Issue 4, 1 1 1998, Pages 571-576 Depressed heart rate variability is associated with events in patients with stable coronary artery disease and preserved left ventricular function. REGRESS Study Group. van Boven AJ, Jukema JW, Haaksma J, Zwinderman AH, Crijns HJ, Lie KI
Background: Little is known about the value of heart rate variability in patients with symptomatic coronary artery disease with a preserved left ventricular function. We hypothesized that in these patients heart rate variability might be a helpful adjunct to conventional parameters to predict clinical events. Methods: In a prospective 2-year follow-up study ambulatory electrocardiographic recordings were performed in 263 consecutive male patients (mean age 56+/-8 years) with stable angina pector... Abstract
Cited 1 times since 1998 (0 per year) source: EuropePMC
The Turkish journal of pediatrics, Volume 40, Issue 2, 1 1 1998, Pages 279-281 Subcutaneous granuloma annulare and IgA-IgG2 deficiency. Kütükçüler N, Tütüncüoğlu S, Yilmaz D, Akalin T, Kandiloğlu G
Subcutaneous granuloma annulare (SGA) is a benign granulomatous disease occurring in childhood, with lesions most commonly located about the elbow, knee and scalp. the etiology of SGA remains obscure. We present a typical case with SGA also showing laboratory findings of IgA and IgG2 deficiency. Histologic findings of the lesions on the scalp were characterized by multiple large foci of complete collagen degeneration with a peripheral pallsade of histiocytes; the foci of degeneration was edemato... Abstract
Cited 5 times since 1998 (0.2 per year) source: EuropePMC
Inflammation, Volume 22, Issue 2, 1 1 1998, Pages 229-242 Expression of adhesion molecules on granulocytes and monocytes from patients with asthma stimulated in vitro with interleukin-8 and monocyte chemotactic protein-1. Verdegaal EM, Zegveld ST, Blokland I, Beekhuizen H, Bakker W, Willems LN, van Furth R
Upregulation of adhesion molecule expression on endothelial cells (EC) and circulating leukocytes, by locally produced inflammatory mediators, may result in the enhanced infiltration of leukocytes into tissue, e.g. the airways of asthma patients. The present study investigates whether the expression of adhesion molecules on granulocytes and monocytes from asthma patients is affected by chemotactic factors, i.e. interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1). Flow cytometric anal... Abstract
Cited 16 times since 1998 (0.6 per year) source: EuropePMC
Free radical biology & medicine, Volume 24, Issue 6, 1 1 1998, Pages 952-958 Ozone-induced airway hyperresponsiveness in patients with asthma: role of neutrophil-derived serine proteinases. Hiltermann TJ, Peters EA, Alberts B, Kwikkers K, Borggreven PA, Hiemstra PS, Dijkman JH, van Bree LA, Stolk J
Proteinase inhibitors may be of potential therapeutic value in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) or asthma. Our aim was to study the role of neutrophils, and neutrophil-derived serine proteinases in an acute model in patients with asthma. Exposure to ozone induces an acute neutrophilic inflammatory reaction accompanied by an increase in airway hyperresponsiveness. It is thought that these two effects of ozone are linked, and that neutrophi... Abstract
Cited 6 times since 1998 (0.2 per year) source: EuropePMC
International journal of cardiac imaging, Volume 14, Issue 2, 1 1 1998, Pages 123-126 Embolization as a treatment of life-threatening haemoptysis in an adult with Tetralogy of Fallot with pulmonary atresia. van der Weijden P, Baur LH, Kool LJ, Vliegen HW, van der Wall EE
Aim: Description of embolization as a treatment for bleeding bronchopulmonary collaterals in congenital heart disease. Methods: After palliative corrective surgery of Tetralogy of Fallot with pulmonary atresia, haemoptysis due to ruptured bronchopulmonary collaterals is a well known complication. We describe a 31 year old patient with haemoptysis after incomplete correction because of Tetralogy of Fallot with pulmonary atresia. Because supportive treatment failed, the bleeding site was localized... Abstract
Cited 33 times since 1998 (1.3 per year) source: EuropePMC
The European respiratory journal, Volume 11, Issue 3, 1 1 1998, Pages 686-693 Asthma severity and susceptibility to air pollution. Hiltermann TJ, Stolk J, van der Zee SC, Brunekreef B, de Bruijne CR, Fischer PH, Ameling CB, Sterk PJ, Hiemstra PS, van Bree L
Exacerbations of asthma have been associated with exposure to ozone or particles with a 50% cut-off aerodynamic diameter of 10 microm (PM10). We postulated in this study that the association of summertime air pollution (i.e. ozone and PM10) with acute respiratory symptoms, medication use and peak expiratory flow differs among patients grouped according to asthma severity. During the summer of 1995, effects of ambient air pollution on these parameters were studied in a panel of 60 nonsmoking pati... Abstract
Cited 3 times since 1998 (0.1 per year) source: EuropePMC
Pediatric research, Volume 43, Issue 3, 1 1 1998, Pages 331-337 Contribution of synchronized atrial systole to left ventricular contraction in the newborn pig heart. Klautz RJ, Baan J, Teitel DF
Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and whether this effect can be fully explained by the Starling mechanism. In neonatal piglets, left ventricular pressure and volume (conductance catheter) were measured during atrial a... Abstract
Cited 13 times since 1998 (0.5 per year) source: EuropePMC
Vision research, Volume 38, Issue 5, 1 1 1998, Pages 659-668 Stereoscopic segregation of transparent surfaces and the effect of motion contrast. Lankheet MJ, Palmen M
Stereoscopic segregation in depth was studied using two superimposed frontoparallel surfaces displayed in dynamic random dot stereograms. The two patterns were positioned symmetrically in front of and behind a binocular fixation point. They were either stationary, or they could move relative to each other. Sensitivity for segregation was established by adding gaussian distributed disparity noise to the disparities specifying the two planes, and finding the noise amplitude that gave threshold seg... Abstract
Cited 10 times since 1998 (0.4 per year) source: EuropePMC
Physiological measurement, Volume 19, Issue 1, 1 1 1998, Pages 27-34 Influences of lung parenchyma density and thoracic fluid on ventilatory EIT measurements. Kunst PW, Vonk Noordegraaf A, Straver B, Aarts RA, Tesselaar CD, Postmus PE, de Vries PM
Ventilatory impedance changes can be measured by electrical impedance tomography (EIT). Several studies have pointed out that the ventilatory-induced impedance change measured over the lungs shows a linear relationship with tidal volume. However, EIT measures the ventilatory impedance changes relative to a reference. Therefore, changes in the reference due to lung parenchyma destruction (increase of thoracic impedance) or lung water (decrease of thoracic impedance) might influence ventilatory EI... Abstract
Cited 55 times since 1998 (2.1 per year) source: EuropePMC
Thorax, Volume 53, Issue 2, 1 1 1998, Pages 114-116 Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option? Tomee JF, Koëter GH, Hiemstra PS, Kauffman HF
Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine protease inhibitor found on various mucosal surfaces and has been ascribed an important role in maintaining the protease-anti-protease balance of the airways. Recent scientific evidence has suggested that SLPI may also have a broad spectrum antibiotic activity that includes antiretroviral, bactericidal, and antifungal activity. Given the unpropitious development of drug resistance to infectious micro-organisms in the human... Abstract
Cited 66 times since 1998 (2.5 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 18, Issue 2, 1 1 1998, Pages 265-271 -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group. de Maat MP, Kastelein JJ, Jukema JW, Zwinderman AH, Jansen H, Groenemeier B, Bruschke AV, Kluft C
Increased plasma fibrinogen levels have been identified as a risk indicator for myocardial infarction, stroke, and thrombosis. Both environmental and genetic factors make an important contribution to plasma fibrinogen levels in humans. In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the relation of plasma levels and polymorphisms of fibrinogen with coronary artery disease (CAD), cross-sectionally at baseline and after a 2-year follow-up period... Abstract
Cited 11 times since 1998 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 81, Issue 3, 1 1 1998, Pages 302-305 Subcutaneous single-incision implantation of cardioverter-defibrillators under local anesthesia by electrophysiologists in the electrophysiology laboratory. van Rugge FP, Savalle LH, Schalij MJ
Implantable cardioverter-defibrillators (ICDs) have traditionally been implanted at the operating room under general anesthesia. Endocardial lead systems and downsized devices allowed implantation by electrophysiologists in the pectoral region. The present study evaluates the safety and efficacy of subcutaneous ICD implantation performed entirely by electrophysiologists using a single-incision approach for lead insertion and device placement under local anesthesia. Between June 1996 and May 1997... Abstract
Cited 2 times since 1998 (0.1 per year) source: EuropePMC
The Netherlands journal of medicine, Volume 52, Issue 2, 1 1 1998, Pages 65-70 Pretreatment serum LDH as additional staging parameter in small-cell lung carcinoma. Stokkel MP, van Eck-Smit BL, Zwinderman AH, Willems LN, Pauwels EK
Background: In patients with limited disease staged small-cell lung cancer (SCLC), overall survival is still poor. Therefore, a retrospective study was carried out of 48 patients with limited disease staged SCLC to select a parameter which can identify prognostic subgroups at the time of diagnosis. Materials and methods: Follow-up varied from 3 to 96 months during which 38 patients died. Based on clinical outcome, patients were clustered into three groups: complete remission (CR) (n = 16); local... Abstract
Cited 102 times since 1998 (3.9 per year) source: EuropePMC
Circulation, Volume 97, Issue 7, 1 1 1998, Pages 666-672 Functional and metabolic evaluation of the athlete's heart by magnetic resonance imaging and dobutamine stress magnetic resonance spectroscopy. Pluim BM, Lamb HJ, Kayser HW, Leujes F, Beyerbacht HP, Zwinderman AH, van der Laarse A, Vliegen HW, de Roos A, van der Wall EE
Background: The question of whether training-induced left ventricular hypertrophy in athletes is a physiological rather than a pathophysiological phenomenon remains unresolved. The purpose of the present study was to detect any abnormalities in cardiac function in hypertrophic hearts of elite cyclists and to examine the response of myocardial high-energy phosphate metabolism to high workloads induced by atropine-dobutamine stress. Methods and results: We studied 21 elite cyclists and 12 healthy... Abstract
Cited 31 times since 1998 (1.2 per year) source: EuropePMC
Clinical and experimental immunology, Volume 111, Issue 2, 1 1 1998, Pages 463-468 Cytokine release and its modulation by dexamethasone in whole blood following exercise. Smits HH, Grünberg K, Derijk RH, Sterk PJ, Hiemstra PS
Glucocorticoids (GC) play an important role in the treatment of inflammatory diseases like asthma. However, in selected patients a relative resistance to GC has been reported. Recently, it has been suggested that GC sensitivity of peripheral blood leucocytes may be regulated in a dynamic fashion during exercise, in association with activation of the hypothalamic-pituitary-adrenal (HPA) axis. The aim of the present study was to explore changes in the GC sensitivity of cytokine production by leuco... Abstract
Cited 28 times since 1998 (1.1 per year) source: EuropePMC
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Volume 147, 1 1 1998, Pages 107-119 Isolated hepatic perfusion with tumor necrosis factor alpha and melphalan: experimental studies in pigs and phase I data from humans. de Vries MR, Borel Rinkes IH, van de Velde CJ, Wiggers T, Tollenaar RA, Kuppen PJ, Vahrmeijer AL, Eggermont AM
We report our experience with isolated hepatic perfusion (IHP) with tumor necrosis factor (TNF) and melphalan in an experimental pig study and of a phase I study in humans. IHP was performed with inflow catheters in the hepatic artery and portal vein and an outflow catheter in eh caval vein. An extracorporeal venovenous bypass was used. IHP consisted of a 60-min perfusion with hyperthermia (> 41 degrees C). For the pig protocol rhTNF alpha 50 micrograms/kg alone (n = 5) or rhTNF alpha 50 micr... Abstract
Cited 48 times since 1998 (1.8 per year) source: EuropePMC
The European respiratory journal, Volume 11, Issue 1, 1 1 1998, Pages 169-172 Radiographically occult lung cancer treated with fibreoptic bronchoscopic electrocautery: a pilot study of a simple and inexpensive technique. van Boxem TJ, Venmans BJ, Schramel FM, van Mourik JC, Golding RP, Postmus PE, Sutedja TG
The curative potential of bronchoscopic intervention, e.g. photodynamic therapy (PDT) and brachytherapy, for resectable radiographically occult lung cancer has been reported previously. Bronchoscopic electrocautery is currently feasible using an insulated flexible bronchoscope to coagulate and vaporize tumour tissue. Since the lesions are usually small, noninvasive bronchoscopic electrocautery may be able to eradicate radiographically occult lung cancer completely. In a prospective study, 13 pat... Abstract
Cited 15 times since 1998 (0.6 per year) source: EuropePMC
Chest, Volume 113, Issue 1 Suppl, 1 1 1998, Pages 28S-31S Chemotherapy for non-small cell lung cancer: the experience of the Lung Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer. Postmus PE
The Lung Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer was founded in 1981. During the past 15 years, the group has participated in the development of treatment of non-small cell lung cancer with chemotherapy. The group performed standard phase II studies of new drugs and phase III studies with new and active drugs. Furthermore, the group performed studies combining chemotherapy with treatment for localized disease. Abstract
Cited 10 times since 1998 (0.4 per year) source: EuropePMC
Journal of cancer research and clinical oncology, Volume 124, Issue 3-4, 1 1 1998, Pages 215-219 Pretreatment serum lactate dehydrogenase as additional staging parameter in patients with small-cell lung carcinoma. Stokkel MP, van Eck-Smit BL, Zwinderman AH, Willems LN, Pauwels EK
Purpose: At present the standard staging procedure in patients with small-cell lung cancer (SCLC) is extensive, expensive and time-consuming. Furthermore, the predictive and prognostic value of the current staging system is poor. To determine the value of pretreatment clinical and biochemical parameters to predict tumour stage and to assess prognosis, a retrospective study was performed of 121 consecutive patients with newly diagnosed SCLC. Methods: On the basis of routine diagnostic procedures,... Abstract
Cited 31 times since 1998 (1.2 per year) source: EuropePMC
Clinical genetics, Volume 53, Issue 1, 1 1 1998, Pages 27-33 The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group. Kastelein JJ, Groenemeyer BE, Hallman DM, Henderson H, Reymer PW, Gagné SE, Jansen H, Seidell JC, Kromhout D, Jukema JW, Bruschke AV, Boerwinkle E, Hayden MR
Two mutations in the lipoprotein lipase (LPL) gene, a T to G transition at position -93 of the proximal promoter region and an Asp9Asn substitution in exon 2, were examined in 762 Dutch males with angiographically-diagnosed coronary artery disease (CAD) and 296 healthy normolipidemic Dutch males. The two mutations exhibited strong linkage disequilibrium (D' = 0.975). A significantly higher proportion of cases (4.86%) than controls (1.37%) carried the -93G/Asn9 allele (p = 0.008). In the com... Abstract