Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7518 results
Cited 72 times since 1998 (2.8 per year) source: EuropePMC
The Journal of investigative dermatology, Volume 111, Issue 6, 1 1 1998, Pages 996-1002 Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. Wingens M, van Bergen BH, Hiemstra PS, Meis JF, van Vlijmen-Willems IM, Zeeuwen PL, Mulder J, Kramps HA, van Ruissen F, Schalkwijk J
Secretory leukocyte protease inhibitor (SLPI) is a small, cationic protein that is known to be constitutively expressed by several glandular epithelia. SLPI inhibits leukocyte-derived proteinases, has anti-HIV-1, antibacterial, and anti-fungal properties, and interferes with the induction of synthesis of proinflammatory mediators in monocytes and macrophages. We now report that at both the mRNA and the protein level, SLPI shows inducible expression in a nonglandular epithelium. A weak expression... Abstract
Cited 18 times since 1998 (0.7 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 66, Issue 6 Suppl, 1 1 1998, Pages S225-32 Tissue chimerism in human cryopreserved homograft valve explants demonstrated by in situ hybridization. Koolbergen DR, Hazekamp MG, Kurvers M, de Heer E, Cornelisse CJ, Huysmans HA, Bruijn JA
Background: The presence of viable cells may contribute to increased homograft valve durability. These cells may be of infiltrating recipient or persisting donor origin. In this study, in situ hybridization was used to assess the origin of cells in cryopreserved homograft valve explants. Methods: A total of 10 homografts with a donor-recipient gender mismatch were acquired from patients whose graft had been explanted at reoperation or at autopsy. The period of implantation varied from 14 days to... Abstract
Cited 37 times since 1998 (1.5 per year) source: EuropePMC
The European respiratory journal, Volume 12, Issue 6, 1 1 1998, Pages 1419-1423 Talc-induced inflammation in the pleural cavity. van den Heuvel MM, Smit HJ, Barbierato SB, Havenith CE, Beelen RH, Postmus PE
Talc administration into the pleural cavity induces pleurodesis. To obtain further insight into the inflammatory process that causes pleurodesis, the cellular kinetics in the pleural space after the administration of talc was studied, along with its relation to chemokine concentrations in the pleural fluid. Thirteen consecutive patients with idiopathic spontaneous pneumothorax and eight patients with malignant pleural effusions received talc pleurodesis. The first group was treated with talc pou... Abstract
Cited 187 times since 1998 (7.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 158, Issue 6, 1 1 1998, Pages 1951-1957 Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. de Boer WI, van Schadewijk A, Sont JK, Sharma HS, Stolk J, Hiemstra PS, van Krieken JH
Chronic airways inflammation is one of the features of chronic obstructive pulmonary disease (COPD). We demonstrated previously that bronchiolar epithelium in COPD contains increased numbers of macrophages and mast cells. Transforming growth factor beta1 (TGF-beta1) may be involved in this influx because it has chemotactic activity for macrophages and mast cells. In this study, we examined expression patterns of TGF-beta1, TGF-beta receptors type I and II (TGF-betaRI and TGF-betaRII) by immunohi... Abstract
Cited 15 times since 1998 (0.6 per year) source: EuropePMC
Development, growth & differentiation, Volume 40, Issue 6, 1 1 1998, Pages 577-582 Hormone-inducible expression of secreted factors in zebrafish embryos. de Graaf M, Zivkovic D, Joore J
The study of gene function at later stages of embryonic development by overexpression experiments is often complicated by genes exerting different functions at multiple stages of development, which renders analysis of stage-specific effects difficult. To address this problem an inducible expression system that supports timed expression of essentially any protein, including secreted proteins was designed. The system is based on a two step mechanism. A glucocorticoid inducible, Gal4-site binding c... Abstract
Cited 39 times since 1998 (1.5 per year) source: EuropePMC
The Journal of biological chemistry, Volume 273, Issue 50, 1 1 1998, Pages 33267-33272 Mitogenic effects of urokinase on melanoma cells are independent of high affinity binding to the urokinase receptor. Koopman JL, Slomp J, de Bart AC, Quax PH, Verheijen JH
The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u-PA purified from urine induced a mitogenic response in quiescent IF6 and M14 cells that ranged from 25 to 40% of the mitogenic response obtained by fetal calf serum. The half-maximum response in M14 and IF6 cel... Abstract
Cited 43 times since 1998 (1.7 per year) source: EuropePMC
Blood, Volume 92, Issue 10, 1 1 1998, Pages 3898-3903 Inhibition of activation of the classical pathway of complement by human neutrophil defensins. van den Berg RH, Faber-Krol MC, van Wetering S, Hiemstra PS, Daha MR
Defensins are small, cationic antimicrobial peptides that are present in the azurophilic granules of neutrophils. Earlier studies have shown that defensins may influence complement activation by specific interaction with activated C1, C1q, and C1-inhibitor. In the present study, we show that the defensin human neutrophil peptide-1 (HNP-1) is able to inhibit activation of the classical complement pathway by inhibition of C1q hemolytic activity. The binding site for HNP-1 on C1q is most likely loc... Abstract
Cited 30 times since 1998 (1.2 per year) source: EuropePMC
Circulation, Volume 98, Issue 20, 1 1 1998, Pages 2168-2179 Endocardial activation mapping of ventricular tachycardia in patients : first application of a 32-site bipolar mapping electrode catheter. Schalij MJ, van Rugge FP, Siezenga M, van der Velde ET
Background: Localization of early activated endocardial areas during ventricular tachycardia (VT) is mandatory for performance of surgical or radiofrequency catheter interventions. The use of a multielectrode catheter may shorten the procedure time and increase the accuracy of the procedure compared with single-electrode mapping techniques. This study was performed to evaluate the safety and efficacy of a 32-bipolar-electrode mapping catheter in patients. Methods and results: The basket-shaped m... Abstract
Cited 63 times since 1998 (2.5 per year) source: EuropePMC
Physiological measurement, Volume 19, Issue 4, 1 1 1998, Pages 481-490 Ventilation and perfusion imaging by electrical impedance tomography: a comparison with radionuclide scanning. Kunst PW, Vonk Noordegraaf A, Hoekstra OS, Postmus PE, de Vries PM
Electrical impedance tomography (EIT) is a technique that makes it possible to measure ventilation and pulmonary perfusion in a volume that approximates to a 2D plane. The possibility of using EIT for measuring the left-right division of ventilation and perfusion was compared with that of radionuclide imaging. Following routine ventilation (81mKr) and perfusion scanning (99mTc-MAA), EIT measurements were performed at the third and the sixth intercostal level in 14 patients with lung cancer. A co... Abstract
Cited 1 times since 1998 (0 per year) source: EuropePMC
The Journal of heart valve disease, Volume 7, Issue 6, 1 1 1998, Pages 615-619 Short-term follow up of the Ross operation in children. Braun J, Hazekamp MG, Schoof PH, Ottenkamp J, Huysmans HA
Background and aims of the study: Aortic valve disease in the pediatric population poses special problems to surgeons and cardiologists. The pulmonary autograft has proven to be a good alternative for aortic valve replacement and left ventricular outflow tract (LVOT) reconstruction in this special group. Methods: Forty-one children (mean age 10.0 +/- 4.8 (SD) years; range: 35 days to 18.8 years) underwent aortic root replacement with a pulmonary autograft between February 1994 and April 1998. Tw... Abstract
Cited 71 times since 1998 (2.8 per year) source: EuropePMC
The European respiratory journal, Volume 12, Issue 5, 1 1 1998, Pages 1200-1208 Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Hiemstra PS, van Wetering S, Stolk J
Neutrophils have the capacity to accumulate in high numbers in the lung during infection and inflammation. Because they play an important role in host defence against infection, but may also cause tissue injury, these cells are thought to be involved in the pathogenesis of various inflammatory lung disorders, including chronic bronchitis and chronic obstructive pulmonary disease. Neutrophil products that may mediate tissue injury at sites of neutrophil-dominated inflammation include the neutroph... Abstract
Cited 37 times since 1998 (1.4 per year) source: EuropePMC
The Journal of biological chemistry, Volume 273, Issue 45, 1 1 1998, Pages 29905-29914 Structural requirements for O-glycosylation of the mouse hepatitis virus membrane protein. de Haan CA, Roestenberg P, de Wit M, de Vries AA, Nilsson T, Vennema H, Rottier PJ
The mouse hepatitis virus (MHV) membrane (M) protein contains only O-linked oligosaccharides. We have used this protein as a model to study the structural requirements for O-glycosylation. We show that MHV M is modified by the addition of a single oligosaccharide side chain at the cluster of 4 hydroxylamino acids present at its extreme amino terminus and identified Thr at position 5 as the functional acceptor site. The hydroxylamino acid cluster, which is quite conserved among O-glycosylated cor... Abstract
Cited 73 times since 1998 (2.8 per year) source: EuropePMC
The Journal of clinical investigation, Volume 102, Issue 8, 1 1 1998, Pages 1583-1590 Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. Welling MM, Hiemstra PS, van den Barselaar MT, Paulusma-Annema A, Nibbering PH, Pauwels EK, Calame W
Neutrophil defensins (or human neutrophil peptides-HNP) are major constituents of the azurophilic granules of human neutrophils and have been shown to display broad-spectrum antimicrobial activity. Other activities of these defensins, which are released from stimulated neutrophils, include cytotoxic, stimulatory, and chemotactic activities toward a variety of target cells. We studied the potential use of HNP-1 for antibacterial therapy of experimental bacterial infections in mice. In experimenta... Abstract
Cited 70 times since 1998 (2.7 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 158, Issue 4, 1 1 1998, Pages 1134-1141 Impaired perception of dyspnea in patients with severe asthma. Relation to sputum eosinophils. Veen JC, Smits HH, Ravensberg AJ, Hiemstra PS, Sterk PJ, Bel EH
Poor dyspnea perception might be a risk factor for developing asthma exacerbations. We investigated whether severe asthmatics with recurrent exacerbations (brittle asthma) have different dyspnea perception and sputum cells compared with equally severe, but stable asthmatics, or patients with mild steroid-naive asthma. Fifteen brittle asthmatics (13 female, median age 28 yr [range, 20 to 47 yr]), 15 matched severe-stable asthmatics (14 female, median age 26 yr [range, 17 to 52 yr]), and 11 mild a... Abstract
Cited 13 times since 1998 (0.5 per year) source: EuropePMC
The Journal of infectious diseases, Volume 178, Issue 4, 1 1 1998, Pages 1067-1074 Stimulation of the adherence of Haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins. Gorter AD, Eijk PP, van Wetering S, Hiemstra PS, Dankert J, van Alphen L
Patients with chronic obstructive pulmonary disease (COPD) frequently have recurrent lower respiratory tract infections with nonencapsulated Haemophilus influenzae. The infected mucosa of these patients is infiltrated with neutrophils, which upon activation may release antimicrobial peptides, including defensins. It was shown that defensins isolated from neutrophils or from sputum samples of COPD patients did not kill H. influenzae from these patients, but they did stimulate its adherence to hum... Abstract
Cited 1 times since 1998 (0 per year) source: EuropePMC
The European respiratory journal, Volume 12, Issue 3, 1 1 1998, Pages 517-518 Immunoglobulin A in asthma: friend or foe? Hiemstra PS
Cited 35 times since 1998 (1.4 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 116, Issue 3, 1 1 1998, Pages 402-406 Bronchoscopic treatment of intraluminal typical carcinoid: a pilot study. van Boxem TJ, Venmans BJ, van Mourik JC, Postmus PE, Sutedja TG
Objective: The curative potential of various bronchoscopic treatments such as Nd:YAG laser, photodynamic therapy, and brachytherapy for the treatment of intraluminal tumor has been reported previously. Bronchoscopic treatment can be used to treat small intraluminal tumor with curative intent, such as in patients with roentgenologically occult squamous cell cancer. In a retrospective study, we showed that bronchoscopic treatment provided excellent local control with surgical proof of cure in 6 of... Abstract
Cited 38 times since 1998 (1.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 32, Issue 3, 1 1 1998, Pages 816-826 Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart. Steendijk P, Baan J, Van der Velde ET, Baan J
Objectives: In this study we quantified the effects of a critical coronary stenosis on global systolic function using pressure-volume relations at baseline and during incremental dobutamine stress. Background: The effects of coronary stenosis have previously been analyzed mainly in terms of regional (dys)function. Global hemodynamics are generally considered normal until coronary flow is substantially reduced. However, pressure-volume analysis might reveal mechanisms not fully exposed by potenti... Abstract
Cited 13 times since 1998 (0.5 per year) source: EuropePMC
Respiratory medicine, Volume 92, Issue 9, 1 1 1998, Pages 1132-1136 The impact of spontaneous pneumothorax, and its treatment, on the smoking behaviour of young adult smokers. Smit HJ, Chatrou M, Postmus PE
The pneumothorax, and its often invasive treatment, are impressive events in otherwise healthy young patients. The relationship between smoking behaviour and the idiopathic spontaneous pneumothorax (ISP) is explained to the patients. The objective of the study was to analyse whether smoking behaviour of patients is influenced by the ISP (re-) event, and its treatment. Of 145 consecutive ISP patients (1991-1995), 112 were tobacco smokers at time of the first ISP. Of the 112, 106 participated in a... Abstract
Cited 31 times since 1998 (1.2 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 8, Issue 5, 1 1 1998, Pages 999-1005 MRI evaluation of right ventricular pressure overload in chronic obstructive pulmonary disease. Marcus JT, Vonk Noordegraaf A, De Vries PM, Van Rossum AC, Roseboom B, Heethaar RM, Postmus PE
In chronic obstructive pulmonary disease (COPD), the development of pulmonary hypertension is common. This study was performed to assess the signs of right ventricular (RV) pressure overload and RV failure in COPD. In 8 COPD patients without primary cardiac disease, RV wall thickness, mass, and end-diastolic volume were measured by cardiac-triggered cine MRI. MR phase-contrast velocity quantification was used to measure stroke volume and the patterns of flow into and out of the RV. Data of patie... Abstract