Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 3 times since 2008 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 152, Issue 16, 1 1 2008, Pages 928-932 [New therapies for the treatment of advanced non-small cell lung cancer: inhibitors of the epidermal growth factor receptor and angiogenesis]. Lind JS, Herder GJ, Smit EF
The recently developed 'targeted' therapies, epidermal growth factor receptor (EGFR) inhibitors and angiogenesis inhibitors, target specific tumour characteristics. EGFR inhibitors, such as gefitinib and erlotinib, can lead to remission, particularly in non-small cell lung cancer (NSCLC) with specific EGFR mutations. These mutations occur more frequently in Asians, women, non-smokers and those with adenocarcinomas. Other mutations in EGFR and K-ras genes lead to resistance. EGFR inhibi... Abstract
Cited 3 times since 2008 (0.2 per year) source: EuropePMC
Minerva cardioangiologica, Volume 56, Issue 2, 1 1 2008, Pages 227-235 Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE
Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (New York Heart Association [NYHA] class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) result in at least 30% of the selected patients with no response to CRT. Recent studies with echocardiography have shown that the presence of LV dyssynchrony is an important predictor for response to CRT. However, the r... Abstract
Cited 4 times since 2008 (0.2 per year) source: EuropePMC
Radiology, Volume 247, Issue 1, 1 1 2008, Pages 293-4; author reply 294 Can the extent of low-attenuation areas on CT scans really demonstrate changes in the severity of emphysema? Stoel BC, Parr DG, Bakker EM, Putter H, Stolk J, Gietema HA, Schilham AM, van Ginneken B, van Klaveren RJ, Lammers JW, Prokop M
Cited 12 times since 2008 (0.7 per year) source: EuropePMC
The Journal of general virology, Volume 89, Issue Pt 4, 1 1 2008, Pages 975-983 Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses. de Graaf M, Herfst S, Schrauwen EJA, Choi Y, van den Hoogen BG, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like mol... Abstract
Cited 114 times since 2008 (7.1 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 51, Issue 16, 1 1 2008, Pages 1588-1596 Long-term prognosis of patients with peripheral arterial disease: a comparison in patients with coronary artery disease. Welten GM, Schouten O, Hoeks SE, Chonchol M, Vidakovic R, van Domburg RT, Bax JJ, van Sambeek MR, Poldermans D
Objectives: This study was designed to compare the long-term outcomes of patients with peripheral arterial disease (PAD) with a risk factor matched population of coronary artery disease (CAD) patients, but without PAD. Background: The PAD is considered to be a risk factor for adverse late outcome. Methods: A total of 2,730 PAD patients undergoing vascular surgery were categorized into groups: 1) carotid endarterectomy (n = 560); 2) elective abdominal aortic surgery (AAA) (n = 923); 3) acute AAA... Abstract
Cited 3 times since 2008 (0.2 per year) source: EuropePMC
Minerva cardioangiologica, Volume 56, Issue 2, 1 1 2008, Pages 215-226 Multi-slice computed tomography coronary angiography: anatomic vs functional assessment in clinical practice. Van Werkhoven JM, Schuijf JD, Jukema JW, Van Der Wall EE, Bax JJ
Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease (CAD). Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-slice computed tomography coronary angiography (CTA), non-invasive imaging of coronary anatomy has also become possible. Studies concerning the diagnostic accuracy have demonstrated... Abstract
Cited 3 times since 2008 (0.2 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 7, Issue 3, 28 4 2008, Pages 517-518 Early atrial septal defect surgery due to a bronchogenic cyst causing congestive heart failure by left atrium compression. Mosquera VX, Rijlaarsdam M, Filippini L, Hazekamp MG
We report on an uncommon case of a 10-month-old patient who required early surgical closure of an ostium secumdum atrial septal defect due to the concomitant presence of a big subcarinal bronchogenic cyst compressing the left atrium and, therefore, increasing the left-to-right shunt. It led to refractory congestive heart failure symptoms, establishing thereby an earlier indication of surgical treatment. Abstract
Cited 77 times since 2008 (4.8 per year) source: EuropePMC
Annals of the rheumatic diseases, Volume 68, Issue 2, 28 4 2008, Pages 191-195 Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis. Hofstee HM, Vonk Noordegraaf A, Voskuyl AE, Dijkmans BA, Postmus PE, Smulders YM, Serné EH
Objective: The aim of this study was to investigate whether there are differences in capillary nailfold changes in patients with systemic sclerosis (SSc) with and without pulmonary arterial hypertension (PAH), and whether these changes are associated with PAH severity and disease specificity. Methods: Capillary density and loop dimensions were studied in 21 healthy controls, 20 patients with idiopathic PAH (IPAH) and 40 patients with SSc. Of the 40 patients with SSc, 19 had no PAH (SSc-nonPAH) a... Abstract
Cited 19 times since 2008 (1.2 per year) source: EuropePMC
Journal of proteomics, Volume 71, Issue 2, 27 4 2008, Pages 211-221 Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha1-antitrypsin deficiency. Fumagalli M, Dolcini L, Sala A, Stolk J, Fregonese L, Ferrari F, Viglio S, Luisetti M, Iadarola P
The non-invasive character of exhaled breath (EBC) collection makes this fluid attractive for monitoring the respiratory tract by the measurement of various compounds. Because EBC is likely to reflect the composition of the airway-lining fluid, it can provide valuable information on possible disease states. Aim of our study was to apply proteomic technology to the study of EBC samples collected from single patients with pulmonary emphysema associated to alpha(1)-antitrypsin deficiency. The prote... Abstract
Cited 19 times since 2008 (1.2 per year) source: EuropePMC
Journal of neuroimmunology, Volume 195, Issue 1-2, 20 3 2008, Pages 164-170 B and T cell imbalances in CSF of patients with Hu-antibody associated PNS. de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW
In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (approximately 20x) and relative (approximately 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolut... Abstract
Cited 51 times since 2008 (3.2 per year) source: EuropePMC
Respiratory medicine, Volume 102, Issue 6, 18 3 2008, Pages 876-884 Alpha-1 antitrypsin Null mutations and severity of emphysema. Fregonese L, Stolk J, Frants RR, Veldhuisen B
Background: Alpha-1 antitrypsin (AAT) deficiency is an autosomal-codominant disorder, caused by mutations in the SERPINA1 gene on chromosome 14. Individuals affected by the most common mutations, SZ and ZZ, have serum AAT concentrations of 25% and 15% of normal levels, and present a higher risk of emphysema. Mutations causing total absence of serum AAT (Null mutations) were suggested to be associated with very early onset emphysema but their clinical phenotype is poorly known. Hypothesis: Absenc... Abstract
Cited 143 times since 2008 (8.9 per year) source: EuropePMC
European heart journal, Volume 29, Issue 13, 17 3 2008, Pages 1688-1695 Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension. Lankhaar JW, Westerhof N, Faes TJ, Gan CT, Marques KM, Boonstra A, van den Berg FG, Postmus PE, Vonk-Noordegraaf A
Aims: Pulmonary arterial compliance (C) is increasingly being recognized as an important contributor to right ventricular afterload, but for monitoring of treatment of pulmonary hypertension (PH) most often still only pulmonary vascular resistance (R) is used. We aimed at testing the hypothesis that R and C are coupled during treatment of PH and that substantial changes in both R and C would result in more haemodynamic improvement than changes in R alone. Methods and results: Data were analysed... Abstract
Cited 45 times since 2008 (2.8 per year) source: EuropePMC
Circulation, Volume 117, Issue 12, 10 2 2008, Pages 1508-1517 Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways. Kolditz DP, Wijffels MC, Blom NA, van der Laarse A, Hahurij ND, Lie-Venema H, Markwald RR, Poelmann RE, Schalij MJ, Gittenberger-de Groot AC
Background: The developmental mechanisms underlying the persistence of myocardial accessory atrioventricular pathways (APs) that bypass the annulus fibrosis are mainly unknown. In the present study, we investigated the role of epicardium-derived cells (EPDCs) in annulus fibrosis formation and the occurrence of APs. Methods and results: EPDC migration was mechanically inhibited by in ovo microsurgery in quail embryos. In ovo ECGs were recorded in wild-type (n=12) and EPDC-inhibited (n=12) hearts... Abstract
Cited 58 times since 2008 (3.6 per year) source: EuropePMC
PloS one, Volume 3, Issue 3, 5 1 2008, Pages e0001722 Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. Gallegos Ruiz MI, Floor K, Roepman P, Rodriguez JA, Meijer GA, Mooi WJ, Jassem E, Niklinski J, Muley T, van Zandwijk N, Smit EF, Beebe K, Neckers L, Ylstra B, Giaccone G
Background: Lung cancer causes approximately 1.2 million deaths per year worldwide, and non-small cell lung cancer (NSCLC) represents 85% of all lung cancers. Understanding the molecular events in non-small cell lung cancer (NSCLC) is essential to improve early diagnosis and treatment for this disease. Methodology and principal findings: In an attempt to identify novel NSCLC related genes, we performed a genome-wide screening of chromosomal copy number changes affecting gene expression using mic... Abstract
Cited 11 times since 2008 (0.7 per year) source: EuropePMC
The American journal of cardiology, Volume 101, Issue 8, 4 1 2008, Pages 1179-1184 Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops. Meliga E, Steendijk P, Valgimigli M, Ten Cate FJ, Serruys PW
The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline... Abstract
Cited 26 times since 2008 (1.6 per year) source: EuropePMC
Molecular therapy : the journal of the American Society of Gene Therapy, Volume 16, Issue 4, 4 1 2008, Pages 741-748 Genetic complementation of human muscle cells via directed stem cell fusion. Gonçalves MA, Swildens J, Holkers M, Narain A, van Nierop GP, van de Watering MJ, Knaän-Shanzer S, de Vries AA
Duchenne muscular dystrophy (DMD) is caused by mutations in the X chromosome-linked DMD gene, which encodes the sarcolemma-stabilizing protein-dystrophin. Initial attempts at DMD therapy deployed muscle progenitor cells from healthy donors. The utilization of these cells is, however, hampered by their immunogenicity, while those from DMD patients are scarce and display limited ex vivo replication. Nonmuscle cells with myogenic capacity may offer valuable alternatives especially if, to allow auto... Abstract
Cited 32 times since 2008 (2 per year) source: EuropePMC
TheScientificWorldJournal, Volume 8, 3 1 2008, Pages 239-269 Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. Jongbloed MR, Mahtab EA, Blom NA, Schalij MJ, Gittenberger-de Groot AC
The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties than the surrounding working myocardium, which can be observed on a histological level, as well as by the expression patterns of several immunohistological and molecular markers. In recent years, many markers have been studied that have helped to el... Abstract
Cited 2 times since 2008 (0.1 per year) source: EuropePMC
Vascular, Volume 16, Issue 2, 1 1 2008, Pages 116-119 Inflammatory aneurysm of the common iliac artery mimicking appendicitis. Mieog JS, Stoot JH, Bosch JJ, Koning OH, Hamming JF
Isolated inflammatory aneurysm of the common iliac artery is a rare condition. Previously reported cases presented with urologic complications owing to entrapment of the ureter in the perianeurysmal fibrosis. We report a case of a healthy young man who presented with acute abdominal pain in the right lower quadrant without urologic complications mimicking acute appendicitis. The pain was caused by an isolated inflammatory aneurysm of the right common iliac artery measuring 4 cm in diameter. Thre... Abstract
Annals of surgery, Volume 247, Issue 3, 1 1 2008, Pages 555; author reply 555-6 Re: Laparoscopic Versus Open Appendectomy in Children: A Meta-analysis. Aziz MI, van der Burg BL, Hamming JF
Cited 5 times since 2008 (0.3 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 1, Issue 2, 1 1 2008, Pages 190-199 Invasive versus noninvasive evaluation of coronary artery disease. Schuijf JD, van Werkhoven JM, Pundziute G, Jukema JW, Decramer I, Stokkel MP, Dibbets-Schneider P, Schalij MJ, Reiber JH, van der Wall EE, Wijns W, Bax JJ
Objectives: We sought to compare the diagnostic information obtained from noninvasive characterization of coronary artery disease by using multidetector computed tomography (MDCT) and myocardial perfusion imaging (MPI) and to compare findings with the use of invasive coronary angiography and intravascular ultrasound (IVUS). Background: Preliminary comparisons have suggested that abnormal myocardial perfusion studies correlate well with significant luminal stenosis on MDCT coronary angiography. H... Abstract