Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
482 results
Cited 1 times since 2013 (0.1 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8, Issue 9, 1 1 2013, Pages 1103-1109 How should I treat acute aortic annulus rupture during transcatheter aortic valve implantation? Debonnaire P, Van Herck PL, Katsanos S, van der Kley F, de Weger A, Palmen M, Marsan NA, Schalij MJ, Delgado V
Cited 23 times since 2012 (2 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 14, Issue 8, 7 1 2012, Pages 774-781 Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival. Bertini M, Höke U, van Bommel RJ, Ng AC, Shanks M, Nucifora G, Auger D, Borleffs CJ, van Rijnsoever EP, van Erven L, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Background: Clinical or echocardiographic mid-term responses to cardiac resynchronization therapy (CRT) may have a different influence on a long-term prognosis of heart failure patients treated with CRT. The aim of the evaluation was to establish which definition of response to CRT, clinical or echocardiographic, best predicts long-term prognosis. Methods and results: A total of 679 heart failure patients treated with CRT were included. All the patients underwent a complete history and physical... Abstract
Cited 15 times since 2012 (1.3 per year) source: EuropePMC
Diabetes care, Volume 36, Issue 4, 5 1 2012, Pages 985-991 Influence of diabetes on left ventricular systolic and diastolic function and on long-term outcome after cardiac resynchronization therapy. Höke U, Thijssen J, van Bommel RJ, van Erven L, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Objective: The influence of diabetes on cardiac resynchronization therapy (CRT) remains unclear. The aims of the current study were to 1) assess the changes in left ventricular (LV) systolic and diastolic function and 2) evaluate long-term prognosis in CRT recipients with diabetes. Research design and methods: A total of 710 CRT recipients (171 with diabetes) were included from an ongoing registry. Echocardiographic evaluation, including LV systolic and diastolic function assessment, was perform... Abstract
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 29, Issue 3, 22 4 2012, Pages 633-641 Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ, Ng AC, Smit JW, Bax JJ, Westenberg JJ, de Roos A
Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle t... Abstract
Cited 12 times since 2012 (1 per year) source: EuropePMC
Current opinion in cardiology, Volume 27, Issue 5, 1 1 2012, Pages 455-464 Contemporary imaging of normal mitral valve anatomy and function. Debonnaire P, Palmen M, Marsan NA, Delgado V
Purpose of review: Mitral valve disease is highly prevalent. Accurate characterization of normal anatomy and function of the mitral valve is crucial to understand the pathophysiology of mitral valve disease. This review summarizes recent advances in noninvasive cardiac imaging to assess normal mitral valve anatomy and function and provides an overview of the clinical applications of these novel imaging techniques in the evaluation of patients with mitral valve disease. Recent findings: Echocardi... Abstract
Cited 126 times since 2012 (10.7 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 5, Issue 5, 8 2 2012, Pages 628-636 Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V
Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat... Abstract
Cited 67 times since 2012 (5.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 98, Issue 16, 1 1 2012, Pages 1229-1236 Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Gripari P, Ewe SH, Fusini L, Muratori M, Ng AC, Cefalù C, Delgado V, Schalij MJ, Bax JJ, Marsan NA, Tamborini G, Pepi M
Background: Post-procedural aortic regurgitation (AR) has been described in a large number of patients receiving transcatheter aortic valve implantation (TAVI). Objective: The aim of this study was to examine the intraoperative 2-dimensional (2D) and 3-dimensional (3D) echocardiographic features of the aortic valve associated with significant post-procedural paravalvular AR. Methods: A total of 135 patients (81±7 years) with severe symptomatic aortic stenosis, who underwent TAVI, were imaged wit... Abstract
Cited 98 times since 2012 (8.3 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 14, Issue 1, 29 5 2012, Pages 69-76 Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair. Witkowski TG, Thomas JD, Debonnaire PJ, Delgado V, Hoke U, Ewe SH, Versteegh MI, Holman ER, Schalij MJ, Bax JJ, Klautz RJ, Marsan NA
Aims: Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global longitudinal strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this s... Abstract
Cited 25 times since 2012 (2.1 per year) source: EuropePMC
Clinical endocrinology, Volume 77, Issue 1, 1 1 2012, Pages 99-105 Changes in heart valve structure and function in patients treated with dopamine agonists for prolactinomas, a 2-year follow-up study. Delgado V, Biermasz NR, van Thiel SW, Ewe SH, Marsan NA, Holman ER, Feelders RA, Smit JW, Bax JJ, Pereira AM
Objective: The use of ergot-derived dopamine agonists (DA) to treat patients with prolactinomas has not been associated with an increased risk of significant heart valve dysfunction. Accordingly, the present study evaluated whether the long-term use of DA for hyperprolactinaemia may be associated with increased risk of significant valvular heart disease. Methods: A total of 74 patients (mean age 48 ± 1·4 years, 23% male) with prolactinoma treated with DA for at least 1 year were evaluated with 2... Abstract
Cited 37 times since 2012 (3.1 per year) source: EuropePMC
The American journal of cardiology, Volume 110, Issue 7, 19 3 2012, Pages 961-967 Value of three-dimensional speckle-tracking longitudinal strain for predicting improvement of left ventricular function after acute myocardial infarction. Abate E, Hoogslag GE, Antoni ML, Nucifora G, Delgado V, Holman ER, Schalij MJ, Bax JJ, Marsan NA
Identification of patients with reversible left ventricular (LV) dysfunction has important prognostic implications after acute myocardial infarction (AMI). This study aimed to determine the value of LV segmental and global longitudinal strains assessed with 3-dimensional (3D) speckle-tracking analysis in predicting improvement of LV function after AMI. One hundred fifty-three patients (80% men, 59 ± 11 years old) with AMI and treated with primary percutaneous coronary intervention underwent 3D e... Abstract
Cited 18 times since 2012 (1.5 per year) source: EuropePMC
International journal of nephrology, Volume 2012, 9 2 2012, Pages 963504 Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants. de Bie MK, Ajmone Marsan N, Gaasbeek A, Bax JJ, Groeneveld M, Gabreels BA, Delgado V, Rabelink TJ, Schalij MJ, Jukema JW
Background. Diastolic dysfunction is common among dialysis patients and is associated with increased morbidity and mortality. Novel echocardiographic speckle tracking strain analysis permits accurate assessment of left ventricular diastolic function, independent of loading conditions and taking all myocardial segments into account. The aim of the study was to evaluate the prevalence of diastolic dysfunction in chronic dialysis patients using this novel technique, and to identify its determinants... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 13, Issue 12, 7 1 2012, Pages 1041-1046 Temporal evolution of left ventricular dyssynchrony after myocardial infarction: relation with changes in left ventricular systolic function. Nucifora G, Bertini M, Ajmone Marsan N, Scholte AJ, Siebelink HM, Holman ER, Schalij MJ, van der Wall EE, Bax JJ, Delgado V
Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and results: In 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were eval... Abstract
Cited 26 times since 2012 (2.2 per year) source: EuropePMC
PloS one, Volume 7, Issue 5, 4 1 2012, Pages e36115 Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers. Yiu KH, Atsma DE, Delgado V, Ng AC, Witkowski TG, Ewe SH, Auger D, Holman ER, van Mil AM, Breuning MH, Tse HF, Bax JJ, Schalij MJ, Marsan NA
Background: To evaluate the presence of myocardial structural alterations and subtle myocardial dysfunction during familial screening in asymptomatic mutation carriers without hypertrophic cardiomyopathy (HCM) phenotype. Methods and findings: Sixteen HCM families with pathogenic mutation were studied and 46 patients with phenotype expression (Mut+/Phen+) and 47 patients without phenotype expression (Mut+/Phen-) were observed. Twenty-five control subjects, matched with the Mut+/Phen- group, were... Abstract
Cited 1 times since 2012 (0.1 per year) source: EuropePMC
Congestive heart failure (Greenwich, Conn.), Volume 18, Issue 4, 18 3 2012, Pages 198-204 Prognostic implications of left ventricular dilation in patients with nonischemic heart failure: interactions with restrictive filling pattern and mitral regurgitation. Ghio S, Temporelli PL, Marsan NA, Poppe K, Giannuzzi P, Dini FL, Rossi A, Doughty RN, Whalley G, MeRGE HF collaborators
The aim of this study was to evaluate whether small left ventricular (LV) volumes increase the negative prognostic impact of a restrictive filling pattern (RFP) and that of mitral regurgitation (MR) in patients with nonischemic heart failure (HF). The Meta-analysis Research Group in Echocardiography (MeRGE) is a meta-analysis that collated individual patient data from several prospective echocardiography outcome studies. This analysis was restricted to 10 studies and 601 patients with nonischemi... Abstract
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 25, Issue 6, 17 3 2012, Pages 674-681 Right ventricular longitudinal peak systolic strain measurements from the subcostal view in patients with suspected pulmonary hypertension: a feasibility study. Haeck ML, Scherptong RW, Antoni ML, Marsan NA, Vliegen HW, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: The assessment of right ventricular (RV) function with two-dimensional echocardiography can be challenging in patients with pulmonary hypertension, especially in those with chronic pulmonary disease. The aim of the present study was to evaluate the feasibility of measuring RV longitudinal peak systolic strain (LPSS) in the echocardiographic subcostal view in patients with suspected pulmonary hypertension. Methods: A total of 179 patients evaluated for pulmonary hypertension were incl... Abstract
Cited 81 times since 2012 (6.7 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 5, Issue 3, 12 2 2012, Pages 383-391 Global longitudinal strain predicts long-term survival in patients with chronic ischemic cardiomyopathy. Bertini M, Ng AC, Antoni ML, Nucifora G, Ewe SH, Auger D, Marsan NA, Schalij MJ, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain (GLS) is a measure of the active shortening of the LV in the longitudinal direction, which can be assessed with speckle-tracking echocardiography. The aims of this evaluation were to validate the prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chronic ischemic cardiomyopathy and to determine the incremental value of GLS to predict long-term outcome over other strong and well-established... Abstract
Cited 28 times since 2012 (2.3 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 93, Issue 3, 31 5 2012, Pages 754-760 Changes in left ventricular function after mitral valve repair for severe organic mitral regurgitation. Witkowski TG, Thomas JD, Delgado V, van Rijnsoever E, Ng AC, Hoke U, Ewe SH, Auger D, Yiu KH, Holman ER, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA
Background: Limited data are available on the changes in left ventricular (LV) contractile function at long-term follow-up after mitral valve repair (MVr). Moreover, assessment of LV systolic function in patients undergoing MVr is troublesome with current methods, given that mitral regurgitation is characterized by increased preload and decreased afterload, potentially masking LV dysfunction. The aim of this study was to assess the value of LV global strain (longitudinal and circumferential) mea... Abstract
Cited 10 times since 2012 (0.8 per year) source: EuropePMC
European heart journal, Volume 33, Issue 15, 22 4 2012, Pages 1934-1941 Predictors of long-term benefit of cardiac resynchronization therapy in patients with right bundle branch block. Leong DP, Höke U, Delgado V, Auger D, Thijssen J, van Erven L, Bax JJ, Schalij MJ, Marsan NA
Aims: The aims of this study were: (i) to characterize consecutive cardiac resynchronization therapy (CRT) recipients with right bundle branch block (RBBB) in comparison with left bundle branch block (LBBB) and (ii) to identify independent predictors of long-term outcome among CRT recipients with RBBB. The presence of RBBB has been associated with poorer prognosis after CRT compared with LBBB; however, little is known about the differences in cardiac mechanics between RBBB and LBBB patients. Fur... Abstract
Cited 60 times since 2011 (4.8 per year) source: EuropePMC
Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ
Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract
Cited 38 times since 2011 (3 per year) source: EuropePMC
European journal of endocrinology, Volume 166, Issue 1, 17 3 2011, Pages 27-34 Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. Yiu KH, Marsan NA, Delgado V, Biermasz NR, Holman ER, Smit JW, Feelders RA, Bax JJ, Pereira AM
Objective: Active Cushing's syndrome (CS) is associated with cardiomyopathy, characterized by myocardial structural, and ultrastructural abnormalities. The extent of myocardial fibrosis in patients with CS has not been previously evaluated. Therefore, the objective of this study was to assess myocardial fibrosis in CS patients, its relationship with left ventricular (LV) hypertrophy and function, and its reversibility after surgical treatment. Design and methods: Fifteen consecutive CS pati... Abstract