Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
240 results
Cited 3 times since 2022 (1.6 per year) source: EuropePMC
Journal of the American Heart Association, Volume 11, Issue 13, 22 4 2022, Pages e024924 Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Bressi E, Crawford TC, Bogun FM, Gu X, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Garlitski AC, Soejima K, Bhan AK, Vedantham V, Dickfeld TM, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium *
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 34, Issue 6, 1 1 2022, Pages 990-998 Long-term follow-up of thoracoscopic ablation in long-standing persistent atrial fibrillation. Harlaar N, Oudeman MA, Trines SA, de Ruiter GS, Mertens BJ, Khan M, Klautz RJM, Zeppenfeld K, Tjon A, Braun J, van Brakel TJ
Objectives: Catheter ablation of long-standing persistent atrial fibrillation (LSPAF) remains challenging, with suboptimal success rates obtained following multiple procedures. Thoracoscopic ablation has shown effective at creating transmural lesions around the pulmonary veins and box; however, long-term rhythm follow-up data are lacking. This study aims, for the first time, to assess the long-term outcomes of thoracoscopic pulmonary vein and box ablation in LSPAF. Methods: Rhythm follow-up cons... Abstract
Cited 6 times since 2022 (3 per year) source: EuropePMC
Heart rhythm, Volume 19, Issue 10, 29 5 2022, Pages e61-e120 2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders. Groh WJ, Bhakta D, Tomaselli GF, Aleong RG, Teixeira RA, Amato A, Asirvatham SJ, Cha YM, Corrado D, Duboc D, Goldberger ZD, Horie M, Hornyak JE, Jefferies JL, Kääb S, Kalman JM, Kertesz NJ, Lakdawala NK, Lambiase PD, Lubitz SA, McMillan HJ, McNally EM, Milone M, Namboodiri N, Nazarian S, Patton KK, Russo V, Sacher F, Santangeli P, Shen WK, Sobral Filho DC, Stambler BS, Stöllberger C, Wahbi K, Wehrens XHT, Weiner MM, Wheeler MT, Zeppenfeld K
This international multidisciplinary document is intended to guide electrophysiologists, cardiologists, other clinicians, and health care professionals in caring for patients with arrhythmic complications of neuromuscular disorders (NMDs). The document presents an overview of arrhythmias in NMDs followed by detailed sections on specific disorders: Duchenne muscular dystrophy, Becker muscular dystrophy, and limb-girdle muscular dystrophy type 2; myotonic dystrophy type 1 and type 2; Emery-Dreifus... Abstract
European heart journal. Case reports, Volume 6, Issue 3, 17 3 2022, Pages ytac087 Successful hybrid cardiac resynchronization therapy in a patient with failing systemic right ventricle and significant tricuspid regurgitation in transposition of the great arteries after atrial switch procedure according to Mustard. Nederend M, Zeppenfeld K, Jongbloed MRM, Egorova AD
Background: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) late after atrial switch are prone to heart failure. Complications like tricuspid valve regurgitation (TR) can further aggravate sRV dysfunction. Tricuspid valve regurgitation is usually secondary to annular dilatation and restriction. Criteria for cardiac resynchronization therapy (CRT) in this patient group are not well defined and should be considered on a case-by-case basis.... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
European heart journal. Case reports, Volume 6, Issue 2, 16 3 2022, Pages ytac067 Case report of the broad spectrum of late complications in an adult patient with univentricular physiology palliated by the Fontan circulation. Nederend M, Egorova AD, Vliegen HW, Roest AAW, Ruijter BN, Korteweg T, Ninaber MK, Zeppenfeld K, Hazekamp MG, Kiès P, Jongbloed MRM
Background: At the most severe end of the spectrum of congenital heart disease are patients with an univentricular physiology. They comprise a heterogeneous group of congenital heart malformations that have the common characteristic that the cardiac morphology is not equipped for sustaining a biventricular circulation. Case summary: Here, we present a case of an adult patient after Fontan palliation, illustrative of the complex clinical course and the broad spectrum of complications that can be... Abstract
Cited 12 times since 2022 (5.3 per year) source: EuropePMC
JAMA cardiology, Volume 7, Issue 2, 1 1 2022, Pages 175-183 Outcomes Associated With Catheter Ablation of Ventricular Tachycardia in Patients With Cardiac Sarcoidosis. Siontis KC, Santangeli P, Muser D, Marchlinski FE, Zeppenfeld K, Hoogendoorn JC, Narasimhan C, Sauer WH, Zipse MM, Kapa S, Vedantham V, Rosenthal DG, Robinson MR, Patton KK, Murgatroyd F, Chicos AB, Soejima K, Roukoz H, Sacher F, Bhan A, Appelbaum J, Dickfeld T, Mankad P, Ellenbogen KA, Kron J, Kim HM, Froehlich J, Eagle KA, Bogun FM, Crawford TC
Importance: Ventricular tachycardia (VT) is associated with high mortality in patients with cardiac sarcoidosis (CS), and medical management of CS-associated VT is limited by high failure rates. The role of catheter ablation has been investigated in small, single-center studies. Objective: To investigate outcomes associated with VT ablation in patients with CS. Design, setting, and participants: This cohort study from the Cardiac Sarcoidosis Consortium registry (2003-2019) included 16 tertiary r... Abstract
Cited 7 times since 2022 (3.1 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 24, Issue 2, 1 1 2022, Pages 296-305 Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy. Bosman LP, Bosman LP, Nielsen Gerlach CL, Cadrin-Tourigny J, Orgeron G, Tichnell C, Murray B, Bourfiss M, van der Heijden JF, Yap SC, Zeppenfeld K, van den Berg MP, Wilde AAM, Asselbergs FW, Tandri H, Calkins H, van Tintelen JP, James CA, Te Riele ASJM
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have an increased risk of ventricular arrhythmias (VA). Four implantable cardioverter-defibrillator (ICD) recommendation algorithms are available The International Task Force Consensus ('ITFC'), an ITFC modification by Orgeron et al. ('mITFC'), the AHA/HRS/ACC guideline for VA management ('AHA'), and the HRS expert consensus statement ('HRS'). This study aims to validate and compare the... Abstract
Cited 3 times since 2022 (1.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 8, Issue 4, 31 5 2022, Pages 437-449 Multielectrode Unipolar Voltage Mapping and Electrogram Morphology to Identify Post-Infarct Scar Geometry: Validation by Histology. Glashan CA, Tofig BJ, Beukers H, Tao Q, Blom SA, Villadsen PR, Lassen TR, de Riva M, Kristiansen SB, Zeppenfeld K
Objectives: This study sought to evaluate the ability of uni- and bipolar electrograms collected with a multielectrode catheter with smaller electrodes to: 1) delineate scar; and 2) determine local scar complexity. Background: Early reperfusion results in variable endocardial scar, often overlaid with surviving viable myocardium. Although bipolar voltage (BV) mapping is considered the pillar of substrate-based ablation, the role of unipolar voltage (UV) mapping has not been sufficiently explored... Abstract
Cited 5 times since 2022 (2.2 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 15, Issue 2, 28 4 2022, Pages e009979 Nonsustained Ventricular Tachycardia Is Independently Associated With Sustained Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy. Piers SR, Androulakis AF, Yim KS, van Rein N, Venlet J, Kapel GF, Siebelink HM, Lamb HJ, Cannegieter SC, Man SC, Zeppenfeld K
Background: Spontaneous nonsustained ventricular tachycardia (NSVT) on Holter, VT inducibility during electrophysiology study, and late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) have been associated with sustained ventricular arrhythmias (SVAs) in nonischemic dilated cardiomyopathy (DCM). This study aimed to analyze whether these parameters carry independent prognostic value for spontaneous SVA in DCM. Methods: Between 2011 and 2018, patients with the DCM clinical spectrum... Abstract
Cited 10 times since 2021 (4.1 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 23, Issue 12, 1 1 2021, Pages 1989-1997 Accuracy of electroanatomical mapping-guided cardiac radiotherapy for ventricular tachycardia: pitfalls and solutions. Abdel-Kafi S, Sramko M, Omara S, de Riva M, Cvek J, Peichl P, Kautzner J, Zeppenfeld K
Aims: To analyse and optimize the interobserver agreement for gross target volume (GTV) delineation on cardiac computed tomography (CCT) based on electroanatomical mapping (EAM) data acquired to guide radiotherapy for ventricular tachycardia (VT). Methods and results: Electroanatomical mapping data were exported and merged with the segmented CCT using manual registration by two observers. A GTV was created by both observers for predefined left ventricular (LV) areas based on preselected endocard... Abstract
Cited 7 times since 2021 (2.8 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 78, Issue 19, 1 1 2021, Pages 1904-1918 AHA/ACC vs ESC Guidelines for Management of Adults With Congenital Heart Disease: JACC Guideline Comparison. Egidy Assenza G, Krieger EV, Baumgartner H, Cupido B, Dimopoulos K, Louis C, Lubert AM, Stout KK, Valente AM, Zeppenfeld K, Opotowsky AR
The American Heart Association and American College of Cardiology published practice guidelines for the management of adult congenital heart disease in 2018 and the European Society of Cardiology published analogous guidelines in 2020. Although there are broad areas of consensus between the 2 documents, there are important differences that impact patient management. This review discusses key areas of agreement and disagreement between the 2 guidelines, with discussion of possible reasons for dis... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 14, Issue 9, 1 1 2021, Pages e009695 Contemporary Patients With Congenital Heart Disease: Uniform Atrial Tachycardia Substrates Allow for Clear Ablation Endpoints With Improved Long-Term Outcome. Brouwer C, Hebe J, Lukac P, Nürnberg JH, Cosedis Nielsen J, de Riva Silva M, Blom N, Hazekamp M, Zeppenfeld K
[Figure: see text]. Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 14, Issue 8, 16 3 2021, Pages e009808 Lesion Size and Lesion Maturation After Radiofrequency Catheter Ablation for Ventricular Tachycardia in Humans With Nonischemic Cardiomyopathy. Glashan CA, Stevenson W, Zeppenfeld K
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 23, Issue 8, 1 1 2021, Pages 1275-1284 Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia. de Riva M, Naruse Y, Ebert M, Watanabe M, Scholte AJ, Wijnmaalen AP, Trines SA, Schalij MJ, Montero-Cabezas JM, Zeppenfeld K
Aims: In patients with post-myocardial infarction (post-MI) ventricular tachycardia (VT), the presence of myocardial calcification (MC) may prevent heating of a subepicardial VT substrate contributing to endocardial ablation failure. The aims of this study were to assess the prevalence of MC in patients with post-MI VT and evaluate the impact of MC on outcome after endocardial ablation. Methods and results: In 158 patients, the presence of MC was retrospectively assessed on fluoroscopy recording... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
Heart rhythm, Volume 18, Issue 11, 30 5 2021, Pages 2023-2024 Reply to the Editor-Precordial R' wave: electrical disturbance-based or abnormal substrate-based? Hoogendoorn JC, Zeppenfeld K
Cited 7 times since 2021 (2.3 per year) source: EuropePMC
Heart rhythm, Volume 18, Issue 9, 3 1 2021, Pages 1539-1547 The precordial R' wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia. Hoogendoorn JC, Venlet J, Out YNJ, Man S, Kumar S, Sramko M, Dechering DG, Nakajima I, Siontis KC, Watanabe M, Nakamura Y, Tedrow UB, Bogun F, Eckardt L, Peichl P, Stevenson WG, Zeppenfeld K
Background: Cardiac sarcoidosis (CS) with right ventricular (RV) involvement can mimic arrhythmogenic right ventricular cardiomyopathy (ARVC). Histopathological differences may result in disease-specific RV activation patterns detectable on the 12-lead electrocardiogram. Dominant subepicardial scar in ARVC leads to delayed activation of areas with reduced voltages, translating into terminal activation delay and occasionally (epsilon) waves with a small amplitude. Conversely, patchy transmural RV... Abstract
Cited 3 times since 2021 (1 per year) source: EuropePMC
European heart journal. Case reports, Volume 5, Issue 4, 12 2 2021, Pages ytab068 Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy. Nederend M, van Erven L, Zeppenfeld K, Vliegen HW, Egorova AD
Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation. Case summary: A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantabl... Abstract
Cited 4 times since 2021 (1.3 per year) source: EuropePMC
Heart rhythm O2, Volume 2, Issue 3, 19 3 2021, Pages 290-297 Predicting early reconnection after cryoballoon ablation with procedural and biophysical parameters. Keçe F, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Mertens BJ, Schalij MJ, Zeppenfeld K, Trines SA
Background: Predicting early reconnection/dormant conduction (ERC) immediately after pulmonary vein isolation (PVI) can avoid a waiting period with adenosine testing. Objective: To identify procedural and biophysical parameters predicting ERC. Methods: Consecutive atrial fibrillation (AF) patients undergoing a first cryoballoon ablation (Arctic Front Advance) between 2014 and 2017 were included. ERC was defined as manifest or dormant pulmonary vein (PV) reconnection with adenosine 30 minutes aft... Abstract
Cited 2 times since 2021 (0.6 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 44, Issue 4, 9 2 2021, Pages 657-666 The prognostic value of J-wave pattern for recurrence of ventricular tachycardia after catheter ablation in patients with myocardial infarction. Naruse Y, de Riva M, Watanabe M, Wijnmaalen AP, Venlet J, Timmer M, Schalij MJ, Zeppenfeld K
Background: J-waves and fragmented QRS (fQRS) on surface ECGs have been associated with the occurrence of ventricular tachyarrhythmias. Whether these non-invasive parameters can also predict ventricular tachycardia (VT) recurrence after radiofrequency catheter ablation (RFCA) is unknown. Of interest, patients with a wide QRS-complex have been excluded from clinical studies on J-waves, although a J-wave like pattern has been described for wide QRS. Methods: We retrospectively included 168 patient... Abstract
Cited 3 times since 2021 (0.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 77, Issue 6, 1 1 2021, Pages 761-771 Preventing Arrhythmic Death in Patients With Tetralogy of Fallot: JACC Review Topic of the Week. Cohen MI, Khairy P, Zeppenfeld K, Van Hare GF, Lakkireddy DR, Triedman JK
Patients with tetralogy of Fallot are at risk for ventricular arrhythmias and sudden cardiac death. These abnormalities are associated with pulmonary regurgitation, right ventricular enlargement, and a substrate of discrete, slowly-conducting isthmuses. Although these arrhythmic events are rare, their prediction is challenging. This review will address contemporary risk assessment and prevention strategies. Numerous variables have been proposed to predict who would benefit from an implantable ca... Abstract