Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
170 results
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
Circulation journal : official journal of the Japanese Circulation Society, Volume 77, Issue 11, 29 5 2013, Pages 2793-2798 Clinical features differ substantially between Caucasian and Asian populations of Marfan syndrome. Franken R, den Hartog AW, van de Riet L, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Zwinderman AH, Groenink M, Yip JW, Mulder BJ
Background: Prevention of aortic dissection and sudden death in patients with Marfan syndrome (MFS) requires accurate diagnosis. MFS is diagnosed by the Ghent criteria, which are primarily based on clinical features of Caucasian MFS populations. We determined whether the Ghent criteria apply to Asian MFS populations. Methods and results: In this multicenter study, we included 255 adult MFS patients according to the Ghent criteria of 2010. Patients were excluded if they were neither Caucasian nor... Abstract
Cited 6 times since 2013 (0.6 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 29, Issue 8, 27 4 2013, Pages 1829-1837 Association of atherosclerosis in the descending thoracic aorta with coronary artery disease on multi detector row computed tomography coronary angiography in patients with suspected coronary artery disease. Roos CJ, Witkowska AJ, de Graaf MA, Veltman CE, Delgado V, de Grooth GJ, Jukema JW, Bax JJ, Scholte AJ
The association between atherosclerosis in the descending thoracic aorta (DTA) visualized on computed tomography coronary angiography (CTA) and coronary artery disease (CAD) has not been extensively explored. Therefore, a comprehensive analysis of DTA atherosclerosis on CTA was performed and the association of DTA atherosclerosis with CAD was evaluated in patients with suspected CAD. A total of 344 patients (54 ± 12 years, 54% men) with suspected CAD underwent CTA. CTA were classified based on C... Abstract
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 96, Issue 4, 16 3 2013, Pages 1390-1397 Variation in coronary anatomy in adult patients late after arterial switch operation: a computed tomography coronary angiography study. Veltman CE, Beeres SLMA, Kalkman DN, Kelder TP, Kiès P, Vliegen HW, Hazekamp MG, Delgado V, Kroft LJM, van der Wall EE, Gittenberger-de Groot AC, Scholte AJHA, Schalij MJ, Jongbloed MRM
Background: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. Methods: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal c... Abstract
Cited 14 times since 2013 (1.3 per year) source: EuropePMC
Radiology, Volume 269, Issue 2, 25 4 2013, Pages 370-377 Aortic disease in patients with Marfan syndrome: aortic volume assessment for surveillance. den Hartog AW, Franken R, de Witte P, Radonic T, Marquering HA, van der Steen WE, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M
Purpose: To assess the reproducibility of aortic volume estimates and to serially test their use in patients with Marfan syndrome. Materials and methods: The study was approved by the medical ethics committee and all subjects gave written informed consent. In 81 patients with Marfan syndrome and seven healthy control subjects, aortic volumes and diameters at baseline were estimated by means of contrast material-enhanced magnetic resonance (MR) imaging. At 3 years of follow-up, aortic expansion r... Abstract
Cited 28 times since 2013 (2.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 15, Issue 1, 21 3 2013, Pages 41-47 Changes in multidirectional LV strain in asymptomatic patients with type 2 diabetes mellitus: a 2-year follow-up study. Roos CJ, Scholte AJ, Kharagjitsingh AV, Bax JJ, Delgado V
Aims: Asymptomatic patients with diabetes mellitus (DM) and normal left ventricular (LV) ejection fraction (EF) may have LV dysfunction as assessed with speckle tracking echocardiography. Whether this subtle LV dysfunction may progress or not over time remains unknown. The present evaluation assessed changes in LV function with two-dimensional (2D) speckle tracking analysis in asymptomatic clinically stable patients with type 2 DM and normal LVEF after 2-year follow-up. Methods and results: A to... Abstract
Cited 3 times since 2013 (0.3 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 40, Issue 8, 29 5 2013, Pages 1171-1180 Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT. de Graaf MA, El-Naggar HM, Boogers MJ, Veltman CE, Broersen A, Kitslaar PH, Dijkstra J, Kroft LJ, Al Younis I, Reiber JH, Bax JJ, Delgado V, Scholte AJ
Purpose: Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial is... Abstract
Cited 43 times since 2013 (3.9 per year) source: EuropePMC
International journal of cardiology, Volume 168, Issue 3, 10 2 2013, Pages 2441-2446 Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome. Franken R, den Hartog AW, de Waard V, Engele L, Radonic T, Lutter R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Groenink M, Mulder BJ
Background: Patients with Marfan syndrome (MFS) are at risk for cardiovascular disease. Marfan associated mutations in the FBN1 gene lead to increased transforming growth factor-β (TGF-β) activation. The aim of this study was to investigate the role of plasma TGF-β as a biomarker for progressive aortic root dilatation and dissection. Methods: Plasma TGF-β level and aortic root diameter by means of echocardiography were assessed in 99 MFS patients. After 38 months of follow-up measurement of the... Abstract
Cited 90 times since 2013 (8 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 29, Issue 5, 16 3 2013, Pages 1177-1190 Automatic quantification and characterization of coronary atherosclerosis with computed tomography coronary angiography: cross-correlation with intravascular ultrasound virtual histology. de Graaf MA, Broersen A, Kitslaar PH, Roos CJ, Dijkstra J, Lelieveldt BP, Jukema JW, Schalij MJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ
Plaque constitution on computed tomography coronary angiography (CTA) is associated with prognosis. At present only visual assessment of plaque constitution is possible. An accurate automatic, quantitative approach for CTA plaque constitution assessment would improve reproducibility and allows higher accuracy. The present study assessed the feasibility of a fully automatic and quantitative analysis of atherosclerosis on CTA. Clinically derived CTA and intravascular ultrasound virtual histology (... Abstract
Cited 14 times since 2013 (1.2 per year) source: EuropePMC
Systematic reviews, Volume 2, 15 3 2013, Pages 13 Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT). Schuetz GM, Schlattmann P, Achenbach S, Budoff M, Garcia MJ, Roehle R, Pontone G, Meijboom WB, Andreini D, Alkadhi H, Honoris L, Bettencourt N, Hausleiter J, Leschka S, Gerber BL, Meijs MF, Shabestari AA, Sato A, Zimmermann E, Schoepf UJ, Diederichsen A, Halon DA, Mendoza-Rodriguez V, Hamdan A, Nørgaard BL, Brodoefel H, Ovrehus KA, Jenkins SM, Halvorsen BA, Rixe J, Sheikh M, Langer C, Martuscelli E, Romagnoli A, Scholte AJ, Marcus RP, Ulimoen GR, Nieman K, Mickley H, Nikolaou K, Tardif JC, Johnson TR, Muraglia S, Chow BJ, Maintz D, Laule M, Dewey M
Unlabelled: Background: Coronary computed tomography angiography has become the foremost noninvasive imaging modality of the coronary arteries and is used as an alternative to the reference standard, conventional coronary angiography, for direct visualization and detection of coronary artery stenoses in patients with suspected coronary artery disease. Nevertheless, there is considerable debate regarding the optimal target population to maximize clinical performance and patient benefit. The most... Abstract
European heart journal. Cardiovascular Imaging, Volume 14, Issue 5, 5 1 2012, Pages 507 Rapid aortic aneurysm formation in Marfan patient with dissection of the entire aorta. Scholte AJ, Hilhorst-Hofstee Y, Versteegh MI, Kroft LJ
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 29, Issue 3, 28 4 2012, Pages 609-616 Relationship between left ventricular diastolic function and arterial stiffness in asymptomatic patients with diabetes mellitus. Roos CJ, Auger D, Djaberi R, de Koning EJ, Rabelink TJ, Pereira AM, Bax JJ, Delgado V, Jukema JW, Scholte AJ
Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are common in patients with diabetes mellitus (DM). However, the relation between these two pathophysiological factors remains unclear. The aim of this study was to investigate the relationship between LV diastolic function and arterial stiffness as assessed with applanation tonometry. In 142 asymptomatic patients with DM (mean age 48 years, 75 (53 %) men, 72 (51 %) patients with type 2 DM) LV diastolic function was ass... Abstract
Cited 25 times since 2012 (2.1 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 6, 20 3 2012, Pages 2977-2982 MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome. Kröner ES, Scholte AJ, de Koning PJ, van den Boogaard PJ, Kroft LJ, van der Geest RJ, Hilhorst-Hofstee Y, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ
Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional... Abstract
Cited 5 times since 2012 (0.4 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 19, Issue 6, 30 5 2012, Pages 1162-1169 Right ventricular ejection fraction measured by multigated planar equilibrium radionuclide ventriculography is an independent prognostic factor in patients with ischemic heart disease. van der Maas N, Braam RL, van der Zaag-Loonen HJ, Meerman J, Cozijnsen L, Scholte AJ
Background: The number of studies on the prognostic value of the right ventricular ejection fraction (RVEF) in patients with ischemic heart disease (IHD) is limited, whereas it is widely accepted that the left ventricular ejection fraction (LVEF) is a strong prognostic factor. We assessed whether RVEF measured by multigated planar equilibrium radionuclide ventriculography (RNV) is an independent prognostic factor in patients with IHD. Methods and results: We retrospectively identified 347 consec... Abstract
Cited 10 times since 2012 (0.9 per year) source: EuropePMC
Clinical genetics, Volume 83, Issue 4, 21 3 2012, Pages 337-344 An unanticipated copy number variant of chromosome 15 disrupting SMAD3 reveals a three-generation family at serious risk for aortic dissection. Hilhorst-Hofstee Y, Scholte AJ, Rijlaarsdam ME, van Haeringen A, Kroft LJ, Reijnierse M, Ruivenkamp CA, Versteegh MI, Pals G, Breuning MH
Several genes involved in the familial appearance of thoracic aortic aneurysms and dissections (FTAAD) have been characterized recently, one of which is SMAD3. Mutations of SMAD3 cause a new syndromic form of aortic aneurysms and dissections associated with skeletal abnormalities. We discovered a small interstitial deletion of chromosome 15, leading to disruption of SMAD3, in a boy with mild mental retardation, behavioral problems and revealed features of the aneurysms-osteoarthritis syndrome (A... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 14, Issue 3, 19 3 2012, Pages 247-252 Impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Boogers MJ, Compier M, Trines SA, Scholte AJ, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V
Aims: Coronary atherosclerosis has been associated with the development of atrial fibrillation (AF). However, little is known about the impact of coronary atherosclerosis on the outcome treatment of AF. The aim of this study was to investigate the impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation (RFCA) for AF using multi-detector row computed tomography (MDCT). Methods: In 125 consecutive patients undergoing RFCA for AF, a pre-procedural MDCT examination (co... Abstract
Cited 34 times since 2012 (2.9 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 39, Issue 10, 13 2 2012, Pages 1599-1608 Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure. Veltman CE, Boogers MJ, Meinardi JE, Al Younis I, Dibbets-Schneider P, Van der Wall EE, Bax JJ, Scholte AJ
Purpose: Despite its high prognostic value, widespread clinical implementation of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization. The purpose of this study was to assess the reliability of planar (123)I-MIBG myocardial scintigraphy in patients with heart failure (HF). Methods: Planar myocardial MIBG images of 70 HF patients were analysed by two experienced and one inexperienced observer. The reproducibility of early and dela... Abstract
Cited 9 times since 2012 (0.8 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 36, Issue 6, 22 4 2012, Pages 1470-1476 Evaluation of sampling density on the accuracy of aortic pulse wave velocity from velocity-encoded MRI in patients with Marfan syndrome. Kröner ES, van der Geest RJ, Scholte AJ, Kroft LJ, van den Boogaard PJ, Hendriksen D, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, Hilhorst-Hofstee Y, Bax JJ, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ
Purpose: To evaluate the effect of spatial (ie, number of sampling locations along the aorta) and temporal sampling density on aortic pulse wave velocity (PWV) assessment from velocity-encoded MRI in patients with Marfan syndrome (MFS). Materials and methods: Twenty-three MFS patients (12 men, mean age 36 ± 14 years) were included. Three PWV-methods were evaluated: 1) reference PWV(i.p.) from in-plane velocity-encoded MRI with dense temporal and spatial sampling; 2) conventional PWV(t.p.) from t... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 13, Issue 12, 7 1 2012, Pages 1041-1046 Temporal evolution of left ventricular dyssynchrony after myocardial infarction: relation with changes in left ventricular systolic function. Nucifora G, Bertini M, Ajmone Marsan N, Scholte AJ, Siebelink HM, Holman ER, Schalij MJ, van der Wall EE, Bax JJ, Delgado V
Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and results: In 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were eval... Abstract
Cited 37 times since 2012 (3.1 per year) source: EuropePMC
PloS one, Volume 7, Issue 3, 30 5 2012, Pages e32963 Inflammation aggravates disease severity in Marfan syndrome patients. Radonic T, de Witte P, Groenink M, de Waard V, Lutter R, van Eijk M, Jansen M, Timmermans J, Kempers M, Scholte AJ, Hilhorst-Hofstee Y, van den Berg MP, van Tintelen JP, Pals G, Baars MJ, Mulder BJ, Zwinderman AH
Background: Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addressed so far. Methodology/principal findings: Here we showed that both TGF-β and inflammation are up-regulated in patients with MFS. We analyzed transcriptome-wide gene expression in 55 MFS patients us... Abstract
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 12, 14 2 2011, Pages 1392-1399.e1 Biventricular performance in patients with marfan syndrome without significant valvular disease: comparison to normal subjects and longitudinal follow-up. Scherptong RW, Vliegen HW, van der Wall EE, Hilhorst-Hofstee Y, Bax JJ, Scholte AJ, Delgado V
Background: The presence and progressive nature of primary myocardial involvement in Marfan syndrome are debated. The aim of this study was to evaluate the clinical relevance of left ventricular (LV) and right ventricular (RV) strain in adult patients with Marfan syndrome without significant valvular disease. Methods: Adult patients with Marfan syndrome (n = 50; mean age, 35.2 ± 12.9 years) were followed prospectively. Echocardiography was performed annually and consisted of comprehensive assess... Abstract