Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 4 times since 1987 (0.1 per year) source: EuropePMC
Cancer treatment reports, Volume 71, Issue 6, 1 1 1987, Pages 599-603 Pharmacokinetics of high-dose teniposide. Holthuis JJ, de Vries LG, Postmus PE, van Oort WW, Verleun H, Hulshoff A, Sleijfer DT, Mulder NH
This paper describes the pharmacokinetics of teniposide (VM-26) after being administered iv in high doses to eight cancer patients (maximum dose, 1.0 g/m2). VM-26 levels in plasma, urine, saliva, duodenal fluid, and cerebrospinal fluid were determined using high-performance liquid chromatography in combination with electrochemical detection. The plasma concentration-time curve of VM-26 showed a triphasic decay with a slow third phase in five patients, whereas in two patients the plasma concentra... Abstract
Cited 23 times since 1987 (0.6 per year) source: EuropePMC
Cardiovascular research, Volume 21, Issue 5, 1 1 1987, Pages 352-357 Morphometric quantification of myocyte dimensions validated in normal growing rat hearts and applied to hypertrophic human hearts. Vliegen HW, van der Laarse A, Huysman JA, Wijnvoord EC, Mentar M, Cornelisse CJ, Eulderink F
To obtain quantitative information on changes in myocyte size in hearts with increased myocardial mass light microscopical morphometry was used in fixed and stained myocardial tissue sections. A modification of the azan staining procedure made longitudinal (sarcolemma) and transverse (intercalated discs) boundaries visible with a contrast that allowed morphometric analysis. The method was validated in left ventricular tissue of rats ranging in age from 4 to 17 weeks. Myocyte width, cut surface a... Abstract
Cited 10 times since 1987 (0.3 per year) source: EuropePMC
Radiographics : a review publication of the Radiological Society of North America, Inc, Volume 7, Issue 3, 1 1 1987, Pages 425-445 Magnetic resonance imaging of primary malignant bone tumors. Bloem JL, Bluemm RG, Taminiau AH, van Oosterom AT, Stolk J, Doornbos J
The authors find that MRI yields more useful information in a single study than CT, Tc scanning or angiography; they use it as the primary local staging procedure in malignant bone tumors. Abstract
Ankara Universitesi Dis Hekimligi Fakultesi dergisi = The Journal of the Dental Faculty of Ankara University, Volume 14, Issue 2, 1 1 1987, Pages 209-212 [Odontogenic myxoma]. Türker M, Güngör N, Yücetaş S, Yilmaz D, Günhan O
Cited 21 times since 1987 (0.6 per year) source: EuropePMC
Journal of bacteriology, Volume 169, Issue 4, 1 1 1987, Pages 1441-1446 Lipopolysaccharides of Pseudomonas spp. that stimulate plant growth: composition and use for strain identification. de Weger LA, Jann B, Jann K, Lugtenberg B
The outer membrane proteins of a series of fluorescent, root-colonizing, plant-growth-stimulating Pseudomonas spp. having been characterized (L. A. de Weger et al., J. Bacteriol. 165:585-594, 1986), the lipopolysaccharides (LPSs) of these strains were examined. The chemical composition of the LPSs of the three best-studied plant-growth-stimulating Pseudomonas strains WCS358, WCS361, and WCS374 and of P. aeruginosa PAO1 as a reference strain was determined and appeared to differ from strain to st... Abstract
Cited 7 times since 1987 (0.2 per year) source: EuropePMC
Cardiovascular research, Volume 21, Issue 3, 1 1 1987, Pages 223-229 Relation between ventricular DNA content and number of myocytes and non-myocytes in hearts of normotensive and spontaneously hypertensive rats. van der Laarse A, Bloys van Treslong CH, Vliegen HW, Ricciardi L
Myocardial DNA concentration and ventricular weight were measured in the hearts of normal and spontaneously hypertensive rats varying in age from 1 day to 1 year and the ventricular DNA content calculated. A linear relation between ventricular DNA content and ventricular weight was observed in both rat strains. This linear relation was deduced theoretically, assuming that the number of ventricular non-myocytes per heart was proportional to ventricular weight and that the number of ventricular my... Abstract
Cited 109 times since 1987 (2.9 per year) source: EuropePMC
European journal of immunology, Volume 17, Issue 3, 1 1 1987, Pages 321-326 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, Van Es LA, Daha MR
In order to study the activation of complement by soluble aggregates of human polyclonal serum IgA, lysis of sheep erythrocytes (E) coated with several IgA preparations was used as a model. A complement nonactivating monoclonal mouse IgG1 against IgA was used to coat the cells. IgA, isolated from normal human serum, was aggregated by either N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP), glutaraldehyde, carbodiimide or heating. Depending on the size of the aggregates, and on the method of a... Abstract
Cited 17 times since 1987 (0.5 per year) source: EuropePMC
Plant physiology, Volume 83, Issue 2, 1 1 1987, Pages 244-247 Control of the development of iron-efficiency reactions in potato as a response to iron deficiency is located in the roots. Bienfait HF, de Weger LA, Kramer D
Roots of potato plants (Solanum tuberosum cv Bintje) growing on low Fe nutrient solution developed the characteristic Fe efficiency reactions, such as high ferric reductase activity, proton extrusion and increased root hair formation. Roots from a tuber with sprout removed, when grown on Fe-free nutrient solution, also expressed these reactions; transfer to iron-containing medium resulted in their complete disappearance within 10 days. Roots growing on 2% sucrose in sterile Murashige-Skoog mediu... Abstract
Cited 1 times since 1987 (0 per year) source: EuropePMC
Cancer treatment reports, Volume 71, Issue 2, 1 1 1987, Pages 155-159 Phase I and pharmacokinetic study of trans-N3P3Az2(NHMe)4. Mulder NH, Meijers WH, van der Meulen JD, Sleijfer DT, Uges DR, de Vries EG, Postmus PE, van de Grampel JC, Willemse PH
trans-N3P3Az2(NHMe)4, an aziridinyl-substituted cyclophosphazene, was tested for its toxicity, pharmacokinetic behavior, and cytostatic activity in a phase I study in 30 patients. A total of 66 courses of a single iv bolus injection were given in five dose steps. Toxicity consisted of leukocytopenia and thrombocytopenia, dose limiting at 70 mg/m2, mild anemia, and some nausea. Leukocyte and platelet count nadirs fell between 2 and 3 weeks, with recovery at 6 weeks. A tendency for cumulative thro... Abstract
Cited 1 times since 1987 (0 per year) source: EuropePMC
European journal of respiratory diseases. Supplement, Volume 149, 1 1 1987, Pages 65-71 High-dose etoposide for central nervous system metastases of small cell lung cancer. Preliminary results. Postmus PE, Haaxma-Reiche H, Sleijfer DT, Kleisbauer JP, ten Velde G, Kirkpatrick A
High-dose etoposide (1.0-1.5 g/m2) was given to 17 small cell lung cancer (SCLC) patients with metastases in the central nervous system. In 4 out of 9 evaluable patients with brain metastases and 4 out of 5 patients with meningeal carcinomatosis a response was seen. In all patients severe myelosuppression was observed. Three patients died of septicemia during the aplastic phase. Despite severe toxicity high-dose etoposide is potentially useful for CNS metastases of SCLC. Abstract
Hormone research, Volume 27, Issue 4, 1 1 1987, Pages 195-199 Bromocriptine is unable to suppress TRH-stimulated beta-endorphin/beta-lipotropin and cortisol secretion in normal pregnant women after delivery. Lamberts SW, Angement R, van der Heijden A, Wladimiroff JW, Hackeng WH, de Jong FH
The course of plasma beta-endorphin/beta-lipotropin, cortisol and prolactin (PRL) levels was followed from 0.5 till 5 h after normal delivery in 13 healthy women. Six subjects who did not want to breast-feed their child received 2.5 mg bromocriptine orally 1 h after delivery. After 3 h the effect of the intravenous administration of 200 micrograms thyrotropin-releasing hormone (TRH) was also measured. Elevated plasma beta-endorphin and cortisol levels decreased after delivery in a (log) linear f... Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1325-1331 Stimulation of human polymorphonuclear leukocytes by serum IgA or secretory IgA. Gorter A, Hiemstra PS, Leijh PC, van Es LA, Daha MR
European journal of respiratory diseases. Supplement, Volume 149, 1 1 1987, Pages 29-36 Genome analysis of small cell lung cancer (SCLC) and clinical significance. Buys CH, Osinga J, van der Veen AY, Mooibroek H, van der Hout AH, de Leij L, Postmus PE, Carritt B
A chromosome analysis of three cell lines derived from SCLC showed deletions of the short arm of chromosome 3 with bands p21-p23 as the shortest region of overlap. Hybridization of a polymorphic 3p21 probe to DNA from leukocytes of seven SCLC patients revealed heterozygosity for two of them. In the tumours of both these patients the probe detected homozygosity. This suggests the presence of a mutant cancer gene in the short arm of chromosome 3 which might express itself and/or activate some onco... Abstract
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1333-1338 Binding and degradation of soluble aggregates of IgA by rat peritoneal macrophages. Gorter A, Hiemstra PS, Klar-Mohamad N, van Es LA, Daha MR
European journal of respiratory diseases. Supplement, Volume 149, 1 1 1987, Pages 19-27 Intermediate filament expression in small cell lung cancer; poor correlation to in vitro data. Berendsen HH, de Ley L, Poppema S, Postmus PE, Sluiter HJ, The TH
A panel of monoclonal antibodies, detecting different intermediate sized filament proteins, was prospectively applied on all specimens derived from S.C.L.C. patients attending our clinic in 1985. Reactivity with the antibodies was subsequently correlated to clinical data. The results indicate a heterogeneous pattern of reactivity of the assessed antibodies. However this heterogeneity is not a straightforward extension of the intermediate sized filament expression in SCLC cell lines. Abstract
Cited 5 times since 1987 (0.1 per year) source: EuropePMC
European journal of cancer & clinical oncology, Volume 23, Issue 1, 1 1 1987, Pages 55-60 In vitro chemosensitivity of human lung cancer for vindesine. De Vries EG, Meijer C, Mulder NH, Postmus PE
Firstly, the effect of Vindesine was studied on four different human lung carcinoma cell lines (two small cell, one adeno and one squamous cell) with the Fast Green dye exclusion assay (FGA) and the clonogenic assay. Both methods demonstrate a clear dose response relationship and the estimated drug efficacy is similar for both assays. In the cell lines with the longest doubling time a plateau was reached in the FGA, most probably due to the short culture time in this assay. Secondly, the effect... Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Journal of cancer research and clinical oncology, Volume 113, Issue 1, 1 1 1987, Pages 99-100 Twice weekly vindesine, a phase II study in lung cancer. Postmus PE, Mulder NH, Schipper DL, de Vries EG
Vindesine 1.75 mg/m2, twice weekly for 2 weeks followed by 2 weeks rest, was given to 26 lung cancer patients. In 6 patients a partial response was seen (23%). Neurotoxicity was present in 15 patients after 1 course; in 6 patients this was the reason for stopping therapy. This regimen has no advantage over weekly vindesine. Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1297-1302 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, van Es LA, Daha MR
Cited 2 times since 1986 (0.1 per year) source: EuropePMC
Thorax, Volume 41, Issue 11, 1 1 1986, Pages 840-845 In vitro effect of a mucolytic thiol agent on the activity of polymorphonuclear leucocyte elastase and antileucoprotease. Stolk J, Kramps JA, Dijkman JH
We have studied the effects of the mucolytic thiol agent mercapto-ethanesulphonate (mesna) on the activity of both polymorphonuclear leucocyte (PMN) elastase and antileucoprotease in vitro. In all tests a specific synthetic substrate was used to measure elastase activity, which was then related to enzyme activity in the absence of mesna. The relative elastase activity decreased to 67.5% of control values after the enzyme had been incubated in a 120 mmol/l mesna solution. In the sol phase of puru... Abstract
Cited 5 times since 1986 (0.1 per year) source: EuropePMC
European journal of respiratory diseases, Volume 69, Issue 4, 1 1 1986, Pages 242-247 Evaluation of antileukoprotease in surgical lung specimens. Willems LN, Kramps JA, de Water R, Stijnen T, Fleuren GJ, Franken C, Dijkman JH
To evaluate the presence of antileukoprotease in the lung and its possible contribution to parenchymal protection, surgically removed lungs or lobes of 41 patients were studied. Tissue slices were stained immunohistochemically for antileukoprotease. Site and number of antileukoprotease-containing cells were recorded. To measure emphysema, the mean linear intercept of each slice was determined. Antileukoprotease was observed in bronchial epithelium and glands and in at least two types of noncilia... Abstract