Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
4430 results
The Journal of allergy and clinical immunology, Volume 153, Issue 4, 23 4 2024, Pages 1155-1161.e4 Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis. Clabbers J, Boesjes C, Spekhorst L, van Gisbergen MW, Maas E, Marshall J, Janssen R, Janssen M, Zuithoff N, Steijlen P, de Graaf M, van Geel M, de Bruin-Weller M, Gostyński A
Background: Pathogenic variants in filaggrin (FLG) are associated with an increased risk of atopic dermatitis (AD). Objective: We evaluated the influence of FLG variants on the effectiveness of dupilumab treatment in AD. Methods: This prospective observational study included adult AD patients treated with dupilumab from the BioDay registry. FLG was analyzed with single-molecule molecular inversion probe-targeted sequencing. Novel mutations were confirmed by Sanger sequencing. Eczema Area and Sev... Abstract
Frontiers in oncology, Volume 13, 23 4 2024, Pages 1330468 Treatment decision for recurrences in non-small cell lung cancer during or after adjuvant osimertinib: an international Delphi consensus report. Mirza M, Shrivastava A, Matthews C, Leighl N, Ng CSH, Planchard D, Popat S, Rotow J, Smit EF, Soo R, Tsuboi M, Yang F, Stiles B, Grohe C, Wu YL
Introduction: Osimertinib is recommended by major guidelines for use in the adjuvant setting in patients with EGFR mutation-positive NSCLC following the significant improvement in disease-free survival observed in the Phase III ADAURA trials. Due to limited real-world data in the adjuvant setting, little guidance exists on how to approach potential recurrences either during or after the completion of the treatment. This study aimed to reach a broad consensus on key treatment decision criteria in... Abstract
Children (Basel, Switzerland), Volume 11, Issue 1, 22 4 2024, Pages 134 Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study). Iseri Nepesov M, Kilic O, Sali E, Yesil E, Akar A, Kaman A, Metin Akcan O, Kilic Cil M, Ozlu C, Lacinel Gurlevik S, Ulusoy E, Cetin BS, Akici N, Cakir D, Uslu Aygun FD, Hancerli CO, Tekin Yilmaz A, Alkan G, Uygun H, Bucak IH, Bursal B, Celik T, Sutcu M, Oz FN, Gayretli Aydin ZG, Karbuz A, Akturk H, Kepenekli E, Emiroglu M, Oncel S, Nuhoglu C, Korucu IH, Incesu M, Kaya A, Bombaci H, Dinleyici M, Carman KB, Duman M, Turel O, Yilmaz D, Alabaz D, Belet N, Tanir G, Turgut M, Celebi S, Kuyucu N, Arisoy ES, Durmaz G, Kaya M, Kara A, Dinleyici EC
Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitaliz... Abstract
NPJ vaccines, Volume 9, Issue 1, 2 1 2024, Pages 1 Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial. Prins MLM, Roozen GVT, Pothast CR, Huisman W, van Binnendijk R, den Hartog G, Kuiper VP, Prins C, Janse JJ, Lamers OAC, Koopman JPR, Kruithof AC, Kamerling IMC, Dijkland RC, de Kroon AC, Azimi S, Feltkamp MCW, Kuijer M, Jochems SP, Heemskerk MHM, Rosendaal FR, Roestenberg M, Visser LG, Roukens AHE
Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in a pandemic. We assessed the immunogenicity and safety of primary intradermal (ID) vaccination, with a 1/5th dose compared with the standard intramuscular (IM) dose of mRNA-1273 in SARS-CoV-2 naïve persons. We conducted an open-label, non-inferiority, randomized controlled trial in the Netherlands between June and December 2021. One hundred and fifty healthy and SARS-CoV-2 naïve participan... Abstract
The New England journal of medicine, Volume 390, Issue 4, 1 1 2024, Pages 387 Liver Transplantation. Kappe NN, Stolk J, van Hoek B
Journal of the American College of Cardiology, Volume 83, Issue 1, 1 1 2024, Pages 47-59 Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure. Alogna A, Berboth L, Faragli A, Faragli A, Ötvös J, Lo Muzio FP, di Mauro V, Modica J, Quarta E, Semmler L, Deißler PM, Berger YW, Tran KL, de Marchi B, Longinotti-Buitoni G, Degli Esposti L, Guillot E, Bazile D, Iafisco M, Dotti A, Bang ML, de Luca C, Brandenberger C, Benazzi L, di Silvestre D, de Palma A, Primeßnig U, Hohendanner F, Perna S, Buttini F, Colombo P, Mühlfeld C, Steendijk P, Mauri P, Tschöpe C, Borlaug B, Pieske BM, Attanasio P, Post H, Heinzel FR, Catalucci D
Background: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking. Objectives: In this study, the authors sought to assess tolerability and efficacy of an inhalable lung-to-heart nano-in-micro technology (LungToHeartNIM) for cardiac-specific targeting of a mimetic peptide... Abstract
Cited 1 times since 2024 (2.6 per year) source: EuropePMC
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Volume 46, Issue s1, 1 1 2024, Pages S327-S340 Blood platelet RNA profiles do not enable for nivolumab response prediction at baseline in patients with non-small cell lung cancer. Muller M, Best MG, van der Noort V, Hiltermann TJN, Niemeijer AN, Post E, Sol N, In 't Veld SGJG, Nogarede T, Visser L, Schouten RD, van den Broek D, Hummelink K, Monkhorst K, de Langen AJ, Schuuring E, Smit EF, Groen HJM, Wurdinger T, van den Heuvel MM
Background: Anti-PD-(L)1 immunotherapy has emerged as a promising treatment approach for non-small cell lung cancer (NSCLC), though the response rates remain low. Pre-treatment response prediction may improve patient allocation for immunotherapy. Blood platelets act as active immune-like cells, thereby constraining T-cell activity, propagating cancer metastasis, and adjusting their spliced mRNA content. Objective: We investigated whether platelet RNA profiles before start of nivolumab anti-PD1 i... Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 54, Issue 4, 30 5 2023, Pages 294-296 Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation. Boesjes CM, Bakker DS, Knol EF, de Graaf M, van Wijk F, de Bruin-Weller MS
The international journal of cardiovascular imaging, Volume 40, Issue 3, 27 4 2023, Pages 499-508 The value of serial echocardiography in risk assessment of patients with paroxysmal atrial fibrillation. Leung M, van Rosendael PJ, van der Bijl P, Regeer MV, van Wijngaarden SE, Leung DY, Delgado V, Marsan NA, Ng ACT, Bax JJ
Progression from paroxysmal to persistent atrial fibrillation (AF) is associated with increased morbidity and mortality. We examined the association of left atrial (LA) remodeling by serial echocardiography, and AF progression over an extended follow-up period. Two-hundred ninety patients (mean age 61 ± 11 years, 73% male) who underwent transthoracic echocardiography performed at first presentation for non-valvular paroxysmal AF (PAF) and repeat echocardiogram 1-year later, were followed for p... Abstract
Frontiers in nutrition, Volume 10, 22 4 2023, Pages 1178134 Identifying barriers and facilitators to adopting healthier dietary choices in clinical care: a cross-sectional observational study. de Frel DL, Wicks H, Bakk Z, van Keulen N, Atsma DE, Janssen VR
Background and aims: Adopting healthier diets can drastically improve societal health. Our environment plays a crucial role in daily dietary choices and hospitals in particular can stimulate patients to adopt healthier eating habits. Unfortunately, no robust clinically applicable cuing tools exist to help guide in-hospital dietary interventions. The purpose of this study was to identify patient-related barriers and facilitators to adopting healthier dietary choices. Methods and results: This cro... Abstract
Journal of general internal medicine, Volume 39, Issue 4, 22 4 2023, Pages 683-689 How to Use Costs in Value-Based Healthcare: Learning from Real-life Examples. van der Poort EKJ, Kidanemariam M, Moriates C, Rakers MM, Tsevat J, Schroijen M, Atsma DE, van den Akker-van Marle ME, Bos WJW, van den Hout WB
Background: Healthcare organizations measure costs for business operations but do not routinely incorporate costs in decision-making on the value of care. Aim: Provide guidance on how to use costs in value-based healthcare (VBHC) delivery at different levels of the healthcare system. Setting and participants: Integrated practice units (IPUs) for diabetes mellitus (DM) and for acute myocardial infarction (AMI) at the Leiden University Medical Center and a collaboration of seven breast cancer IPUs... Abstract
BMC health services research, Volume 23, Issue 1, 21 3 2023, Pages 1455 An iterative approach to developing a multifaceted implementation strategy for a complex eHealth intervention within clinical practice. IJzerman RVH, van der Vaart R, Breeman LD, Arkenbout K, Keesman M, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Background: The number of complex eHealth interventions has increased considerably. Despite available implementation theory outlining well-designed strategies, implementing complex interventions within practice proves challenging and often does not lead to sustainable use. To improve sustainability, theory and practice should be addressed during the development of an implementation strategy. By subsequently transparently reporting the executed theory-based steps and their corresponding practice... Abstract
JACC. Clinical electrophysiology, Volume 10, Issue 3, 20 3 2023, Pages 585-603 Mapping and Ablation of Ventricular Tachycardia in Inherited Left Ventricular Cardiomyopathies. Zeppenfeld K, Kimura Y, Ebert M
Advances in the field of human genetics have led to an accumulating understanding of the genetic basis of distinct nonischemic cardiomyopathies associated with ventricular tachycardias (VTs) and sudden cardiac death. To date, there is an increasing proportion of patients with inherited cardiomyopathies requiring catheter ablation for VTs. This review provides an overview of disease-causing gene mutations frequently encountered and relevant for clinical electrophysiologists. Available data on VT... Abstract
Computer methods and programs in biomedicine, Volume 244, 17 3 2023, Pages 107984 Quantification of the intrinsic neural plexus of the heart - The missing link in histological tissue analysis. Chen HS, Voortman LM, van Munsteren JC, Wisse LJ, deRuiter MC, Zeppenfeld K, Jongbloed MRM
Background and objective: The heart is under strict regulation of the autonomic nervous system, during which, in a healthy state, the effects of sympathetic and parasympathetic branches are balanced. In recent years, there has been increasing interest in pathological remodeling and outgrowth of cardiac autonomic nerves in relation to arrhythmogenesis. However, the small size of the cardiac nerves in relatively large tissues renders research using histological quantification of these nerves extre... Abstract
Cancers, Volume 15, Issue 24, 13 2 2023, Pages 5831 Relation between Coronary Artery Calcium Score and Cardiovascular Events in Hodgkin Lymphoma Survivors: A Cross-Sectional Matched Cohort Study. Polomski EAS, Heemelaar JC, de Graaf MA, Krol ADG, Louwerens M, Stöger JL, van Dijkman PRM, Schalij MJ, Jukema JW, Antoni ML
Background: Thoracic radiotherapy is one of the corner stones of HL treatment, but it is associated with increased risk of cardiovascular events. As HL is often diagnosed at a young age, long-term follow-up including screening for coronary artery disease (CAD) is recommended. Objectives: This study aims to evaluate the presence of coronary artery calcium score (CACS) in relation to cardiovascular events in HL patients treated with thoracic radiotherapy compared to a non-cancer control group. Met... Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 103, Issue 2, 13 2 2023, Pages 308-316 Balloon atrial septostomy for transposition of the great arteries: Safety and experience with the Z-5 balloon catheter. Weeda JA, Bokenkamp-Gramann R, Straver BB, Rammeloo L, Hahurij ND, Bertels RA, Haak MC, Te Pas AB, Hazekamp MG, Blom NA, van der Palen RLF
Background: Balloon atrial septostomy (BAS) is an emergent and essential cardiac intervention to enhance intercirculatory mixing at atrial level in deoxygenated patients diagnosed with transposition of the great arteries (TGA) and restrictive foramen ovale. The recent recall of several BAS catheters and the changes in the European legal framework for medical devices (MDR 2017/745), has led to an overall scarcity of BAS catheters and raised questions about the use, safety, and experience of the r... Abstract
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 50, Issue 2, 12 2 2023, Pages 107317 Consensus conference statement on fluorescence-guided surgery (FGS) ESSO course on fluorescence-guided surgery. van Dam MA, Bijlstra OD, Faber RA, Warmerdam MI, Achiam MP, Boni L, Cahill RA, Chand M, Diana M, Gioux S, Kruijff S, Van der Vorst JR, Rosenthal RJ, Polom K, Vahrmeijer AL, Mieog JSD
Background: Fluorescence-guided surgery (FGS) has emerged as an innovative technique with promising applications in various surgical specialties. However, clinical implementation is hampered by limited availability of evidence-based reference work supporting the translation towards standard-of-care use in surgical practice. Therefore, we developed a consensus statement on current applications of FGS. Methods: During an international FGS course, participants anonymously voted on 36 statements. Co... Abstract
Annals of medicine, Volume 55, Issue 2, 8 2 2023, Pages 2283195 Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis. Chen HS, van Roon L, Schoones J, Zeppenfeld K, DeRuiter MC, Jongbloed MRM
Background: Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with arrhythmogenesis and sudden cardiac death. The characteristics of cardiac sympathetic hyperinnervation remain underexposed. Objective: To provide a systematic review on cardiac sympathetic hyperinnervation after MI, taking into account: (1) definition, experimental model and quantification method and (2) location, amount and timing, in order to obtain an overview of current knowledge and to expos... Abstract
Nature reviews. Disease primers, Volume 9, Issue 1, 7 1 2023, Pages 70 Degenerative mitral regurgitation. Delgado V, Ajmone Marsan N, Bonow RO, Hahn RT, Norris RA, Zühlke L, Borger MA
Degenerative mitral regurgitation is a major threat to public health and affects at least 24 million people worldwide, with an estimated 0.88 million disability-adjusted life years and 34,000 deaths in 2019. Improving access to diagnostic testing and to timely curative therapies such as surgical mitral valve repair will improve the outcomes of many individuals. Imaging such as echocardiography and cardiac magnetic resonance allow accurate diagnosis and have provided new insights for a better def... Abstract
Journal of medical Internet research, Volume 25, 4 1 2023, Pages e48461 Guide Development for eHealth Interventions Targeting People With a Low Socioeconomic Position: Participatory Design Approach. Faber JS, Al-Dhahir I, Kraal JJ, Breeman LD, van den Berg-Emons RJG, Reijnders T, van Dijk S, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM
Background: People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities. Objective: We aimed to develop a web-based guide to support professionals in the development, adaptation, evaluation, and implementation of eHealth interve... Abstract