Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 55 times since 2009 (3.7 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 25, Issue 7, 30 5 2009, Pages 669-676 Right ventricular peak systolic longitudinal strain is a sensitive marker for right ventricular deterioration in adult patients with tetralogy of Fallot. Scherptong RW, Mollema SA, Blom NA, Kroft LJ, de Roos A, Vliegen HW, van der Wall EE, Bax JJ, Holman ER
The aim of this study was to evaluate the feasibility of right ventricular (RV) longitudinal peak systolic strain (LPSS) assessment for the follow-up of adult patients with corrected tetralogy of Fallot (TOF). Adult patients (n = 18) with corrected TOF underwent echocardiography and CMR twice with a time interval of 4.2 +/- 1.7 years. RV performance was derived from CMR, and included RV volumes and ejection fraction (EF). LPSS was calculated globally (GLPSS) and in the RV free wall (LPSS FW), wi... Abstract
Cited 34 times since 2009 (2.3 per year) source: EuropePMC
The American journal of cardiology, Volume 103, Issue 10, 1 1 2009, Pages 1451-1456 Relation of resting heart rate to prognosis in patients with idiopathic pulmonary arterial hypertension. Henkens IR, Van Wolferen SA, Gan CT, Boonstra A, Swenne CA, Twisk JW, Kamp O, van der Wall EE, Schalij MJ, Vonk-Noordegraaf A, Vliegen HW
Heart rate (HR) at rest is an important marker of prognosis in heart failure, but has not been addressed in pulmonary arterial hypertension (PAH). To determine the prognostic value of HR at rest in patients with PAH, we retrospectively analyzed 140 consecutive patients with idiopathic PAH. Electrocardiogram (ECG)-derived HR at rest was evaluated as a potential predictor of adverse prognosis (death or lung transplantation), in addition to World Health Organization functional class, 6-minute walk... Abstract
Cited 44 times since 2009 (2.9 per year) source: EuropePMC
Circulation, Volume 119, Issue 11, 9 2 2009, Pages 1467-1472 Tricuspid valve surgery in adults with a dysfunctional systemic right ventricle: repair or replace? Scherptong RW, Vliegen HW, Winter MM, Holman ER, Mulder BJ, van der Wall EE, Hazekamp MG
Background: In patients with a right ventricle (RV) in the systemic position, tricuspid valve surgery for regurgitation beyond adolescence is a subject of debate. The aim of the present study was to evaluate the complications, survival, and benefit of tricuspid surgery in adult patients with an atrium-level correction for transposition of the great arteries or congenitally corrected transposition of the great arteries. Methods and results: All adult patients (n=16; 7 men, 9 women; age 35+/-11 ye... Abstract
Cited 34 times since 2008 (2.2 per year) source: EuropePMC
Radiology, Volume 249, Issue 3, 21 3 2008, Pages 801-809 Aortic elasticity and left ventricular function after arterial switch operation: MR imaging--initial experience. Grotenhuis HB, Ottenkamp J, Fontein D, Vliegen HW, Westenberg JJ, Kroft LJ, de Roos A
Purpose: To prospectively assess aortic dimensions, aortic elasticity, aortic valve competence, and left ventricular (LV) systolic function in patients after the arterial switch operation (ASO) by using magnetic resonance (MR) imaging. Materials and methods: Informed consent was obtained from all participants for this local ethics committee-approved study. Fifteen patients (11 male patients, four female patients; mean age, 16 years +/- 4 [standard deviation]; imaging performed 16.1 years after s... Abstract
Cited 48 times since 2008 (3.1 per year) source: EuropePMC
Journal of electrocardiology, Volume 41, Issue 6, 25 4 2008, Pages 648-655 Normal limits of the spatial QRS-T angle and ventricular gradient in 12-lead electrocardiograms of young adults: dependence on sex and heart rate. Scherptong RW, Henkens IR, Man SC, Le Cessie S, Vliegen HW, Draisma HH, Maan AC, Schalij MJ, Swenne CA
Background and purpose: Normal limits of the spatial QRS-T angle and spatial ventricular gradient (SVG) are only available from Frank vectorcardiograms (VCGs) of male subjects. We determined normal limits for these variables derived from standard 12-lead electrocardiograms (ECGs) of 660 male and female students aged 18 to 29 years. Methods: A computer algorithm was used that constructed approximated VCG leads by inverse Dower matrix transformation of the 12-lead ECG and subsequently calculated t... Abstract
Cited 9 times since 2008 (0.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 7-8, 1 1 2008, Pages 250-254 Pulmonary hypertension: the role of the electrocardiogram. Henkens IR, Scherptong RW, van Kralingen KW, Said SA, Vliegen HW
A 54-year-old female was referred to our centre for further evaluation of recently established severe pulmonary hypertension. Six months prior to presentation to the cardiologist of the referring centre, the patient had first experienced exertional dyspnoea. At the time of presentation to the referring cardiologist, the patient's ECG showed signs of an increased right heart load. Interestingly, this patient had undergone a thorough cardiac evaluation in the referring centre seven years befo... Abstract
Cited 5 times since 2008 (0.3 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 24, Issue 8, 24 4 2008, Pages 867-870 Diastolic dysfunction: a new additional criterion for optimal timing of pulmonary valve replacement in adult patient with tetralogy of Fallot? Mulder BJ, Vliegen HW, van der Wall EE
Cited 25 times since 2008 (1.6 per year) source: EuropePMC
Chest, Volume 134, Issue 6, 18 3 2008, Pages 1250-1257 ECG monitoring of treatment response in pulmonary arterial hypertension patients. Henkens IR, Gan CT, van Wolferen SA, Hew M, Boonstra A, Twisk JWR, Kamp O, van der Wall EE, Schalij MJ, Vonk Noordegraaf A, Vliegen HW
Background: The potential use of the ECG for monitoring treatment effects in patients with pulmonary arterial hypertension (PAH) has not been investigated. We evaluated whether the ECG is useful for monitoring treatment response based on changes in pulmonary vascular resistance (PVR). Methods: An ECG was recorded in 81 PAH patients at the time of diagnostic right heart catheterization and after 1 year of treatment. Patients were treated according to the guidelines. Patients were divided into two... Abstract
Cited 9 times since 2008 (0.6 per year) source: EuropePMC
Congenital heart disease, Volume 3, Issue 4, 1 1 2008, Pages 277-283 Menstrual cycle and its disorders in women with congenital heart disease. Drenthen W, Hoendermis ES, Moons P, Heida KY, Roos-Hesselink JW, Mulder BJ, Van Dijk AP, Vliegen HW, Sollie KM, Berger RM, Lely AT, Canobbio MM, Pieper PG
Objectives: To investigate the age at menarche, the prevalence of menstrual cycle (interval) disorders, and determinants in women with congenital heart disease (CHD). Design: Using two CHD registries, 1802 (82%) of the 2196 women with CHD contacted (aged 18-58 years) provided written informed consent. After exclusion of patients with genetic disorders known to be associated with menstrual cycle disorders, 1593 eligible patients remained. Interviews by telephone and reviews of medical records wer... Abstract
Cited 62 times since 2008 (3.9 per year) source: EuropePMC
Circulation, Volume 118, Issue 1, 16 3 2008, Pages 26-32 Gender and outcome in adult congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Vliegen HW, van Dijk AP, Bouma BJ, Grobbee DE, Mulder BJ
Background: Gender differences in prognosis have frequently been reported in cardiovascular disease but less so in congenital heart disease. We investigated whether gender is associated with outcome in adult patients with congenital heart disease. Methods and results: From the CONgenital CORvitia (CONCOR) national registry for adults with congenital heart disease, 7414 patients were identified. All outcomes before entry into the registry and during subsequent follow-up were recorded, and differe... Abstract
Cited 26 times since 2008 (1.6 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 294, Issue 5, 29 5 2008, Pages H2150-7 Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging. Henkens IR, Mouchaers KT, Vonk-Noordegraaf A, Boonstra A, Swenne CA, Maan AC, Man SC, Twisk JW, van der Wall EE, Schalij MJ, Vliegen HW
The study aimed to assess whether the 12-lead ECG-derived ventricular gradient, a vectorial representation of ventricular action potential duration heterogeneity directed toward the area of shortest action potential duration, can improve ECG diagnosis of chronic right ventricular (RV) pressure load. ECGs from 72 pulmonary arterial hypertension patients recorded 1 with R > 0.5 mV in V1, and QRS axis >90 degrees ) had a sensitivity of 89% and a specificity of 93% for presence of chronic RV... Abstract
Cited 12 times since 2007 (0.7 per year) source: EuropePMC
Radiology, Volume 246, Issue 2, 4 1 2007, Pages 394-400 MR imaging of right ventricular function after the Ross procedure for aortic valve replacement: initial experience. Grotenhuis HB, de Roos A, Ottenkamp J, Schoof PH, Vliegen HW, Kroft LJ
Purpose: To prospectively assess right ventricular (RV) function after the Ross procedure by using magnetic resonance (MR) imaging. Materials and methods: The local ethics committee approved the study and informed consent was obtained from all participants prior to enrollment in the study. Seventeen patients (15 male, two female; mean age +/- standard deviation, 19 years +/- 3.9; imaging performed 8.3 years after surgery +/- 3.2) and 17 matched controls (15 male, two female; mean age +/- standar... Abstract
Cited 9 times since 2007 (0.5 per year) source: EuropePMC
Cardiology, Volume 109, Issue 2, 14 2 2007, Pages 105-109 Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle. Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Hoendermis ES, Voors AA, Mulder BJ, van Dijk AP, Yap SC, Vliegen HW, Moons P, Ebels T, van Veldhuisen DJ
Objectives: To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV). Methods: Using 2 congenital heart disease registries, 21 female patients with DORV (aged 18-39 years) were retrospectively identified. Detailed recordings of each patient and their completed (>20 weeks gestation) pregnancies were recorded. Results: Overall, 10 patients had 19 pregnancies, including 3 spontaneous miscarriages (16%). During the 16 live birth pregnancies, primarily (... Abstract
Cited 298 times since 2007 (17.7 per year) source: EuropePMC
Circulation, Volume 116, Issue 5, 9 2 2007, Pages 545-551 Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance. Oosterhof T, van Straten A, Vliegen HW, Meijboom FJ, van Dijk AP, Spijkerboer AM, Bouma BJ, Zwinderman AH, Hazekamp MG, de Roos A, Mulder BJ
Background: To facilitate the optimal timing of pulmonary valve replacement, we analyzed preoperative thresholds of right ventricular (RV) volumes above which no decrease or normalization of RV size takes place after surgery. Methods and results: Between 1993 and 2006, 71 adult patients with corrected tetralogy of Fallot underwent pulmonary valve replacement in a nationwide, prospective follow-up study. Patients were evaluated with cardiovascular magnetic resonance both preoperatively and postop... Abstract
Cited 15 times since 2007 (0.9 per year) source: EuropePMC
The Journal of heart valve disease, Volume 16, Issue 4, 1 1 2007, Pages 398-403 Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease. Yap SC, Drenthen W, Pieper PG, Moons P, Mulder BJ, Klieverik LM, Vliegen HW, van Dijk AP, Meijboom FJ, Roos-Hesselink JW, ZAHARA investigators
Background and aim of the study: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft valve replacement is limited. Methods: Using a nationwide Dutch registry (CONCOR) and a local Belgian tertiary care center database, 17 women (age range: 18 to 45 years) with pulmonary autograft valve replacement w... Abstract
Cited 237 times since 2007 (14 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 49, Issue 24, 4 1 2007, Pages 2303-2311 Outcome of pregnancy in women with congenital heart disease: a literature review. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ, ZAHARA Investigators
A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more... Abstract
Cited 29 times since 2007 (1.7 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 293, Issue 2, 11 2 2007, Pages H1300-7 Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography. Henkens IR, Mouchaers KT, Vliegen HW, van der Laarse WJ, Swenne CA, Maan AC, Draisma HH, Schalij I, van der Wall EE, Schalij MJ, Vonk-Noordegraaf A
The study aim was to assess three-dimensional electrocardiogram (ECG) changes during development of pulmonary arterial hypertension (PAH). PAH was induced in male Wistar rats (n = 23) using monocrotaline (MCT; 40 mg/kg sc). Untreated healthy rats served as controls (n = 5). ECGs were recorded with an orthogonal three-lead system on days 0, 14, and 25 and analyzed with dedicated computer software. In addition, left ventricular (LV)-to-right ventricular (RV) fractional shortening ratio was determi... Abstract
Cited 60 times since 2007 (3.5 per year) source: EuropePMC
International journal of cardiology, Volume 126, Issue 2, 4 1 2007, Pages 240-246 Risk of complications during pregnancy in women with congenital aortic stenosis. Yap SC, Drenthen W, Pieper PG, Moons P, Mulder BJ, Mostert B, Vliegen HW, van Dijk AP, Meijboom FJ, Steegers EA, Roos-Hesselink JW, ZAHARA investigators
Background: Pregnancy in women with congenital aortic stenosis (AS) is associated with increased cardiac complications. Data on non-cardiac complications are limited, and this information is crucial for prenatal counselling and perinatal care. The aim of this study was to present the maternal and perinatal outcome of pregnancy in women with congenital AS. Methods: By review of the Dutch CONCOR national registry and a local Belgian tertiary care centre database, 35 women with congenital AS with a... Abstract
Cited 10 times since 2007 (0.6 per year) source: EuropePMC
International journal of cardiology, Volume 124, Issue 3, 11 2 2007, Pages 301-306 Pulmonary valve replacement in tetralogy of Fallot improves the repolarization. Hooft van Huysduynen B, Henkens IR, Swenne CA, Oosterhof T, Draisma HH, Maan AC, Hazekamp MG, de Roos A, Schalij MJ, van der Wall EE, Vliegen HW
Objective: To assess the effect of pulmonary valve replacement (PVR) on the repolarization of patients with tetralogy of Fallot. Background: Pulmonary valve regurgitation may cause right ventricular failure in adult patients with Fallot's tetralogy. In these patients, prolonged depolarization and disturbed repolarization are associated with ventricular arrhythmias and sudden cardiac death. Methods: Thirty Fallot patients (age 32+/-9 years, 19 male) eligible for PVR were studied with cardiac... Abstract
Cited 51 times since 2007 (3 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 83, Issue 3, 1 1 2007, Pages 907-911 Predicting outcome of pulmonary valve replacement in adult tetralogy of Fallot patients. Henkens IR, van Straten A, Schalij MJ, Hazekamp MG, de Roos A, van der Wall EE, Vliegen HW
Background: Predicting changes in right ventricular (RV) size and function after pulmonary valve replacement (PVR) is important for timely reintervention in adult tetralogy of Fallot patients. Methods: We analyzed the influence of pulmonary regurgitation severity and RV size and function before PVR on the outcome of RV size and function after PVR in 27 adult Fallot patients who had cardiac magnetic resonance imaging before and after PVR. RV dimensions were indexed for body surface area. Results:... Abstract