Cited 9 times since 2007 (0.5 per year) source: EuropePMC Cardiology, Volume 109, Issue 2, 14 2 2007, Pages 105-109 Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle. Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Hoendermis ES, Voors AA, Mulder BJ, van Dijk AP, Yap SC, Vliegen HW, Moons P, Ebels T, van Veldhuisen DJ
Objectives
To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV).
Methods
Using 2 congenital heart disease registries, 21 female patients with DORV (aged 18-39 years) were retrospectively identified. Detailed recordings of each patient and their completed (>20 weeks gestation) pregnancies were recorded.
Results
Overall, 10 patients had 19 pregnancies, including 3 spontaneous miscarriages (16%). During the 16 live birth pregnancies, primarily (serious) noncardiac complications were observed, e.g. premature labor/delivery (n = 7 and n = 3, respectively), small for gestational age (n = 4), preeclampsia (n = 2) and recurrence of congenital heart disease (n = 2). Except for postpartum endocarditis and deterioration of subpulmonary obstruction, only mild cardiac complication pregnancies were recorded. Two women with children reported secondary female infertility. Several menstrual cycle disorders were reported: secondary amenorrhea (n = 4), primary amenorrhea (n = 3) and oligomenorrhea (n = 2).
Conclusion
Successful pregnancy in women with DORV is possible. Primarily noncardiac complications were observed and only few (minor) cardiac complications. Infertility and menstrual cycle disorders appear to be more prevalent.
