Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 24 times since 2007 (1.4 per year) source: EuropePMC
Anesthesiology, Volume 107, Issue 4, 1 1 2007, Pages 537-544 Guidelines for cardiac management in noncardiac surgery are poorly implemented in clinical practice: results from a peripheral vascular survey in the Netherlands. Hoeks SE, Scholte op Reimer WJ, Lenzen MJ, van Urk H, Jörning PJ, Boersma E, Simoons ML, Bax JJ, Poldermans D
Background: The American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for Perioperative Cardiovascular Evaluation for Noncardiac Surgery recommend an algorithm for a stepwise approach to preoperative cardiac assessment in vascular surgery patients. The authors' main objective was to determine adherence to the ACC/AHA guidelines on perioperative care in daily clinical practice. Methods: Between May and December 2004, data on 711 consecutive peripheral vascular surg... Abstract
Cited 83 times since 2007 (5 per year) source: EuropePMC
Radiology, Volume 245, Issue 1, 1 1 2007, Pages 251-257 Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. van der Meer RW, Doornbos J, Kozerke S, Schär M, Bax JJ, Hammer S, Smit JW, Romijn JA, Diamant M, Rijzewijk LJ, de Roos A, Lamb HJ
Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age+/-standard error, 31 years+/-2.8 [range, 19-60 years]; body mass index, 19-30 kg/m... Abstract
Cited 32 times since 2007 (1.9 per year) source: EuropePMC
The Journal of general virology, Volume 88, Issue Pt 10, 1 1 2007, Pages 2702-2709 Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains. Herfst S, de Graaf M, Schrauwen EJA, Ulbrandt ND, Barnes AS, Senthil K, Osterhaus ADME, Fouchier RAM, van den Hoogen BG
Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate antigenic differences. The clinical impact of hMPV warrants the development of vaccines. Recombinant soluble fusion (F) proteins of prototype viruses of the two main lineages of hMPV that can be pr... Abstract
Cited 1 times since 2007 (0.1 per year) source: EuropePMC
Revista espanola de cardiologia, Volume 60, Issue 10, 1 1 2007, Pages 1083-1091 [Coronary risk assessment in the management of patients undergoing noncardiac vascular surgery]. Schouten O, Bax JJ, Poldermans D
Patients scheduled for noncardiac vascular surgery are at significant risk of cardiovascular morbidity and mortality due to underlying symptomatic or asymptomatic coronary artery disease. This review will give an overview of current preoperative cardiac risk assessment strategies for patients undergoing noncardiac vascular surgery. Clinical cardiac risk scores are useful tools for the simple identification of patients with an increased perioperative cardiac risk. These risk scores include factor... Abstract
Cited 19 times since 2007 (1.1 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 17, 1 1 2007, Pages 1649-1656 Intensity of statin therapy in relation to myocardial ischemia, troponin T release, and clinical cardiac outcome in patients undergoing major vascular surgery. Feringa HH, Schouten O, Karagiannis SE, Brugts J, Elhendy A, Boersma E, Vidakovic R, van Sambeek MR, Noordzij PG, Bax JJ, Poldermans D
Objectives: This study sought to examine whether higher statin doses and lower low-density lipoprotein (LDL) cholesterol are associated with improved cardiac outcome in vascular surgery patients. Background: Statins may have cardioprotective effects during major vascular surgery. Methods: In a prospective study of 359 vascular surgery patients, statin dose and cholesterol levels were recorded preoperatively. Myocardial ischemia and heart rate variability were assessed by 72-h 12-lead electrocard... Abstract
Cited 8 times since 2007 (0.5 per year) source: EuropePMC
The European respiratory journal, Volume 30, Issue 4, 1 1 2007, Pages 810-812 Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, Macnee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
Cited 89 times since 2007 (5.4 per year) source: EuropePMC
Circulation, Volume 116, Issue 17, 1 1 2007, Pages 1931-1941 CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. Kraaijeveld AO, de Jager SC, de Jager WJ, Prakken BJ, McColl SR, Haspels I, Putter H, van Berkel TJ, Nagelkerken L, Jukema JW, Biessen EA
Background: Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. Methods and results: Plasma samples of 54 patients with Braunwald class IIIB UAP were examined at baseline for 11 chemokines and 5 inflammatory mediators via multiplex analysis. Levels of CC chemokine ligand (CCL)-5 (... Abstract
Cited 67 times since 2007 (4 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 16, 1 1 2007, Pages 1532-1540 Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling. Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Gorcsan J, Bax JJ
Objectives: We sought to identify predictors of left ventricular (LV) remodeling after acute myocardial infarction. Background: Left ventricular remodeling after myocardial infarction is associated with an adverse long-term prognosis. Early identification of patients prone to LV remodeling is needed to optimize therapeutic management. Methods: A total of 178 consecutive patients presenting with acute myocardial infarction who underwent primary percutaneous coronary intervention were included. Wi... Abstract
Cited 59 times since 2007 (3.6 per year) source: EuropePMC
Journal of internal medicine, Volume 262, Issue 6, 1 1 2007, Pages 678-689 Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ, Kastelein JJ, Khaw KT
Background: We examined the relationship between granulocyte, lymphocyte and monocyte counts and risk of coronary heart disease (CHD) and cardiovascular disease (CVD) in men and women. There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD. Methods: This prospective study comprised 7073 men and 9035 women who were 45-79 years of age and were residents of Norfolk. United Kingdom. Results: During an average of 8 years of follow-up we identifi... Abstract
Cited 16 times since 2007 (1 per year) source: EuropePMC
The FEBS journal, Volume 274, Issue 20, 26 4 2007, Pages 5425-5437 Aplysia temptin - the 'glue' in the water-borne attractin pheromone complex. Cummins SF, Xie F, de Vries MR, Annangudi SP, Misra M, Degnan BM, Sweedler JV, Nagle GT, Schein CH
Temptin, a component of the complex of water-borne protein pheromones that stimulate attraction and mating behavior in the marine mollusk Aplysia, has sequence homology to the epidermal growth factor (EGF)-like domains of higher organisms that mediate protein-cell surface contact during fertilization and blood coagulation. In this work, recombinant temptin for structural and functional studies was produced in Escherichia coli using a cold shock promoter and purified by RP-HPLC. CD spectra confir... Abstract
Cited 177 times since 2007 (10.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 15, 24 4 2007, Pages 1476-1483 Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. Gorcsan J, Tanabe M, Bleeker GB, Suffoletto MS, Thomas NC, Saba S, Tops LF, Schalij MJ, Bax JJ
Objectives: The purpose of this study was to test the hypothesis that a combined echocardiographic assessment of longitudinal dyssynchrony by tissue Doppler imaging (TDI) and radial dyssynchrony by speckle-tracking strain may predict left ventricular (LV) functional response to cardiac resynchronization therapy (CRT). Background: Mechanical LV dyssynchrony is associated with response to CRT; however, complex patterns may exist. Methods: We studied 190 heart failure patients (ejection fraction [E... Abstract
Cited 39 times since 2007 (2.3 per year) source: EuropePMC
Radiology, Volume 245, Issue 2, 21 3 2007, Pages 416-423 Evaluation of patients with previous coronary stent implantation with 64-section CT. Schuijf JD, Pundziute G, Jukema JW, Lamb HJ, Tuinenburg JC, van der Hoeven BL, de Roos A, Reiber JH, van der Wall EE, Schalij MJ, Bax JJ
Purpose: To prospectively evaluate the diagnostic accuracy of 64-section computed tomography (CT) for the assessment of in-stent or peristent restenosis, with conventional coronary angiography as the reference standard. Materials and methods: The study was approved by the medical ethics committee, and informed consent was obtained in all 50 enrolled patients (40 men, 10 women; mean age, 60 years +/- 11 [standard deviation]). In addition to conventional coronary angiography with quantitative coro... Abstract
Cited 58 times since 2007 (3.5 per year) source: EuropePMC
Atherosclerosis, Volume 197, Issue 1, 14 2 2007, Pages 57-63 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice. de Haan W, van der Hoogt CC, Westerterp M, Hoekstra M, Dallinga-Thie GM, Princen HM, Romijn JA, Jukema JW, Havekes LM, Rensen PC
Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP expression. Methods and results: APOE*3-Leiden (E3L) mice, with a human-like lipoprotein profile and a human-like responsiveness to statin treatment, were crossbred with mice expressing human CETP und... Abstract
Cited 56 times since 2007 (3.4 per year) source: EuropePMC
American heart journal, Volume 154, Issue 6, 14 2 2007, Pages 1160-1165 Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Ypenburg C, Sieders A, Bleeker GB, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). Methods: Thirty-one consecutive patients with heart failure (LV ejection fraction [LVEF] 26% +/- 7%, 35% nonischemic cardiomyopathy) underwent echocardiography during low-dose dobutamine infusion before CRT impla... Abstract
Cited 48 times since 2007 (2.9 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 35, Issue 1, 12 2 2007, Pages 166-173 Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ
Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal cou... Abstract
Cited 9 times since 2007 (0.5 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 43, Issue 16, 10 2 2007, Pages 2345-2350 Phase III study of cyclophosphamide, doxorubicin, and etoposide compared with carboplatin and paclitaxel in patients with extensive disease small-cell lung cancer. de Jong WK, Groen HJ, Koolen MG, Biesma B, Willems LN, Kwa HB, van Bochove A, van Tinteren H, Smit EF
The progression-free survival (PFS) of cyclophosphamide/doxorubicin/etoposide (CDE) and carboplatin/paclitaxel (CP) was compared in chemonaive patients with extensive disease small-cell lung cancer (ED-SCLC). A total of 203 patients were randomised to three-weekly CDE (n=102) or CP (n=101) for five cycles. Tumour response rates in CDE and CP were 60% and 61%. PFS of CP was 5.2 months, PFS of CDE 4.9 months (p=0.60). The major difference in toxicity between CDE and CP was grade 4 leukocytopaenia... Abstract
Cited 11 times since 2007 (0.7 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 293, Issue 5, 7 1 2007, Pages L1321-31 Microtubule dynamics and Rac-1 signaling independently regulate barrier function in lung epithelial cells. Lorenowicz MJ, Fernandez-Borja M, van Stalborch AM, van Sterkenburg MA, Hiemstra PS, Hordijk PL
Cadherin-mediated cell-cell adhesion controls the morphology and function of epithelial cells and is a critical component of the pathology of chronic inflammatory disorders. Dynamic interactions between cadherins and the actin cytoskeleton are required for stable cell-cell contact. Besides actin, microtubules also target intercellular, cadherin-based junctions and contribute to their formation and stability. Here, we studied the role of microtubules in conjunction with Rho-like GTPases in the re... Abstract
Cited 35 times since 2007 (2.1 per year) source: EuropePMC
The European respiratory journal, Volume 31, Issue 1, 5 1 2007, Pages 70-77 Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies. Snoeck-Stroband JB, Lapperre TS, Gosman MM, Boezen HM, Timens W, ten Hacken NH, Sont JK, Sterk PJ, Hiemstra PS, Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group
The presence of chronic bronchitis predicts a more rapid decline of forced expiratory volume in one second (FEV(1)) in patients with chronic obstructive pulmonary disease (COPD). The hallmark of COPD is airway inflammation. It was hypothesised that COPD patients with chronic bronchitis are characterised by a distinct inflammatory cell profile, as measured in bronchial biopsies and sputum. From 114 COPD patients (male/female ratio 99/15, mean+/-sd age 62+/-8 yrs, current smoking 63%, post-broncho... Abstract
Cited 104 times since 2007 (6.2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 12, 4 1 2007, Pages 1180-1188 Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing. Tops LF, Suffoletto MS, Bleeker GB, Boersma E, van der Wall EE, Gorcsan J, Schalij MJ, Bax JJ
Objectives: Speckle-tracking strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall strain and left ventricular (LV) dyssynchrony. Background: Recent studies have shown detrimental effects of RV pacing, possibly related to the induction of LV dyssynchrony. Methods: Fifty-eight patients treated with His bundle ablation and pacemaker implantation were studied. To assess the effect of RV pacing on time-to-peak radial... Abstract
Cited 137 times since 2007 (8.2 per year) source: EuropePMC
Circulation, Volume 116, Issue 13, 4 1 2007, Pages 1440-1448 Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline. Bleeker GB, Mollema SA, Holman ER, Van de Veire N, Ypenburg C, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Background: Recent studies have demonstrated that a positive response to cardiac resynchronization therapy (CRT) is related to the presence of preimplantation left ventricular (LV) dyssynchrony. The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown. Methods and results: One hundred consecutive patients scheduled for implantation of a CRT device were prospectively included if they met the following criteria: New York... Abstract