Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 15 times since 2018 (2.6 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 156, Issue 6, 18 3 2018, Pages 2260-2269 Coding of coronary arterial origin and branching in congenital heart disease: The modified Leiden Convention. Gittenberger-de Groot AC, Koenraadt WMC, Bartelings MM, Bökenkamp R, DeRuiter MC, Hazekamp MG, Bogers AJJC, Quaegebeur JM, Schalij MJ, Vliegen HW, Poelmann RE, Jongbloed MRM
Objectives: Variations in coronary anatomy are common and may relate to the position of the coronary ostium relative to the aortic sinus, the angle of coronary take-off, or the course of the coronary arterial branches. Several classification systems have been proposed. However, they all lack a simple rationale that is applicable irrespective of the relative position of the great arteries, as well as in bicuspid aortic valves. We present a modification of a relatively simple system introduced in... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
International journal of cardiology, Volume 273, 24 4 2018, Pages 203-206 ECG derived ventricular gradient exceeds echocardiography in the early detection of pulmonary hypertension in scleroderma patients. Meijer FMM, Kies P, Jongbloed MRM, van Wijngaarden SE, Swenne CA, Man S, Schalij MJ, de Vries-Bouwstra JK, Vliegen HW
Background: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
Heart, lung & circulation, Volume 28, Issue 6, 8 2 2018, Pages 893-900 Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic Liver Transplantation Recipients With Endstage Cirrhosis. Couperus LE, Vliegen HW, Sorgdrager BJ, den Dulk AC, Beeres SLMA, Sarton EY, Dubbeld J, Schalij MJ, Jukema JW, van Hoek B, Scherptong RWC
Background: Severely increased right ventricular (RV) afterload is considered a contra-indication for orthotopic liver transplantation (OLT). This study assesses the effects of mildly increased RV afterload on long-term outcome after OLT in relation to RV function. Methods: 139 OLT recipients (53±12years, 76% male) were included. Preoperative RV afterload was assessed invasively or, if not available, echocardiographically and categorised as normal, high-normal (mean pulmonary artery pressure [PA... Abstract
Cited 20 times since 2017 (3.1 per year) source: EuropePMC
Circulation, Volume 137, Issue 14, 8 2 2017, Pages 1463-1471 Effect of Losartan on Right Ventricular Dysfunction: Results From the Double-Blind, Randomized REDEFINE Trial (Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-Angiotensin-Aldosterone System) in Adults With Repaired Tetralogy of Fallot. Bokma JP, Winter MM, van Dijk AP, Vliegen HW, van Melle JP, Meijboom FJ, Post MC, Berbee JK, Boekholdt SM, Groenink M, Zwinderman AH, Mulder BJM, Bouma BJ
Background: The effect of angiotensin II receptor blockers on right ventricular (RV) function is still unknown. Angiotensin II receptor blockers are beneficial in patients with acquired left ventricular dysfunction, and recent findings have suggested a favorable effect in symptomatic patients with systemic RV dysfunction. The current study aimed to determine the effect of losartan, an angiotensin II receptor blocker, on subpulmonary RV dysfunction in adults after repaired tetralogy of Fallot. Me... Abstract
Cited 3 times since 2017 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 243, 2 1 2017, Pages 191-193 Clinical course of tricuspid regurgitation in repaired tetralogy of Fallot. Woudstra OI, Bokma JP, Winter MM, Kiès P, Jongbloed MRM, Vliegen HW, Groenink M, Meijboom FJ, Mulder BJM, Bouma BJ
Background: Little is known on the clinical course of tricuspid regurgitation (TR) in patients with repaired tetralogy of Fallot (rTOF) and which patients are at particular risk. This study aims to determine TR course, characteristics associated with TR progression, and the prognostic relevance of TR in rTOF patients. Methods: In this dualcenter cohort study, rTOF patients from a prospective national registry with ≥1 cardiac magnetic resonance imaging study and ≥2 echocardiograms available were... Abstract
Cited 25 times since 2017 (3.6 per year) source: EuropePMC
JAMA cardiology, Volume 2, Issue 6, 1 1 2017, Pages 678-683 Value of Cardiovascular Magnetic Resonance Imaging in Noninvasive Risk Stratification in Tetralogy of Fallot. Bokma JP, de Wilde KC, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Zwinderman AH, Groenink M, Mulder BJM, Bouma BJ
Importance: Adults late after total correction of tetralogy of Fallot (TOF) are at risk for major complications. Cardiovascular magnetic resonance (CMR) imaging is recommended to quantify right ventricular (RV) and left ventricular (LV) function. However, a commonly used risk model by Khairy et al requires invasive investigations and lacks CMR imaging to identify high-risk patients. Objective: To implement CMR imaging in noninvasive risk stratification to predict major adverse clinical outcomes.... Abstract
Cited 7 times since 2017 (1 per year) source: EuropePMC
European journal of preventive cardiology, Volume 24, Issue 12, 25 4 2017, Pages 1319-1327 Chance of surgery in adult congenital heart disease. Verheugt CL, Uiterwaal CS, Vaartjes I, van der Velde ET, Zomer AC, Meijboom FJ, Pieper PG, Post MC, Vliegen HW, Hazekamp MG, Grobbee DE, Mulder BJ
Background Young patients with congenital heart disease reaching adulthood face mandatory transition to adult cardiology. Their new cardiologist needs to assess the chances of major future events such as surgery. Using a large national registry, we assessed if patient characteristics at the age of 18 years could predict the chance of congenital heart surgery in adulthood. Design and methods Of 10,300 patients from the CONCOR national registry, we used general patient characteristics at age 18 ye... Abstract
Cited 2 times since 2017 (0.3 per year) source: EuropePMC
American heart journal, Volume 186, 2 1 2017, Pages 83-90 Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system (REDEFINE) trial: Rationale and design of a randomized, double-blind, placebo-controlled clinical trial. Bokma JP, Winter MM, Kornaat EM, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Post MC, Berbee JK, Zwinderman AH, Mulder BJM, Bouma BJ
Renin-angiotensin-aldosterone system (RAAS) inhibition with angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors is beneficial in patients with acquired left ventricular dysfunction. Adult patients with tetralogy of Fallot (TOF) with right ventricular (RV) dysfunction are at high risk for heart failure, arrhythmias, and sudden cardiac death. However, the efficacy of RAAS inhibition has not been established in these patients. Methods: The REDEFINE is an investigator-initia... Abstract
Cited 28 times since 2016 (3.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 103, Issue 9, 1 1 2016, Pages 666-671 QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot. Bokma JP, Winter MM, Vehmeijer JT, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Post MC, Zwinderman AH, Mulder BJ, Bouma BJ
Background: Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented QRS complexes, a simple measurement on ECG, are related to myocardial fibrosis and dysfunction in patients with TOF. Our objective was to determine whether QRS fragmentation predicts major outcomes in TOF. Methods: This multicentre study included adult patients with TOF from a prospective registry. Notches in the QRS complex in ≥2 con... Abstract
Journal of electrocardiology, Volume 50, Issue 1, 8 2 2016, Pages 115-122 Detection of elevated pulmonary pressures by the ECG-derived ventricular gradient: A comparison of conversion matrices in patients with suspected pulmonary hypertension. Haeck ML, Kapel GF, Scherptong RW, Swenne CA, Maan AC, Bax JJ, Schalij MJ, Vliegen HW
Background: The aim was to assess the diagnostic value of the Inverse Dower (INVD)-derived vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH). Methods: In 132 patients, morphologic variables were evaluated by comparing the VCG parameters synthesized by INVD and Kors matrix. Comparison of the diagnostic accuracy of detecting SPAP ≥50mmHg between the matrices was performed by ROC curve analysis and l... Abstract
Cited 4 times since 2016 (0.5 per year) source: EuropePMC
The American journal of cardiology, Volume 118, Issue 3, 14 2 2016, Pages 326-331 Prognostic Implications of Elevated Pulmonary Artery Pressure After ST-Segment Elevation Myocardial Infarction. Haeck ML, Hoogslag GE, Boden H, Velders MA, Katsanos S, Al Amri I, Debonnaire P, Schalij MJ, Vliegen HW, Bax JJ, Marsan NA, Delgado V
Elevated systolic pulmonary artery pressure (SPAP) after ST-segment elevation myocardial infarction (STEMI) has been associated with adverse outcome. However, little is known about the development of increased SPAP after STEMI treated with primary percutaneous coronary intervention. The aims of this study were to investigate the incidence and determinants of elevated SPAP (SPAP ≥36 mm Hg at 12 months) after first STEMI and to analyze its prognostic implications. A total of 705 patients (60 ± 12 ... Abstract
Cited 2 times since 2016 (0.2 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 6, 20 3 2016, Pages 400-409 Tailored circulatory intervention in adults with pulmonary hypertension due to congenital heart disease. Couperus LE, Henkens IR, Jongbloed MRM, Hazekamp MG, Schalij MJ, Vliegen HW
Background: Adults with pulmonary hypertension associated with congenital heart disease (PH-CHD) often have residual shunts. Invasive interventions aim to optimise pulmonary flow and prevent right ventricular failure. However, eligibility for procedures strongly depends on the adaptation potential of the pulmonary vasculature and right ventricle to resultant circulatory changes. Current guidelines are not sufficiently applicable to individual patients, who exhibit great diversity and complexity... Abstract
Cited 14 times since 2016 (1.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 3, 16 3 2016, Pages 456-463 Follow-up after tricuspid valve surgery in adult patients with systemic right ventricles. Koolbergen DR, Ahmed Y, Bouma BJ, Scherptong RW, Bruggemans EF, Vliegen HW, Holman ER, Mulder BJ, Hazekamp MG
Objectives: In patients with congenitally corrected transposition of the great arteries (ccTGA) or after atrial (Mustard or Senning) correction for transposition of the great arteries (acTGA), the right ventricle (RV) supports the systemic circulation. The tricuspid valve (TV) (systemic atrioventricular valve) is prone to regurgitation in these patients and this is associated with impending RV failure and decreased survival. This study evaluates mid-term functional improvements, echocardiographi... Abstract
Cited 7 times since 2016 (0.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 67, Issue 9, 1 1 2016, Pages 1123-1124 Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, Bouma BJ
Cited 17 times since 2016 (2.1 per year) source: EuropePMC
European heart journal, Volume 37, Issue 47, 22 4 2016, Pages 3536-3543 The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century? Bank I, Vliegen HW, Bruschke AV
In 1816, Laennec discovered that auscultation of the heart and lungs could effectively be performed by placing a hollow cylinder (initially made of a roll of paper) between the chest of the patient and the ear of the examiner. This was the first step in the development of the stethoscope, which was a breakthrough in the diagnosis and management of cardiac and pulmonary patients. Technical improvements of the stethoscope followed and in cardiac patients auscultation soon became a major diagnostic... Abstract
Cited 10 times since 2016 (1.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 102, Issue 12, 10 2 2016, Pages 943-949 Coronary anatomy as related to bicuspid aortic valve morphology. Koenraadt WM, Tokmaji G, DeRuiter MC, Vliegen HW, Scholte AJ, Siebelink HM, Gittenberger-de Groot AC, de Graaf MA, Wolterbeek R, Mulder BJ, Bouma BJ, Schalij MJ, Jongbloed MR
Objective: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA). Methods: Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 154-155 An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography. de Graaf MA, van Rosendael AR, Kroft LJ, Vliegen HW, Hazekamp MG, Bax JJ, Scholte AJ
Cited 48 times since 2015 (5.8 per year) source: EuropePMC
Journal of thrombosis and haemostasis : JTH, Volume 14, Issue 1, 29 5 2016, Pages 121-128 Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuß G, Huisman MV, Konstantinides S, Lankeit M
Unlabelled: Essentials Predicting chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism is hard. We studied 772 patients with pulmonary embolism who were followed for CTEPH (incidence 2.8%). Logistic regression analysis revealed 7 easily collectable clinical variables that combined predict CTEPH. Our score identifies patients at low (0.38%) or higher (10%) risk of CTEPH. Summary: Introduction Validated risk factors for the diagnosis of chronic thromboembolic pulmonary hy... Abstract
Cited 29 times since 2015 (3.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 101, Issue 24, 5 1 2015, Pages 1989-1995 Contemporary survival of adults with congenital heart disease. van der Bom T, Mulder BJ, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Konings TC, Zwinderman AH, Bouma BJ
Background: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available. Objectives: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD. Methods: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised gen... Abstract
Cited 46 times since 2015 (5.4 per year) source: EuropePMC
European heart journal, Volume 37, Issue 10, 27 4 2015, Pages 829-835 Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after pulmonary valve replacement in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ
Aims: The right ventricle (RV) remodels early after pulmonary valve replacement (PVR) in tetralogy of Fallot (TOF) patients. Previously reported preoperative thresholds to achieve early postoperative RV normalization were consistently close to 80 mL/m(2) for end-systolic volume (ESV) and 160 mL/m(2) for end-diastolic volume (EDV). Our objective was to determine whether these thresholds were also associated with mid-to-late RV normalization and clinical events. Methods and results: Out of a multi... Abstract