Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7507 results
Cited 73 times since 2007 (4.3 per year) source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 13, Issue 8, 1 1 2007, Pages 2414-2421 Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung. Wittgen BP, Kunst PW, van der Born K, van Wijk AW, Perkins W, Pilkiewicz FG, Perez-Soler R, Nicholson S, Peters GJ, Postmus PE
Purpose: To investigate the safety and pharmacokinetics of aerosolized Sustained Release Lipid Inhalation Targeting (SLIT) Cisplatin in patients with lung carcinoma. Experimental design: Phase I, dose-escalating study of SLIT Cisplatin given in two sessions daily. Safety data, including laboratory variables, adverse events, pulmonary function tests, and radiographic imaging, were collected and analyzed for all patients to determine toxicity. Pharmacokinetic monitoring was done during the first c... Abstract
Cited 36 times since 2007 (2.1 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 133, Issue 4, 1 1 2007, Pages 973-978 Initial bronchoscopic treatment for patients with intraluminal bronchial carcinoids. Brokx HA, Risse EK, Paul MA, Grünberg K, Golding RP, Kunst PW, Eerenberg JP, van Mourik JC, Postmus PE, Mooi WJ, Sutedja TG
Objective: Carcinoid of the lung is considered low-grade malignancy, and less invasive treatment may therefore be considered. We analyzed the long-term outcome of initial bronchoscopic treatment in patients with intraluminal bronchial carcinoids. Methods: Initial bronchoscopic treatment was applied to improve presurgical condition, to obtain tissue samples for proper histologic classification, and to enable less extensive parenchymal resection. For intraluminal bronchial carcinoid, complete tumo... Abstract
Cited 31 times since 2007 (1.8 per year) source: EuropePMC
The Journal of general virology, Volume 88, Issue Pt 4, 1 1 2007, Pages 1251-1259 Experimental infection of macaques with human metapneumovirus induces transient protective immunity. van den Hoogen BG, Herfst S, de Graaf M, Sprong L, van Lavieren R, van Amerongen G, Yüksel S, Fouchier RAM, Osterhaus ADME, de Swart RL
Human metapneumovirus (hMPV), a member of the family Paramyxoviridae, is a causative agent of acute respiratory-tract illness. Two main hMPV lineages circulate worldwide and reinfections occur frequently. It is unclear what level of protection is induced by natural hMPV infection, what the durability of this protection is and whether it differs for reinfection with homologous or heterologous viruses. Here, protective immunity in cynomolgus macaques at different time points after inoculation with... Abstract
Cited 28 times since 2007 (1.6 per year) source: EuropePMC
Annals of the New York Academy of Sciences, Volume 1100, 1 1 2007, Pages 189-198 Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study. Trompet S, Pons D, DE Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, Jukema JW
Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are implicated in the development of atherosclerosis. The role of anti-inflammatory cytokines, like IL-10, is largely unknown. We investigated the association of four single nucleotide polymorphisms (SNPs) in the promoter region of the IL-10 gene (4259AG, -1082GA, -592CA, and -2849GA), with coronary and cerebrovascular disease in participants of the PROspective Study of Pravastatin in the Elderly at... Abstract
Cited 11 times since 2007 (0.6 per year) source: EuropePMC
The International journal of biological markers, Volume 22, Issue 2, 1 1 2007, Pages 114-123 Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. Westerman BA, Breuer RH, Poutsma A, Chhatta A, Noorduyn LA, Koolen MG, Postmus PE, Blankenstein MA, Oudejans CB
Microarray-based expression profiling studies of lung adenocarcinomas have defined neuroendocrine subclasses with poor prognosis. As neuroendocrine development is regulated by members of the achaete-scute and atonal classes of basic helix-loop-helix (bHLH) transcription factors, we analyzed lung tumors for expression of these factors. Out of 13 bHLH genes tested, 4 genes, i.e., achaete-scute complex-like 1 (ASCL1, HASH1, Mash1), atonal homolog 1 (ATOH1, HATH1, MATH1), NEUROD4 (ATH-3, Atoh3, MATH... Abstract
Cited 10 times since 2007 (0.6 per year) source: EuropePMC
The European respiratory journal, Volume 29, Issue 4, 1 1 2007, Pages 617-618 Antimicrobial peptides in the real world: implications for cystic fibrosis. Hiemstra PS
Cited 62 times since 2007 (3.6 per year) source: EuropePMC
The oncologist, Volume 12, Issue 4, 1 1 2007, Pages 465-477 Design of clinical trials of radiation combined with antiangiogenic therapy. Senan S, Smit EF
Clinical trials showing longer survival when chemotherapy is combined with antiangiogenic agents (AAs) have led to growing interest in designing combined modality protocols that exploit abnormalities in tumor vasculature. Approved agents include bevacizumab, a recombinant monoclonal antibody that binds to vascular endothelial growth factor, and two small molecule multitargeted tyrosine kinase inhibitors of angiogenesis (SU11248 and BAY-43-9006) that have been approved for therapy of renal cancer... Abstract
Cited 2 times since 2007 (0.1 per year) source: EuropePMC
International journal of pediatric otorhinolaryngology, Volume 71, Issue 6, 26 4 2007, Pages 857-861 Immunohistochemical assesment of heat shock protein 70 in adenoid tissue. Aktepe F, Sahin O, Dilek H, Yilmaz D, Kahveci O, Derekoy S
Objectives: To evaluate the expression of heat shock protein 70 (HSP70) and its relation to histopathologic parameters in adenoid hypertrophy and hyperplasia. In addition, HSP70 expression in adenoid tissue was compared with in adult and childhood. Methods: Paraffin-embedded adenoid tissue sections were obtained from 19 childhood and 15 adult patients. Expression of HSP70 was evaluated by immunohistochemical staining using anti-HSP70 monoclonal antibody and correlated with histopathologic parame... Abstract
Cited 42 times since 2007 (2.4 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 293, Issue 1, 23 4 2007, Pages L35-44 Inhaled nitric oxide attenuates pulmonary inflammation and fibrin deposition and prolongs survival in neonatal hyperoxic lung injury. ter Horst SA, Walther FJ, Walther FJ, Poorthuis BJ, Hiemstra PS, Wagenaar GT
Administration of inhaled nitric oxide (iNO) is a potential therapeutic strategy to prevent bronchopulmonary dysplasia (BPD) in premature newborns with respiratory distress syndrome. We evaluated this approach in a rat model, in which premature pups were exposed to room air, hyperoxia, or a combination of hyperoxia and NO (8.5 and 17 ppm). We investigated the anti-inflammatory effects of prolonged iNO therapy by studying survival, histopathology, fibrin deposition, and differential mRNA expressi... Abstract
Cited 65 times since 2007 (3.8 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 176, Issue 2, 22 4 2007, Pages 121-128 Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ
Rationale: Deep inspirations provide physiologic protection against airway narrowing in healthy subjects, which is impaired in asthma and chronic obstructive pulmonary disease (COPD). Airway inflammation has been suggested to alter airway mechanics during deep inspiration. Objectives: We tested the hypothesis that the number of bronchial inflammatory cells is related to deep inspiration-induced bronchodilation in asthma and COPD. Methods: In a cross-sectional study, three modified methacholine c... Abstract
Cited 10 times since 2007 (0.6 per year) source: EuropePMC
The American journal of cardiology, Volume 99, Issue 9, 15 3 2007, Pages 1193-1195 Prognostic significance of myocardial ischemia during dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus and no prior history of coronary events. Sozzi FB, Elhendy A, Rizzello V, Biagini E, van Domburg RT, Schinkel AF, Bax JJ, Vourvouri E, Danzi GB, Poldermans D
The prognostic significance of myocardial ischemia assessed by dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus who have no previous coronary artery disease remains unclear. We assessed the value of dobutamine stress echocardiography for risk stratification in 161 asymptomatic patients with type 2 diabetes (mean 62 +/- 12 years of age; 96 men) who had no previous myocardial infarction or revascularization. End point during follow-up was hard cardiac events (card... Abstract
Cited 59 times since 2007 (3.4 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 6, 15 3 2007, Pages 1426-1432 Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia. van Weel V, Seghers L, de Vries MR, Kuiper EJ, Schlingemann RO, Bajema IM, Lindeman JH, Delis-van Diemen PM, van Hinsbergh VW, van Bockel JH, Quax PH
Objective: Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery disease. Methods and results: Expression patterns of VEGF, SDF-1, and CXCR4 were studied in amputated limbs of 16 patients. VEGF-A was expressed in vascula... Abstract
Cited 54 times since 2007 (3.1 per year) source: EuropePMC
Journal of vascular surgery, Volume 45, Issue 5, 13 2 2007, Pages 936-943 The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease. Feringa HH, Karagiannis SE, van Waning VH, Boersma E, Schouten O, Bax JJ, Poldermans D
Background: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are associated with improved outcome in patients with peripheral arterial disease. Statins may also have beneficial properties beyond their lipid-lowering effect. Methods: A prospective, observational cohort study was conducted at a university hospital from 1990 to 2005 to examine whether higher doses of statins and lower low-density lipoprotein (LDL) cholesterol levels are both independently associated with imp... Abstract
Cited 98 times since 2007 (5.7 per year) source: EuropePMC
Circulation, Volume 115, Issue 11, 12 2 2007, Pages 1426-1432 Noninvasive evaluation of coronary sinus anatomy and its relation to the mitral valve annulus: implications for percutaneous mitral annuloplasty. Tops LF, Van de Veire NR, Schuijf JD, de Roos A, van der Wall EE, Schalij MJ, Bax JJ
Background: Percutaneous mitral annuloplasty has been proposed as an alternative to surgical annuloplasty. In this respect, evaluation of the coronary sinus (CS) and its relation with the mitral valve annulus (MVA) and the coronary arteries is relevant. The feasibility of evaluating these issues noninvasively with multislice computed tomography was determined. Methods and results: In 105 patients (72 men, age 59+/-11 years), 64-slice multislice computed tomography was performed for noninvasive e... Abstract
Cited 165 times since 2007 (9.6 per year) source: EuropePMC
The American journal of cardiology, Volume 99, Issue 8, 6 1 2007, Pages 1072-1081 Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Valgimigli M, Serruys PW, Tsuchida K, Vaina S, Morel MA, van den Brand MJ, Colombo A, Morice MC, Dawkins K, de Bruyne B, Kornowski R, de Servi S, Guagliumi G, Jukema JW, Mohr FW, Kappetein AP, Wittebols K, Stoll HP, Boersma E, Parrinello G, ARTS II
The Syntax score (SXscore) was recently developed as a comprehensive angiographic scoring system aiming to assist in patient selection and risk stratification of patients with extensive coronary artery disease undergoing contemporary revascularization. A validation of this angiographic classification scheme is lacking. We assessed its predictive value in patients who underwent percutaneous intervention (PCI) for 3-vessel disease and explored its performance in comparison with the modified lesion... Abstract
Cited 84 times since 2007 (4.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 49, Issue 11, 6 1 2007, Pages 1137-1148 Role of imaging in cardiac stem cell therapy. Beeres SL, Bengel FM, Bartunek J, Atsma DE, Hill JM, Vanderheyden M, Penicka M, Schalij MJ, Wijns W, Bax JJ
Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for... Abstract
Cited 15 times since 2007 (0.9 per year) source: EuropePMC
Stroke, Volume 38, Issue 4, 1 1 2007, Pages 1374-1376 Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: results from the PROSPER MRI study. Box FM, van der Grond J, de Craen AJ, Palm-Meinders IH, van der Geest RJ, Jukema JW, Reiber JH, van Buchem MA, Blauw GJ, PROSPER Study Group
Background and purpose: Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. Methods: In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. Results: WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased fast... Abstract
Cited 325 times since 2007 (18.9 per year) source: EuropePMC
Journal of the National Cancer Institute, Volume 99, Issue 6, 1 1 2007, Pages 442-450 Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. van Meerbeeck JP, Kramer GW, Van Schil PE, Legrand C, Smit EF, Schramel F, Tjan-Heijnen VC, Biesma B, Debruyne C, van Zandwijk N, Splinter TA, Giaccone G, European Organisation for Research and Treatment of Cancer-Lung Cancer Group
Background: Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy. Methods: Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. Respondi... Abstract
Cited 51 times since 2007 (3 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 83, Issue 3, 1 1 2007, Pages 907-911 Predicting outcome of pulmonary valve replacement in adult tetralogy of Fallot patients. Henkens IR, van Straten A, Schalij MJ, Hazekamp MG, de Roos A, van der Wall EE, Vliegen HW
Background: Predicting changes in right ventricular (RV) size and function after pulmonary valve replacement (PVR) is important for timely reintervention in adult tetralogy of Fallot patients. Methods: We analyzed the influence of pulmonary regurgitation severity and RV size and function before PVR on the outcome of RV size and function after PVR in 27 adult Fallot patients who had cardiac magnetic resonance imaging before and after PVR. RV dimensions were indexed for body surface area. Results:... Abstract
Cited 7 times since 2007 (0.4 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 175, Issue 6, 1 1 2007, Pages 527-528 Epithelial responses to oxidative stress in chronic obstructive pulmonary disease: lessons from expression profiling. Luppi F, Hiemstra PS