Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
133 results
Cited 23 times since 2011 (1.8 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 13 2 2011, Pages 66-73 Prophylactic implantable cardioverter-defibrillator treatment in the elderly: therapy, adverse events, and survival gain. van Rees JB, Borleffs CJ, Thijssen J, de Bie MK, van Erven L, Cannegieter SC, Bax JJ, Schalij MJ
Aims: In elderly patients, obscurity remains regarding the benefit of implantable cardioverter-defibrillator (ICD) treatment as primary prevention of sudden cardiac death. This study assesses implant rates, therapy, adverse events, and survival gain in the elderly primary prevention ICD patient. Methods and results: A total of 1395 patients treated with an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center were included and allocated to three groups accord... Abstract
Cited 18 times since 2011 (1.4 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 27 4 2011, Pages 112-116 Trans-venous lead removal without the use of extraction sheaths, results of >250 removal procedures. de Bie MK, Fouad DA, Borleffs CJ, van Rees JB, Thijssen J, Trines SA, Bootsma M, Schalij MJ, van Erven L
Aims: The number of implanted cardiac rhythm devices has rapidly increased in the past decade. Subsequently, the need for lead extraction has also increased. Several techniques of lead removal have been documented from manual traction of the lead to lead extraction assisted with mechanical or laser sheaths. The goal of this study was to review our experience with lead removal using manual traction without the assistance of extraction sheaths. Methods and results: In the Leiden University Medical... Abstract
Cited 13 times since 2011 (1 per year) source: EuropePMC
European journal of heart failure, Volume 13, Issue 10, 25 4 2011, Pages 1133-1139 The effect of cardiac resynchronization therapy on left ventricular diastolic function assessed with speckle-tracking echocardiography. Shanks M, Antoni ML, Hoke U, Bertini M, Ng AC, Auger D, Marsan NA, van Erven L, Holman ER, Schalij MJ, Bax JJ, Delgado V
Aims: Changes in left ventricular (LV) diastolic function after cardiac resynchronization therapy (CRT) in relation to LV reverse remodelling and heart failure aetiology have not been extensively characterized. The aims of the study were to evaluate changes in LV diastolic function with speckle-tracking echocardiography in relation to: (i) cardiac resynchronization therapy response (LV remodelling) and (ii) heart failure aetiology. Methods and results: A total of 192 heart failure patients under... Abstract
Cited 134 times since 2011 (10.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 58, Issue 10, 1 1 2011, Pages 995-1000 Implantation-related complications of implantable cardioverter-defibrillators and cardiac resynchronization therapy devices: a systematic review of randomized clinical trials. van Rees JB, de Bie MK, Thijssen J, Borleffs CJ, Schalij MJ, van Erven L
The number of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT) implantations is increasing drastically worldwide, and hence, the number of implanting centers is also increasing. Despite abundant data on the beneficial effect of these devices, little is known regarding safety and complication rates. Eleven ICD and 7 CRT trials were systematically reviewed to provide data on the frequency of in-hospital mortality and complications related to the implantation... Abstract
Cited 22 times since 2011 (1.7 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 22, Issue 12, 21 3 2011, Pages 1346-1350 Primary prevention implantable cardioverter defibrillator recipients: the need for defibrillator back-up after an event-free first battery service-life. Van Welsenes GH, Van Rees JB, Thijssen J, Trines SA, Van Erven L, Schalij MJ, Borleffs CJ
Introduction: In primary prevention implantable cardioverter defibrillator (ICD) patients, the relatively low incidence of ventricular arrhythmias (VA) combined with the limited battery service-life potentially results in a large group of patients who have had no benefit of the ICD during first service-life. Data on the occurrence of VA after device replacement remain scarce. The purpose of this study was to give clinicians better insight in the dilemma whether or not to replace an ICD after an... Abstract
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 453-459 Predictive power of T-wave alternans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary prevention cardioverter-defibrillator patients. Man S, De Winter PV, Maan AC, Thijssen J, Borleffs CJ, van Meerwijk WP, Bootsma M, van Erven L, van der Wall EE, Schalij MJ, Burattini L, Burattini R, Swenne CA
Background and purpose: Left ventricular ejection fraction lacks specificity to predict sudden cardiac death in heart failure. T-wave alternans (TWA; beat-to-beat T-wave instability, often measured during exercise) is deemed a promising noninvasive predictor of major cardiac arrhythmic event. Recently, it was demonstrated that TWA during recovery from exercise has additional predictive value. Another mechanism that potentially contributes to arrhythmogeneity is exercise-recovery hysteresis in ac... Abstract
Cited 12 times since 2011 (0.9 per year) source: EuropePMC
Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 410-415 Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction. Man S, Algra AM, Schreurs CA, Borleffs CJ, Scherptong RW, van Erven L, van der Wall EE, Cannegieter SC, Schalij MJ, Swenne CA
Background and purpose: Several studies have demonstrated that the spatial mean QRS-T angle (SA) predicts cardiac events and mortality. Spatial mean QRS-T angle is a vectorcardiographic variable. Because in clinical practice, 12-lead standard electrocardiograms (ECGs) are recorded rather than vectorcardiograms (VCGs) according to Frank, VCGs are commonly obtained by synthesizing them from 12-lead ECGs, by using a VCG synthesis matrix. Hence, the thus computed SA is an estimate of the real SA mea... Abstract
Cited 23 times since 2011 (1.8 per year) source: EuropePMC
European heart journal, Volume 32, Issue 21, 5 1 2011, Pages 2678-2687 Driving restrictions after implantable cardioverter defibrillator implantation: an evidence-based approach. Thijssen J, Borleffs CJ, van Rees JB, de Bie MK, van der Velde ET, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ
Aims: Little evidence is available regarding restrictions from driving following implantable cardioverter defibrillator (ICD) implantation or following first appropriate or inappropriate shock. The purpose of the current analysis was to provide evidence for driving restrictions based on real-world incidences of shocks (appropriate and inappropriate). Methods and results: A total of 2786 primary and secondary prevention ICD patients were included. The occurrence of shocks was noted during a media... Abstract
Cited 240 times since 2011 (18 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 57, Issue 5, 1 1 2011, Pages 556-562 Inappropriate implantable cardioverter-defibrillator shocks: incidence, predictors, and impact on mortality. van Rees JB, Borleffs CJ, de Bie MK, Stijnen T, van Erven L, Bax JJ, Schalij MJ
Objectives: The purpose of this study was to assess the incidence, predictors, and outcome of inappropriate shocks in implantable cardioverter-defibrillator (ICD) patients. Background: Despite the benefits of ICD therapy, inappropriate defibrillator shocks continue to be a significant drawback. The prognostic importance of inappropriate shocks outside the setting of a clinical trial remains unclear. Methods: From 1996 to 2006, all recipients of defibrillator devices equipped with intracardiac el... Abstract
Cited 55 times since 2011 (4.1 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 3, 5 1 2011, Pages 389-394 Long-term follow-up of primary and secondary prevention implantable cardioverter defibrillator patients. van Welsenes GH, van Rees JB, Borleffs CJ, Cannegieter SC, Bax JJ, van Erven L, Schalij MJ
Aims: The beneficial effects of implantable cardioverter defibrillators (ICDs) in primary and secondary prevention patients are well established. However, data on potential differences between both groups in mortality and ICD therapy rates during long-term follow-up are scarce. The aim of the study was to assess differences in mortality and ICD therapy between secondary and primary prevention ICD recipients. Methods and results: With the exception of patients with congenital monogenetic cardiac... Abstract
Cited 33 times since 2010 (2.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 19, 1 1 2010, Pages 1593-1600 Amiodarone: an effective antiarrhythmic drug with unusual side effects. van Erven L, Schalij MJ
Cited 42 times since 2010 (3 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 8, 1 1 2010, Pages 1176-1177 Deactivation of implanted cardioverter-defibrillators at the end of life: results of the EHRA survey. Marinskis G, van Erven L, EHRA Scientific Initiatives Committee
This survey assesses the current opinion on and practice of the management of terminally ill patients with implanted cardioverter-defibrillators (ICDs) in 47 large European centres. The principal findings of this survey were that most physicians (62%) from European centres who responded to this survey would consider deactivating ICDs at the patient's end of life. In these circumstances, multiple appropriate ICD shocks may be an indication to deactivate an ICD (83% positive answers). Remote... Abstract
Cited 3 times since 2010 (0.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 11, 16 3 2010, Pages 1581-1588 Right ventricular stimulation threshold at ICD implant predicts device therapy in primary prevention patients with ischaemic heart disease. Atary JZ, Borleffs CJ, van der Bom JG, Trines SA, Bootsma M, Zeppenfeld K, van Erven L, Schalij MJ
Aims: Myocardial excitability is known (amongst other reasons) to be related to the degree of ischaemia, contractile dysfunction and heart failure. It was hypothesized that the right ventricular (RV) stimulation threshold has prognostic value with respect to the occurrence of ventricular arrhythmias (VAs) and patient survival in recipients of an implantable cardioverter defibrillator (ICD). Methods and results: Ischaemic heart disease patients receiving an ICD at Leiden University Medical Center... Abstract
Cited 44 times since 2010 (3.1 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 33, Issue 8, 27 4 2010, Pages 1013-1019 Recurrent implantable cardioverter-defibrillator replacement is associated with an increasing risk of pocket-related complications. Borleffs CJ, Thijssen J, de Bie MK, van Rees JB, van Welsenes GH, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ
Background: Despite beneficial effects of implantable cardioverter-defibrillator (ICD) therapy, limited service life results in replacement within the majority of patients. Data concerning the effect of replacement procedures on the occurrence of pocket-related adverse events are scarce. In this study, the requirement for pocket-related surgical re-interventions following ICD treatment and the effect of device replacement were evaluated. Methods: From 1992 to 2008, 2,415 patients receiving an IC... Abstract
Cited 37 times since 2010 (2.6 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 55, Issue 9, 1 1 2010, Pages 879-885 Prognostic importance of atrial fibrillation in implantable cardioverter-defibrillator patients. Borleffs CJ, van Rees JB, van Welsenes GH, van der Velde ET, van Erven L, Bax JJ, Schalij MJ
Objectives: This study aimed to assess the prevalence of different types of atrial fibrillation (AF) and their prognostic importance in implantable cardioverter-defibrillator (ICD) patients. Background: The prevalence of AF has taken epidemic proportions in the population with cardiovascular disease. The prognostic importance of different types of AF in ICD patients remains unclear. Methods: Data on 913 consecutive patients (79% men, mean age 62 + or - 13 years) receiving an ICD at the Leiden Un... Abstract
Cited 17 times since 2010 (1.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 2, 1 1 2010, Pages 275-276 Attitude towards redundant leads and the practice of lead extractions: a European survey. van Erven L, Morgan JM, Scientific Initiatives Committee (SIC)
This survey has compared attitudes towards (endocardial) lead extraction, among European electrophysiology centres, with special attention paid to 'redundant leads'. The main findings of this survey are: (i) most of the centres performing lead extractions do so in low volume even though the number of implants may be high. (ii) Approaches to the practice of lead extraction are based largely on clinical experience and individual sentiment but not on a rigorous evidence based. (iii) Tract... Abstract
Cited 3 times since 2010 (0.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 3, 6 1 2010, Pages 378-384 Structured care for patients after acute myocardial infarction: sudden cardiac death prevention--data from the Leiden MISSION! AMI study. Atary JZ, Borleffs CJ, Liem SS, Bax JJ, van der Hoeven BL, Bootsma M, van der Wall EE, van Erven L, Schalij MJ
Aims: To assess the number of patients in daily clinical practice that meets criteria for implantation of an implantable cardioverter defibrillator (ICD) following acute myocardial infarction (AMI) when treated according to an aggressive treatment protocol. Methods and results: Patients were treated according to the MISSION! protocol. The protocol encompasses pre-hospital, in-hospital, and outpatient clinical framework for the acute and chronic treatment of AMI patients and the decision making r... Abstract
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 33, Issue 4, 1 1 2009, Pages 431-436 Implementation of lead safety recommendations. VAN Rees JB, Borleffs CJ, Bax JJ, Nagtegaal EM, VAN DER Velde ET, VAN Erven L, Schalij MJ
Background: The Medtronic Sprint Fidelis (SF) implantable cardioverter defibrillator (ICD; Medtronic Inc., Minneapolis, MN, USA) lead has a higher than expected failure rate. Because of patient safety, Medtronic announced two advisories consisting of (1) adjustments in device settings (October 2007) and (2) installation of a lead integrity algorithm (May 2008). The objective of this study was to evaluate the effect of Medtronic's announcements on patient safety. Methods: To comply with the... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 6, 23 4 2009, Pages 712-718 Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease. Borleffs CJ, van Welsenes GH, van Bommel RJ, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Rosendaal FR, Schalij MJ
Aims: To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease. Methods and results: Since 1996, data of all consecutive patients who received an ICD system in the Leiden University Medical Center were collected and assessed at implantation. For the current study, all 1036 patients [age 63 (SD 11) years, 81% male] with a primary indication for defibrillator implant... Abstract
Cited 72 times since 2009 (4.9 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 5, 5 1 2009, Pages 548-554 Predicting ventricular arrhythmias in patients with ischemic heart disease: clinical application of the ECG-derived QRS-T angle. Borleffs CJ, Scherptong RW, Man SC, van Welsenes GH, Bax JJ, van Erven L, Swenne CA, Schalij MJ
Background: In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease. Methods and results: ICD patients (n=412, 361 men; age, 63+/-11 years) with ischemic heart... Abstract