Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Cited 4 times since 2005 (0.2 per year) source: EuropePMC
Critical care medicine, Volume 33, Issue 3, 1 1 2005, Pages 688-690 Sepsis and intracellular calcium homeostasis, a sparkling story. Steendijk P
Cited 4 times since 2005 (0.2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 4, 6 1 2005, Pages 599-605 Left ventricular function and chronotropic responses after normothermic cardiopulmonary bypass with intermittent antegrade warm blood cardioplegia in patients undergoing coronary artery bypass grafting. Tulner SA, Klautz RJ, Engbers FH, Bax JJ, Baan J, van der Wall EE, Dion RA, Steendijk P
Objective: Recent studies indicate that normothermic cardiopulmonary bypass (CPB) with intermittent antegrade warm blood cardioplegia (IAWBC) may have metabolic and clinical advantages, but limited data exist on its effects on myocardial function. Therefore, we investigated the acute effects of this approach on systolic and diastolic left ventricular function and on chronotropic responses. Methods: In 10 patients undergoing isolated CABG we obtained on-line left ventricular pressure-volume loops... Abstract
Cited 78 times since 2005 (4 per year) source: EuropePMC
The American journal of cardiology, Volume 95, Issue 1, 1 1 2005, Pages 140-142 Frequency of left ventricular dyssynchrony in patients with heart failure and a narrow QRS complex. Bleeker GB, Schalij MJ, Molhoek SG, Holman ER, Verwey HF, Steendijk P, van der Wall EE, Bax JJ
Cardiac resynchronization therapy (CRT) is considered a major advance in the treatment of patients with heart failure. The presence of left ventricular (LV) dyssynchrony seems mandatory for a positive response to CRT. Currently, only patients with wide QRS complexes are considered for CRT, although patients with narrow QRS complexes may also have LV dyssynchrony. In the present study, the incidence of LV dyssynchrony was prospectively evaluated in 64 patients with heart failure and narrow QRS co... Abstract
Cited 5 times since 2005 (0.3 per year) source: EuropePMC
Cell biochemistry and biophysics, Volume 43, Issue 1, 1 1 2005, Pages 45-52 Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus. Tschöpe C, Westermann D, Dhayat N, Dhayat S, Altmann C, Steendijk P, Schultheiss HP, Walther T
Hearts of normotensive angiotensin II type 2 receptor (AT2)-deficient mice do not develop fibrosis after angiotensin II-induced chronic hypertension. Thus, the goal of our study was to clarify whether AT2 knockouts (KOs) are also characterized by altered left ventricular (LV) function and modified remodeling of the extracellular matrix (ECM) after induction of myocardial infarction (MI). MI was induced in 5-mo-old female AT2-deficient mice and controls by occlusion of the left coronary artery. T... Abstract
Cited 32 times since 2005 (1.7 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 129, Issue 1, 1 1 2005, Pages 138-145 Acute decrease of left ventricular mechanical dyssynchrony and improvement of contractile state and energy efficiency after left ventricular restoration. Schreuder JJ, Castiglioni A, Maisano F, Steendijk P, Donelli A, Baan J, Alfieri O
Objective: Surgical left ventricular restoration by means of endoventricular patch aneurysmectomy in patients with postinfarction aneurysm should result in acute improved left ventricular performance by decreasing mechanical dyssynchrony and increasing energy efficiency. Methods: Nine patients with left ventricular postinfarction aneurysm were studied intraoperatively before and after ventricular restoration with a conductance volume catheter to analyze pressure-volume relationships, energy effi... Abstract
Cited 32 times since 2005 (1.7 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 7, Issue 2, 1 1 2005, Pages 383-389 Disparity between dobutamine stress and physical exercise magnetic resonance imaging in patients with an intra-atrial correction for transposition of the great arteries. Oosterhof T, Tulevski II, Roest AA, Steendijk P, Vliegen HW, van der Wall EE, de Roos A, Tijssen JG, Mulder BJ
Background: In patients with an intra-atrial correction for transposition of the great arteries (TGA) an abnormal response to stress testing is common. However, hemodynamic responses may vary substantially when different stress tests are used. We compared the hemodynamic response to dobutamine stress with the response to physical exercise in patients and controls. Methods: Thirty-nine patients and 25 age/sex-matched control subjects underwent either dobutamine stress (15 microg/kg/min) or submax... Abstract
Cited 68 times since 2004 (3.5 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 288, Issue 5, 9 2 2004, Pages H2140-5 Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output. Gaynor SL, Maniar HS, Prasad SM, Steendijk P, Moon MR
The purpose of this study was to investigate the relationship between right atrial (RA) reservoir and conduit function and to determine how hemodynamic changes influence this relationship and its impact on cardiac output. In 11 open-chest sheep, RA reservoir and conduit function were quantified as RA inflow with the tricuspid valve closed versus open, respectively. Conduit function was separated into early (before A wave) and late (after A wave) components. The effects of inotropic stimulation,... Abstract
Cited 141 times since 2004 (7.2 per year) source: EuropePMC
The American journal of cardiology, Volume 94, Issue 12, 1 1 2004, Pages 1506-1509 Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic atrial fibrillation. Molhoek SG, Bax JJ, Bleeker GB, Boersma E, van Erven L, Steendijk P, van der Wall EE, Schalij MJ
Cardiac resynchronization therapy (CRT) is a new therapeutic option for patients who have drug-refractory end-stage heart failure. Much information has been obtained from patients who have sinus rhythm, but the use of CRT in patients who have chronic atrial fibrillation (AF) has not been studied extensively. Accordingly, we evaluated the clinical response and long-term survival rate of CRT in patients who had heart failure and chronic AF, and the results were compared with those in patients who... Abstract
Cited 28 times since 2004 (1.4 per year) source: EuropePMC
Pediatric research, Volume 57, Issue 1, 5 1 2004, Pages 16-21 Systolic and diastolic ventricular function assessed by pressure-volume loops in the stage 21 venous clipped chick embryo. Stekelenburg-de Vos S, Steendijk P, Ursem NT, Wladimiroff JW, Delfos R, Poelmann RE
Cardiac pressure-volume relations enable quantification of intrinsic ventricular diastolic and systolic properties independent of loading conditions. The use of pressure-volume loop analysis in early stages of development could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. The venous clip model is an intervention model for the chick embryo in which permanent obstruction of the right lateral vitelline vein temporarily reduces the mechanic... Abstract
Cited 696 times since 2004 (35.6 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 44, Issue 9, 1 1 2004, Pages 1834-1840 Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy. Bax JJ, Bleeker GB, Marwick TH, Molhoek SG, Boersma E, Steendijk P, van der Wall EE, Schalij MJ
Objectives: This study was designed to predict the response and prognosis after cardiac resynchronization therapy (CRT) in patients with end-stage heart failure (HF). Background: Cardiac resynchronization therapy improves HF symptoms, exercise capacity, and left ventricular (LV) function. Because not all patients respond, preimplantation identification of responders is needed. In the present study, response to CRT was predicted by the presence of LV dyssynchrony assessed by tissue Doppler imagin... Abstract
Cited 8 times since 2004 (0.4 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 98, Issue 3, 29 5 2004, Pages 1044-1049 Is carbon monoxide-mediated cyclic guanosine monophosphate production responsible for low blood pressure in neonatal respiratory distress syndrome? van Bel F, Latour V, Vreman HJ, Wong RJ, Stevenson DK, Steendijk P, Egberts J, Krediet TG
Infant respiratory distress syndrome (RDS) involves inflammatory processes, causing an increased expression of inducible heme oxygenase with subsequent production of carbon monoxide (CO). We hypothesized that increased production of CO during RDS might be responsible for increased plasma levels of vasodilatory cGMP and, consequently, low blood pressure observed in infants with RDS. Fifty-two infants (no-RDS, n = 21; RDS, n = 31), consecutively admitted to the neonatal intensive care unit (NICU)... Abstract
Cited 44 times since 2004 (2.2 per year) source: EuropePMC
Circulation, Volume 110, Issue 16, 11 2 2004, Pages 2395-2400 Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance. Bleasdale RA, Turner MS, Mumford CE, Steendijk P, Paul V, Tyberg JV, Morris-Thurgood JA, Frenneaux MP
Background: Left ventricular (LV) pacing improves hemodynamics in patients with heart failure. We hypothesized that at least part of this benefit occurs by minimization of external constraint to LV filling from ventricular interaction. Methods and results: We present median values (interquartile ranges) for 13 heart failure patients with LV pacing systems implanted for New York Heart Association class III/IV limitation. We used the conductance catheter method to measure LV pressure and volume si... Abstract
Cited 6 times since 2004 (0.3 per year) source: EuropePMC
Cardiovascular research, Volume 64, Issue 1, 1 1 2004, Pages 9-11 Heart failure with preserved ejection fraction. Diastolic dysfunction, subtle systolic dysfunction, systolic-ventricular and arterial stiffening, or misdiagnosis? Steendijk P
Cited 193 times since 2004 (9.8 per year) source: EuropePMC
Circulation, Volume 110, Issue 14, 27 4 2004, Pages 2010-2016 Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M, Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I, Lange P
Background: The aims of this study were to validate MRI-derived right ventricular (RV) pressure-volume loops for assessment of RV myocardial contractility and then to apply this technique in patients with chronic RV pressure overload for assessment of myocardial contractility, ventricular pump function, and VA coupling. Methods and results: Flow-directed catheters were guided under MR fluoroscopy (1.5 T) into the RV for invasive pressure measurements. Simultaneously, ventricular volumes and myoc... Abstract
Cited 11 times since 2004 (0.6 per year) source: EuropePMC
European journal of pharmacology, Volume 493, Issue 1-3, 1 1 2004, Pages 161-165 Angiotensin deficiency in mice leads to dilated cardiomyopathy. Walther T, Steendijk P, Westermann D, Hohmann C, Schulze K, Heringer-Walther S, Schultheiss HP, Tschöpe C
To explore the role of angiotensin II, we assessed hemodynamics and cardiac function in angiotensinogen-deficient mice in comparison to wild-type animals. Left ventricular end-diastolic diameter and wall thickness were evaluated by echocardiography and systolic and diastolic left ventricular function by pressure-volume relations using a micro-conductance catheter. Compared to wild-type animals, the angiotensinogen-deficient mice were hypotensive and showed impaired systolic function. The hearts... Abstract
Cited 2 times since 2004 (0.1 per year) source: EuropePMC
Intensive care medicine, Volume 30, Issue 7, 4 1 2004, Pages 1370-1376 Transcardiac conductance for continuous measurement of left ventricular volume: validation vs. angiography in patients. Staal EM, Baan J, Jukema JW, van der Wall EE, Steendijk P
Objective: To test the feasibility of the transcardiac conductance (TCC) method for continuous, on-line measurement of absolute left ventricular (LV) volume and to validate the method by comparison with biplane angiography. Design and setting: Prospective clinical feasibility and validation study in a cardiac catheterization laboratory in a university hospital. Patients and interventions: Ten patients scheduled for electrophysiological studies ( n=5), percutaneous transluminal coronary angioplas... Abstract
Cited 12 times since 2004 (0.6 per year) source: EuropePMC
European journal of pharmacology, Volume 491, Issue 2-3, 1 1 2004, Pages 173-179 Hemodynamic characterization of left ventricular function in experimental coxsackieviral myocarditis: effects of carvedilol and metoprolol. Tschöpe C, Westermann D, Steendijk P, Noutsias M, Rutschow S, Weitz A, Schwimmbeck PL, Schultheiss HP, Pauschinger M
Background: Carvedilol, a vasodilating nonselective beta-adrenoceptor antagonist, but not metoprolol, a selective beta1-adrenoceptor antagonist, has been shown to increase the production of cardiac antiinflammatory cytokines in experimental myocarditis. However, the hemodynamic consequences of these differences had not been investigated until today. Therefore, we determined the effects of carvedilol and metoprolol on left ventricular function in a murine model of coxsackievirus B3 (CVB3)-induced... Abstract
Cited 239 times since 2004 (11.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 15, Issue 5, 1 1 2004, Pages 544-549 Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. Bleeker GB, Schalij MJ, Molhoek SG, Verwey HF, Holman ER, Boersma E, Steendijk P, Van Der Wall EE, Bax JJ
Introduction: Patients with end-stage heart failure and a wide QRS complex are considered candidates for cardiac resynchronization therapy (CRT). However, 20% to 30% of patients do not respond to CRT. Lack of left ventricular dyssynchrony may explain the nonresponse. Accordingly, we evaluated the presence of left ventricular dyssynchrony using tissue Doppler imaging (TDI) in 90 consecutive patients with heart failure. Methods and results: Ninety patients with severe heart failure (left ventricul... Abstract
Cited 39 times since 2004 (1.9 per year) source: EuropePMC
Basic research in cardiology, Volume 99, Issue 5, 16 3 2004, Pages 351-359 Left ventricular pressure-volume measurements in mice: comparison of closed-chest versus open-chest approach. Lips DJ, van der Nagel T, Steendijk P, Palmen M, Janssen BJ, van Dantzig JM, de Windt LJ, Doevendans PA
Objective: We investigated whether in vivo closed-chest left ventricular pressure-volume measurements would yield similar values for LV hemodynamics compared with open-chest PV measurements under several anesthetics. Methods: The right common carotid of C57Bl/6 mice was cannulated with a combined pressure-conductance catheter and inserted retrogradely into the left ventricle in the closed-chest model. The open-chest model consisted of an abdominal approach involving the opening of the thoracic c... Abstract
Cited 67 times since 2004 (3.3 per year) source: EuropePMC
The American journal of cardiology, Volume 93, Issue 7, 1 1 2004, Pages 860-863 Comparison of benefits from cardiac resynchronization therapy in patients with ischemic cardiomyopathy versus idiopathic dilated cardiomyopathy. Molhoek SG, Bax JJ, van Erven L, Bootsma M, Boersma E, Steendijk P, van der Wall EE, Schalij MJ
Cardiac resynchronization therapy (CRT) is a recently introduced therapeutic option for patients with severe heart failure and intraventricular conduction disturbances. However, it is estimated that 20% to 30% of patients may not respond to CRT. Patients with ischemic cardiomyopathy (IC) may respond less favorably to CRT compared with patients with idiopathic dilated cardiomyopathy (IDC). Accordingly, the beneficial effects of CRT were evaluated in 2 subsets of patients (IC and IDC). Seventy-fou... Abstract