Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
170 results
European heart journal. Cardiovascular Imaging, 6 1 2024, Pages jeae058 Plasma Lipidomics and Coronary Plaque Changes: A Substudy of the SMARTool Clinical Trial. Smit JM, Rocchiccioli S, Signore G, Michelucci E, Di Giorgi N, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Parodi O, Pelosi G, Scholte AJ
Aims: To date, no studies have investigated the association between lipid species and coronary plaque changes over time, quantitatively assessed by serial imaging. We aimed to prospectively determine the association between lipid species quantified by plasma lipidomic analysis, with coronary plaque changes according to composition assessed by quantitative serial analysis of coronary computed tomography angiography (CTA). Methods and results: Patients with suspected coronary artery disease (CAD)... Abstract
The American journal of cardiology, Volume 186, 1 1 2022, Pages 228-235 Relation Between Coronary Plaque Composition Assessed by Intravascular Ultrasound Virtual Histology and Myocardial Ischemia Assessed by Quantitative Flow Ratio. Smit JM, El Mahdiui M, de Graaf MA, Montero-Cabezas JM, Reiber JHC, Jukema JW, Scholte AJ, Knuuti J, Wijns W, Narula J, Bax JJ
Coronary plaque composition may play an important role in the induction of myocardial ischemia. Our objective was to further clarify the relation between coronary plaque composition and myocardial ischemia in patients with chest pain symptoms. The study population consisted of 103 patients who presented to the outpatient clinic or emergency department with chest pain symptoms and were referred for diagnostic invasive coronary angiography. Intravascular ultrasound virtual histology was used for t... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
International journal of cardiology. Heart & vasculature, Volume 43, 17 3 2022, Pages 101128 <b>A</b>bnormal aortic hemodynamics are associated with risk factors for aortic complications in patients with marfan syndrome. van Andel MM, van Ooij P, de Waard V, Gottwald LM, van Kimmenade RRJ, Scholte AJ, Dickinson MG, Zwinderman AH, Mulder BJM, Nederveen AJ, Groenink M
Background: It is difficult to assess the risk for aortic dissection beyond the aortic root in patients with Marfan syndrome (MFS). To aid risk assessment in these patients, we investigated aortic flow and wall shear stress (WSS) by 4D flow magnetic resonance imaging (MRI) in patients with MFS and compared the results with healthy volunteers. We hypothesized that MFS patients with a high-risk profile for aortic dissection would show abnormal hemodynamics in aortic regions associated with aortic... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 8, Issue 10, 28 4 2022, Pages 1234-1245 Ventricular Arrhythmia Substrate Distribution and Its Relation to Sympathetic Innervation in Nonischemic Cardiomyopathy Patients. Chen HS, Jungen C, Kimura Y, Dibbets-Schneider P, Piers SR, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: Nonischemic cardiomyopathy patients referred for catheter ablation of ventricular arrhythmias (VAs) typically have either inferolateral (ILS) or anteroseptal (ASS) VA substrate locations, with poorer outcomes for ASS. Sympathetic denervation is an important determinant of arrhythmogenicity. Its relation to nonischemic fibrosis in general and to the different VA substrates is unknown. Objectives: This study sought to evaluate the association between VA substrates, myocardial fibrosis,... Abstract
American heart journal, Volume 249, 15 3 2022, Pages 66-75 Computed tomography follow-up after elective proximal aortic surgery: Less is more? de Oliveira Marreiros DJ, Tomšič A, van Brakel TJ, Hamming JF, Scholte AJHA, Hjortnaes J, Klautz RJM
Study objective: The added value of computed tomography (CT) follow-up after elective proximal aortic surgery is unclear. We evaluated the benefit of CT follow-up by assessing the incidence of aorta-related complications and reinterventions detected during routine CT follow-up. Methods: Data on 314 patients undergoing first time elective proximal aortic surgery between 2000 and 2015 were collected. The primary study end points were aorta-related complications and reinterventions, detected during... Abstract
European journal of radiology open, Volume 9, 31 5 2022, Pages 100417 Correlation between quantification of myocardial area at risk and ischemic burden at cardiac computed tomography. van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Jukema JW, Scholte AJHA
Purpose: This study aims to investigate the correlation between myocardial area at risk at coronary computed tomography angiography (CCTA) and the ischemic burden derived from myocardial computed tomography perfusion (CTP) by using the 17-segment model. Methods: Forty-two patients with chest pain complaints who underwent a combined CCTA and CTP protocol were identified. Patients with reversible ischemia at CTP and at least one stenosis of ≥ 50% at CCTA were selected. Myocardial area at risk was... Abstract
Radiology case reports, Volume 17, Issue 5, 24 4 2022, Pages 1734-1736 Transmural ischemia visualized using routine Chest CTA. van Driest FY, Hertgers O, Scholte AJHA, Jukema JW, de Graaf MA
Chest computed tomography (CT) is not routinely used for the diagnosis of myocardial infarction. However, there have been some reports of patients undergoing chest CT for other indications in which ultimately MI was diagnosed due to the presence of areas of myocardial hypoperfusion. The authors present the case of a 60-years old male who is referred due to acute chest pain radiating between the scapulae. Thoracic computed tomography angiography to rule out an aortic dissection revealed an occlus... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
European radiology, Volume 32, Issue 5, 8 2 2022, Pages 3408-3422 Utilizing (serial) coronary computed tomography angiography (CCTA) to predict plaque progression and major adverse cardiac events (MACE): results, merits and challenges. van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Scholte AJHA, Jukema JW
Objectives: To present an overview of studies using serial coronary computed tomography angiography (CCTA) as a tool for finding both quantitative (changes) and qualitative plaque characteristics as well as epicardial adipose tissue (EAT) volume changes as predictors of plaque progression and/or major adverse cardiac events (MACE) and outline the challenges and advantages of using a serial non-invasive imaging approach for assessing cardiovascular prognosis. Methods: A literature search was perf... Abstract
Cited 3 times since 2021 (1.3 per year) source: EuropePMC
International journal of cardiology. Heart & vasculature, Volume 38, 13 2 2021, Pages 100926 Ascending aorta curvature and flow displacement are associated with accelerated aortic growth at long-term follow-up: A MRI study in Marfan and thoracic aortic aneurysm patients. van Hout MJP, Juffermans JF, Lamb HJ, Kröner ESJ, van den Boogaard PJ, Schalij MJ, Dekkers IA, Scholte AJ, Westenberg JJ
Background: Aortic aneurysm formation is associated with increased risk of aortic dissection. Current diagnostic strategies are focused on diameter growth, the predictive value of aortic morphology and function remains underinvestigated. We aimed to assess the long-term prognostic value of ascending aorta (AA) curvature radius, regional pulse wave velocity (PWV) and flow displacement (FD) on aortic dilatation/elongation and evaluated adverse outcomes (proximal aortic surgery, dissection/rupture,... Abstract
Magnetic resonance imaging, Volume 84, 6 1 2021, Pages 132-134 COVID-19 associated perimyocarditis. van Driest FY, Fejzovic V, Scholte AJHA, Jukema JW, Lamb HJ
Perimyocarditis is a well-known acute inflammation of the pericardium and the underlying myocardium. Most commonly perimyocarditis is of viral aetiology, specifically the coxsackie B virus. However, nowadays SARS-CoV-2 associated with COVID-19 infections has emerged as a potential rare cause of perimyocarditis. This case report will demonstrate a case of a young female with perimyocarditis as diagnosed by magnetic resonance imaging (MRI) accompanied by antigens indicating a past COVID-19 infecti... Abstract
European heart journal. Case reports, Volume 5, Issue 8, 27 4 2021, Pages ytab288 4D flow MRI of type B dissection with later retrograde progression to type A dissection in Marfan: a case report. van Hout MJP, Juffermans JF, Scholte AJ, Lamb HJ
Background: Due to the malfunction of connective tissue, Marfan patients are at increased risk of aortic dissection. Uncomplicated acute type B dissection is usually managed with medical therapy. Retrograde progression or new type A dissection is a relatively rare but often fatal complication that occur most frequently in the first 6 months after acute type B dissection. Case summary: We present a 31-year-old male with Marfan syndrome and a recent uncomplicated type B dissection from the left su... Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 23, Issue 8, 1 1 2021, Pages 1275-1284 Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia. de Riva M, Naruse Y, Ebert M, Watanabe M, Scholte AJ, Wijnmaalen AP, Trines SA, Schalij MJ, Montero-Cabezas JM, Zeppenfeld K
Aims: In patients with post-myocardial infarction (post-MI) ventricular tachycardia (VT), the presence of myocardial calcification (MC) may prevent heating of a subepicardial VT substrate contributing to endocardial ablation failure. The aims of this study were to assess the prevalence of MC in patients with post-MI VT and evaluate the impact of MC on outcome after endocardial ablation. Methods and results: In 158 patients, the presence of MC was retrospectively assessed on fluoroscopy recording... Abstract
Cited 6 times since 2021 (2.2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 38, Issue 1, 25 4 2021, Pages 183-193 Estimated pulse wave velocity (ePWV) as a potential gatekeeper for MRI-assessed PWV: a linear and deep neural network based approach in 2254 participants of the Netherlands Epidemiology of Obesity study. van Hout MJ, Dekkers IA, Lin L, Westenberg JJ, Schalij MJ, Jukema JW, Widya RL, Boone SC, de Mutsert R, Rosendaal FR, Scholte AJ, Lamb HJ
Pulse wave velocity (PWV) assessed by magnetic resonance imaging (MRI) is a prognostic marker for cardiovascular events. Prediction modelling could enable indirect PWV assessment based on clinical and anthropometric data. The aim was to calculate estimated-PWV (ePWV) based on clinical and anthropometric measures using linear ridge regression as well as a Deep Neural Network (DNN) and to determine the cut-off which provides optimal discriminative performance between lower and higher PWV values. I... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 37, Issue 11, 23 4 2021, Pages 3313-3322 Quantification of myocardial ischemia and subtended myocardial mass at adenosine stress cardiac computed tomography: a feasibility study. van Driest FY, van der Geest RJ, Broersen A, Dijkstra J, El Mahdiui M, Jukema JW, Scholte AJHA
Combination of coronary computed tomography angiography (CCTA) and adenosine stress CT myocardial perfusion (CTP) allows for coronary artery lesion assessment as well as myocardial ischemia. However, myocardial ischemia on CTP is nowadays assessed semi-quantitatively by visual analysis. The aim of this study was to fully quantify myocardial ischemia and the subtended myocardial mass on CTP. We included 33 patients referred for a combined CCTA and adenosine stress CTP protocol, with good or excel... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
EJNMMI physics, Volume 8, Issue 1, 16 3 2021, Pages 48 Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease. van de Burgt A, Dibbets-Schneider P, Slump CH, Scholte AJHA, Atsma DE, de Geus-Oei LF, van Velden FHP
Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD). Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying siz... Abstract
Cited 5 times since 2021 (1.7 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 15, Issue 6, 12 2 2021, Pages 485-491 Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease - Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study. Dewey M, Rochitte CE, Ostovaneh MR, Chen MY, George RT, Niinuma H, Kitagawa K, Laham R, Kofoed K, Nomura C, Sakuma H, Yoshioka K, Mehra VC, Jinzaki M, Kuribayashi S, Laule M, Paul N, Scholte AJ, Cerci R, Hoe J, Tan SY, Rybicki FJ, Matheson MB, Vavere AL, Arai AE, Miller JM, Cox C, Brinker J, Clouse ME, Di Carli M, Lima JAC, Arbab-Zadeh A
Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnor... Abstract
European heart journal, Volume 42, Issue 18, 1 1 2021, Pages 1811 A case of tortuous anatomy: cervical aortic arch. van Driest FY, Stöger JL, Scholte AJHA, Jukema JW, Egorova AD
Cited 11 times since 2021 (3.6 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 23, Issue 1, 19 3 2021, Pages 46 Normal and reference values for cardiovascular magnetic resonance-based pulse wave velocity in the middle-aged general population. van Hout MJ, Dekkers IA, Westenberg JJ, Schalij MJ, Widya RL, de Mutsert R, Rosendaal FR, de Roos A, Jukema JW, Scholte AJ, Lamb HJ
Background: Aortic stiffness, assessed through pulse wave velocity (PWV), is an independent predictor for cardiovascular disease risk. However, the scarce availability of normal and reference values for cardiovascular magnetic resonance imaging (CMR) based PWV is limiting clinical implementation. The aim of this study was to determine normal and reference values for CMR assessed PWV in the general population. Methods: From the 2,484 participants of the Netherlands Epidemiology of Obesity (NEO) s... Abstract
Cited 3 times since 2021 (1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 37, Issue 7, 10 2 2021, Pages 2311-2321 Sex differences in coronary plaque changes assessed by serial computed tomography angiography. El Mahdiui M, Smit JM, van Rosendael AR, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Magnacca M, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ
Long-term data on sex-differences in coronary plaque changes over time is lacking in a low-to-intermediate risk population of stable coronary artery disease (CAD). The aim of this study was to evaluate the role of sex on long-term plaque progression and evolution of plaque composition. Furthermore, the influence of menopause on plaque progression and composition was also evaluated. Patients that underwent a coronary computed tomography angiography (CTA) were prospectively included to undergo a f... Abstract
Cited 3 times since 2021 (0.9 per year) source: EuropePMC
European radiology, Volume 31, Issue 7, 6 1 2021, Pages 5068-5076 Associations between left ventricular function, vascular function and measures of cerebral small vessel disease: a cross-sectional magnetic resonance imaging study of the UK Biobank. van Hout MJP, Dekkers IA, Westenberg JJM, Schalij MJ, Scholte AJHA, Lamb HJ
Objectives: Impaired cardiovascular function has been associated with cognitive deterioration; however, to what extent cardiovascular dysfunction plays a role in structural cerebral changes remains unclear. We studied whether vascular and left ventricular (LV) functions are associated with measures of cerebral small vessel disease (cSVD) in the middle-aged general population. Methods: In this cross-sectional analysis of the UK Biobank, 4366 participants (54% female, mean age 61 years) underwent... Abstract