Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
4430 results
Cited 10 times since 1987 (0.3 per year) source: EuropePMC
Radiographics : a review publication of the Radiological Society of North America, Inc, Volume 7, Issue 3, 1 1 1987, Pages 425-445 Magnetic resonance imaging of primary malignant bone tumors. Bloem JL, Bluemm RG, Taminiau AH, van Oosterom AT, Stolk J, Doornbos J
The authors find that MRI yields more useful information in a single study than CT, Tc scanning or angiography; they use it as the primary local staging procedure in malignant bone tumors. Abstract
Cited 7 times since 1987 (0.2 per year) source: EuropePMC
Cardiovascular research, Volume 21, Issue 3, 1 1 1987, Pages 223-229 Relation between ventricular DNA content and number of myocytes and non-myocytes in hearts of normotensive and spontaneously hypertensive rats. van der Laarse A, Bloys van Treslong CH, Vliegen HW, Ricciardi L
Myocardial DNA concentration and ventricular weight were measured in the hearts of normal and spontaneously hypertensive rats varying in age from 1 day to 1 year and the ventricular DNA content calculated. A linear relation between ventricular DNA content and ventricular weight was observed in both rat strains. This linear relation was deduced theoretically, assuming that the number of ventricular non-myocytes per heart was proportional to ventricular weight and that the number of ventricular my... Abstract
Cited 109 times since 1987 (2.9 per year) source: EuropePMC
European journal of immunology, Volume 17, Issue 3, 1 1 1987, Pages 321-326 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, Van Es LA, Daha MR
In order to study the activation of complement by soluble aggregates of human polyclonal serum IgA, lysis of sheep erythrocytes (E) coated with several IgA preparations was used as a model. A complement nonactivating monoclonal mouse IgG1 against IgA was used to coat the cells. IgA, isolated from normal human serum, was aggregated by either N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP), glutaraldehyde, carbodiimide or heating. Depending on the size of the aggregates, and on the method of a... Abstract
Cited 1 times since 1987 (0 per year) source: EuropePMC
Cancer treatment reports, Volume 71, Issue 2, 1 1 1987, Pages 155-159 Phase I and pharmacokinetic study of trans-N3P3Az2(NHMe)4. Mulder NH, Meijers WH, van der Meulen JD, Sleijfer DT, Uges DR, de Vries EG, Postmus PE, van de Grampel JC, Willemse PH
trans-N3P3Az2(NHMe)4, an aziridinyl-substituted cyclophosphazene, was tested for its toxicity, pharmacokinetic behavior, and cytostatic activity in a phase I study in 30 patients. A total of 66 courses of a single iv bolus injection were given in five dose steps. Toxicity consisted of leukocytopenia and thrombocytopenia, dose limiting at 70 mg/m2, mild anemia, and some nausea. Leukocyte and platelet count nadirs fell between 2 and 3 weeks, with recovery at 6 weeks. A tendency for cumulative thro... Abstract
Hormone research, Volume 27, Issue 4, 1 1 1987, Pages 195-199 Bromocriptine is unable to suppress TRH-stimulated beta-endorphin/beta-lipotropin and cortisol secretion in normal pregnant women after delivery. Lamberts SW, Angement R, van der Heijden A, Wladimiroff JW, Hackeng WH, de Jong FH
The course of plasma beta-endorphin/beta-lipotropin, cortisol and prolactin (PRL) levels was followed from 0.5 till 5 h after normal delivery in 13 healthy women. Six subjects who did not want to breast-feed their child received 2.5 mg bromocriptine orally 1 h after delivery. After 3 h the effect of the intravenous administration of 200 micrograms thyrotropin-releasing hormone (TRH) was also measured. Elevated plasma beta-endorphin and cortisol levels decreased after delivery in a (log) linear f... Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1325-1331 Stimulation of human polymorphonuclear leukocytes by serum IgA or secretory IgA. Gorter A, Hiemstra PS, Leijh PC, van Es LA, Daha MR
European journal of respiratory diseases. Supplement, Volume 149, 1 1 1987, Pages 29-36 Genome analysis of small cell lung cancer (SCLC) and clinical significance. Buys CH, Osinga J, van der Veen AY, Mooibroek H, van der Hout AH, de Leij L, Postmus PE, Carritt B
A chromosome analysis of three cell lines derived from SCLC showed deletions of the short arm of chromosome 3 with bands p21-p23 as the shortest region of overlap. Hybridization of a polymorphic 3p21 probe to DNA from leukocytes of seven SCLC patients revealed heterozygosity for two of them. In the tumours of both these patients the probe detected homozygosity. This suggests the presence of a mutant cancer gene in the short arm of chromosome 3 which might express itself and/or activate some onco... Abstract
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1333-1338 Binding and degradation of soluble aggregates of IgA by rat peritoneal macrophages. Gorter A, Hiemstra PS, Klar-Mohamad N, van Es LA, Daha MR
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Journal of cancer research and clinical oncology, Volume 113, Issue 1, 1 1 1987, Pages 99-100 Twice weekly vindesine, a phase II study in lung cancer. Postmus PE, Mulder NH, Schipper DL, de Vries EG
Vindesine 1.75 mg/m2, twice weekly for 2 weeks followed by 2 weeks rest, was given to 26 lung cancer patients. In 6 patients a partial response was seen (23%). Neurotoxicity was present in 15 patients after 1 course; in 6 patients this was the reason for stopping therapy. This regimen has no advantage over weekly vindesine. Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1297-1302 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, van Es LA, Daha MR
Cited 28 times since 1986 (0.7 per year) source: EuropePMC
European journal of cancer & clinical oncology, Volume 22, Issue 10, 1 1 1986, Pages 1149-1155 Pharmacokinetics of high dose etoposide (VP 16-213). Holthuis JJ, Postmus PE, Van Oort WJ, Hulshoff B, Verleun H, Sleijfer DT, Mulder NH
This paper describes the pharmacokinetics of etoposide in cancer patients after high dose administration (up to 3.5 g/m2). High performance liquid chromatography with electrochemical detection was used to determine etoposide, cis etoposide and the glucuronide of etoposide in plasma, bile, cerebro-spinal fluid, urine, saliva and ascites, the detection limit being 2 ng etoposide/ml plasma. The plasma concentration time curve shows a tri-phasic decay. The terminal phase is very slow. It was conclud... Abstract
Cited 66 times since 1986 (1.7 per year) source: EuropePMC
The American review of respiratory disease, Volume 133, Issue 5, 1 1 1986, Pages 882-890 Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. De Water R, Willems LN, Van Muijen GN, Franken C, Fransen JA, Dijkman JH, Kramps JA
The present report describes the ultrastructural localization of bronchial antileukoprotease (ALP) in human central and peripheral airways by using polyclonal as well as monoclonal ALP-specific antibodies in a two-step gold-labeling procedure. In the serous cells of bronchial glands, ALP could be demonstrated in secretory granules. These granules, among which 4 phenotypes could be distinguished morphologically in ultrathin sections, showed the following labeling patterns: phenotype I, which had... Abstract
Cited 52 times since 1986 (1.4 per year) source: EuropePMC
Journal of bacteriology, Volume 165, Issue 2, 1 1 1986, Pages 585-594 Siderophores and outer membrane proteins of antagonistic, plant-growth-stimulating, root-colonizing Pseudomonas spp. de Weger LA, van Boxtel R, van der Burg B, Gruters RA, Geels FP, Schippers B, Lugtenberg B
As an approach to understanding the molecular basis of the reduction in plant yield depression by root-colonizing Pseudomonas spp. and especially of the role of the bacterial cell surfaces in this process, we characterized 30 plant-root-colonizing Pseudomonas spp. with respect to siderophore production, antagonistic activity, plasmid content, and sodium dodecyl sulphate-polyacrylamide gel electrophoresis patterns of their cell envelope proteins. The results showed that all strains produce hydrox... Abstract
Cited 8 times since 1986 (0.2 per year) source: EuropePMC
Histochemistry, Volume 84, Issue 4-6, 1 1 1986, Pages 348-354 Methodological aspects of flow cytometric analysis of DNA polyploidy in human heart tissue. Vliegen HW, Vossepoel AM, van der Laarse A, Eulderink F, Cornelisse CJ
The purpose of the study was to investigate the possibilities of flow cytometry (FCM) for the analysis of DNA polyploidy in human heart tissue. Suspensions of single nuclei were prepared with the detergent-trypsin procedure and stained with propidium iodide. A mathematical correction procedure was developed to correct for background and clumping. For diploid model populations of chicken and trout red blood cells this correction reduced artifactual fractions in the FCM DNA profile to less than 0.... Abstract
Cited 2 times since 1986 (0.1 per year) source: EuropePMC
The Netherlands journal of medicine, Volume 29, Issue 11, 1 1 1986, Pages 359-364 High-dosage chemotherapy with autologous bone marrow reinfusion in the treatment of patients with solid tumours. The Groningen experience, 1981-1986. Mulder NH, Mulder PO, Van der Geest S, Halie MR, Maas A, Orie JL, Postmus PE, Sleijfer DT, Smit Sibinga CT, De Vries EG
Cited 91 times since 1985 (2.4 per year) source: EuropePMC
Cancer research, Volume 45, Issue 12 Pt 1, 1 1 1985, Pages 6024-6033 Characterization of three new variant type cell lines derived from small cell carcinoma of the lung. de Leij L, Postmus PE, Buys CH, Elema JD, Ramaekers F, Poppema S, Brouwer M, van der Veen AY, Mesander G, The TH
Three new, well growing cell lines (GLC-1, GLC-2, and GLC-3) have been established from small cell lung carcinoma (SCLC) and characterized. A subclone (GLC-1-M13) markedly different from its parent line GLC-1 was also isolated and characterized. Cytogenetic analysis of the cell lines revealed deletions in the short arm of chromosome 3 as a most consistent chromosomal aberration. The deleted region was not identical in all metaphases, 3p(21-23) being the shortest region of overlap. Despite their... Abstract
Chest, Volume 88, Issue 4, 1 1 1985, Pages 635-636 Endoscopic treatment of a whistling middle-lobe bronchus. Hirschler-Schulte CJ, Postmus PE, van Overbeek JJ
A 32-year old man presented with dyspnea and a loud inspiratory wheeze. Examination revealed a nonfibrous, fissure-shaped entrance to the middle-lobe bronchus. The cause of this stenosis was unclear. Endoscopic treatment consisted of splitting the spur and resulted in complete disappearance of the wheeze. Abstract
Cited 14 times since 1985 (0.4 per year) source: EuropePMC
Archives of internal medicine, Volume 145, Issue 8, 1 1 1985, Pages 1513-1515 A case of carbimazole-induced intrahepatic cholestasis. An immune-mediated reaction? Blom H, Stolk J, Schreuder HB, von Blomberg-van der Flier M
A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of a... Abstract
Cited 519 times since 1984 (13.1 per year) source: EuropePMC
Circulation, Volume 70, Issue 5, 1 1 1984, Pages 812-823 Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Baan J, van der Velde ET, de Bruin HG, Smeenk GJ, Koops J, van Dijk AD, Temmerman D, Senden J, Buis B
An eight-electrode conductance catheter previously developed by us and used to determine stroke volume in dogs was applied in human beings and dogs to measure absolute left ventricular volume quantitatively. For calibration we developed the formula V(t) = (1/alpha)(L2/sigma b)G(t) - Vc, where V(t) is time-varying left ventricular volume, alpha is a dimensionless constant, L is the electrode separation, sigma b is the conductivity of blood obtained by a sampling cuvette, and G(t) is the measured... Abstract
Cited 17 times since 1984 (0.4 per year) source: EuropePMC
European journal of cancer & clinical oncology, Volume 20, Issue 6, 1 1 1984, Pages 777-782 Cyclophosphamide and VP 16-213 with autologous bone marrow transplantation. A dose escalation study. Postmus PE, de Vries EG, De Vries-Hospers HG, Vriesendorp R, van Imhoff GW, Holthuis JJ, Sibinga CT, Sleijfer DT, Mulder NH
In 13 patients with therapy-resistant solid tumors the feasibility of high-dose cyclophosphamide (7 g/m2) in combination with increasing doses of VP 16-213 with autologous bone marrow transplantation was studied. Dose-limiting extramedullary toxicity appeared to be mucositis and occurred after 2.5 g/m2. Two toxic deaths were observed in patients older than 55 yr. Responses were seen in eight out of nine evaluable patients. Two patients with ovarian cancer still have no signs of disease progressi... Abstract