Cited 14 times since 1985 (0.4 per year) source: EuropePMC Archives of internal medicine, Volume 145, Issue 8, 1 1 1985, Pages 1513-1515 A case of carbimazole-induced intrahepatic cholestasis. An immune-mediated reaction? Blom H, Stolk J, Schreuder HB, von Blomberg-van der Flier M
A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of an immune-mediated reaction, especially as it has been shown that sensitized lymphocytes may produce a cholestatic factor on stimulation with antigen.
