Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
240 results
Cited 3 times since 2010 (0.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 11, 16 3 2010, Pages 1581-1588 Right ventricular stimulation threshold at ICD implant predicts device therapy in primary prevention patients with ischaemic heart disease. Atary JZ, Borleffs CJ, van der Bom JG, Trines SA, Bootsma M, Zeppenfeld K, van Erven L, Schalij MJ
Aims: Myocardial excitability is known (amongst other reasons) to be related to the degree of ischaemia, contractile dysfunction and heart failure. It was hypothesized that the right ventricular (RV) stimulation threshold has prognostic value with respect to the occurrence of ventricular arrhythmias (VAs) and patient survival in recipients of an implantable cardioverter defibrillator (ICD). Methods and results: Ischaemic heart disease patients receiving an ICD at Leiden University Medical Center... Abstract
Cited 33 times since 2010 (2.4 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 1, 13 2 2010, Pages 4-12 Three-year outcome of sirolimus-eluting versus bare-metal stents for the treatment of ST-segment elevation myocardial infarction (from the MISSION! Intervention Study). Atary JZ, van der Hoeven BL, Liem SS, Jukema JW, van der Bom JG, Atsma DE, Bootsma M, Zeppenfeld K, van der Wall EE, Schalij MJ
To compare the long-term efficacy and safety of sirolimus-eluting stents (SES) to those of bare-metal stents (BMS) for ST-segment elevation myocardial infarction, outcomes were assessed in 310 patients (mean age age 59 +/- 11 years, 78% men) included in the randomized MISSION! Intervention Study: A Prospective Randomised Controlled Trial to Evaluate the Efficacy of Drug-Eluting Stents Versus Bare-Metal Stents for the Treatment of Acute Myocardial Infarction after a median follow-up period of 38... Abstract
Cited 43 times since 2010 (3.1 per year) source: EuropePMC
Circulation, Volume 121, Issue 17, 19 3 2010, Pages 1887-1895 Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K
Background: Reperfusion therapy during acute myocardial infarction results in myocardial salvage and improved ventricular function but may also influence the arrhythmogenic substrate for ventricular tachycardia (VT). This study used electroanatomic mapping and infarct histology to assess the impact of reperfusion on the substrate and on VT characteristics late after acute myocardial infarction. Methods and results: The study population consisted of 36 patients (32 men; age, 63+/-15 years) referr... Abstract
Cited 4 times since 2009 (0.3 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 5, Issue 5, 1 1 2009, Pages 565-572 Impact of sirolimus-eluting stent implantation compared to bare-metal stent implantation for acute myocardial infarction on coronary plaque composition at nine months follow-up: a Virtual Histology intravascular ultrasound analysis. Results from the Leiden MISSION! intervention study. Atary JZ, Bergheanu SC, van der Hoeven BL, Atsma DE, Bootsma M, van der Kley F, Zeppenfeld K, Jukema JW, Schalij MJ
Aims: To evaluate effects of sirolimus-eluting stents (SES) compared to bare-metal stents (BMS) at stent edges in patients with acute myocardial infarction (AMI). Methods and results: Clinical, angiographic, intravascular ultrasound (lVUS) and virtual histology (VH)-IVUS results were obtained and analysed in 20 SES and 20 BMS AMI patients at the index procedure and at nine months follow-up. Quantitative angiography and IVUS showed a trend toward decreases in mean lumen diameter, vessel volume, m... Abstract
Cited 5 times since 2009 (0.3 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 5, 1 1 2009, Pages e28-30 Real-time integration of intracardiac echocardiography to facilitate atrial tachycardia ablation in a patient with a Senning baffle. den Uijl DW, Blom NA, Wijnmaalen AP, Bax JJ, Schalij MJ, Zeppenfeld K
Cited 26 times since 2009 (1.8 per year) source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 74, Issue 2, 1 1 2009, Pages 335-343 In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimization program. Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ
Objectives: Our aim was to evaluate the effects of early abciximab administration in the ambulance on immediate, short, and long term outcomes. Background: Early abciximab administration before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is recommended in practice guidelines. However, optimal timing of administration remains indistinct. Methods: Within a fixed protocol for PPCI, December 2006 was the cut-off point for this prospective... Abstract
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 20, Issue 10, 26 4 2009, Pages 1119-1127 Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K
Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and ventricular tachycardia (VT) are at risk of VT recurrence and sudden death. Data on patients with VT due to right ventricular (RV) scar not fulfilling TF criteria are lacking. The purpose of this study was to assess the long-term arrhythmia recurrence rate and outcome in patients with scar-related right VT with and without a diagnosis of ARVC/D. Methods... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
European heart journal, Volume 30, Issue 13, 2 1 2009, Pages 1621-1626 Recurrence of ventricular arrhythmias in ischaemic secondary prevention implantable cardioverter defibrillator recipients: long-term follow-up of the Leiden out-of-hospital cardiac arrest study (LOHCAT). Borleffs CJ, van Erven L, Schotman M, Boersma E, Kiès P, van der Burg AE, Zeppenfeld K, Bootsma M, van der Wall EE, Bax JJ, Schalij MJ
Aims: To assess the long-term rate of mortality and the recurrence of potentially life-threatening ventricular arrhythmias in secondary prevention implantable cardioverter defibrillator (ICD) patients and to construct a model for baseline risk stratification. Methods and results: Since 1996, all patients with ischaemic heart disease, receiving ICD therapy for secondary prevention of sudden death, were included in the current study. Patients were evaluated at implantation and during long-term fol... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 3, 17 3 2009, Pages 249-257 Long-term improvement in left ventricular strain after successful catheter ablation for atrial fibrillation in patients with preserved left ventricular systolic function. Tops LF, Den Uijl DW, Delgado V, Marsan NA, Zeppenfeld K, Holman E, van der Wall EE, Schalij MJ, Bax JJ
Background: The effect of successful catheter ablation on left ventricular (LV) strain in patients with preserved LV systolic function is unknown. The aim of the present study was to assess the long-term effects of catheter ablation for atrial fibrillation (AF) on LV strain and strain rate in patients with preserved LV ejection fraction. Methods and results: In 78 patients undergoing catheter ablation for AF, speckle tracking strain imaging was performed to assess LV strain in 3 directions (radi... Abstract
Cited 247 times since 2009 (16.3 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 2, Issue 3, 23 4 2009, Pages 183-190 Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmia in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator. Roes SD, Borleffs CJ, van der Geest RJ, Westenberg JJ, Marsan NA, Kaandorp TA, Reiber JH, Zeppenfeld K, Lamb HJ, de Roos A, Schalij MJ, Bax JJ
Background: The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, the study purpose was to evaluate the predictive value of infarct tissue heterogeneity assessed with contrast-enhanced MRI on the occurrence of spontaneous ventricular arrhythmia with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate of sudden cardiac death) in patients with pre... Abstract
Cited 82 times since 2009 (5.4 per year) source: EuropePMC
American journal of human genetics, Volume 84, Issue 4, 12 2 2009, Pages 468-476 Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, Koopmann TT, Christiaans I, Postema PG, Beekman L, Tanck MW, Zeppenfeld K, Loh P, Koch KT, Demolombe S, Mannens MM, Bezzina CR, Wilde AA
Idiopathic Ventricular Fibrillation (IVF) is defined as spontaneous VF without any known structural or electrical heart disease. A family history is present in up to 20% of probands with the disorder, suggesting that at least a subset of IVF is hereditary. A genome-wide haplotype-sharing analysis was performed for identification of the responsible gene in three distantly related families in which multiple individuals died suddenly or were successfully resuscitated at young age. We identified a h... Abstract
Cited 79 times since 2009 (5.2 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 2, 18 3 2009, Pages 135-145 Acute effects of right ventricular apical pacing on left ventricular synchrony and mechanics. Delgado V, Tops LF, Trines SA, Zeppenfeld K, Marsan NA, Bertini M, Holman ER, Schalij MJ, Bax JJ
Background: Chronic right ventricular (RV) apical pacing has a detrimental effect on left ventricular (LV) function. However, the acute effects of RV apical pacing on LV mechanics remain unclear. The purpose of the study was to assess the acute impact of RV apical pacing on global LV function, evaluating LV contraction synchrony and LV shortening and twist, using 2D speckle-tracking strain imaging. Methods and results: A group of 25 patients with structural normal hearts referred for electrophys... Abstract
Cited 127 times since 2008 (8.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 9, 26 4 2008, Pages 715-720 Risk factors and time delay associated with cardiac device infections: Leiden device registry. Lekkerkerker JC, van Nieuwkoop C, Trines SA, van der Bom JG, Bernards A, van de Velde ET, Bootsma M, Zeppenfeld K, Jukema JW, Borleffs JW, Schalij MJ, van Erven L
Aims: A nested case-control study of 75 patients with cardiac device infections (CDI) and 75 matched controls was conducted to evaluate time course, risk factors, culture results and frequency of CDI. Methods and results: CDI occurred in 75/3410 (2.2%) device implantation and revision procedures, performed between 2000 and 2007. The time delay between device procedure and infection ranged from 0 to 64 months (mean 14 (SD 16)), 21 patients (28%) had an early infection (12 months). Of interest, 18... Abstract
Cited 27 times since 2008 (1.7 per year) source: EuropePMC
Heart rhythm, Volume 5, Issue 10, 24 4 2008, Pages 1403-1410 Real-time integration of intracardiac echocardiography and multislice computed tomography to guide radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Tops LF, Tolosana JM, Schuijf JD, Trines SA, Zeppenfeld K, Bax JJ, Schalij MJ
Background: Multislice computed tomography (MSCT) integration is commonly used to guide radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). MSCT provides detailed anatomical information but lacks the ability to provide real-time anatomy during RFCA. Intracardiac echocardiography (ICE) allows real-time visualization of cardiac structures. Objective: The purpose of this study was to investigate the feasibility of three-dimensional (3D) anatomical mapping of the left atrium (LA) w... Abstract
Cited 73 times since 2008 (4.6 per year) source: EuropePMC
The American journal of cardiology, Volume 102, Issue 7, 18 3 2008, Pages 847-853 Comparison of left atrial volumes and function by real-time three-dimensional echocardiography in patients having catheter ablation for atrial fibrillation with persistence of sinus rhythm versus recurrent atrial fibrillation three months later. Marsan NA, Tops LF, Holman ER, Van de Veire NR, Zeppenfeld K, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Real-time 3-dimensional echocardiography (RT3DE) can provide a unique combination of accurate left atrial (LA) volume quantification and rapid, automatic assessment of LA function. The aim of the study was to evaluate the changes in LA volumes and function in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation (RFCA) using RT3DE; 57 consecutive patients referred for RFCA were studied. Paroxysmal AF was present in 43 patients (75%) and persistent AF in 14 (25%). Aft... Abstract
Cited 47 times since 2008 (2.9 per year) source: EuropePMC
JACC. Cardiovascular interventions, Volume 1, Issue 2, 1 1 2008, Pages 192-201 Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study. van der Hoeven BL, Liem SS, Dijkstra J, Bergheanu SC, Putter H, Antoni ML, Atsma DE, Bootsma M, Zeppenfeld K, Jukema JW, Schalij MJ
Objectives: Acute and late stent malapposition (SM) after bare-metal stents (BMS) and sirolimus-eluting stents (SES) in ST-segment elevation myocardial infarction patients were studied. Background: Stent thrombosis may be caused by SM after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients. Methods: Post-procedure and follow-up intravascular ultrasound data were available in 184 out of 310 patients (60%; 104 SES, 80 BMS) included in the MISSION! In... Abstract
Cited 23 times since 2008 (1.4 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 31, Issue 3, 1 1 2008, Pages 358-374 Ablation of ventricular tachycardia in patients with structural heart disease. Zeppenfeld K, Stevenson WG
Catheter ablation is an important therapeutic option for controlling recurrent ventricular arrhythmias in patients with heart disease. Although implantable defibrillators are generally first line therapy in this patient population, a substantial number of patients require additional therapy with either antiarrhythmic drugs, ablation, or both. Studies of mapping and ablation have produced further insights into pathophysiologic mechanisms of these arrhythmias, which are now well characterized. The... Abstract
Cited 89 times since 2008 (5.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 51, Issue 6, 1 1 2008, Pages 618-626 Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ
Objectives: Our purpose was to evaluate the efficacy and safety of drug-eluting stents in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). Background: There is inconsistent and limited evidence about the efficacy and safety of drug-eluting stents in STEMI patients. Methods: A single-blind, single-center, randomized study was performed to compare bare-metal stents (BMS) with sirolimus-eluting stents (SES) in 310 STEMI patients. The... Abstract
Cited 153 times since 2007 (9.3 per year) source: EuropePMC
Circulation, Volume 116, Issue 20, 29 5 2007, Pages 2241-2252 Catheter ablation of ventricular tachycardia after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmus. Zeppenfeld K, Schalij MJ, Bartelings MM, Tedrow UB, Koplan BA, Soejima K, Stevenson WG
Background: Catheter ablation of ventricular tachycardia (VT) after repair of congenital heart disease can be difficult because of nonmappable VTs and complex anatomy. Insights into the relation between anatomic isthmuses identified by delineating unexcitable tissue using substrate mapping techniques and critical reentry circuit isthmuses might facilitate ablation. Methods and results: Sinus rhythm voltage mapping of the right ventricle was performed in 11 patients with sustained VT after repair... Abstract
Cited 4 times since 2007 (0.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 93, Issue 1, 1 1 2007, Pages 113-114 Feasibility of trans-endocardial cell transplantation in chronic ischaemia. Beeres SL, Bax JJ, Zeppenfeld K, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE