Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
61 results
European heart journal. Digital health, Volume 2, Issue 2, 22 4 2021, Pages 215-223 Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure. Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD
Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w... Abstract
Cited 2 times since 2021 (0.6 per year) source: EuropePMC
Sensors (Basel, Switzerland), Volume 21, Issue 4, 15 3 2021, Pages 1361 Early Detection of Fluid Retention in Patients with Advanced Heart Failure: A Review of a Novel Multisensory Algorithm, HeartLogic<sup>TM</sup>. Feijen M, Egorova AD, Beeres SLMA, Treskes RW
Heart failure (HF) hospitalisations due to decompensation are associated with shorter life expectancy and lower quality of life. These hospitalisations pose a significant burden on the patients, doctors and healthcare resources. Early detection of an upcoming episode of decompensation may facilitate timely optimisation of the ambulatory medical treatment and thereby prevent heart-failure-related hospitalisations. The HeartLogicTM algorithm combines data from five sensors of cardiac implantable e... Abstract
Cited 16 times since 2021 (4.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 107, Issue 21, 15 3 2021, Pages 1725-1730 Sacubitril/valsartan in the treatment of systemic right ventricular failure. Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circ... Abstract
Cited 3 times since 2021 (0.9 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 32, Issue 1, 1 1 2021, Pages 122-129 The significance of symptoms before and after surgery for anomalous aortic origin of coronary arteries in adolescents and adults. Meijer FMM, Egorova AD, Jongbloed MRM, Koppel C, Habib G, Hazekamp MG, Vliegen HW, Kies P
Objectives: The aim of this study is to describe the significance of symptoms preoperatively and at medium-term follow-up in adolescent and adult patients who underwent surgery of anomalous aortic origin of a coronary artery (AAOCA). Methods: Consecutive patients who underwent surgery for AAOCA in our tertiary referral centre between 2001 and 2018 were included. Clinical characteristics and symptoms were evaluated and medium-term outcomes were recorded. Symptoms were classified according to the... Abstract
Cited 2 times since 2020 (0.6 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 44, Issue 1, 12 2 2020, Pages 120-128 Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach. Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L
The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range... Abstract
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
European heart journal. Case reports, Volume 4, Issue 5, 15 3 2020, Pages 1-3 Pulmonary hypertension causing left main coronary artery compression. Verheijen DBH, Meijer FMM, Kiès P, Egorova AD
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
Clinical case reports, Volume 8, Issue 11, 6 1 2020, Pages 2320-2321 The constrictive consequences of pericardial calcifications. Egorova AD, Schalij MJ, Kiès P
A 53-year-old man presented with symptomatic severe pulmonary valve regurgitation. He underwent a diagnostic catheterization. A heavily calcified pericardium and the pressure tracings illustrate typical features of constrictive pericarditis physiology, including the "square root sign." This condition is important to recognize given the progressive nature and poor prognosis if untreated. Abstract
Journal of electrocardiology, Volume 61, 5 1 2020, Pages 141-146 Lack of diagnostic utility of the ECG-derived ventricular gradient in patients with suspected acute pulmonary embolism. Meijer FMM, Hendriks SV, Huisman MV, van der Hulle T, Swenne CA, Kies P, Jongbloed MRM, Egorova AD, Vliegen HW, Klok FA
Introduction: The YEARS algorithm was successfully developed to reduce the number of computed tomography pulmonary angiography (CTPA) investigations in the diagnostic management of patients with suspected pulmonary embolism (PE), although half of patients still needed to be referred for CTPA. We hypothesized that ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO), an easy to use tool for detecting PE-induced pulmonary hypertension (PH), may further impro... Abstract
Cited 5 times since 2020 (1.2 per year) source: EuropePMC
European heart journal. Case reports, Volume 4, Issue 3, 17 3 2020, Pages 1-5 Anomalous left coronary artery from the pulmonary artery: a rare cause of an out-of-hospital cardiac arrest in an adult-a case report. Regeer MV, Bondarenko O, Zeppenfeld K, Egorova AD
Background: Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital disorder resulting in ischaemia and myocardial infarction which can act as a potential substrate for life-threatening arrhythmias and sudden cardiac death. Case summary: A 19-year-old man was admitted to the hospital after successful resuscitation from an out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation occurring during jogging. In the diagnostic work-up of the OHCA, computed t... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
European heart journal. Case reports, Volume 4, Issue 2, 21 3 2020, Pages 1-6 <b>Successful percutaneous occlusion of a large left circumflex coronary artery fistula draining into the coronary sinus using a</b> ventricular septal defect <b>occluder: a case report</b>. Egorova AD, Ewert P, Hadamitzky M, Eicken A
Background: Coronary artery fistula (CAF) is a congenital anomaly of the coronaries that can lead to significant intracardiac shunting and myocardial ischaemia. Case summary: We describe the case of a 15-year-old male with an incidentally documented precordial cardiac murmur. An evidently dilated coronary sinus (CS) on transthoracic echocardiography prompted further investigation. A computed tomography (CT) revealed the presence of a large CAF from the left circumflex coronary artery to the CS.... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 2, 1 1 2020, Pages 110-111 A 55-year-old man with mild shortness of breath. Egorova AD, Smit JM, Kiès P
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 2, 1 1 2020, Pages 104-107 A 55-year-old man with mild shortness of breath. Egorova AD, Smit JM, Kiès P
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 1 1 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF
Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally correct... Abstract
Cited 54 times since 2012 (4.4 per year) source: EuropePMC
Science signaling, Volume 5, Issue 212, 21 3 2012, Pages pt2 TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia. Ten Dijke P, Egorova AD, Goumans MJ, Poelmann RE, Hierck BP
Endothelial-to-mesenchymal transition (EndoMT) is an instrumental step in the development of valves in the embryonic heart. This process is driven by activation of transforming growth factor-β (TGF-β) signaling and is characterized by the loss of endothelial and gain of mesenchymal phenotype, and by delamination of cells from the surface into the underlying endocardial cushion matrix. The endothelial cells (ECs) overlying the cushions are typically exposed to high blood flow and concomitant shea... Abstract
Cited 45 times since 2011 (3.6 per year) source: EuropePMC
Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP
Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract
Cited 27 times since 2011 (2.2 per year) source: EuropePMC
In vitro cellular & developmental biology. Animal, Volume 48, Issue 1, 20 3 2011, Pages 21-29 Endothelial colony-forming cells show a mature transcriptional response to shear stress. Egorova AD, DeRuiter MC, de Boer HC, van de Pas S, Gittenberger-de Groot AC, van Zonneveld AJ, Poelmann RE, Hierck BP
Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic applications. The extent to which these cells respond to shear stress as adult vascular EC remains to be elucidated. Here, we study the transcr... Abstract
Cited 39 times since 2011 (3 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 7, 20 3 2011, Pages 1670-1680 Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells. Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJ, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP
Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC in areas of high shear stress, i.e., in the cardiac outflow tract and atrioventricular canal, are characterized by high expression of Krüppel-like factor 2 (Klf2) and by transforming growth factor-beta (Tgfβ)-driven endothelial-to-mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results in congenital heart m... Abstract
Cited 120 times since 2011 (9.1 per year) source: EuropePMC
Circulation research, Volume 108, Issue 9, 10 2 2011, Pages 1093-1101 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP
Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitric oxide production and initiation of gene expression. Cilia are present on ECs in areas of low or disturbed flow and absent in areas of high flow. In the embryonic heart, high-flow regime applies to the endocardial cushion area, and the absence of cilia here coincides with the p... Abstract
Cited 20 times since 2011 (1.5 per year) source: EuropePMC
International review of cell and molecular biology, Volume 290, 1 1 2011, Pages 87-119 Role for primary cilia as flow detectors in the cardiovascular system. Van der Heiden K, Egorova AD, Poelmann RE, Wentzel JJ, Hierck BP
The cardiovascular system is exposed to biochemical and biomechanical signals. Various sensors for these signals have been described and they contribute to cardiovascular development, maintenance of vessel integrity during adult life, and to pathogenesis. In the past 10years, primary cilia, membrane-covered, rod-like cellular protrusions, were discovered on multiple cell types of the cardiovascular system. Primary cilia are sensory organelles involved in several key (developmental) signaling pat... Abstract
Cited 1 times since 1968 (0 per year) source: EuropePMC
Meditsinskaia parazitologiia i parazitarnye bolezni, Volume 37, Issue 3, 1 1 1968, Pages 302-305 [Natural infection of chigger mites with Rickettsia tsutsugamushi in the Primorsky territory]. Kudriashova NI, Miroliubova LV, Tarasevich IV, Plotnikova LF, Egorova AD