Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
70 results
Cited 4 times since 2015 (0.5 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 9, 1 1 2015, Pages 447-449 Heart failure in 2015: let's get organised! Lucas CM, van Pol PE, Eysink Smeets JB, Niesing M, Verwey HF, Beeres SL
Cited 9 times since 2015 (1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 2, 1 1 2015, Pages 102-108 Left ventricular assist device for end-stage heart failure: results of the first LVAD destination program in the Netherlands. Haeck ML, Beeres SL, Höke U, Palmen M, Couperus LE, Delgado V, Logeman EA, Maas JJ, Klautz RJ, Schalij MJ, Verwey HF
Purpose: Mechanical circulatory support with a continuous-flow left ventricular assist device (LVAD) may be a valuable treatment in end-stage heart failure patients for an extended period of time. The purpose of this study was to evaluate the safety and efficacy of implantation of a continuous-flow LVAD in end-stage heart failure patients within the first destination program in the Netherlands. Methods: A third-generation LVAD was implanted in 16 heart failure patients (age 61 ± 8; 81 % male; le... Abstract
Cited 7 times since 2014 (0.7 per year) source: EuropePMC
International journal of cardiology, Volume 175, Issue 3, 2 1 2014, Pages 539-544 Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. Rodrigo SF, van Ramshorst J, Mann I, Leong DP, Cannegieter SC, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE
Background: We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to assess whether patient characteristics, procedural data and baseline measurements influence the response to intramyocardi... Abstract
Cited 5 times since 2014 (0.5 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 30, Issue 3, 31 5 2014, Pages 583-589 Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. van Ramshorst J, Beeres SL, Rodrigo SF, Dibbets-Schneider P, Scholte AJ, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE
Intramyocardial bone marrow cell injection has been associated with improvements in myocardial perfusion and left ventricular function. The current substudy of a randomized, placebo-controlled, double-blinded study, investigated the effect of intramyocardial bone marrow cell injection on myocardial sympathetic innervation in patients with chronic myocardial ischemia. In a total of 16 patients (64 ± 8 years, 13 men), early and late iodine-123 metaiodobenzylguanidine (MIBG) imaging was performed b... Abstract
Cited 67 times since 2013 (6.3 per year) source: EuropePMC
Journal of cardiovascular translational research, Volume 6, Issue 5, 28 4 2013, Pages 816-825 Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up. Rodrigo SF, van Ramshorst J, Hoogslag GE, Boden H, Velders MA, Cannegieter SC, Roelofs H, Al Younis I, Dibbets-Schneider P, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE
In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis. Clinical data however, are scarce. Therefore, the present study evaluates the safety and feasibility of intramyocardial MSC injection in nine patients, shortly after AMI during short-term and 5-year follow-up. Periprocedural safety analysis demonstrated one transient ischemic attack. No other adverse events related t... Abstract
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 96, Issue 4, 16 3 2013, Pages 1390-1397 Variation in coronary anatomy in adult patients late after arterial switch operation: a computed tomography coronary angiography study. Veltman CE, Beeres SLMA, Kalkman DN, Kelder TP, Kiès P, Vliegen HW, Hazekamp MG, Delgado V, Kroft LJM, van der Wall EE, Gittenberger-de Groot AC, Scholte AJHA, Schalij MJ, Jongbloed MRM
Background: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. Methods: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal c... Abstract
Cited 7 times since 2013 (0.6 per year) source: EuropePMC
International journal of cardiology, Volume 168, Issue 3, 26 4 2013, Pages 3031-3032 Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. van Ramshorst J, Rodrigo SF, Beeres SL, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Atsma DE
Cited 17 times since 2012 (1.5 per year) source: EuropePMC
American heart journal, Volume 164, Issue 5, 16 3 2012, Pages 771-778 Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. Rodrigo SF, van Ramshorst J, Beeres SL, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE
Background: We recently demonstrated in a randomized, double-blind, placebo-controlled trial that intramyocardial bone marrow cell (BMC) injection is associated with improvements in myocardial perfusion and anginal symptoms in chronic myocardial ischemia patients. In the present study the results of the crossover phase of this trial, in which patients previously treated with placebo received autologous BMC injections are reported. This allows a unique intra-patient comparison on the effect of BM... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
Current pharmaceutical design, Volume 17, Issue 30, 1 1 2011, Pages 3308-3327 Cell therapy for the treatment of chronic ischemic heart disease. Rodrigo SF, Ramshorst Jv, Beeres SL, Bax JJ, Schalij MJ, Atsma DE
Over the last decade, much was learned about the biology of several types of stem and progenitor cells. It has become apparent that various cell sources may have the capacity to promote cardiomyogenesis and new blood vessel formation through different mechanisms, forming the rationale for cell-based therapy in patients with chronic ischemic heart disease. After initial clinical studies have provided evidence for safety of cell administration, larger randomized trials demonstrated variable effect... Abstract
Cited 15 times since 2011 (1.1 per year) source: EuropePMC
Journal of cardiovascular translational research, Volume 4, Issue 2, 7 1 2011, Pages 182-191 Bone marrow cell injection for chronic myocardial ischemia: the past and the future. van Ramshorst J, Rodrigo SF, Schalij MJ, Beeres SL, Bax JJ, Atsma DE
Intramyocardial bone marrow cell injection is currently being investigated as a new therapeutic option for the treatment of chronic myocardial ischemia. Experimental studies and early phase clinical trials established a favorable safety profile of this approach and suggested that bone marrow cell injection was associated with clinical and functional improvements. Recently, a randomized, double-blind, placebo-controlled trial demonstrated that intramyocardial bone marrow cell injection was associ... Abstract
Cited 12 times since 2011 (0.9 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 4, Issue 2, 5 1 2011, Pages 122-129 Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. van Ramshorst J, Antoni ML, Beeres SL, Roes SD, Delgado V, Rodrigo SF, de Roos A, Holman ER, Fibbe WE, Lamb HJ, Zwaginga JJ, Boersma E, van der Wall EE, Schalij MJ, Atsma DE, Bax JJ
Background: The present substudy of a recently published randomized trial aimed to investigate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Methods and results: In a total of 50 patients, diastolic function was evaluated before and 3 months after bone marrow cell injection using standard echocardiography and strain analysis. In addition, MRI-derived transmitral flow measurements were obtained in a subset of 36 patien... Abstract
Cited 176 times since 2009 (11.7 per year) source: EuropePMC
JAMA, Volume 301, Issue 19, 1 1 2009, Pages 1997-2004 Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. van Ramshorst J, Bax JJ, Beeres SL, Dibbets-Schneider P, Roes SD, Stokkel MP, de Roos A, Fibbe WE, Zwaginga JJ, Boersma E, Schalij MJ, Atsma DE
Context: Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with chronic myocardial ischemia. Objective: To investigate the effect of intramyocardial bone marrow cell injection on myocardial perfusion and LV function in patients with chronic myocardial ischemia. Design, setting, and patients: Randomized, double-blind, placebo-controlled trial at a Netherlands university hospital, May 1, 2005-March 3, 200... Abstract
Cited 25 times since 2008 (1.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 94, Issue 9, 1 1 2008, Pages 1214-1226 Cell therapy for ischaemic heart disease. Beeres SL, Atsma DE, van Ramshorst J, Schalij MJ, Bax JJ
Cited 17 times since 2008 (1.1 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 27, Issue 5, 1 1 2008, Pages 992-997 Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Beeres SL, Lamb HJ, Roes SD, Holman ER, Kaandorp TA, Fibbe WE, de Roos A, van der Wall EE, Schalij MJ, Bax JJ, Atsma DE
Purpose: To evaluate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Materials and methods: In 24 patients (19 male; 65 +/- 9 years) with refractory angina (Canadian Cardiovascular Society [CCS] class III-IV) 84.6 +/- 28.7 x 10(6) bone marrow-derived mononuclear cells were injected intramyocardially (using the NOGA system) in regions with ischemia on Tc-99m tetrofosmin single photon emission computed tomography (SPECT).... Abstract
Cited 14 times since 2008 (0.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 2, 15 3 2008, Pages 119-124 Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. van Ramshorst J, Atsma DE, Beeres SL, Mollema SA, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infar... Abstract
Cited 43 times since 2007 (2.6 per year) source: EuropePMC
The American journal of cardiology, Volume 100, Issue 7, 18 3 2007, Pages 1094-1098 Intramyocardial injection of autologous bone marrow mononuclear cells in patients with chronic myocardial infarction and severe left ventricular dysfunction. Beeres SL, Bax JJ, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE
The present study investigated the safety, feasibility, and potential efficacy of autologous bone marrow cell injection in patients with chronic myocardial infarction and severe left ventricular (LV) dysfunction. In 15 patients (63 +/- 9 years; 14 men) bone marrow was aspirated from the iliac crest. Using the NOGA system (Biosense-Webster, Waterloo, Belgium), 94 +/- 14 x 10(6) bone marrow-derived mononuclear cells were injected into the infarction border zone. Bone marrow cell injection was perf... Abstract
Cited 84 times since 2007 (4.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 49, Issue 11, 6 1 2007, Pages 1137-1148 Role of imaging in cardiac stem cell therapy. Beeres SL, Bengel FM, Bartunek J, Atsma DE, Hill JM, Vanderheyden M, Penicka M, Schalij MJ, Wijns W, Bax JJ
Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for... Abstract
Cited 4 times since 2007 (0.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 93, Issue 1, 1 1 2007, Pages 113-114 Feasibility of trans-endocardial cell transplantation in chronic ischaemia. Beeres SL, Bax JJ, Zeppenfeld K, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE
Cited 5 times since 2007 (0.3 per year) source: EuropePMC
Acute cardiac care, Volume 9, Issue 4, 1 1 2007, Pages 243-251 Intramyocardial bone marrow cell transplantation and the progression of coronary atherosclerosis in patients with chronic myocardial ischemia. Beeres SL, Bax JJ, Roes SD, Lamb HJ, Fibbe WE, De Roos A, Van Der Wall EE, Schalij MJ, Atsma DE
Background: Cell therapy has been proposed as a novel treatment strategy for patients with ischemic heart disease. However, two recent studies suggested that cardiac cell transplantation might aggravate coronary atherosclerosis. The aim of the current study was to assess whether intramyocardial bone marrow cell transplantation in patients with chronic myocardial ischemia is associated with progression of coronary atherosclerosis. Methods: In 30 patients with chronic ischemia, bone marrow was asp... Abstract
Cited 22 times since 2006 (1.3 per year) source: EuropePMC
Heart rhythm, Volume 4, Issue 3, 10 2 2006, Pages 257-265 Electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic ischemic heart disease. Beeres SL, Zeppenfeld K, Bax JJ, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Atsma DE, Schalij MJ
Background: Bone marrow cell injection has been introduced to treat patients with ischemic heart disease. However, focal application of bone marrow cells may generate an arrhythmogenic substrate. Objectives: To assess the electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic myocardial ischemia. Methods: Bone marrow was aspirated in 20 patients (65+/-11 years, 19 male) with drug-refractory angina and myocardial ischemia. Electroana... Abstract