Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
240 results
Cited 22 times since 2006 (1.3 per year) source: EuropePMC
Heart rhythm, Volume 4, Issue 3, 10 2 2006, Pages 257-265 Electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic ischemic heart disease. Beeres SL, Zeppenfeld K, Bax JJ, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Atsma DE, Schalij MJ
Background: Bone marrow cell injection has been introduced to treat patients with ischemic heart disease. However, focal application of bone marrow cells may generate an arrhythmogenic substrate. Objectives: To assess the electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic myocardial ischemia. Methods: Bone marrow was aspirated in 20 patients (65+/-11 years, 19 male) with drug-refractory angina and myocardial ischemia. Electroana... Abstract
Cited 16 times since 2006 (0.9 per year) source: EuropePMC
Heart rhythm, Volume 4, Issue 1, 9 2 2006, Pages 88-91 Incessant ventricular tachycardia in fulminant lymphocytic myocarditis: Evidence for origin in the Purkinje system and successful treatment with ablation. Zeppenfeld K, Blom NA, Bootsma M, Schalij MJ
Cited 17 times since 2006 (1 per year) source: EuropePMC
Circulation, Volume 114, Issue 3, 1 1 2006, Pages e51-2 Images in cardiovascular medicine. Epicardial radiofrequency catheter ablation of ventricular tachycardia in the vicinity of coronary arteries is facilitated by fusion of 3-dimensional electroanatomical mapping with multislice computed tomography. Zeppenfeld K, Tops LF, Bax JJ, Schalij MJ
Cited 20 times since 2006 (1.1 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 17, Issue 6, 1 1 2006, Pages 586-593 Serial reevaluation for ARVD/C is indicated in patients presenting with left bundle branch block ventricular tachycardia and minor ECG abnormalities. Kiès P, Bootsma M, Bax JJ, Zeppenfeld K, van Erven L, Wijffels MC, van der Wall EE, Schalij MJ
Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is based on a set of criteria proposed by the International Task Force (TF) for Cardiomyopathies in 1994. To fulfill these criteria, presence of both electrocardiographic and anatomical abnormalities must be assessed with ECG and imaging techniques, respectively. This may be difficult in patients with early/mild forms of the disease as detectable structural abnormalities may still be absent. We evaluate... Abstract
Cited 39 times since 2006 (2.2 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 47, Issue 4, 1 1 2006, Pages 574-580 Effect of intramyocardial injection of autologous bone marrow-derived mononuclear cells on perfusion, function, and viability in patients with drug-refractory chronic ischemia. Beeres SL, Bax JJ, Dibbets P, Stokkel MP, Zeppenfeld K, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE
Unlabelled: Intramyocardial injection of bone marrow cells has been proposed as a new therapeutic option for patients with chronic ischemic heart disease. We investigated whether autologous bone marrow-derived mononuclear cell injection into the myocardium of patients with drug-refractory ischemia reduces anginal symptoms, improves left ventricular (LV) function, increases myocardial perfusion, and alters the extent of scar tissue. Methods: In 25 patients (mean age +/- SD, 64 +/- 10 y; 21 male)... Abstract
Cited 41 times since 2006 (2.3 per year) source: EuropePMC
The American journal of cardiology, Volume 97, Issue 9, 20 3 2006, Pages 1326-1331 Usefulness of intramyocardial injection of autologous bone marrow-derived mononuclear cells in patients with severe angina pectoris and stress-induced myocardial ischemia. Beeres SL, Bax JJ, Kaandorp TA, Zeppenfeld K, Lamb HJ, Dibbets-Schneider P, Stokkel MP, Fibbe WE, de Roos A, van der Wall EE, Schalij MJ, Atsma DE
Bone marrow cell transplantation has been proposed as a novel therapeutic option for patients with coronary artery disease. This study investigated whether autologous bone marrow-derived mononuclear cell injection into the ischemic myocardium of patients with severe angina pectoris could safely reduce anginal symptoms, improve myocardial perfusion, and increase left ventricular (LV) function. In a total of 20 patients (63 +/- 10 years old; 16 men) with angina pectoris, myocardial segments with s... Abstract
Cited 65 times since 2006 (3.6 per year) source: EuropePMC
The American journal of cardiology, Volume 97, Issue 8, 2 1 2006, Pages 1220-1222 Effect of radiofrequency catheter ablation for atrial fibrillation on left atrial cavity size. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, van der Wall EE, Schalij MJ
Left atrial (LA) remodeling is associated with atrial fibrillation (AF). Radiofrequency catheter ablation offers a good treatment option for AF, with reasonable long-term results. The purpose of the present study was to assess whether LA reverse remodeling occurs after successful catheter ablation. Fifty-seven consecutive patients (45 men; age 53 +/- 8 years) with symptomatic drug-refractory AF were treated with radiofrequency catheter ablation. The patients were divided into 2 groups on the bas... Abstract
Cited 64 times since 2006 (3.5 per year) source: EuropePMC
Heart rhythm, Volume 3, Issue 5, 28 4 2006, Pages 526-535 Ablation of focal atrial arrhythmia in patients with congenital heart defects after surgery: role of circumscribed areas with heterogeneous conduction. de Groot NM, Zeppenfeld K, Wijffels MC, Chan WK, Blom NA, Van der Wall EE, Schalij MJ
Background: In patients late after surgical repair of congenital heart disease (CHD), areas with abnormal electrophysiologic properties may serve as slow conducting pathways within a macroreentrant circuit or may be the source of focal atrial tachycardia. Objectives: The purpose of this study was to evaluate the role of abnormal areas during focal atrial tachycardia prior to ablation. Methods: Electroanatomic activation mapping of 62 atrial tachycardias was performed in 43 consecutive patients (... Abstract
Cited 13 times since 2006 (0.7 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 17, Issue 1, 1 1 2006, Pages 101-103 Acceleration-dependent left bundle branch block with severe left ventricular dyssynchrony results in acute heart failure: are there more patients who benefit from cardiac resynchronization therapy? Zeppenfeld K, Schalij MJ, Bleeker GB, Holman ER, Bax JJ
Cardiac resynchronization therapy (CRT) has been proposed to improve hemodynamics in patients with heart failure and left bundle branch block (LBBB) by resynchronization of left ventricular (LV) dyssynchrony. The current report concerns a patient with narrow QRS complex without LV dyssynchrony who experienced an acute exacerbation of heart failure following exercise. Careful analysis revealed that an increase of heart rate induced acceleration-dependent LBBB with severe LV dyssynchrony and mitra... Abstract
Cited 124 times since 2005 (6.7 per year) source: EuropePMC
Heart rhythm, Volume 2, Issue 10, 1 1 2005, Pages 1076-1081 Fusion of multislice computed tomography imaging with three-dimensional electroanatomic mapping to guide radiofrequency catheter ablation procedures. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, Lamb HJ, van der Wall EE, Schalij MJ
Background: The outcome of catheter ablation procedures of cardiac arrhythmias depends on the ability to evaluate the underlying mechanism and to depict target sites for ablation. Fusion of different imaging modalities within one system may improve electroanatomic modeling and facilitate ablation procedures. Objectives: The purpose of this study was to study the feasibility of fusion of multislice computed tomography (MSCT) with electroanatomic mapping to guide radiofrequency catheter ablation o... Abstract
Cited 37 times since 2005 (2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 92, Issue 4, 13 2 2005, Pages 490-494 Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm. Kiès P, Leclercq C, Bleeker GB, Crocq C, Molhoek SG, Poulain C, van Erven L, Bootsma M, Zeppenfeld K, van der Wall EE, Daubert JC, Schalij MJ, Bax JJ
Objective: To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF). Patients: 74 consecutive patients (age 68 (8) years; 67 men) with advanced heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT device. Main outcome measures: Patients were evaluated clinically (New York Heart Association (NYHA)... Abstract
Cited 27 times since 2005 (1.4 per year) source: EuropePMC
Heart rhythm, Volume 2, Issue 9, 1 1 2005, Pages 940-950 Identification of successful catheter ablation sites in patients with ventricular tachycardia based on electrogram characteristics during sinus rhythm. Zeppenfeld K, Kiès P, Wijffels MC, Bootsma M, van Erven L, Schalij MJ
Background: Zones of slow conduction facilitate reentry, the major mechanism of ventricular tachycardia (VT) after myocardial infarction (MI). Identification of these zones during sinus rhythm (SR) is desirable for radiofrequency (RF) catheter ablation of VT. Local conduction velocity may correlate with electrogram duration. Objectives: The purpose of this study was to revise the definition of normal electrogram characteristics and to reevaluate the significance of low-amplitude, long-duration e... Abstract
Cited 23 times since 2005 (1.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 91, Issue 7, 1 1 2005, Pages 981-990 Clinical applications of intracardiac echocardiography in interventional procedures. Jongbloed MR, Schalij MJ, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Bax JJ
Cited 4 times since 2005 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 24, 1 1 2005, Pages 1339-1346 [Radiofrequency catheter ablation for treating children with cardiac arrhythmias: favourable results after a mean of 4 years]. Kolditz DP, Blom NA, Bökenkamp R, Bootsma M, Zeppenfeld K, Schalij MJ
Objective: Analysis of long-term results with radiofrequency catheter ablation (RF ablation) in children. Design: Retrospective. Method: Data were analysed from all 118 paediatric patients < or =18 years old who underwent RF ablation at the Leiden University Medical Centre (LUMC), the Netherlands, during the period 1 December 1992-31 May 2004. Results: The group consisted of 6o boys and 58 girls with a mean age of 12.7 years (SD: 4.6). They underwent 140 RF ablation procedures for 122 disorde... Abstract
Cited 16 times since 2005 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 95, Issue 9, 1 1 2005, Pages 1111-1114 Effect of cardiac resynchronization therapy on inducibility of ventricular tachyarrhythmias in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, van Erven L, Steendijk P, van der Wall EE, Schalij MJ
We evaluated whether long-term cardiac resynchronization therapy affects the inducibility of ventricular tachyarrhythmias in relation to reverse remodeling in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Clinical, electrophysiologic, and echocardiographic data of 18 patients were obtained before and after 6 months of cardiac resynchronization. Abstract
Cited 71 times since 2005 (3.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 45, Issue 3, 1 1 2005, Pages 343-350 Multislice computed tomography versus intracardiac echocardiography to evaluate the pulmonary veins before radiofrequency catheter ablation of atrial fibrillation: a head-to-head comparison. Jongbloed MR, Bax JJ, Lamb HJ, Dirksen MS, Zeppenfeld K, van der Wall EE, de Roos A, Schalij MJ
Objectives: The purpose of this study was to perform a head-to-head comparison between multislice computed tomography (MSCT) and intracardiac echocardiography (ICE). Background: Different imaging techniques have been used to visualize the pulmonary veins (PV) before radiofrequency ablation of atrial fibrillation. Methods: The PV and their atrial insertion were evaluated in 42 patients (35 men, 49 +/- 9 years) admitted for ablation of PV ostia. Ostia were measured in two directions (anterior-post... Abstract
Cited 25 times since 2004 (1.3 per year) source: EuropePMC
The American journal of cardiology, Volume 94, Issue 1, 1 1 2004, Pages 130-132 Effect of left ventricular remodeling after cardiac resynchronization therapy on frequency of ventricular arrhythmias. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, St John Sutton M, van Erven L, van der Wall EE, Schalij MJ
We evaluated whether cardiac resynchronization therapy affects the prevalence of ventricular tachycardia in relation to reverse remodeling in patients with end-stage heart failure. Clinical, echocardiographic, and implantable cardioverter-defibrillator (ICD) data of 17 patients with ICDs were obtained before and after they had received an upgrade to an ICD-cardiac resynchronization therapy device. Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue 5, 1 1 2004, Pages 255-256 Recommendations for pacemaker implantation for the treatment of atrial tachyarrhythmias and resynchronisation therapy for heart failure. Wijffels MC, Bootsma M, van Erven L, Zeppenfeld K, Schalij MJ, van Hemel NM
Cited 9 times since 2004 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 93, Issue 10, 1 1 2004, Pages 1298-1302 Anatomical observations of the pulmonary veins with intracardiac echocardiography and hemodynamic consequences of narrowing of pulmonary vein ostial diameters after radiofrequency catheter ablation of atrial fibrillation. Jongbloed MR, Bax JJ, Zeppenfeld K, van der Wall EE, Schalij MJ
Intracardiac echocardiography was used to explore pulmonary venous (PV) anatomy and to monitor PV stenosis in 31 patients referred for radiofrequency catheter ablation at PV ostia. Interindividual variations in PV anatomy and insertion in the left atrium were observed. Narrowing of PV ostia after radiofrequency catheter ablation did not produce significant hemodynamic changes. Abstract
Cited 57 times since 2003 (2.8 per year) source: EuropePMC
Circulation, Volume 108, Issue 17, 29 5 2003, Pages 2099-2106 Voltage and activation mapping: how the recording technique affects the outcome of catheter ablation procedures in patients with congenital heart disease. de Groot NM, Schalij MJ, Zeppenfeld K, Blom NA, Van der Velde ET, Van der Wall EE
Background: Endocardial mapping is mandatory before radiofrequency catheter ablation (RFCA). Mapping can be performed with either unipolar or bipolar recordings. Impact of the recording technique used was studied in patients with and without structural heart disease using the 3D electroanatomic CARTO mapping system. Methods and results: Patients (n=44; 16 males; age 43+/-16 years) referred for RFCA of atrial flutter (AFL, n=18), focal atrial tachycardia (FAT, n=4), AV nodal reentrant tachycardia... Abstract