Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Cited 285 times since 2009 (18.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 53, Issue 6, 1 1 2009, Pages 501-510 Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. Timmers L, Henriques JP, de Kleijn DP, Devries JH, Kemperman H, Steendijk P, Verlaan CW, Kerver M, Piek JJ, Doevendans PA, Pasterkamp G, Hoefer IE
Objectives: This study sought to examine whether exenatide is capable of reducing myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue with insulinotropic and insulinomimetic properties. Because insulin and GLP-1 have been described as reducing apoptosis, exenatide might confer cardioprotection after acute myocardial infarction (MI). Methods: Pigs were randomized to exenatide or phosphate-buffered saline (PBS) treatment after 75 min of coronary artery ligati... Abstract
Cited 2 times since 2008 (0.1 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 296, Issue 2, 5 1 2008, Pages H342-9 Cardiac phase-dependent time normalization reduces load dependence of time-varying elastance. Kind T, Westerhof N, Faes TJ, Lankhaar JW, Steendijk P, Vonk-Noordegraaf A
The time-varying elastance concept provides a comprehensive description of the intrinsic mechanical properties of the left ventricle that are assumed to be load independent. Based on pressure-volume measurements obtained with combined pressure conductance catheterization in six open-chest anesthetized sheep, we show that the time to reach end systole (defined as maximal elastance) is progressively prolonged for increasing ventricle pressures, which challenges the original (load-independent) time... Abstract
Cited 22 times since 2008 (1.4 per year) source: EuropePMC
Acta anaesthesiologica Scandinavica, Volume 52, Issue 9, 1 1 2008, Pages 1194-1203 Establishment of a porcine right ventricular infarction model for cardioprotective actions of xenon and isoflurane. Hein M, Roehl AB, Baumert JH, Bantes B, Bleilevens C, Bernstein N, Steendijk P, Rossaint R
Background: Right ventricular (RV) function is an important determinant of post-operative outcome. Consequences of RV infarction might be limited by pre-conditioning with volatile anesthetic drugs. Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of isoflurane and xenon on the extent and degree of myocardial injury. Methods: IR injury was induced by a 90-min ligation of the distal right coronary artery and 120-min reperfusion in thiopental anes... Abstract
Cited 10 times since 2008 (0.6 per year) source: EuropePMC
Critical care medicine, Volume 36, Issue 9, 1 1 2008, Pages 2576-2582 Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban). van der Hoorn JW, Jukema JW, Bekkers ME, Princen HM, Corda S, Emeis JJ, Steendijk P
Objective: Selective cyclooxygenase-2 inhibition by rofecoxib was associated with increased risk of cardiovascular events. We hypothesized that concomitant treatment with thromboxane prostanoid receptor antagonist S18886 might ameliorate possible negative effects. We evaluated the effects of S18886, rofecoxib, and the interaction of both compounds in a combined treatment on myocardial infarct (MI) size and cardiac function after experimental ischemia/reperfusion injury in hyperlipidemic APOE*3Le... Abstract
Cited 1 times since 2008 (0.1 per year) source: EuropePMC
Journal of cardiothoracic and vascular anesthesia, Volume 22, Issue 6, 12 2 2008, Pages 823-831 The relationship between carotid blood-flow velocity and the left ventricular area during acute regional ischemia. Broscheit JA, Weidemann F, Strotmann J, Steendijk P, Eberbach N, Karle H, Schuster F, Roewer N, Greim CA
Objective: Myocardial contractility can be described by the relationship between blood-flow velocity in the carotid artery and the left ventricular cross-sectional area. The authors investigated whether critical myocardial ischemia influences the derived contractility index, E'(es). Design: A prospective animal study. Setting: A university research laboratory. Participants: Eleven Göttinger minipigs. Interventions: Within the closed-chest model, the authors placed a U-shaped 8-MHz miniature... Abstract
Cited 15 times since 2008 (0.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 94, Issue 10, 1 1 2008, Pages 1318-1322 Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy. Steendijk P, Meliga E, Valgimigli M, Ten Cate FJ, Serruys PW
Objective: Hypertrophic obstructive cardiomyopathy (HOCM) often leads to heart failure, severe symptoms and death. Percutaneous transluminal septal myocardial ablation (PTSMA) by alcohol injection efficiently reduces left ventricular (LV) outflow tract pressure gradient and improves symptoms. We determined acute changes in haemodynamics and systolic and diastolic LV function after PTSMA. Methods: In 17 consecutive patients with symptomatic HOCM referred for PTSMA, the target vessel was determine... Abstract
Cited 4 times since 2008 (0.2 per year) source: EuropePMC
European journal of heart failure, Volume 10, Issue 5, 24 4 2008, Pages 467-474 Haemodynamics and left ventricular function in heart failure patients: comparison of awake versus intra-operative conditions. ten Brinke EA, Klautz RJ, Tulner SA, Engbers FH, Verwey HF, Atsma DE, Schalij MJ, van der Wall EE, Bax JJ, Putter H, Dion RA, Steendijk P
Background: Heart failure patients are increasingly subjected to surgery. Left ventricular (LV) function is generally assessed in awake patients, but intra-operative LV function is not well studied. Aim: To investigate the relation between LV function indices obtained in the catheterization laboratory and those obtained intra-operatively. Methods: We enrolled 11 patients with heart failure (NYHA III-IV) scheduled for surgical interventions. LV function was assessed by pressure-volume loops (cond... Abstract
Cited 18 times since 2008 (1.1 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 194, Issue 2, 17 3 2008, Pages 111-122 Left ventricular function in the post-infarct failing mouse heart by magnetic resonance imaging and conductance catheter: a comparative analysis. Winter EM, Grauss RW, Atsma DE, Hogers B, Poelmann RE, van der Geest RJ, Tschöpe C, Schalij MJ, Gittenberger-de Groot AC, Steendijk P
Aim: Murine myocardial infarction (MI) models are increasingly used in heart failure studies. Magnetic resonance imaging (MRI) and pressure-volume loops by conductance catheter (CC) enable physiological phenotyping. We performed a comparative analysis of MRI vs. CC to assess left ventricular (LV) function in the failing mouse heart. Methods: MI was created by LAD ligation. MRI (day 14) and CC (day 15) were used to determine LV end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fr... Abstract
Cited 271 times since 2008 (16.9 per year) source: EuropePMC
Circulation, Volume 117, Issue 16, 14 2 2008, Pages 2051-2060 Role of left ventricular stiffness in heart failure with normal ejection fraction. Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C
Background: Increased left ventricular stiffness is a distinct finding in patients who have heart failure with normal ejection fraction (HFNEF). To elucidate how diastolic dysfunction contributes to heart failure symptomatology during exercise, we conducted a study using an invasive pressure-volume loop approach and measured cardiac function at rest and during atrial pacing and handgrip exercise. Methods and results: Patients with HFNEF (n=70) and patients without heart failure symptoms (n=20) w... Abstract
Cited 11 times since 2008 (0.7 per year) source: EuropePMC
The American journal of cardiology, Volume 101, Issue 8, 4 1 2008, Pages 1179-1184 Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops. Meliga E, Steendijk P, Valgimigli M, Ten Cate FJ, Serruys PW
The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline... Abstract
Cited 18 times since 2008 (1.1 per year) source: EuropePMC
Journal of anatomy, Volume 212, Issue 3, 1 1 2008, Pages 286-294 Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response. Leeuwenburgh BP, Helbing WA, Wenink AC, Steendijk P, de Jong R, Dreef EJ, Gittenberger-de Groot AC, Baan J, van der Laarse A
Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We hypothesized that chronic right ventricular pressure overload imposed on neonatal hearts initiates a hyperplastic response in the right ventricular myocardium. To test this, young l... Abstract
Cited 41 times since 2008 (2.5 per year) source: EuropePMC
Stem cells (Dayton, Ohio), Volume 26, Issue 4, 17 3 2008, Pages 1083-1093 Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts. Grauss RW, van Tuyn J, Steendijk P, Winter EM, Pijnappels DA, Hogers B, Gittenberger-De Groot AC, van der Geest R, van der Laarse A, de Vries AA, Schalij MJ, Atsma DE
Human mesenchymal stem cells (hMSCs) have only a limited differentiation potential toward cardiomyocytes. Forced expression of the cardiomyogenic transcription factor myocardin may stimulate hMSCs to acquire a cardiomyogenic phenotype, thereby improving their possible therapeutic potential. hMSCs were transduced with green fluorescent protein (GFP) and myocardin (hMSC(myoc)) or GFP and empty vector (hMSC). After coronary ligation in immune-compromised NOD/scid mice, hMSC(myoc) (n = 10), hMSC (n... Abstract
Cited 22 times since 2007 (1.3 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 104, Issue 2, 13 2 2007, Pages 446-450 Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats. Bal MP, de Vries WB, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P
Dexamethasone is clinically applied in preterm infants to treat or prevent chronic lung disease. However, concern has emerged about adverse side effects. The cardiovascular short-term side effects of neonatal dexamethasone treatment are well documented, but long-term consequences are unknown. Previous studies showed suppressed mitosis during dexamethasone treatment, leading to reduced ventricular weight, depressed systolic function, and compensatory dilatation in prepubertal rats. In addition, r... Abstract
Cited 23 times since 2007 (1.4 per year) source: EuropePMC
Pathology, research and practice, Volume 203, Issue 12, 29 5 2007, Pages 863-872 Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, Hessel M, Steendijk P, Bax W, Schutte C, Schalij M, van der Wall E, Atsma D, van der Laarse A
Pulmonary hypertension induces right ventricular (RV) overload, which is transmitted to cardiomyocytes via integrins that activate intracellular messengers, including focal adhesion kinase (FAK) and neuronal nitric oxide synthase (NOS1). We investigated whether RV hypertrophy (RVH) and RV failure (RVF) were associated with activation of FAK, NOS1, and matrix metalloproteinases (MMPs). Rats were treated without (RVC) or with a low dose of monocrotaline (30mg/kg) to induce RVH, and with a high dos... Abstract
Cited 14 times since 2007 (0.8 per year) source: EuropePMC
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, Volume 30, Issue 3, 1 1 2007, Pages 325-331 Systolic and diastolic ventricular function in the normal and extra-embryonic venous clipped chicken embryo of stage 24: a pressure-volume loop assessment. Stekelenburg-de Vos S, Steendijk P, Ursem NT, Wladimiroff JW, Poelmann RE
Objectives: Fluid mechanical forces affect cardiac development. In the chicken embryo, permanent obstruction of the right lateral vitelline vein by clipping reduces the mechanical load on the embryonic myocardium, which has been shown to induce a spectrum of outflow tract anomalies. Insight into the effects of this intervention on the mechanical function of the developing myocardium could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. We... Abstract
Cited 91 times since 2007 (5.4 per year) source: EuropePMC
Circulation, Volume 116, Issue 8, 7 1 2007, Pages 917-927 Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart. Winter EM, Grauss RW, Hogers B, van Tuyn J, van der Geest R, Lie-Venema H, Steijn RV, Maas S, DeRuiter MC, deVries AA, Steendijk P, Doevendans PA, van der Laarse A, Poelmann RE, Schalij MJ, Atsma DE, Gittenberger-de Groot AC
Background: Proper development of compact myocardium, coronary vessels, and Purkinje fibers depends on the presence of epicardium-derived cells (EPDCs) in embryonic myocardium. We hypothesized that adult human EPDCs might partly reactivate their embryonic program when transplanted into ischemic myocardium and improve cardiac performance after myocardial infarction. Methods and results: EPDCs were isolated from human adult atrial tissue. Myocardial infarction was created in immunodeficient mice,... Abstract
Cited 362 times since 2007 (21.6 per year) source: EuropePMC
Circulation, Volume 116, Issue 6, 23 4 2007, Pages 637-647 Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study. Kasner M, Westermann D, Steendijk P, Gaub R, Wilkenshoff U, Weitmann K, Hoffmann W, Poller W, Schultheiss HP, Pauschinger M, Tschöpe C
Background: Various conventional and tissue Doppler echocardiographic indexes were compared with pressure-volume loop analysis to assess their accuracy in detecting left ventricular (LV) diastolic dysfunction in patients with heart failure with normal ejection fraction (HFNEF). Methods and results: Diastolic dysfunction was confirmed by pressure-volume loop analysis obtained by conductance catheter in 43 patients (19 men) with HFNEF. Their Doppler indexes were compared with those of 12 control p... Abstract
Cited 37 times since 2007 (2.2 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 293, Issue 4, 20 3 2007, Pages H2438-47 Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction. Grauss RW, Winter EM, van Tuyn J, Pijnappels DA, Steijn RV, Hogers B, van der Geest RJ, de Vries AA, Steendijk P, van der Laarse A, Gittenberger-de Groot AC, Schalij MJ, Atsma DE
Mesenchymal stem cells (MSCs) from healthy donors improve cardiac function in experimental acute myocardial infarction (AMI) models. However, little is known about the therapeutic capacity of human MSCs (hMSCs) from patients with ischemic heart disease (IHD). Therefore, the behavior of hMSCs from IHD patients in an immune-compromised mouse AMI model was studied. Enhanced green fluorescent protein-labeled hMSCs from IHD patients (hMSC group: 2 x 10(5) cells in 20 microl, n = 12) or vehicle only (... Abstract
Cited 7 times since 2007 (0.4 per year) source: EuropePMC
Journal of cardiac failure, Volume 13, Issue 3, 1 1 2007, Pages 178-183 Clinical efficacy of surgical heart failure therapy by ventricular restoration and restrictive mitral annuloplasty. Tulner SA, Steendijk P, Klautz RJ, Tops L, Bax JJ, Versteegh MI, Verwey HF, Schalij MJ, van der Wall EE, Dion RA
Background: Treatment of heart failure by advanced surgical procedures such as ventricular restoration (SVR) and restrictive mitral annuloplasty (RMA) is increasingly applied. We studied clinical efficacy of heart failure surgery in patients with severe heart failure. Methods and results: Thirty-three patients (New York Heart Association (NYHA) class III/IV, left ventricular ejection fraction < or =35%) were included. Patients with moderate to severe mitral regurgitation underwent RMA (85%) a... Abstract
Cited 72 times since 2007 (4.2 per year) source: EuropePMC
Circulation, Volume 115, Issue 3, 8 2 2007, Pages 326-332 Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig. Timmers L, Sluijter JP, Verlaan CW, Steendijk P, Cramer MJ, Emons M, Strijder C, Gründeman PF, Sze SK, Hua L, Piek JJ, Borst C, Pasterkamp G, de Kleijn DP
Background: Cyclooxygenase (COX)-2 expression in the heart increases after myocardial infarction (MI). In murine models of MI, COX-2 inhibition preserves left ventricular dimensions and function. We studied the effect of selective COX-2 inhibition on left ventricular remodeling and function after MI in a pig model. Methods and results: Twenty-two pigs were assigned to COX-2 inhibition with a COX-2 inhibitor (COX-2i; celecoxib 400 mg twice daily; n=14) or a control group (n=8). MI was induced by... Abstract