Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
55 results
Cited 6 times since 2015 (0.7 per year) source: EuropePMC
Rheumatology (Oxford, England), Volume 55, Issue 3, 15 3 2015, Pages 504-512 Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis. Yiu KH, Ninaber MK, Kroft LJ, Schouffoer AA, Stolk J, Scherer HU, Meijs J, de Vries-Bouwstra J, Tse HF, Delgado V, Bax JJ, Huizinga TW, Marsan NA
Objectives: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function. Methods: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function. Results: A total of 51 (50%) SSc patients did not h... Abstract
Cited 9 times since 2015 (1 per year) source: EuropePMC
European journal of radiology, Volume 84, Issue 5, 22 4 2015, Pages 975-979 Lung structure and function relation in systemic sclerosis: application of lung densitometry. Ninaber MK, Stolk J, Smit J, Le Roy EJ, Kroft LJ, Bakker ME, de Vries Bouwstra JK, Schouffoer AA, Staring M, Stoel BC
Introduction: Interstitial lung disease occurs frequently in patients with systemic sclerosis (SSc). Quantitative computed tomography (CT) densitometry using the percentile density method may provide a sensitive assessment of lung structure for monitoring parenchymal damage. Therefore, we aimed to evaluate the optimal percentile density score in SSc by quantitative CT densitometry, against pulmonary function. Material and methods: We investigated 41 SSc patients by chest CT scan, spirometry and... Abstract
Cited 51 times since 2014 (5.4 per year) source: EuropePMC
European journal of heart failure, Volume 17, Issue 1, 27 4 2014, Pages 51-62 Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis. Joyce E, Ninaber MK, Katsanos S, Debonnaire P, Kamperidis V, Bax JJ, Taube C, Delgado V, Ajmone Marsan N
Aims: Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. Methods and results: A total of 130 patients with proven sarcoidosis undergoing echocardiography at our referral centre were identi... Abstract
Clinical and experimental rheumatology, Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7 Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J
Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi... Abstract
QJM : monthly journal of the Association of Physicians, Volume 108, Issue 1, 13 2 2014, Pages 33-38 The global peripheral chemoreflex drive in patients with systemic sclerosis: a rebreathing and exercise study. Ninaber MK, Hamersma WB, Schouffoer AA, van 't Wout EF, Stolk J
Background: Exercise intolerance (EI) in systemic sclerosis (SSc) is difficult to manage by the clinician. The peripheral chemoreflex drive compensates for metabolic acidosis during exercise and may be related to EI. Aim: To assess the global peripheral chemoreflex drive (GPCD) in patients with SSc at rest and during exercise. Methods: Consecutively tested SSc patients (n = 49) were evaluated by pulmonary function tests, carbon dioxide (CO2) rebreathing studies and non-invasive cardiopulmonary e... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
BMC pulmonary medicine, Volume 14, 4 1 2014, Pages 57 Increased respiratory drive relates to severity of dyspnea in systemic sclerosis. Ninaber MK, Hamersma WB, Schuerwegh AJ, Stolk J
Background: Dyspnea may be a presenting symptom in progressive systemic sclerosis (SSc). Respiratory drive (mouth occlusion pressure, MOP, at rest and during CO2 rebreathing, 7% CO2, 93% O2) is a major determinant of dyspnea and may relate to the magnitude of dyspnea. Methods: In a prospective design, MOP at 0.1 sec (P0.1) was measured in 73 SSc patients while breathing room air and during CO2 rebreathing. An abnormal V'E/P0.1 is defined as < 8 L/min/cm H2O. Dyspnea scores were assessed... Abstract
Cited 5 times since 2013 (0.5 per year) source: EuropePMC
Sleep & breathing = Schlaf & Atmung, Volume 18, Issue 1, 9 2 2013, Pages 103-109 Carotid body tumors are not associated with an increased risk for sleep-disordered breathing. van Hulsteijn LT, van Duinen N, Ninaber MK, Romijn JA, van Dijk JG, van Kralingen KW, Havekes B, Smid L, Lammers GJ, Jansen JC, Smit JW, Thijs RD, Corssmit EP
Purpose: Tumors in the carotid bodies may interfere with their function as peripheral chemoreceptors. An altered control of ventilation may predispose to sleep-disordered breathing. This study aimed to assess whether patients with unilateral or bilateral carotid body tumors (uCBT or bCBT, respectively) or bilateral CBT resection (bCBR) display sleep-disordered breathing and to evaluate the global contribution of the peripheral chemoreceptor to the hypercapnic ventilatory response. Methods: Eight... Abstract
Cited 2 times since 2013 (0.2 per year) source: EuropePMC
European heart journal, Volume 34, Issue 17, 7 1 2013, Pages 1278 The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis. Joyce E, Delgado V, Ninaber MK, Marsan NA
Cited 27 times since 2012 (2.3 per year) source: EuropePMC
Respiratory medicine, Volume 106, Issue 8, 11 2 2012, Pages 1170-1176 "Feelings are facts": illness perceptions in patients with lung cancer. Hoogerwerf MA, Ninaber MK, Willems LN, Kaptein AA
Given the high degree of psychosocial problems in patients with lung cancer, quality medical care would benefit from exploring and addressing and providing potential solutions for these problems. Patients with recently diagnosed non-small-cell lung cancer filled out a questionnaire that assessed illness perceptions and made a drawing of how they perceived their diseased lungs look. They also participated in an interview about the impact of lung cancer in their lives. Scores on the Brief Illness... Abstract
Cited 60 times since 2011 (4.8 per year) source: EuropePMC
Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ
Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract
Cited 30 times since 2011 (2.3 per year) source: EuropePMC
Arthritis care & research, Volume 63, Issue 6, 1 1 2011, Pages 909-917 Randomized comparison of a multidisciplinary team care program with usual care in patients with systemic sclerosis. Schouffoer AA, Ninaber MK, Beaart-van de Voorde LJ, van der Giesen FJ, de Jong Z, Stolk J, Voskuyl AE, Scherptong RW, van Laar JM, Schuerwegh AJ, Huizinga TW, Vlieland TP
Objective: To compare the effectiveness of a multidisciplinary team care program with usual outpatient care in patients with systemic sclerosis (SSc; scleroderma). Methods: We performed a randomized controlled trial comparing a 12-week multidisciplinary team care program (1 day per week; individual treatments, group exercises, and group education) with outpatient clinic care. Outcome measures included the Hand Mobility in Scleroderma (HAMIS) test, grip strength, maximal mouth opening (MMO), 6-mi... Abstract
Cited 1 times since 2009 (0.1 per year) source: EuropePMC
Respiratory care, Volume 54, Issue 3, 1 1 2009, Pages 393-397 Severe arterial hypoxemia in liver cirrhosis. Ninaber MK, de Vaal JB, Corsmit OT, Cluitmans FH, de Leeuw JG, Smit F
Cited 2 times since 2007 (0.1 per year) source: EuropePMC
Respiration; international review of thoracic diseases, Volume 76, Issue 2, 6 1 2007, Pages 187-192 A syringe simulation of biological controls for quality assessment of prospective lung volume measurements. Ninaber MK, Schot R, Fregonese L, Stolk J
Background: At present a syringe is being used for calibration of lung function devices, but biological controls are used to detect prospectively the variability and reproducibility of lung volumes measured by spirometers. Laboratory personnel is often used as biological control and therefore the cost for these measurements is substantial and may be reduced by replacement of a syringe procedure to increase the capacity of the laboratory to measure more patients. Objectives: To develop a mechanic... Abstract
Cited 42 times since 2005 (2.2 per year) source: EuropePMC
The Journal of pediatrics, Volume 147, Issue 2, 1 1 2005, Pages 239-243 A national prospective study on childhood celiac disease in the Netherlands 1993-2000: an increasing recognition and a changing clinical picture. Steens RF, Csizmadia CG, George EK, Ninaber MK, Hira Sing RA, Mearin ML
Objectives: To investigate prospectively whether the incidence of diagnosed celiac disease (CD) is increasing in the Netherlands and whether the clinical presentation is changing. Study design: All newly diagnosed cases of CD throughout the Netherlands were registered prospectively from 1993 to 2000. The clinical picture was compared with that noted in our former study (1975-1990). Results: The overall incidence rate of CD was 0.81/1000 live births, with a linear increase from 1993 to 2000. Ther... Abstract
Cited 120 times since 2005 (6.2 per year) source: EuropePMC
European journal of gastroenterology & hepatology, Volume 17, Issue 1, 1 1 2005, Pages 85-91 Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study. Collin P, Kaukinen K, Vogelsang H, Korponay-Szabó I, Sommer R, Schreier E, Volta U, Granito A, Veronesi L, Mascart F, Ocmant A, Ivarsson A, Lagerqvist C, Bürgin-Wolff A, Hadziselimovic F, Furlano RI, Sidler MA, Mulder CJ, Goerres MS, Mearin ML, Ninaber MK, Gudmand-Høyer E, Fabiani E, Catassi C, Tidlund H, Alainentalo L, Mäki M
Objective: To investigate the value of serum antitissue transglutaminase IgA antibodies (IgA-TTG) and IgA antiendomysial antibodies (IgA-EMA) in the diagnosis of coeliac disease in cohorts from different geographical areas in Europe. The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology. Methods: A total of 144 cases with coeliac disease [median age 19.5 years (range 0.9-81.4)], and 127 disease controls [median age 29.2 years (range... Abstract