Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
138 results
Journal of the American College of Cardiology, Volume 83, Issue 15, 25 4 2024, Pages 1403-1414 Effect of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Congenital Heart Disease. Neijenhuis RML, MacDonald ST, Zemrak F, Mertens BJA, Dinsdale A, Hunter A, Walker NL, Swan L, Reddy S, Rotmans JI, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD
Background: Heart failure (HF) is the principal cause of morbidity and mortality in adults with congenital heart disease (ACHD). Robust evidence-based treatment options are lacking. Objectives: This study aims to evaluate the safety, tolerability, and short-term HF-related effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in a real-world ACHD population. Methods: All patients with ACHD treated with SGLT2i in 4 European ACHD centers were included in this retrospective study. Data were... Abstract
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, Volume 34, Issue 1, 23 4 2024, Pages 45-77 The relevance of the superior cervical ganglion for cardiac autonomic innervation in health and disease: a systematic review. Chen HS, van Roon L, Ge Y, van Gils JM, Schoones JW, DeRuiter MC, Zeppenfeld K, Jongbloed MRM
Purpose: The heart receives cervical and thoracic sympathetic contributions. Although the stellate ganglion is considered the main contributor to cardiac sympathetic innervation, the superior cervical ganglia (SCG) is used in many experimental studies. The clinical relevance of the SCG to cardiac innervation is controversial. We investigated current morphological and functional evidence as well as controversies on the contribution of the SCG to cardiac innervation. Methods: A systematic literatu... Abstract
Journal of the American Heart Association, Volume 13, Issue 3, 31 5 2024, Pages e033122 Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria. Van den Eynde J, Westenberg JJM, Hazekamp MG, Lamb HJ, Jongbloed MRM, Wentzel JJ, Kenjeres S, Dekkers IA, Van De Bruaene A, Rijnberg FM, Roest AAW
Background: Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. Methods and results: A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular magnetic resonance assessment, including 4-dimensional flow imaging and computational fluid dynamics. Estimated glomerular filtration rate (eGFR) 3 mg/mmol... Abstract
Computer methods and programs in biomedicine, Volume 244, 17 3 2023, Pages 107984 Quantification of the intrinsic neural plexus of the heart - The missing link in histological tissue analysis. Chen HS, Voortman LM, van Munsteren JC, Wisse LJ, deRuiter MC, Zeppenfeld K, Jongbloed MRM
Background and objective: The heart is under strict regulation of the autonomic nervous system, during which, in a healthy state, the effects of sympathetic and parasympathetic branches are balanced. In recent years, there has been increasing interest in pathological remodeling and outgrowth of cardiac autonomic nerves in relation to arrhythmogenesis. However, the small size of the cardiac nerves in relatively large tissues renders research using histological quantification of these nerves extre... Abstract
Annals of medicine, Volume 55, Issue 2, 8 2 2023, Pages 2283195 Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis. Chen HS, van Roon L, Schoones J, Zeppenfeld K, DeRuiter MC, Jongbloed MRM
Background: Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with arrhythmogenesis and sudden cardiac death. The characteristics of cardiac sympathetic hyperinnervation remain underexposed. Objective: To provide a systematic review on cardiac sympathetic hyperinnervation after MI, taking into account: (1) definition, experimental model and quantification method and (2) location, amount and timing, in order to obtain an overview of current knowledge and to expos... Abstract
Circulation. Genomic and precision medicine, Volume 16, Issue 6, 11 2 2023, Pages e004184 New Genetic Variant in the <i>MYH7</i> Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family. Polyakova E, van Gils JM, Stöger JL, Kiès P, Egorova AD, Koopmann TT, van Dijk T, DeRuiter MC, Barge-Schaapveld DQCM, Jongbloed MRM
Cited 1 times since 2023 (1.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 109, Issue 20, 28 4 2023, Pages 1525-1532 Tolerability and beneficial effects of sacubitril/valsartan on systemic right ventricular failure. Nederend M, Kiès P, Regeer MV, Vliegen HW, Mertens BJ, Robbers-Visser D, Bouma BJ, Tops LF, Schalij MJ, Jongbloed MRM, Egorova AD
Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV. Methods: In this two-centre, prospective cohort study, all consecutive adult patients with symptomatic h... Abstract
Journal of clinical medicine, Volume 12, Issue 14, 20 3 2023, Pages 4798 Catheter-Based Techniques for Addressing Atrioventricular Valve Regurgitation in Adult Congenital Heart Disease Patients: A Descriptive Cohort. El Bouziani A, Witte LS, Bouma BJ, Jongbloed MRM, Robbers-Visser D, Straver B, Beijk MAM, Kiès P, Koolbergen DR, van der Kley F, Schalij MJ, de Winter RJ, Egorova AD
Introduction: Increasing survival of adult congenital heart disease (ACHD) patients comes at the price of a range of late complications-arrhythmias, heart failure, and valvular dysfunction. Transcatheter valve interventions have become a legitimate alternative to conventional surgical treatment in selected acquired heart disease patients. However, literature on technical aspects, hemodynamic effects, and clinical outcomes of percutaneous atrioventricular (AV) valve interventions in ACHD patients... Abstract
Cited 1 times since 2023 (1.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 9, Issue 8 Pt 3, 19 3 2023, Pages 1652-1664 Quantification of Large Transmural Biopsies Reveals Heterogeneity in Innervation Patterns in Chronic Myocardial Infarction. Chen HS, Voortman LM, van Munsteren JC, Wisse LJ, Tofig BJ, Kristiansen SB, Glashan CA, DeRuiter MC, Zeppenfeld K, Jongbloed MRM
Background: Abnormal cardiac innervation plays an important role in arrhythmogenicity after myocardial infarction (MI). Data regarding reperfusion models and innervation abnormalities in the medium to long term after MI are sparse. Histologic quantification of the small-sized cardiac nerves is challenging, and transmural analysis has not been performed. Objectives: This study sought to assess cardiac innervation patterns in transmural biopsy sections in a porcine reperfusion model of MI (MI-R) u... Abstract
Cited 1 times since 2023 (1.2 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 10, 26 4 2023, Pages 1093201 The potential of sodium-glucose cotransporter 2 inhibitors for the treatment of systemic right ventricular failure in adults with congenital heart disease. Neijenhuis RML, Nederend M, Jongbloed MRM, Kiès P, Rotmans JI, Vliegen HW, Jukema JW, Egorova AD
Aims: Given the compelling evidence on the effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the conventional heart failure population, SGLT2i deserve exploration in systemic right ventricular (sRV) failure. The initial experience with dapagliflozin in sRV failure patients is described, with a focus on tolerability and short-term effects on clinical outcomes. Methods and results: Ten patients (70% female, median age 50 years [46.5-52]) with symptomatic sRV failure who receiv... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 25, Issue 6, 1 1 2023, Pages euad139 The R″ wave in V1 and the negative terminal QRS vector in aVF combine to a novel 12-lead ECG algorithm to identify slow conducting anatomical isthmus 3 in patients with tetralogy of Fallot. Wallet J, Kimura Y, Blom NA, Man S, Jongbloed MRM, Zeppenfeld K
Aims: Patients with repaired tetralogy of Fallot (rTOF) have an increased risk of ventricular tachycardia (VT), with slow conducting anatomical isthmus (SCAI) 3 as dominant VT substrate. In patients with right bundle branch block (RBBB), SCAI 3 leads to local activation delay with a shift of terminal RV activation towards the lateral RV outflow tract which may be detected by terminal QRS vector changes on sinus rhythm electrocardiogram (ECG). Methods and results: Consecutive rTOF patients aged ≥... Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 5, 1 1 2023, Pages ezad029 Outcomes of the modified Yacoub aortocoronary flap technique for 'non-separable' single sinus coronary arteries with intramural course in the neonatal arterial switch operation. Van den Eynde J, van der Palen RLF, Knobbe I, Straver B, Stöger L, Ricciardi G, Konings TC, Jongbloed MRM, Hazekamp MG
Objectives: Coronary transfer remains the most crucial part of the arterial switch operation (ASO); yet, certain coronary anatomies prohibit the use of button or trap-door transfer techniques. In the rare setting of 'non-separable' single sinus coronary arteries with intramural course, the modified Yacoub aortocoronary flap technique is a viable option. The aim of this study is to describe this operative technique and review its early- and mid-term outcomes. Methods: This retrospective... Abstract
Journal of cardiovascular development and disease, Volume 10, Issue 4, 20 3 2023, Pages 180 Cardiac Fibrosis and Innervation State in Uncorrected and Corrected Transposition of the Great Arteries: A Postmortem Histological Analysis and Systematic Review. Engele LJ, van der Palen RLF, Egorova AD, Bartelings MM, Wisse LJ, Glashan CA, Kiès P, Vliegen HW, Hazekamp MG, Mulder BJM, Ruiter MC, Bouma BJ, Jongbloed MRM
In the transposition of the great arteries (TGA), alterations in hemodynamics and oxygen saturation could result in fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis and innervation state in the full spectrum of TGA and correlate findings to clinical literature. Twenty-two human postmortem TGA hearts, including TGA without surgical correction (n = 8), after Mustard/Senning (n = 6), and arterial switch operation (ASO, n = 8), were studied. In newborn uncor... Abstract
European heart journal. Case reports, Volume 7, Issue 4, 6 1 2023, Pages ytad176 Genetic variant in the <i>BRAF</i> gene compatible with Noonan spectrum disorders in an adult Fontan patient with refractory protein losing enteropathy: a follow-up report. Nederend M, Stoger JL, Egorova AD, Barge-Schaapveld DQCM, Jongbloed MRM
Background: Patients with a univentricular heart form a morphological heterogenous group of patients at the most severe end of the congenital heart disease (CHD) spectrum. Over the past decades, more awareness and knowledge has been raised on the genetic contributions to CHD. To date, only a limited number of genes have been identified in the hypoplastic heart, mainly in left-sided hypoplasia. There is still much more to be elucidated in this field. Case summary: Here, we present a follow-up rep... Abstract
Journal of cardiovascular development and disease, Volume 10, Issue 3, 17 3 2023, Pages 129 Contemporary Management Strategies of Baffle Leaks in Adults with a Failing Systemic Right Ventricle Late after Atrial Switch: A Case Series and Literature Overview. Neijenhuis RML, Regeer MV, van der Kley F, Vliegen HW, Jongbloed MRM, Kiès P, Schalij MJ, Jukema JW, Egorova AD
Baffle leaks are a frequently encountered and often overlooked complication after the atrial switch procedure for transposition of the great arteries. Baffle leaks are present in up to 50% of non-selected patients, and while they initially may not cause clear symptoms, they can complicate the hemodynamic course and influence the prognosis in this complex patient group. A shunt from the pulmonary venous atrium (PVA) to the systemic venous atrium (SVA) can lead to pulmonary overflow and subpulmona... Abstract
CJC pediatric and congenital heart disease, Volume 2, Issue 3, 8 2 2023, Pages 124-133 Anomalous Aortic Origin of the Right Coronary Artery: Invasive Haemodynamic Assessment in Adult Patients With High-Risk Anatomic Features. Verheijen DBH, Egorova AD, Jongbloed MRM, van der Kley F, Koolbergen DR, Hazekamp MG, Lamb HJ, Jukema JW, Kiès P, Vliegen HW
Background: Anomalous aortic origin of a right coronary artery (AAORCA) with an interarterial course merits further evaluation; however, robust risk assessment strategies for myocardial ischemia and sudden cardiac death are currently lacking. The aim of this study is to explore the potential role of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and intravascular ultrasound (IVUS) in patients with AAORCA. Methods: Consecutive adult patients with AAORCA with an interarterial... Abstract
Frontiers in cardiovascular medicine, Volume 9, 22 4 2022, Pages 1012147 A percutaneous treatment strategy of an adult patient with a bicuspid aortic valve, coarctation of the aorta, and an exceptionally large aneurysm of a collateral artery: Case report and literature overview. Verheijen DBH, Stöger JL, van der Kley F, Schalij MJ, Jongbloed MRM, Vliegen HW, Kiès P, Egorova AD
Coarctation of the aorta (CoA) is a congenital heart defect that is associated with a bicuspid aortic valve (BAV), ascending aorta dilatation, intracerebral aneurysms, and premature atherosclerotic disease. The first presentation during late adulthood is rare and is frequently driven by late sequelae. Hypertrophic collateral arteries can develop aneurysms which are at risk for spontaneous rupture, however, treatment recommendations for these aneurysms are scarce. Here, we describe the clinical c... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 1, 1 1 2022, Pages ezac522 Haemodynamic performance of 16-20-mm extracardiac Goretex conduits in adolescent Fontan patients at rest and during simulated exercise. Rijnberg FM, van 't Hul LC, Hazekamp MG, van den Boogaard PJ, Juffermans JF, Lamb HJ, Terol Espinosa de Los Monteros C, Kroft LJM, Kenjeres S, le Cessie S, Jongbloed MRM, Westenberg JJM, Roest AAW, Wentzel JJ
Objectives: To date, it is not known if 16-20-mm extracardiac conduits are outgrown during somatic growth from childhood to adolescence. This study aims to determine total cavopulmonary connection (TCPC) haemodynamics in adolescent Fontan patients at rest and during simulated exercise and to assess the relationship between conduit size and haemodynamics. Methods: Patient-specific, magnetic resonance imaging-based computational fluid dynamic models of the TCPC were performed in 51 extracardiac Fo... Abstract
European heart journal. Case reports, Volume 6, Issue 11, 28 4 2022, Pages ytac432 Anomalous connection of the circumflex coronary artery to the pulmonary trunk in a patient with Taussig-Bing anomaly: a case report. Van den Eynde J, Rammeloo LAJ, Jongbloed MRM, Hazekamp MG, van der Palen RLF
Background: Coronary anomalies are present in one-third of all patients with transposition of the great arteries (TGA) and have been associated with increased risk of adverse outcomes after the arterial switch operation. Therefore, knowledge about coronary anatomy remains key. Case summary: A 5-day-old girl with prenatal diagnosis of Taussig-Bing anomaly (double outlet right ventricle with TGA and large subpulmonary ventricular septal defect) along with aortic arch hypoplasia and coarctation of... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Acta paediatrica (Oslo, Norway : 1992), Volume 112, Issue 2, 17 3 2022, Pages 186-199 Somatic growth in single ventricle patients: A systematic review and meta-analysis. Van den Eynde J, Bartelse S, Rijnberg FM, Kutty S, Jongbloed MRM, de Bruin C, Hazekamp MG, Le Cessie S, Roest AAW
Aim: To map somatic growth patterns throughout Fontan palliation and summarise evidence on its key modifiers. Methods: Databases were searched for relevant articles published from January 2000 to December 2021. Height and weight z scores at each time point (birth, Glenn procedure, Fontan procedure and >5 years after Fontan completion) were pooled using a random effects meta-analysis. A random effects meta-regression model was fitted to model the trend in z scores over time. Results: Nineteen... Abstract