Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
248 results
Cited 24 times since 2018 (4.1 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 38, Issue 8, 1 1 2018, Pages 1796-1805 Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm. Adam M, Kooreman NG, Jagger A, Wagenhäuser MU, Mehrkens D, Wang Y, Kayama Y, Toyama K, Raaz U, Schellinger IN, Maegdefessel L, Spin JM, Hamming JF, Quax PHA, Baldus S, Wu JC, Tsao PS
Objective- Recruitment of immunologic competent cells to the vessel wall is a crucial step in formation of abdominal aortic aneurysms (AAA). Innate immunity effectors (eg, macrophages), as well as mediators of adaptive immunity (eg, T cells), orchestrate a local vascular inflammatory response. IL-10 (interleukin-10) is an immune-regulatory cytokine with a crucial role in suppression of inflammatory processes. We hypothesized that an increase in systemic IL-10-levels would mitigate AAA progressio... Abstract
Cited 11 times since 2018 (1.9 per year) source: EuropePMC
BMJ quality & safety, Volume 28, Issue 3, 21 3 2018, Pages 180-189 Connecting perspectives on quality and safety: patient-level linkage of incident, adverse event and complaint data. de Vos MS, Hamming JF, Chua-Hendriks JJC, Marang-van de Mheen PJ
Background and objective: Incident, adverse event (AE) and complaint data are typically used separately, but may be related at the patient level with one event triggering a cascade of events, ultimately resulting in a complaint. This study examined relations between incidents, AEs and complaints that co-occurred in admissions. Methods: Independently and routinely collected incident, AE and complaint data were retrospectively linked for surgical admissions in an academic centre (2008-2014). Two i... Abstract
Cited 6 times since 2018 (1 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 121, 4 1 2018, Pages 16-24 The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease. Simons KH, de Vries MR, Peters HAB, Hamming JF, Jukema JW, Quax PHA
Background: Venous grafts are commonly used as conduits to bypass occluded arteries. Unfortunately, patency rates are limited by vein graft disease (VGD). Toll like receptors (TLRs) can be activated in vein grafts by endogenous ligands. This study aims to investigate the role of TLR3 in VGD. Methods: Vein graft surgery was performed by donor caval vein interpositioning in the carotid artery of recipient Tlr2-/-, Tlr3-/-, Tlr4-/- and control mice. Vein grafts were harvested 7, 14 and 28d after su... Abstract
Cited 11 times since 2018 (1.8 per year) source: EuropePMC
International journal of cardiology, Volume 260, 1 1 2018, Pages 184-190 The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis. Simons KH, Aref Z, Peters HAB, Welten SP, Nossent AY, Jukema JW, Hamming JF, Arens R, de Vries MR, Quax PHA
Background: T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has yet to be established. The aim of this study was to investigate the role T cell co-stimulation and inhibition in angiogenesis, arteriogenesis and vasculogenesis. Methods and results: Hind limb ischemia was induced by do... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
The American journal of pathology, Volume 188, Issue 7, 22 4 2018, Pages 1524-1529 Leukocyte Dynamics during the Evolution of Human Coronary Atherosclerosis: Conclusions from a Sevenfold, Chromogen-Based, Immunohistochemical Evaluation. Zuiderwijk M, Geerts M, van Rhijn CJ, van den Bogaerdt A, Hamming JF, van Dijk RA, Lindeman JH
Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward sevenfold staining protocol for simultaneous assessment of dominant leukocyte classes, vascularization, and expression of the putative foam cell maker CD36. The method was applied on human coronaries covering the full spectrum of atherosclerotic disease. Results confirm the progressive association of macrophages and T cells with the process and a global presence of mast cells. B cells are excl... Abstract
Cited 6 times since 2018 (1 per year) source: EuropePMC
Cytokine, Volume 108, 26 4 2018, Pages 96-104 CXCL8 hyper-signaling in the aortic abdominal aneurysm. Kokje VBC, Gäbel G, Dalman RL, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an evaluation of a role for CXCL8 in AAA progression relevant. ELISA's, real time PCR and array analysis were used to explore CXCL8 signaling in AAA wall samples. A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
Transplant international : official journal of the European Society for Organ Transplantation, Volume 31, Issue 6, 5 1 2018, Pages 610-619 The center effect in liver transplantation in the Eurotransplant region: a retrospective database analysis. Blok JJ, de Boer JD, Putter H, Rogiers X, Guba MO, Strassburg CP, Samuel U, van Hoek B, Hamming JF, Braat AE, Eurotransplant Liver Intestine Advisory Committee
Apart from donor and recipient risk factors, the effect of center-related factors has significant impact on graft survival after liver transplantation (LT). To investigate this effect in Eurotransplant, a retrospective database analysis was performed, including all LT's in adult recipients (≥18 years) in the Eurotransplant region from 1.1.2007 until 31.12.2013. Additionally, a survey was sent out to all transplant centers requesting information on surgeons' experience and exposure. In... Abstract
Journal of vascular surgery, Volume 67, Issue 3, 1 1 2018, Pages 993 Reply. Tomee SM, Hamming JF, Lindeman JH
Cited 70 times since 2018 (11.2 per year) source: EuropePMC
Cell stem cell, Volume 22, Issue 4, 15 3 2018, Pages 501-513.e7 Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo. Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesot... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
PloS one, Volume 13, Issue 2, 8 2 2018, Pages e0189372 Randomized trial of one-hour sodium bicarbonate vs standard periprocedural saline hydration in chronic kidney disease patients undergoing cardiovascular contrast procedures. Kooiman J, de Vries JPM, Van der Heyden J, Sijpkens YWJ, van Dijkman PRM, Wever JJ, van Overhagen H, Vahl AC, Aarts N, Verberk-Jonkers IJAM, Brulez HFH, Hamming JF, van der Molen AJ, Cannegieter SC, Putter H, van den Hout WB, Kilicsoy I, Rabelink TJ, Huisman MV
Background: Guidelines advise periprocedural saline hydration for prevention of contrast induced-acute kidney injury (CI-AKI). We analysed whether 1-hour sodium bicarbonate hydration administered solely prior to intra-arterial contrast exposure is non-inferior to standard periprocedural saline hydration in chronic kidney disease (CKD) patients undergoing elective cardiovascular diagnostic or interventional contrast procedures. Methods: We performed an open-label multicentre non-inferiority trial... Abstract
Cited 4 times since 2018 (0.6 per year) source: EuropePMC
Patient preference and adherence, Volume 12, 15 3 2018, Pages 119-128 Patients' perceptions of conservative treatment for a small abdominal aortic aneurysm. Tomee SM, Gebhardt WA, de Vries JP, Hamelinck VC, Hamming JF, Lindeman JH
Background: An abdominal aortic aneurysm (AAA) is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men). In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter a period of conservative surveillance. An important question is how patients perceive and cope with ri... Abstract
Cited 16 times since 2018 (2.5 per year) source: EuropePMC
BMJ quality & safety, Volume 27, Issue 9, 3 1 2018, Pages 758-762 The problem with using patient complaints for improvement. de Vos MS, Hamming JF, Marang-van de Mheen PJ
'The Problem with…' series covers controversial topics related to efforts to improve healthcare quality, including widely recommended, but deceptively difficult strategies for improvement and pervasive problems that seem to resist solution. Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
The journal of vascular access, Volume 19, Issue 1, 1 1 2018, Pages 84-88 Supervised preoperative forearm exercise to increase blood vessel diameter in patients requiring an arteriovenous access for hemodialysis: rationale and design of the PINCH trial. Wilschut ED, Rotmans JI, Bos EJ, van Zoest D, Eefting D, Hamming JF, van der Bogt KEA
Background: Failure of maturation occurs in 30%-60% of arteriovenous fistula (AVF) creation for hemodialysis, with highest rates in distal radiocephalic fistulas. This is partly due to initial small blood vessel size with limited blood flow capacity. Forearm exercise has shown potential as stimulus for increasing blood vessel size in patients with end-stage renal disease (ESRD) and may promote maturation of AVFs in the upper limb when applied postoperatively. However, it is unknown if forearm ex... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
BMJ open, Volume 7, Issue 11, 12 2 2017, Pages e018833 Barriers and facilitators to learn and improve through morbidity and mortality conferences: a qualitative study. de Vos MS, Hamming JF, Marang-van de Mheen PJ
Objectives: To explore barriers and facilitators to successful morbidity and mortality conferences (M&M), driving learning and improvement. Design: This is a qualitative study with semistructured interviews. Inductive, thematic content analysis was used to identify barriers and facilitators, which were structured across a pre-existing framework for change in healthcare. Setting: Dutch academic surgical department with a long tradition of M&M. Participants: An interview sample of surgeons... Abstract
Cited 27 times since 2017 (4.1 per year) source: EuropePMC
Annals of surgery, Volume 266, Issue 5, 1 1 2017, Pages 898-904 Textbook Outcome: A Composite Measure for Quality of Elective Aneurysm Surgery. Karthaus EG, Lijftogt N, Busweiler LAD, Elsman BHP, Wouters MWJM, Vahl AC, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit, the Dutch Institute for Clinical Auditing
Objective: To investigate a new composite quality measurement, which comprises a desirable outcome for elective aneurysm surgery, called "Textbook Outcome" (TO). Background: Single-quality indicators in vascular surgery are often not distinctive and insufficiently reflect the quality of care. Methods: All patients undergoing elective abdominal aortic aneurysm repair, registered in the Dutch Surgical Aneurysm Audit between 2014 and 2015 were included. TO was defined as the percentage of... Abstract
Cited 11 times since 2017 (1.7 per year) source: EuropePMC
Journal of vascular surgery, Volume 67, Issue 3, 28 4 2017, Pages 735-739 A registry-based rationale for discrete intervention thresholds for open and endovascular elective abdominal aortic aneurysm repair in female patients. Tomee SM, Lijftogt N, Vahl A, Hamming JF, Lindeman JHN
Objective: An evidence-based consensus for a female-specific intervention threshold for abdominal aortic aneurysms (AAAs) is missing. This study aims to analyze sex-related differences in the epidemiology of ruptured AAA to establish an intervention threshold for women. Methods: The Dutch Surgical Aneurysm Audit (DSAA) is a compulsory, nation-wide registry of AAA repairs in The Netherlands. All patients with emergency or elective AAA repair between January 1, 2013, and December 31, 2015, were in... Abstract
Cited 19 times since 2017 (2.8 per year) source: EuropePMC
Journal of vascular surgery, Volume 67, Issue 6, 11 2 2017, Pages 1891-1900.e4 Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm. Doderer SA, Gäbel G, Kokje VBC, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Objective: The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies effectively quench aneurysm progression in preclinical models, so far all clinical interventions failed. These observations hint at an incomplete understanding of the processes involved in AAA progression and rupture. Interestingly, strong clinical and molecular associations exist between popliteal artery aneurysms (PAAs) and AAAs; howe... Abstract
Cited 25 times since 2017 (3.7 per year) source: EuropePMC
Cell reports, Volume 20, Issue 8, 1 1 2017, Pages 1978-1990 Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with human hematopoietic and immune cells could prove to be useful. In this study, an in-depth analysis of graft-infiltrating human lymphocytes and splenocy... Abstract
Cited 9 times since 2017 (1.3 per year) source: EuropePMC
Journal of surgical education, Volume 75, Issue 1, 15 3 2017, Pages 33-42 Toward Best Practices for Surgical Morbidity and Mortality Conferences: A Mixed Methods Study. de Vos MS, Marang-van de Mheen PJ, Smith AD, Mou D, Whang EE, Hamming JF
Objective: To assess formats for surgical morbidity and mortality conferences (M&M) for strengths and challenges. Design: A mixed methods approach with local observations to assess key domains of M&M practice (i.e., goals, structure, and process/content) and surveys to assess participants' expectations and experiences. Setting: Surgical departments of two teaching hospitals (Boston, USA and Leiden, Netherlands). Participants: Participants of surgical M&M, including attending sur... Abstract
Cited 5 times since 2017 (0.7 per year) source: EuropePMC
The British journal of surgery, Volume 104, Issue 8, 1 1 2017, Pages 964-976 Systematic review of mortality risk prediction models in the era of endovascular abdominal aortic aneurysm surgery. Lijftogt N, Luijnenburg TWF, Vahl AC, Wilschut ED, Leijdekkers VJ, Fiocco MF, Wouters MWJM, Hamming JF
Background: The introduction of endovascular aneurysm repair (EVAR) has reduced perioperative mortality after abdominal aortic aneurysm (AAA) surgery. The objective of this systematic review was to assess existing mortality risk prediction models, and identify which are most useful for patients undergoing AAA repair by either EVAR or open surgical repair. Methods: A systematic search of the literature was conducted for perioperative mortality risk prediction models for patients with AAA publishe... Abstract