Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
36 results
Cited 8 times since 2021 (3 per year) source: EuropePMC
Open heart, Volume 8, Issue 2, 1 1 2021, Pages e001772 Comparative evaluation of coronary disease burden: bicuspid valve disease is not atheroprotective. Dolmaci OB, Driessen AHG, Klautz RJM, Poelmann R, Lindeman JHN, Grewal N
Objective: Bicuspid aortic valve (BAV) has been associated with less atherosclerosis as compared with tricuspid aortic valve (TAV) patients. It, however, remains unclear whether this reflects the older age of TAV patients and/or accumulation of atherosclerotic risk factors or that the BAV phenotype is atheroprotective. Therefore, we compared the atherosclerotic disease burden of BAV and TAV patients, with that of the general (age-matched) population. Methods: The prevalence of coronary artery di... Abstract
Cited 10 times since 2021 (3.4 per year) source: EuropePMC
Journal of the American Heart Association, Volume 10, Issue 12, 2 1 2021, Pages e020080 Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves. Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A... Abstract
Cited 12 times since 2021 (3.7 per year) source: EuropePMC
Journal of cardiovascular development and disease, Volume 8, Issue 2, 27 4 2021, Pages 12 A Systematic Histopathologic Evaluation of Type-A Aortic Dissections Implies a Uniform Multiple-Hit Causation. Grewal N, Velders BJJ, Gittenberger-de Groot AC, Poelmann R, Klautz RJM, Van Brakel TJ, Lindeman JHN
(1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall specimens (n = 58, mean age 63 years) with TAAD were collected. Autopsy tissues (n = 17, mean age 63 years) served as controls. All sections were studied histopathologically. (3) Results: Pathomorphology in TAAD showed predominantly moderate elastic f... Abstract
Cited 12 times since 2020 (2.9 per year) source: EuropePMC
Journal of clinical medicine, Volume 9, Issue 4, 26 4 2020, Pages E908 The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration. Grewal N, Gittenberger-de Groot AC, Thusen JV, Wisse LJ, Bartelings MM, DeRuiter MC, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic-70 years) and 32 BAV specimens (fetal-72 years, categorized in eigh... Abstract
Cited 7 times since 2020 (1.7 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 162, Issue 6, 12 2 2020, Pages 1684-1695 Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation. Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E
Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo... Abstract
Cited 14 times since 2019 (2.7 per year) source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Volume 41, 1 1 2019, Pages 29-37 The role of hemodynamics in bicuspid aortopathy: a histopathologic study. Grewal N, Girdauskas E, DeRuiter M, Goumans MJ, Poelmann RE, Klautz RJM, Gittenberger-de Groot AC
Background: A bicuspid aortic valve (BAV) is the most common congenital cardiac malformation and is associated with ascending aortic dilation in 60%-80% of patients. In this study, we aimed to address the role of hemodynamic influences on the development of aortopathy in BAV patients. Patient and methods: BAV (n=36) and tricuspid aortic valve (TAV) patients (n=17) undergoing aortic valve replacement underwent preoperative flow magnetic resonance imaging (MRI) assessment to detect the area of max... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
Frontiers in physiology, Volume 10, 19 3 2019, Pages 225 Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy? Grewal N, Gittenberger-de Groot AC
Atherosclerosis, Volume 278, 31 5 2018, Pages 317-318 The senescence of vascular smooth muscle cells in BAV-associated aortopathy. Mohamed SA, Grewal N, Gittenberger-de Groot AC
, 23 4 2018 Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing? Gittenberger-de Groot AC, Bokenkamp R, Raz V, van Munsteren C, Poelmann RE, Grewal N, DeRuiter MC
The ductus arteriosus (DA) is a fetal vessel bypassing the still nonfunctional lungs. Closure of the DA at birth is essential for the transition from a fetal to a neonatal circulation. This closing process begins with a physiological contraction followed by definitive anatomical closure. The latter process starts already before birth by development of intimal thickening followed after birth by degeneration of the inner media, including cytolytic necrosis and apoptosis. The DA will remain patent... Abstract
Cited 27 times since 2018 (4.3 per year) source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Volume 33, 2 1 2018, Pages 62-69 Pathogenesis of aortic wall complications in Marfan syndrome. Grewal N, Gittenberger-de Groot AC
Background: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as distinct pathways of clinical relevance, we compared the histopathological substrates of aortic pathology. Patient and methods: Ascending aortic wall specimen were divided in five groups: BAV (n=36) and TAV (n=23) without and with dilation and non-d... Abstract
Cited 13 times since 2016 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 127-133 The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation. Koenraadt WM, Grewal N, Gaidoukevitch OY, DeRuiter MC, Gittenberger-de Groot AC, Bartelings MM, Holman ER, Klautz RJ, Schalij MJ, Jongbloed MR
Background: The clinical course of bicuspid aortic valves (BAVs) is variable. Data on predictors of aortopathy and valvular dysfunction mainly focus on valve morphology. Aim: To determine whether the presence and extent of the raphe (fusion site of valve leaflets) is associated with the degree of aortopathy and valvular dysfunction in patients with isolated BAV and associated aortic coarctation (CoA). Methods: Valve morphology and aortic dimensions of 255 BAV patients were evaluated retrospectiv... Abstract
Cited 24 times since 2015 (2.7 per year) source: EuropePMC
Heart and vessels, Volume 31, Issue 5, 1 1 2015, Pages 795-806 Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? Grewal N, Franken R, Mulder BJ, Goumans MJ, Lindeman JH, Jongbloed MR, DeRuiter MC, Klautz RJ, Bogers AJ, Poelmann RE, Groot AC
Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic featu... Abstract
The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 5, 4 1 2014, Pages 2440-2442 Reply to the editor. Grewal N, Gittenberger-de Groot AC, DeRuiter MC
Cited 19 times since 2014 (2 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 9, 1 1 2014, Pages 363-369 Normal and abnormal development of the aortic wall and valve: correlation with clinical entities. Grewal N, DeRuiter MC, Jongbloed MR, Goumans MJ, Klautz RJ, Poelmann RE, Gittenberger-de Groot AC
Dilation of the wall of the thoracic aorta can be found in patients with a tricuspid (TAV) as well as a bicuspid aortic valve (BAV) with and without a syndromic component. BAV is the most common congenital cardiovascular malformation, with a population prevalence of 0.5-2 %. The clinical course is often characterised by aneurysm formation and in some cases dissection. The non-dilated aortic wall is less well differentiated in all BAV as compared with TAV, thereby conferring inherent developmenta... Abstract
Cited 19 times since 2014 (2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 5, 26 4 2014, Pages 831-839 Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. Grewal N, Gittenberger-de Groot AC, DeRuiter MC, Klautz RJ, Poelmann RE, Duim S, Lindeman JH, Koenraadt WM, Jongbloed MR, Mohamed SA, Sievers HH, Bogers AJ, Goumans MJ
Objectives: The clinical course of many patients with a bicuspid aortic valve (BAV) is complicated by ascending aortic dilatation. Currently, the indication for aortic surgery is solely based on the aortic diameter and subsequently only a small proportion of BAV patients undergoing valve surgery require concomitant ascending aortic replacement based on these recommendations. Unfortunately, a substantial number of BAV patients still develop aortic dilatation in the future and would potentially be... Abstract
Cited 46 times since 2014 (4.5 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 25 4 2014, Pages 1583-1590 Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, Gittenberger-de Groot AC, Poelmann RE, Klautz RJ, Lindeman JH, Goumans MJ, Palmen M, Mohamed SA, Sievers HH, Bogers AJ, DeRuiter MC
Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made. Methods: Ascending aortic wall biopsies were divided into 4 groups: bicuspid (n=36) and tricuspid (n=23) without and with dilation. The expression of vascular smo... Abstract