Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
174 results
Cited 25 times since 2019 (5.3 per year) source: EuropePMC
Molecular nutrition & food research, Volume 64, Issue 15, 16 3 2019, Pages e1900732 Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice. Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, Smits HH, Bouter KE, Rensen PCN, Quax PHA, Nieuwdorp M, Netea MG, de Vos WM, Cani PD, Belzer C, van Dijk KW, Berbée JFP, van Harmelen V
Scope: Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti-inflammatory properties both in the intestine and other organs. The aim is to investigate the effects of oral administration of A. muciniphila on lipid metabolism, immunity, and cuff-induced neointima formation in hyperlipidemic APOE*3-Leiden (E3L).CETP mice. Methods and results: Hyperlipidemic male E3L.CETP mice are daily treated with 2 × 108 CFU A. muciniphila by oral gavage for 4 weeks and the effects are det... Abstract
Cited 14 times since 2019 (2.9 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 6, 8 2 2019, Pages 113 miRMap: Profiling 14q32 microRNA Expression and DNA Methylation Throughout the Human Vasculature. Goossens EAC, de Vries MR, Simons KH, Putter H, Quax PHA, Nossent AY
Aims: MicroRNAs are regulators of (patho)physiological functions with tissue-specific expression patterns. However, little is known about inter-vascular differences in microRNA expression between blood vessel types or vascular beds. Differences in microRNA expression could influence cardiovascular pathophysiology at specific sites in the vasculature. Therefore, we aimed to map expression profiles of vasoactive 14q32 microRNAs throughout the human vasculature, as well as expression of vasoactive... Abstract
Cited 17 times since 2019 (3.5 per year) source: EuropePMC
Cardiovascular research, Volume 115, Issue 10, 1 1 2019, Pages 1519-1532 Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in human cardiovascular disease. Håkansson KEJ, Goossens EAC, Trompet S, van Ingen E, de Vries MR, van der Kwast RVCT, Ripa RS, Kastrup J, Hohensinner PJ, Kaun C, Wojta J, Böhringer S, Le Cessie S, Jukema JW, Quax PHA, Nossent AY
Aims: We have shown that 14q32 microRNAs are highly involved in vascular remodelling and cardiovascular disease. However, the 14q32 locus also encodes 41 'orphan' small nucleolar RNAs (snoRNAs). We aimed to gather evidence for an independent role for 14q32 snoRNAs in human cardiovascular disease. Methods and results: We performed a lookup of the 14q32 region within the dataset of a genome wide association scan in 5244 participants of the PROspective Study of Pravastatin in the Elderly... Abstract
Cited 33 times since 2019 (6.9 per year) source: EuropePMC
International journal of molecular sciences, Volume 20, Issue 15, 29 5 2019, Pages E3704 Variations in Surgical Procedures for Inducing Hind Limb Ischemia in Mice and the Impact of These Variations on Neovascularization Assessment. Aref Z, de Vries MR, Quax PHA
Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial disease and critical limb ischemia. This model is used to investigate the mechanisms of neovascularization and to develop new therapeutic agents. The literature shows many variations in the model, including the method of occlusion, the number of occlusions, and the position at which the occlusions are made to induce hind limb ischemia. Furthermore, predefined end points and the histopathological and radiol... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 6, 13 2 2019, Pages 77 CD8+ T Cells Protect During Vein Graft Disease Development. Simons KH, de Vries MR, Peters HAB, Jukema JW, Quax PHA, Arens R
Aims: Vein grafts are frequently used conduits for arterial reconstruction in patients with cardiovascular disease. Unfortunately, vein graft disease (VGD) causes diminished patency rates. Innate immune system components are known to contribute to VGD. However, the role of T cells has yet to be established. The purpose of this study was to investigate the role of T cells and T cell activation pathways via the T cell receptor (TCR), co-stimulation and bystander effect in VGD. Methods and results:... Abstract
Cited 46 times since 2019 (9.3 per year) source: EuropePMC
Nature reviews. Cardiology, Volume 16, Issue 6, 1 1 2019, Pages 325-343 T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword. Simons KH, de Jong A, Jukema JW, de Vries MR, Arens R, Quax PHA
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Immune checkpoint inhibitors (ICIs) targeting T cell inhibition pathways have revolutionized cancer treatment and improved survival in patients with cancer. However, ICIs might induce cardiovascular toxicity via... Abstract
Cited 13 times since 2019 (2.5 per year) source: EuropePMC
Cells, Volume 8, Issue 4, 9 2 2019, Pages E334 Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis. Kritikou E, Depuydt MAC, de Vries MR, Mulder KE, Govaert AM, Smit MD, van Duijn J, Foks AC, Wezel A, Smeets HJ, Slütter B, Quax PHA, Kuiper J, Bot I
The presence of mast cells in human atherosclerotic plaques has been associated with adverse cardiovascular events. Mast cell activation, through the classical antigen sensitized-IgE binding to their characteristic Fcε-receptor, causes the release of their cytoplasmic granules. These granules are filled with neutral proteases such as tryptase, but also with histamine and pro-inflammatory mediators. Mast cells accumulate in high numbers within human atherosclerotic tissue, particularly in the sho... Abstract
Cited 12 times since 2019 (2.3 per year) source: EuropePMC
Journal of cellular and molecular medicine, Volume 23, Issue 6, 1 1 2019, Pages 3888-3896 IRF3 and IRF7 mediate neovascularization via inflammatory cytokines. Simons KH, de Vries MR, de Jong RCM, Peters HAB, Jukema JW, Quax PHA
Objective: To elucidate the role of interferon regulatory factor (IRF)3 and IRF7 in neovascularization. Methods: Unilateral hind limb ischaemia was induced in Irf3-/- , Irf7-/- and C57BL/6 mice by ligation of the left common femoral artery. Post-ischaemic blood flow recovery in the paw was measured with laser Doppler perfusion imaging. Soleus, adductor and gastrocnemius muscles were harvested to investigate angiogenesis and arteriogenesis and inflammation. Results: Post-ischaemic blood flow reco... Abstract
Cited 3 times since 2019 (0.6 per year) source: EuropePMC
Journal of orthopaedic trauma, Volume 33, Issue 4, 1 1 2019, Pages e124-e130 Ultrasound-Guided Nerve Blocks as Analgesia for Nonoperative Management of Distal Radius Fractures-Two Consecutive Randomized Controlled Trials. Siebelt M, Hartholt KA, van Winden DFM, Boot F, Papathanasiou D, Verdouw BC, de Vries MR, Mathijssen NM, Kraan GA
Objectives: To investigate whether a conventional fracture hematoma block (FHB) or an ultrasound-guided peripheral nerve block has more superior analgesic effect during nonoperative management of distal radius fractures in an emergency department setting. Two peripheral nerve block types were investigated, one at the level of the elbow, or cubital nerve block (CNB), and another an axillary nerve block (ANB). Design: Two prospective randomized controlled studies were performed to compare the diff... Abstract
Cited 80 times since 2019 (15 per year) source: EuropePMC
The Journal of pathology, Volume 247, Issue 3, 16 3 2019, Pages 333-346 Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2. Sánchez-Duffhues G, García de Vinuesa A, van de Pol V, Geerts ME, de Vries MR, Janson SG, van Dam H, Lindeman JH, Goumans MJ, Ten Dijke P
Endothelial-to-mesenchymal transition (EndMT) has been unveiled as a common cause for a multitude of human pathologies, including cancer and cardiovascular disease. Vascular calcification is a risk factor for ischemic vascular disorders and slowing calcification may reduce mortality in affected patients. The absence of early biomarkers hampers the identification of patients at risk. EndMT and vascular calcification are induced upon cooperation between distinct stimuli, including inflammatory cyt... Abstract
Cited 31 times since 2018 (5.4 per year) source: EuropePMC
Journal of internal medicine, Volume 285, Issue 1, 7 1 2018, Pages 59-74 Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels. de Vries MR, Parma L, Peters HAB, Schepers A, Hamming JF, Jukema JW, Goumans MJTH, Guo L, Finn AV, Virmani R, Ozaki CK, Quax PHA
Background: Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a natural occurring process to fulfil the increasing demand of oxygen and nourishment of the vessel wall. However, inadequate formed, immature plaque neovessels are leaky and cause intraplaque haemorrhage. Objective: Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resu... Abstract
Cited 10 times since 2018 (1.7 per year) source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 8 2 2018, Pages fj201800437R Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas. Bezhaeva T, de Vries MR, Geelhoed WJ, van der Veer EP, Versteeg S, van Alem CMA, Voorzaat BM, Eijkelkamp N, van der Bogt KE, Agoulnik AI, van Zonneveld AJ, Quax PHA, Rotmans JI
The pathophysiology of arteriovenous fistula (AVF) maturation failure is not completely understood but impaired outward remodeling (OR) and intimal hyperplasia are thought to be contributors. This adverse vascular response after AVF surgery results from interplay between vascular smooth muscle cells (VSMCs), the extracellular matrix (ECM), and inflammatory cells. Relaxin (RLN) is a hormone that acts on the vasculature via interaction with RLN/insulin-like peptide family receptor 1 (RXFP1), resul... Abstract
Cited 6 times since 2018 (1 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 121, 4 1 2018, Pages 16-24 The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease. Simons KH, de Vries MR, Peters HAB, Hamming JF, Jukema JW, Quax PHA
Background: Venous grafts are commonly used as conduits to bypass occluded arteries. Unfortunately, patency rates are limited by vein graft disease (VGD). Toll like receptors (TLRs) can be activated in vein grafts by endogenous ligands. This study aims to investigate the role of TLR3 in VGD. Methods: Vein graft surgery was performed by donor caval vein interpositioning in the carotid artery of recipient Tlr2-/-, Tlr3-/-, Tlr4-/- and control mice. Vein grafts were harvested 7, 14 and 28d after su... Abstract
Cited 11 times since 2018 (1.8 per year) source: EuropePMC
International journal of cardiology, Volume 260, 1 1 2018, Pages 184-190 The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis. Simons KH, Aref Z, Peters HAB, Welten SP, Nossent AY, Jukema JW, Hamming JF, Arens R, de Vries MR, Quax PHA
Background: T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has yet to be established. The aim of this study was to investigate the role T cell co-stimulation and inhibition in angiogenesis, arteriogenesis and vasculogenesis. Methods and results: Hind limb ischemia was induced by do... Abstract
Cited 25 times since 2018 (4.1 per year) source: EuropePMC
Scientific reports, Volume 8, Issue 1, 30 5 2018, Pages 6753 Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response. de Jong RCM, Pluijmert NJ, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV) function and remodeling three weeks after myocardial ischemia-reperfusion (MI-R) injury in hypercholesterolemic ApoE*3-Leiden mice. Using a mouse model for MI-R injury, we demonstrate AnxA5 treatment resulted in a 27% reduction of contrast-enhanced MRI asse... Abstract
Cited 8 times since 2018 (1.3 per year) source: EuropePMC
Nutrients, Volume 10, Issue 2, 3 1 2018, Pages E172 The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice. Hoving LR, de Vries MR, de Jong RCM, Katiraei S, Pronk A, Quax PHA, van Harmelen V, Willems van Dijk K
The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce ac... Abstract
Acta radiologica (Stockholm, Sweden : 1987), Volume 59, Issue 9, 29 5 2018, Pages 1074-1081 Early animal model evaluation of an implantable contrast agent to enhance magnetic resonance imaging of arterial bypass vein grafts. Mitsouras D, Tao M, de Vries MR, Trocha K, Miranda OR, Vemula PK, Ding K, Imanzadeh A, Schoen FJ, Karp JM, Ozaki CK, Rybicki FJ
Background Non-invasive monitoring of autologous vein graft (VG) bypass grafts is largely limited to detecting late luminal narrowing. Although magnetic resonance imaging (MRI) delineates vein graft intima, media, and adventitia, which may detect early failure, the scan time required to achieve sufficient resolution is at present impractical. Purpose To study VG visualization enhancement in vivo and delineate whether a covalently attached MRI contrast agent would enable quicker longitudinal imag... Abstract
Cited 49 times since 2018 (7.8 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 5, 24 4 2018, Pages 3 Inflammation in Vein Graft Disease. de Vries MR, Quax PHA
Bypass surgery is one of the most frequently used strategies to revascularize tissues downstream occlusive atherosclerotic lesions. For venous bypass surgery the great saphenous vein is the most commonly used vessel. Unfortunately, graft efficacy is low due to the development of vascular inflammation, intimal hyperplasia and accelerated atherosclerosis. Moreover, failure of grafts leads to significant adverse outcomes and even mortality. The last couple of decades not much has changed in the tre... Abstract
Cited 18 times since 2017 (2.7 per year) source: EuropePMC
PloS one, Volume 12, Issue 10, 10 2 2017, Pages e0185820 The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. de Jong RCM, Ewing MM, de Vries MR, Karper JC, Bastiaansen AJNM, Peters HAB, Baghana F, van den Elsen PJ, Gongora C, Jukema JW, Quax PHA
Objective: Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia development. We studied the contributing role of PCAF in post-interventional intimal hyperplasia. Methods and results: PCAF contribution to inflammation and intimal hyperplasia was assessed in leukocytes, macrophages and vascular smoot... Abstract
Cited 8 times since 2017 (1.2 per year) source: EuropePMC
Journal of internal medicine, Volume 282, Issue 6, 27 4 2017, Pages 522-536 A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons. Simons KH, Peters HAB, Jukema JW, de Vries MR, Quax PHA
Background: Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type I interferons (IFN) and type I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with regard to the interplay of IRFs and TLRs in VGD development. The aim of this study was to investigate the role of IRF3 and IRF7 signaling downstream TLRs and the effect of IRF3 and IRF7 in VGD. Methods a... Abstract