Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
240 results
Cited 20 times since 2017 (2.8 per year) source: EuropePMC
Cardiovascular research, Volume 113, Issue 3, 1 1 2017, Pages 354-366 Optogenetic manipulation of anatomical re-entry by light-guided generation of a reversible local conduction block. Watanabe M, Feola I, Majumder R, Jangsangthong W, Teplenin AS, Ypey DL, Schalij MJ, Zeppenfeld K, de Vries AA, Pijnappels DA
Aims: Anatomical re-entry is an important mechanism of ventricular tachycardia, characterized by circular electrical propagation in a fixed pathway. It's current investigative and therapeutic approaches are non-biological, rather unspecific (drugs), traumatizing (electrical shocks), or irreversible (ablation). Optogenetics is a new biological technique that allows reversible modulation of electrical function with unmatched spatiotemporal precision using light-gated ion channels. We therefor... Abstract
Cited 9 times since 2017 (1.2 per year) source: EuropePMC
Archives of cardiovascular diseases, Volume 110, Issue 5, 17 3 2017, Pages 354-362 Ventricular arrhythmias and sudden death in tetralogy of Fallot. Maury P, Sacher F, Rollin A, Mondoly P, Duparc A, Zeppenfeld K, Hascoet S, Réseau francophone de rythmologie pédiatrique et congénitale
Malignant ventricular arrhythmias and sudden cardiac death may late happen in repaired tetralogy of Fallot, although probably less frequently than previously thought, especially with the advent of new surgical techniques/management. Ventricular tachycardias are caused by reentry around the surgical scars/patches and valves. Many predictive factors have been proposed, which suffer from poor accuracy. There is currently no recommended indication for prophylactic implantable cardioverter defibrilla... Abstract
Cited 27 times since 2017 (3.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 69, Issue 5, 1 1 2017, Pages 497-507 Isolated Subepicardial Right Ventricular Outflow Tract Scar in Athletes With Ventricular Tachycardia. Venlet J, Piers SR, Jongbloed JD, Androulakis AF, Naruse Y, den Uijl DW, Kapel GF, de Riva M, van Tintelen JP, Barge-Schaapveld DQ, Schalij MJ, Zeppenfeld K
Background: High-level endurance training has been associated with right ventricular pathological remodeling and ventricular tachycardia (VT). Although overlap with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been suggested, the arrhythmogenic substrate for VTs in athletes is unknown. Objectives: The goal of this study was to evaluate whether electroanatomic scar patterns related to sustained VT can distinguish exercise-induced arrhythmogenic remodeling from ARVC and post-inflamma... Abstract
Cited 39 times since 2017 (5.3 per year) source: EuropePMC
European heart journal, Volume 38, Issue 4, 1 1 2017, Pages 268-276 Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired Tetralogy of Fallot. Kapel GF, Sacher F, Dekkers OM, Watanabe M, Blom NA, Thambo JB, Derval N, Schalij MJ, Jalal Z, Wijnmaalen AP, Zeppenfeld K
Cardiac electrophysiology clinics, Volume 9, Issue 1, 24 4 2016, Pages 107-117 Ablation of Ventricular Tachycardia in Congenital and Infiltrative Heart Disease. Wijnmaalen AP, Zeppenfeld K
Radiofrequency catheter ablation (RFCA) is an important treatment modality to prevent ventricular tachycardia (VT) recurrence in patients with repaired congenital heart disease. Identification and ablation of anatomic isthmuses has improved acute ablation outcome with excellent VT-free survival in those with preserved biventricular function. Reports on RFCA for VT in patients with infiltrative disease are sparse and cardiac sarcoidosis seems to be the most prevalent cause for ventricular arrhyth... Abstract
Cited 9 times since 2016 (1.2 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 9, Issue 12, 1 1 2016, Pages e004432 Prognostic Impact of the Timing of Recurrence of Infarct-Related Ventricular Tachycardia After Catheter Ablation. Siontis KC, Kim HM, Stevenson WG, Fujii A, Bella PD, Vergara P, Shivkumar K, Tung R, Do DH, Daoud EG, Okabe T, Zeppenfeld K, Riva Silva M, Hindricks G, Arya A, Weber A, Kuck KH, Metzner A, Mathew S, Riedl J, Yokokawa M, Jongnarangsin K, Latchamsetty R, Morady F, Bogun FM
Background: Recurrence of ventricular tachycardia (VT) after ablation in patients with previous myocardial infarction is associated with adverse prognosis. However, the impact of the timing of VT recurrence on outcomes is unclear. Methods and results: We analyzed data from a multicenter collaborative database of patients who underwent catheter ablation for infarct-related VT. Multivariable Cox regression analyses investigated the effect of the timing of VT recurrence on the composite outcome of... Abstract
Cited 118 times since 2016 (15.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 68, Issue 21, 1 1 2016, Pages 2299-2307 Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers. Kumar S, Baldinger SH, Gandjbakhch E, Maury P, Sellal JM, Androulakis AF, Waintraub X, Charron P, Rollin A, Richard P, Stevenson WG, Macintyre CJ, Ho CY, Thompson T, Vohra JK, Kalman JM, Zeppenfeld K, Sacher F, Tedrow UB, Lakdawala NK
Background: Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain. Objectives: This study sought to describe the arrhythmic and nonarrhythmic outcomes of LMNA mutation carriers and to assess the prognostic s... Abstract
Cited 395 times since 2016 (52 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 5, 23 4 2016, Pages e1-e88 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K
Cited 828 times since 2016 (107.9 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 18, Issue 11, 27 4 2016, Pages 1609-1678 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K
Cited 8 times since 2016 (1 per year) source: EuropePMC
Arrhythmia & electrophysiology review, Volume 5, Issue 2, 1 1 2016, Pages 150-160 Anatomical Substrates and Ablation of Reentrant Atrial and Ventricular Tachycardias in Repaired Congenital Heart Disease. Brouwer C, Hazekamp MG, Zeppenfeld K
Advances in surgical repair techniques for various types of congenital heart disease have improved survival into adulthood over the past decades, thus exposing these patients to a high risk of atrial and ventricular arrhythmias later in life. These arrhythmias arise from complex arrhythmogenic substrates. Substrate formation may depend on both pathological myocardial remodelling and variable anatomical boundaries, determined by the type and timing of prior corrective surgery. Accordingly, arrhyt... Abstract
Cited 32 times since 2016 (4.1 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 9, Issue 8, 1 1 2016, Pages e004357 Multicenter Experience With Catheter Ablation for Ventricular Tachycardia in Lamin A/C Cardiomyopathy. Kumar S, Androulakis AF, Sellal JM, Maury P, Gandjbakhch E, Waintraub X, Rollin A, Richard P, Charron P, Baldinger SH, Macintyre CJ, Koplan BA, John RM, Michaud GF, Zeppenfeld K, Sacher F, Lakdawala NK, Stevenson WG, Tedrow UB
Background: Lamin A/C (LMNA) cardiomyopathy is a genetic disease with a proclivity for ventricular arrhythmias. We describe the multicenter experience with percutaneous catheter ablation of sustained monomorphic ventricular tachycardia (VT) in LMNA cardiomyopathy. Methods and results: Twenty-five consecutive LMNA mutation patients from 4 centers were included (mean age, 55±9 years; ejection fraction, 34±12%; VT storm in 36%). Complete atrioventricular block was present in 11 patients; 3 patients... Abstract
Cited 5 times since 2016 (0.6 per year) source: EuropePMC
Herzschrittmachertherapie & Elektrophysiologie, Volume 27, Issue 2, 19 3 2016, Pages 131-136 Ventricular tachycardia in repaired congenital heart disease. Zeppenfeld K
Ventricular arrhythmias are an important cause of late morbidity and sudden cardiac death in the growing population of adults with repaired congenital heart disease. Risk stratification remains challenging because of the heterogeneity of the malformations and the surgical approaches. Therapeutic interventions depend on the type of ventricular arrhythmia, which can be polymorphic ventricular tachycardia (VT) or ventricular fibrillation in patients without ventricular scars, but also potentially f... Abstract
Cited 6 times since 2016 (0.7 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 143-151 Outcome of stand-alone thoracoscopic epicardial left atrial posterior box isolation with bipolar radiofrequency energy for longstanding persistent atrial fibrillation. Compier MG, Braun J, Tjon A, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA
Introduction: Catheter ablation of longstanding (> 1 year) persistent atrial fibrillation (AF) is associated with poor outcome. This might be due to remodelling and fibrosis formation, mainly located in the posterior left atrial (LA) wall. Therefore, we adopted a thoracoscopic epicardial box isolation of the posterior left atrium using bipolar RF energy with intraoperative testing of conduction block. Methods and results: Bilateral thoracoscopic box isolation was performed with a bipolar RF c... Abstract
Cited 3 times since 2015 (0.4 per year) source: EuropePMC
Heart rhythm, Volume 13, Issue 4, 14 2 2015, Pages 860-869 QRS prolongation after premature stimulation is associated with polymorphic ventricular tachycardia in nonischemic cardiomyopathy: Results from the Leiden Nonischemic Cardiomyopathy Study. Piers SR, Askar SF, Venlet J, Androulakis AF, Kapel GF, de Riva Silva M, Jongbloed JJ, van Tintelen JP, Schalij MJ, Pijnappels DA, Zeppenfeld K
Background: Progressive activation delay after premature stimulation has been associated with ventricular fibrillation in nonischemic cardiomyopathy (NICM). Objectives: The objectives of this study were (1) to investigate prolongation of the paced QRS duration (QRSd) after premature stimulation as a marker of activation delay in NICM, (2) to assess its relation to induced ventricular arrhythmias, and (3) to analyze its underlying substrate by late gadolinium enhancement cardiac magnetic resonanc... Abstract
Cited 20 times since 2015 (2.4 per year) source: EuropePMC
Heart rhythm, Volume 13, Issue 4, 8 2 2015, Pages 905-912 Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus. Ten Sande JN, Postema PG, Boekholdt SM, Tan HL, van der Heijden JF, de Groot NM, Volders PG, Zeppenfeld K, Boersma LV, Nannenberg EA, Christiaans I, Wilde AA
Background: Familial idiopathic ventricular fibrillation (IVF) is a severe disease entity and is notoriously difficult to manage because there are no clinical risk indicators for premature cardiac arrest. Previously, we identified a link between familial IVF and a risk haplotype on chromosome 7q36 (involving the arrhythmia gene DPP6). Objective: The purpose of this study was to expand our knowledge of familial IVF and to discuss its (extended) clinical characteristics. Methods: We studied 601 fa... Abstract
Journal of the American College of Cardiology, Volume 66, Issue 22, 1 1 2015, Pages 2576-2577 Reply: Elimination of All Inducible Ventricular Tachycardias as the Endpoint for Ablation. Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun F
Cited 19 times since 2015 (2.3 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 27, Issue 1, 25 4 2015, Pages 80-87 VT Recurrence After Ablation: Incomplete Ablation or Disease Progression? A Multicentric European Study. Berte B, Sacher F, Venlet J, Andreu D, Mahida S, Aldhoon B, DE Potter T, Sarkozy A, Tavernier R, Andronache M, Deneke T, Kautzner J, Berruezo A, Cochet H, Zeppenfeld K, Jaïs P
Aim: To determine whether ventricular tachycardia (VT) recurrences in arrhythmogenic RV cardiomyopathy (ARVC) and nonischemic cardiomyopathy (NICM) are related to incomplete ablation or disease progression. Methods: ARVC and NICM patients with two substrate maps of the same diseased ventricle with an interprocedural delay of ≥12 months were included. Disease progression was defined as ≥1 factor: scar area progression (PROG, +5%), ventricular remodeling (dilatation [+25 mL] or decreased ejection... Abstract
Cited 9 times since 2015 (1 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 6, 18 3 2015, Pages 1452-1459 Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function. van Huls van Taxis CF, Piers SR, de Riva Silva M, Dekkers OM, Pijnappels DA, Schalij MJ, Wijnmaalen AP, Zeppenfeld K
Background: High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients may be symptomatic before left ventricular (LV) dysfunction develops. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and circumferential end-systolic wall stress (cESS) on echocardiography are markers for increased ventricular wall stress. This study aimed to evaluate the relation between presenting symptoms, PVC burden, and increased ventricular wall s... Abstract
Cited 7 times since 2015 (0.8 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 4, 1 1 2015, Pages 951-962 Twelve-lead ECG of ventricular tachycardia in structural heart disease. de Riva M, Watanabe M, Zeppenfeld K
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 9, 1 1 2015, Pages 453-454 Carotid sinus massage for diagnosis in narrow QRS tachycardia. Henkens IR, Zeppenfeld K, Hauer AD