Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 24 times since 2011 (1.8 per year) source: EuropePMC
Thrombosis research, Volume 128, Issue 1, 30 5 2011, Pages 21-26 A simple non-invasive diagnostic algorithm for ruling out chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Klok FA, Surie S, Kempf T, Eikenboom J, van Straalen JP, van Kralingen KW, van Dijk AP, Vliegen HW, Bresser P, Wollert KC, Huisman MV
Background: Our aim was to construct a diagnostic model for ruling out chronic thromboembolic pulmonary hypertension (CTEPH) in symptomatic patients after acute pulmonary embolism (PE) that is based on simple, non-invasive tests. Methods: Plasma levels of various CTEPH associated biomarkers and conventional ECG criteria for right ventricular pressure overload were assessed in 82 consecutive patients with confirmed CTEPH and 160 consecutive patients with a history of PE who were suspected to have... Abstract
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 3 2011 WITHDRAWN: Predictors of long-term survival in pulmonary hypertension treated with bosentan. Bresser P, Vis JC, Berger RM, Vliegen HW, Vonk MC, Snijder RJ, van den Toorn LM, van Dijk AP, Boomars KA, van Daal GJ, Mulder BJ
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy. Abstract
Cited 5 times since 2011 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 158, Issue 3, 12 2 2011, Pages 359-363 Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot. Luijnenburg SE, de Koning WB, Romeih S, van den Berg J, Vliegen HW, Mulder BJ, Helbing WA
Background: We hypothesized 1) that long-term ventricular outcome and exercise capacity would be better in patients with isolated pulmonary valve stenosis (PS) treated with balloon pulmonary valvuloplasty (BPV) than in patients operated for tetralogy of Fallot (TOF), and 2) that ventricular outcome and exercise capacity would not be different in PS patients and healthy controls. Methods: We included 21 PS patients after BPV (16.2 ± 5.2 years) and 21 patients operated for TOF (16.6 ± 5.6 years),... Abstract
Cited 18 times since 2011 (1.4 per year) source: EuropePMC
American heart journal, Volume 161, Issue 2, 1 1 2011, Pages 269-275.e1 Associations between cardiovascular parameters and uteroplacental Doppler (blood) flow patterns during pregnancy in women with congenital heart disease: Rationale and design of the Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II study. Balci A, Sollie KM, Mulder BJ, de Laat MW, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG
Background: Previous research has shown that women with congenital heart disease (CHD) are more susceptible to cardiovascular, obstetric, and offspring events. The causative pathophysiologic mechanisms are incompletely understood. Inadequate uteroplacental circulation is an important denominator in adverse obstetric events and offspring outcome. The relation between cardiac function and uteroplacental perfusion has not been investigated in women with CHD. Moreover, the effects of physiologic cha... Abstract
Cited 37 times since 2011 (2.8 per year) source: EuropePMC
American heart journal, Volume 161, Issue 2, 15 3 2011, Pages 307-313 Pregnancy in women with corrected tetralogy of Fallot: occurrence and predictors of adverse events. Balci A, Drenthen W, Mulder BJ, Roos-Hesselink JW, Voors AA, Vliegen HW, Moons P, Sollie KM, van Dijk AP, van Veldhuisen DJ, Pieper PG
Background: In women with corrected tetralogy of Fallot (ToF), pregnancy is associated with maternal cardiac, obstetric, and offspring complications. Our aim is to investigate the magnitude and determinants of pregnancy outcome in women with corrected ToF. Methods: In this retrospective international multicenter study using 2 congenital heart disease registries, 204 women with corrected ToF were identified. Within this group, 74 women had 157 pregnancies, including 30 miscarriages and 4 terminat... Abstract
Cited 10 times since 2010 (0.7 per year) source: EuropePMC
American heart journal, Volume 160, Issue 5, 1 1 2010, Pages 812-818 Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesslink JW, Zwinderman AH, Mulder BJ
Background: Angiotensin II receptor blockers have been proven to be beneficial in left ventricular failure. In patients with a morphologic right ventricle supporting the systemic circulation, its efficacy has not yet been established. Methods: We designed a multicenter, prospective, randomized, double-blind, placebo-controlled trial studying the effect of valsartan in patients with a systemic right ventricle due to a congenitally or surgically corrected transposition of the great arteries. The p... Abstract
Cited 35 times since 2010 (2.6 per year) source: EuropePMC
Respiratory medicine, Volume 104, Issue 11, 1 1 2010, Pages 1744-1749 Prevalence and potential determinants of exertional dyspnea after acute pulmonary embolism. Klok FA, van Kralingen KW, van Dijk AP, Heyning FH, Vliegen HW, Huisman MV
Background: The exact prevalence and etiology of exertional dyspnea in the clinical course of acute pulmonary embolism (PE) have not yet been established. Methods: A large cohort of consecutive patients diagnosed with acute PE was subjected to a dyspnea questionnaire and invited for cardiopulmonary work-up including the 6-min walk test, spirometry and echocardiography. The prevalence, severity, determinants and underlying diseases of exertional dyspnea were evaluated. Results: Of the registered... Abstract
Cited 10 times since 2010 (0.7 per year) source: EuropePMC
American heart journal, Volume 160, Issue 5, 1 1 2010, Pages 870-876 Ventricular response to stress predicts outcome in adult patients with a systemic right ventricle. Winter MM, Scherptong RW, Kumar S, Bouma BJ, Tulevski II, Tops LF, Roest AA, Vliegen HW, de Roos A, Groenink M, Mulder BJ
Background: Previous studies demonstrated that ventricular response to stress cardiovascular magnetic resonance (CMR) is frequently abnormal in patients with a systemic right ventricle (RV). However, the clinical implications of these findings remained unknown. We sought to evaluate whether abnormal response to stress CMR predicts adverse outcome in patients with a systemic RV. Methods: Thirty-nine adult patients (54% male; mean age 26, range 18-65 years) with a systemic RV underwent stress CMR... Abstract
Cited 11 times since 2010 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 8, 1 1 2010, Pages 1163-8, 1168.e1-8 Sexuality in adult patients with congenital heart disease and their partners. Winter MM, Reisma C, Kedde H, Bouma BJ, Vis JC, Luijendijk P, de Witte P, Zwinderman AH, Vliegen HW, Pieper PG, van Dijk AP, Mulder BJ
Data on relational and sexuality issues in adult patients with congenital heart disease (CHD) are scarce. The present study aimed to evaluate relational and sexual behaviors, satisfaction, and functioning in a representative sample of patients with CHD and their partners. In addition, we aimed to evaluate the relation between sexuality parameters and quality of life. Relational and sexuality issues were assessed using a sexuality questionnaire in 133 patients (52% men, 37 ± 13 years old) with CH... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 18, Issue 10, 1 1 2010, Pages 464-465 Coronary artery anomalies, detection by dual-source computed tomography angiography. Vliegen HW
Cited 49 times since 2010 (3.6 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 56, Issue 18, 1 1 2010, Pages 1486-1492 Follow-up after pulmonary valve replacement in adults with tetralogy of Fallot: association between QRS duration and outcome. Scherptong RW, Hazekamp MG, Mulder BJ, Wijers O, Swenne CA, van der Wall EE, Schalij MJ, Vliegen HW
Objectives: The aim of this study was to analyze whether QRS duration, before and after pulmonary valve replacement (PVR), is related to long-term outcome in patients with tetralogy of Fallot (TOF). Background: Key factors that determine outcome after PVR in adult TOF patients are largely unknown. Recognition of such factors assists the identification of patients at increased risk of adverse events. Methods: Adults who previously underwent total correction for TOF (n=90; age 31.4±10.3 years) and... Abstract
Cited 217 times since 2010 (15.7 per year) source: EuropePMC
European heart journal, Volume 31, Issue 17, 28 4 2010, Pages 2124-2132 Predictors of pregnancy complications in women with congenital heart disease. Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, Vliegen HW, van Dijk AP, Voors AA, Yap SC, van Veldhuisen DJ, Pieper PG, ZAHARA Investigators
Aims: Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited. Methods and results: In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7%) and heart failure (1.6%). Factors independently associated with maternal cardiac complications were the presence of cy... Abstract
Cited 72 times since 2010 (5.2 per year) source: EuropePMC
Chest, Volume 138, Issue 6, 21 3 2010, Pages 1432-1440 Quality of life in long-term survivors of acute pulmonary embolism. Klok FA, van Kralingen KW, van Dijk AP, Heyning FH, Vliegen HW, Kaptein AA, Huisman MV
Background: To our knowledge, studies evaluating the quality of life (QoL) in patients with a history of acute pulmonary embolism (PE) are not available, even though QoL is a key outcome component of medical care and a predictor of disease-specific prognosis. Methods: As part of a large follow-up study, the Short Form 36 (SF-36) was presented to consecutive patients who had survived one or more episodes of acute PE. The results of all nine subscales of the SF-36 were compared with sex- and age-a... Abstract
Cited 257 times since 2010 (18.2 per year) source: EuropePMC
European heart journal, Volume 31, Issue 10, 5 1 2010, Pages 1220-1229 Mortality in adult congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, van Dijk AP, Vliegen HW, Grobbee DE, Mulder BJ
Aims: Mortality in adults with congenital heart disease is known to be increased, yet its extent and the major mortality risks are unclear. Methods and results: The Dutch CONCOR national registry for adult congenital heart disease was linked to the national mortality registry. Cox's regression was used to assess mortality predictors. Of 6933 patients, 197 (2.8%) died during a follow-up of 24 865 patient-years. Compared with the general national population, there was excess mortality, partic... Abstract
Cited 18 times since 2010 (1.3 per year) source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology, Volume 117, Issue 6, 15 3 2010, Pages 683-689 Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect. Yap SC, Drenthen W, Pieper PG, Moons P, Mulder BJ, Vliegen HW, van Dijk AP, Meijboom FJ, Jaddoe VW, Steegers EA, Boersma E, Roos-Hesselink JW, ZAHARA investigators
Objective: To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD). Design: A retrospective multicentre study. Setting: Tertiary centres in the Netherlands and Belgium. Methods: Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy (n = 147... Abstract
Cited 112 times since 2010 (7.8 per year) source: EuropePMC
Haematologica, Volume 95, Issue 6, 6 1 2010, Pages 970-975 Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Klok FA, van Kralingen KW, van Dijk AP, Heyning FH, Vliegen HW, Huisman MV
Background: Chronic thromboembolic pulmonary hypertension after pulmonary embolism is associated with high morbidity and mortality. Understanding the incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism is important for evaluating the need for screening but is also a subject of debate because of different inclusion criteria among previous studies. We determined the incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism and the uti... Abstract
Cited 76 times since 2009 (5.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 181, Issue 5, 3 1 2009, Pages 501-506 Patient outcomes after acute pulmonary embolism. A pooled survival analysis of different adverse events. Klok FA, Zondag W, van Kralingen KW, van Dijk AP, Tamsma JT, Heyning FH, Vliegen HW, Huisman MV
Rationale: There is a lack of information on the long-term prognosis of patients with acute pulmonary embolism (PE). Objectives: To assess the long-term risk for adverse events after PE. Methods: Consecutive patients diagnosed with PE between January 2001 and July 2007, and patients in whom PE was ruled out from a previous study were followed until July 2008 for the occurrence of adverse clinical events: mortality, symptomatic recurrent venous thromboembolism, cancer, arterial cardiovascular eve... Abstract
Cited 66 times since 2009 (4.5 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 26, Issue 1, 16 3 2009, Pages 57-64 Intra-observer and interobserver variability of biventricular function, volumes and mass in patients with congenital heart disease measured by CMR imaging. Luijnenburg SE, Robbers-Visser D, Moelker A, Vliegen HW, Mulder BJ, Helbing WA
Cardiovascular magnetic resonance (CMR) imaging provides highly accurate measurements of biventricular volumes and mass and is frequently used in the follow-up of patients with acquired and congenital heart disease (CHD). Data on reproducibility are limited in patients with CHD, while measurements should be reproducible, since CMR imaging has a main contribution to decision making and timing of (re)interventions. The aim of this study was to assess intra-observer and interobserver variability of... Abstract
Cited 20 times since 2009 (1.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 23, 25 4 2009, Pages 1931-1936 Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement. Grotenhuis HB, Ottenkamp J, de Bruijn L, Westenberg JJ, Vliegen HW, Kroft LJ, de Roos A
Background: Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function. Objective: To assess aortic dimensions, aortic elasticity, aortic valve competence and biventricular function in repaired TOF patients after pulmonary valve replacement (PVR) using magnetic resonance imaging (MRI). Methods: MRI was performed in 16 patients with TOF after PVR (10 male; mean a... Abstract
Cited 40 times since 2009 (2.7 per year) source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology, Volume 116, Issue 12, 13 2 2009, Pages 1593-1601 Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect. Yap SC, Drenthen W, Meijboom FJ, Moons P, Mulder BJ, Vliegen HW, van Dijk AP, Jaddoe VW, Steegers EA, Roos-Hesselink JW, Pieper PG, ZAHARA investigators
Objective: To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design: A retrospective multicentre study. Setting: Tertiary centres in the Netherlands and Belgium. Population: Women with ASD without associated complex cardiac lesions. Methods: Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 m... Abstract